Cited by 426Traumatic Brain Injury and Neurovascular DisturbancesTraumatic Brain Injury ResearchAutomotive and Human Injury Biomechanics

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The pathophysiology of traumatic brain injury at a glance

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Prins, Mayumi, Greco, Tiffany, Alexander, Daya, Giza, Christopher C.·2013·Disease Models & Mechanisms

DOI 10.1242/dmm.011585PMC PMC3820255

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Abstract

Summary: Traumatic brain injury (TBI) is defined as an impact, penetration or rapid movement of the brain within the skull that results in altered mental state. TBI occurs more than any other disease, including breast cancer, AIDS, Parkinson’s disease and multiple sclerosis, and affects all age groups and both genders. In the US and Europe, the magnitude of this epidemic has drawn national attention owing to the publicity received by injured athletes and military personnel. This increased public awareness has uncovered a number of unanswered questions concerning TBI, and we are increasingly aware of the lack of treatment options for a crisis that affects millions. Although each case of TBI is unique and affected individuals display different degrees of injury, different regional patterns of injury and different recovery profiles, this review and accompanying poster aim to illustrate some of the common underlying neurochemical and metabolic responses to TBI. Recognition of these recurrent features could allow elucidation of potential therapeutic targets for early intervention.

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See all 426

Authors: Prins, M., Greco, T., Alexander, D., & Giza, C. C.
Affiliations: University of California, Los Angeles (US)
Corresponding author: Prins, Mayumi
ORCID: Prins, Mayumi
Greco, Tiffany
Giza, Christopher C.
Venue: Disease Models & Mechanisms
Publisher: The Company of Biologists
Published: 2013-01-01
Volume: 6
Issue: 6
Pages: 1307-15
ISSN: 1754-8403 (ISSN-L)
1754-8411
DOI: 10.1242/dmm.011585
PMC: PMC3820255
OpenAlex: W2141923055
Cited by: 426
References: 114
Citations by year: 2026: 7 · 2025: 29 · 2024: 37 · 2023: 40 · 2022: 41 · 2021: 55 · 2020: 55 · 2019: 40 · 2018: 46 · 2017: 27 · 2016: 14 · 2015: 24 · 2014: 8 · 2013: 3
FWCI: 10.37
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/2.0/ (am, 3059 d)
Locations: Disease Models & Mechanisms (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, other-oa)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: National Institute of Neurological Disorders and Stroke (NS-058489, P01NS058489)
Topics: Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury and Neurovascular Disturbances
Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury Research
Physical Sciences › Engineering › Biomedical Engineering › Automotive and Human Injury Biomechanics
Keywords: traumatic brain injury, pathophysiology, brain metabolism, altered mental status, injury patterns, recovery profiles, therapeutic target, TBI epidemiology
MeSH terms: Brain, Brain Injuries, Free Radicals, Glucose, Humans, Mitochondria

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