The DOI matches its Crossref record; 167 of the 167 references it cites were found in a registry or an index.
The role of mitochondria in stem cell fate and aging
Open accessAbstract
The importance of mitochondria in energy metabolism, signal transduction and aging in post-mitotic tissues has been well established. Recently, the crucial role of mitochondrial-linked signaling in stem cell function has come to light and the importance of mitochondria in mediating stem cell activity is becoming increasingly recognized. Despite the fact that many stem cells exhibit low mitochondrial content and a reliance on mitochondrial-independent glycolytic metabolism for energy, accumulating evidence has implicated the importance of mitochondrial function in stem cell activation, fate decisions and defense against senescence. In this Review, we discuss the recent advances that link mitochondrial metabolism, homeostasis, stress responses, and dynamics to stem cell function, particularly in the context of disease and aging. This Review will also highlight some recent progress in mitochondrial therapeutics that may present attractive strategies for improving stem cell function as a basis for regenerative medicine and healthy aging.
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1 retracted
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Cited by
RNA modifications modulate gene expression during development
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Fumarate is a terminal electron acceptor in the mammalian electron transport chain
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Metadata
- Authors
- Zhang, H., Menzies, K. J., & Auwerx, J.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2018-04-13
- Volume
- 145
- Issue
- 8
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2796961799
- Cited by
- 284
- References
- 167
- FWCI
- 9.97
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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