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A high-sugar diet produces obesity and insulin resistance in wild-type Drosophila

Open access
Palanker Musselman, Laura, Fink, Jill L., Narzinski, Kirk, Ramachandran, Prasanna Venkatesh, Sukumar Hathiramani, Sumitha, Cagan, Ross L., Baranski, Thomas J.·2011·Disease Models & Mechanisms
DOI 10.1242/dmm.007948
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Abstract

SUMMARY: Insulin-resistant, ‘type 2’ diabetes (T2D) results from a complex interplay between genes and environment. In particular, both caloric excess and obesity are strongly associated with T2D across many genetic backgrounds. To gain insights into how dietary excess affects insulin resistance, we studied the simple model organism Drosophila melanogaster. Larvae reared on a high-sugar diet were hyperglycemic, insulin resistant and accumulated fat – hallmarks of T2D – compared with those reared on control diets. Excess dietary sugars, but not fats or proteins, elicited insulin-resistant phenotypes. Expression of genes involved in lipogenesis, gluconeogenesis and β-oxidation was upregulated in high-sugar-fed larvae, as were FOXO targets, consistent with known mechanisms of insulin resistance in humans. These data establish a novel Drosophila model of diet-induced insulin resistance that bears strong similarity to the pathophysiology of T2D in humans.

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Show all 10 references

Research works printed but not linked: 31

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Metadata

Authors
Palanker Musselman, L., Fink, J. L., Narzinski, K., Ramachandran, P. V., Sukumar Hathiramani, S., Cagan, R. L., & Baranski, T. J.
Venue
Disease Models & Mechanisms
Publisher
The Company of Biologists
Published
2011-11-01
Volume
4
Issue
6
Pages
842-849
ISSN
  • 1754-8403 (ISSN-L)
  • 1754-8411
DOI
10.1242/dmm.007948
OpenAlex
W2153551557
Cited by
563
References
10
FWCI
12.71
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: A high-sugar diet produces obesity and insulin resistance in wild-type Drosophila. https://app.cochat.ai/papers/10.1242/dmm.007948
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Palanker Musselman, L., Fink, J. L., Narzinski, K., Ramachandran, P. V., Sukumar Hathiramani, S., Cagan, R. L., & Baranski, T. J. (2011). A high-sugar diet produces obesity and insulin resistance in wild-type Drosophila. Disease Models & Mechanisms. https://doi.org/10.1242/dmm.007948

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