The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Dietary composition specifies consumption, obesity, and lifespan in Drosophila melanogaster
Open accessAbstract
Summary: The inability to properly balance energy intake and expenditure with nutrient supply forms the basis for some of today's most pressing health issues, including diabetes and obesity. Mechanisms of nutrient homeostasis may also lie at the root of dietary restriction, a manipulation whereby reduced nutrient availability extends lifespan and ameliorates age‐related deteriorations in many species. The traditional belief that the most important aspect of the diet is its energetic (i.e. caloric) content is currently under scrutiny. Hypotheses that focus on diet composition and highlight more subtle characteristics are beginning to emerge. Using Drosophila melanogaster, we asked whether diet composition alone, independent of its caloric content, was sufficient to impact behavior, physiology, and lifespan. We found that providing flies with a yeast‐rich diet produced lean, reproductively competent animals with reduced feeding rates. Excess dietary sugar, on the other hand, promoted obesity, which was magnified during aging. Addition of dietary yeast often limited or reversed the phenotypic changes associated with increased dietary sugar and vice versa, and dietary imbalance was associated with reduced lifespan. Our data reveal that diet composition, alone and in combination with overall caloric intake, modulates lifespan, consumption, and fat deposition in flies, and they provide a useful foundation for dissecting the underlying genetic mechanisms that link specific nutrients with important aspects of general health and longevity.
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Cites
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Evolutionary medicine: from dwarf model systems to healthy centenarians?
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“Dietary restriction extends lifespan in a range of species, and it delays or eliminates a wide range of diseases and age-dependent deteriorations in mammals (Longo & Finch, 2003).”
BackgroundBody composition estimates from NHANES III bioelectrical impedance data
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BackgroundDietary deprivation extends lifespan in Caenorhabditis elegans
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“Diets with a low protein/carbohydrate ratio may stimulate increased feeding, and therefore increased energy uptake, in order to satisfy a basic requirement for protein-based energy (Sorensen et al., 2008).”
Background
Cited by
Amino-acid imbalance explains extension of lifespan by dietary restriction in Drosophila
Grandison, R. C., Piper, M. D. W., & Partridge, L. (2009) · Nature · doi:10.1038/nature08619 · Cited by 773
Paternal Diet Defines Offspring Chromatin State and Intergenerational Obesity
Öst, A., Lempradl, A., Casas, E., Weigert, M., Tiko, T., Deniz, M., Pantano, L., Boenisch, U., Itskov, P. M., Stoeckius, M., et al. (2014) · Cell · doi:10.1016/j.cell.2014.11.005 · Cited by 406
Dietary restriction and lifespan: lessons from invertebrate models
Kapahi, P., Kaeberlein, M., & Hansen, M. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2016.12.005 · Cited by 340
Drosophila as a model for ageing
Piper, M. D. W., & Partridge, L. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2017.09.016 · Cited by 273
Macronutrient balance, reproductive function, and lifespan in aging mice
Solon-Biet, S. M., Walters, K. A., Simanainen, U. K., McMahon, A. C., Ruohonen, K., Ballard, J. W. O., Raubenheimer, D., Handelsman, D. J., Le Couteur, D. G., & Simpson, S. J. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1422041112 · Cited by 243
Metadata
- Authors
- Skorupa, D. A., Dervisefendic, A., Zwiener, J., & Pletcher, S. D.
- Venue
- Aging Cell
- Publisher
- Wiley
- Published
- 2008-07-10
- Volume
- 7
- Issue
- 4
- Pages
- 478-490
- ISSN
- 1474-9718 (ISSN-L)
- 1474-9726
- OpenAlex
- W2114008231
- Cited by
- 437
- References
- 7
- FWCI
- 4.88
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Skorupa, D. A., Dervisefendic, A., Zwiener, J., & Pletcher, S. D. (2008). Dietary composition specifies consumption, obesity, and lifespan in Drosophila melanogaster. Aging Cell. https://doi.org/10.1111/j.1474-9726.2008.00400.x
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