The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
RNA modifications modulate gene expression during development
Open accessAbstract
RNA modifications have recently emerged as critical posttranscriptional regulators of gene expression programs. They affect diverse eukaryotic biological processes, and the correct deposition of many of these modifications is required for normal development. Messenger RNA (mRNA) modifications regulate various aspects of mRNA metabolism. For example, N 6 -methyladenosine (m 6 A) affects the translation and stability of the modified transcripts, thus providing a mechanism to coordinate the regulation of groups of transcripts during cell state maintenance and transition. Similarly, some modifications in transfer RNAs are essential for RNA structure and function. Others are deposited in response to external cues and adapt global protein synthesis and gene-specific translational accordingly and thereby facilitate proper development.
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Cites
N6-methyladenosine-dependent regulation of messenger RNA stability
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“For example, YTHDF2 binds to m 6 A in mRNA and targets the transcripts for degradation ( 3, 8 ), and YTHDF1, YTHDF3 and eIF3a promote translation of m 6 A containing transcripts ( 3, 9, 10 ).”
Self-citationComprehensive Analysis of mRNA Methylation Reveals Enrichment in 3′ UTRs and near Stop Codons
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Self-citationALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility
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Self-citationN6-methyladenosine Modulates Messenger RNA Translation Efficiency
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Self-citationRecognition of RNA N6-methyladenosine by IGF2BP proteins enhances mRNA stability and translation
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Self-citationm6A RNA methylation promotes XIST-mediated transcriptional repression
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Biogenesis and function of tRNA fragments during sperm maturation and fertilization in mammals
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R-2HG Exhibits Anti-tumor Activity by Targeting FTO/m6A/MYC/CEBPA Signaling
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“Inhibition of FTO reduces AML cell proliferation and viability in these cell types ( 59, 60 ).”
Self-citationCodon optimality, bias and usage in translation and mRNA decay
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“1B) ( 15, 16 ).”
Cited by
Liu, J., Dou, X., Chen, C., Chen, C., Liu, C., Xu, M. M., Zhao, S., Shen, B., Gao, Y., Han, D., et al. (2020) · Science · doi:10.1126/science.aay6018 · Cited by 709
Self-citationChang, G., Shi, L., Ye, Y., Shi, H., Zeng, L., Tiwary, S., Huse, J. T., Huo, L., Ma, L., Ma, Y., et al. (2020) · Cancer Cell · doi:10.1016/j.ccell.2020.10.004 · Cited by 412
Self-citationThe m6A epitranscriptome: transcriptome plasticity in brain development and function
Livneh, I., Moshitch-Moshkovitz, S., Amariglio, N., Rechavi, G., & Dominissini, D. (2020) · Nature Reviews Neuroscience · doi:10.1038/s41583-019-0244-z · Cited by 330
Alternative ORFs and small ORFs: shedding light on the dark proteome
Orr, M. W., Mao, Y., Storz, G., & Qian, S.-B. (2020) · Nucleic Acids Research · doi:10.1093/nar/gkz734 · Cited by 319
Crosstalk between epitranscriptomic and epigenetic mechanisms in gene regulation
Kan, R. L., Chen, J., & Sallam, T. (2022) · Trends in Genetics · doi:10.1016/j.tig.2021.06.014 · Cited by 308
Metadata
- Authors
- Frye, M., Harada, B. T., Behm, M., & He, C.
- Venue
- Science
- Published
- 2018-09-28
- Volume
- 361
- Issue
- 6409
- Pages
- 1346-1349
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2893050222
- Cited by
- 1,249
- References
- 17
- FWCI
- 29.66
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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