Traumatic Brain Injury: Mechanistic Insight on Pathophysiology and Potential Therapeutic Targets

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Minocycline and Neurodegenerative Diseases

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Severe traumatic brain injury: targeted management in the intensive care unit

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Antioxidant therapies in traumatic brain and spinal cord injury

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Apoptosis After Traumatic Brain Injury

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NBQX Attenuates Excitotoxic Injury in Developing White Matter

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Clinical characteristics and pathophysiological mechanisms of focal and diffuse traumatic brain injury

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Time Course of Post-Traumatic Mitochondrial Oxidative Damage and Dysfunction in a Mouse Model of Focal Traumatic Brain Injury: Implications for Neuroprotective Therapy

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Role of CCL2 (MCP-1) in traumatic brain injury (TBI): evidence from severe TBI patients and CCL2-/- mice

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Rack1, a Receptor for Activated Protein Kinase C, Interacts with Integrin β Subunit

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Cyclosporin A Attenuates Acute Mitochondrial Dysfunction Following Traumatic Brain Injury

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Rapamycin is a neuroprotective treatment for traumatic brain injury

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Oxidative stress and modification of synaptic proteins in hippocampus after traumatic brain injury

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Simvastatin-Mediated Upregulation of VEGF and BDNF, Activation of the PI3K/Akt Pathway, and Increase of Neurogenesis Are Associated with Therapeutic Improvement after Traumatic Brain Injury

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Role of Nuclear Factor Kappa B (NF-κB) Signalling in Neurodegenerative Diseases: An Mechanistic Approach

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Angiogenesis, neurogenesis and brain recovery of function following injury.

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Regulation of death receptor-mediated apoptosis pathways

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<i>In Situ</i> Detection of Inflammatory Mediators in <i>Post Mortem</i> Human Brain Tissue after Traumatic Injury

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TGF-β1 modulates microglial phenotype and promotes recovery after intracerebral hemorrhage

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The ER stress factor XBP1s prevents amyloid-β neurotoxicity

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Exacerbation of Damage and Altered NF-κB Activation in Mice Lacking Tumor Necrosis Factor Receptors after Traumatic Brain Injury

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Influence of GluN2 subunit identity on NMDA receptor function

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Stem cell repair of central nervous system injury

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Inflammasome: Its role in traumatic brain and spinal cord injury

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Role of extracellular glutamate measured by cerebral microdialysis in severe traumatic brain injury

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Embracing failure: What the Phase III progesterone studies can teach about TBI clinical trials

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Altered Calcium Signaling Following Traumatic Brain Injury

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Neurogenesis in the adult hippocampus

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Erythropoietin is neuroprotective, improves functional recovery, and reduces neuronal apoptosis and inflammation in a rodent model of experimental closed head injury

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Selective NLRP3 inflammasome inhibitor reduces neuroinflammation and improves long-term neurological outcomes in a murine model of traumatic brain injury

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Transient neuroprotection by minocycline following traumatic brain injury is associated with attenuated microglial activation but no changes in cell apoptosis or neutrophil infiltration

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Ubiquitous Calpains Promote Caspase-12 and JNK Activation during Endoplasmic Reticulum Stress-induced Apoptosis

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Mammalian Target of Rapamycin (mTOR) Activation Increases Axonal Growth Capacity of Injured Peripheral Nerves

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Rapamycin Attenuates the Development of Posttraumatic Epilepsy in a Mouse Model of Traumatic Brain Injury

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CB 1 cannabinoid receptors are involved in neuroprotection via NF-κB inhibition

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RhoA-ROCK Signaling as a Therapeutic Target in Traumatic Brain Injury

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Sulforaphane enhances aquaporin-4 expression and decreases cerebral edema following traumatic brain injury

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Progesterone Improves Acute Recovery after Traumatic Brain Injury in the Aged Rat

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Acute Minocycline Treatment Mitigates the Symptoms of Mild Blast-Induced Traumatic Brain Injury

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Alterations in Blood-Brain Barrier Permeability to Large and Small Molecules and Leukocyte Accumulation after Traumatic Brain Injury: Effects of Post-Traumatic Hypothermia

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TRPMs and neuronal cell death

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Basic fibroblast growth factor-enhanced neurogenesis contributes to cognitive recovery in rats following traumatic brain injury

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Deregulated inflammasome signaling in disease

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Temporal relationship of peroxynitrite-induced oxidative damage, calpain-mediated cytoskeletal degradation and neurodegeneration after traumatic brain injury

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Messengers of cell death: apoptotic signaling in health and disease.

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Minocycline effects on cerebral edema: Relations with inflammatory and oxidative stress markers following traumatic brain injury in mice

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High Cyclophilin D Content of Synaptic Mitochondria Results in Increased Vulnerability to Permeability Transition

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Neuroprotective effects of metformin on traumatic brain injury in rats associated with NF-κB and MAPK signaling pathway

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Post-Traumatic Hypoxia Exacerbates Brain Tissue Damage: Analysis of Axonal Injury and Glial Responses

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Rho-ROCK Inhibition in the Treatment of Spinal Cord Injury

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STAT3 signaling after traumatic brain injury

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Roles of Rho GTPases in Intracellular Transport and Cellular Transformation

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Apoptotic Mechanisms for Neuronal Cells in Early Brain Injury After Subarachnoid Hemorrhage

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Clinical use of amantadine in brain injury rehabilitation

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Local Inhibition of Rho Signaling by Cell-Permeable Recombinant Protein BA-210 Prevents Secondary Damage and Promotes Functional Recovery following Acute Spinal Cord Injury

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Intravenous Autologous Bone Marrow Mononuclear Cell Transplantation for Stroke: Phase1/2a Clinical Trial in a Homogeneous Group of Stroke Patients

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N-acetylcysteine amide confers neuroprotection, improves bioenergetics and behavioral outcome following TBI

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Effect of N -Acetylcysteine on Mitochondrial Function Following Traumatic Brain Injury in Rats

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Rho-ROCK Inhibitors as Emerging Strategies to Promote Nerve Regeneration

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Attenuation of acute mitochondrial dysfunction after traumatic brain injury in mice by NIM811, a non-immunosuppressive cyclosporin A analog

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A common constitutional JAK2 haplotype predisposes to Myeloprolifrative Neoplasms

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Role of glycogen synthase kinase-3β in early depressive behavior induced by mild traumatic brain injury

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Association of glycogen synthase kinase-3β with Parkinson’s disease (Review)

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Peroxisome Proliferator-Activated Receptor-Gamma (PPAR-ɣ): Molecular Effects and Its Importance as a Novel Therapeutic Target for Cerebral Ischemic Injury

Mannan, A., Garg, N., Singh, T. G., & Kang, H. K. (2021) · Neurochemical Research · doi:10.1007/s11064-021-03402-1 · Cited by 68 · see citing works

Therapeutic implications of cyclooxygenase (COX) inhibitors in ischemic injury

Khan, H., Sharma, K., Kumar, A., Kaur, A., & Singh, T. G. (2022) · Inflammation Research · doi:10.1007/s00011-022-01546-6 · Cited by 60 · see citing works

Intervention of neuroinflammation in the traumatic brain injury trajectory: In vivo and clinical approaches

Prabhakar, N. K., Khan, H., Grewal, A. K., & Singh, T. G. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2022.108902 · Cited by 58 · see citing works

Exosomes derived from bone marrow mesenchymal stem cells attenuate neurological damage in traumatic brain injury by alleviating glutamate-mediated excitotoxicity

Zhuang, Z., Liu, M., Luo, J., Zhang, X., Dai, Z., Zhang, B., Chen, H., Xue, J., He, M., Xu, H., et al. (2022) · Experimental Neurology · doi:10.1016/j.expneurol.2022.114182 · Cited by 59 · see citing works

Neuropeptides: Potential neuroprotective agents in ischemic injury

Saklani, P., Khan, H., Gupta, S., Kaur, A., & Singh, T. G. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.120186 · Cited by 56 · see citing works

Rescuing mitochondria in traumatic brain injury and intracerebral hemorrhages - A potential therapeutic approach

Ahluwalia, M., Kumar, M., Ahluwalia, P. K., Rahimi, S. Y., Vender, J. R., Raju, R. P., Hess, D. C., Baban, B., Vale, F. Ĺ., Dhandapani, K. M., et al. (2021) · Neurochemistry International · doi:10.1016/j.neuint.2021.105192 · Cited by 54 · see citing works

A Comprehensive Review of Essential Oils and Their Pharmacological Activities in Neurological Disorders: Exploring Neuroprotective Potential

Qneibi, M., Bdir, S., Maayeh, C., Bdair, M., Sandouka, D., Basit, D., & Hallak, M. (2023) · Neurochemical Research · doi:10.1007/s11064-023-04032-5 · Cited by 49 · see citing works

Calpain Inhibitors as Potential Therapeutic Modulators in Neurodegenerative Diseases

Khan, H., Garg, N., Singh, T. G., Kaur, A., & Thapa, K. (2022) · Neurochemical Research · doi:10.1007/s11064-021-03521-9 · Cited by 47 · see citing works

Caspase-mediated regulation of the distinct signaling pathways and mechanisms in neuronal survival

Khan, H., Bangar, A., Grewal, A. K., Bansal, P., & Singh, T. G. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2022.108951 · Cited by 44 · see citing works

Immune Response in Traumatic Brain Injury

Cáceres, E. L., Olivella-Gómez, J., Napoli, M. D., Raihane, A. S., & Divani, A. A. (2024) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-024-01382-7 · Cited by 49 · see citing works

Mechanistic Insight on Autophagy Modulated Molecular Pathways in Cerebral Ischemic Injury: From Preclinical to Clinical Perspective

Kalra, P., Khan, H., Kaur, A., & Singh, T. G. (2022) · Neurochemical Research · doi:10.1007/s11064-021-03500-0 · Cited by 41 · see citing works

Responsive nanoparticles synergize with Curcumin to break the “reactive oxygen Species-Neuroinflammation” vicious cycle, enhancing traumatic brain injury outcomes

Fu, X., Zhang, Y., Chen, G., Mao, G.-Y., Tang, J., Jin, X., Han, Y., Chen, H., & Ding, L. (2025) · Journal of Nanobiotechnology · doi:10.1186/s12951-025-03251-y · Cited by 42 · see citing works

Therapeutic implications of sonic hedgehog pathway in metabolic disorders: Novel target for effective treatment

Garg, C., Khan, H., Kaur, A., Singh, T. G., Sharma, V., & Singh, S. K. (2022) · Pharmacological Research · doi:10.1016/j.phrs.2022.106194 · Cited by 37 · see citing works

TREM2 alleviates white matter injury after traumatic brain injury in mice might be mediated by regulation of DHCR24/LXR pathway in microglia

Zhao, L., Yu, S., Li, L., Zhou, C., Wang, L., Tang, S., Gu, N., Zhang, Z., Huang, Z., Chen, H., et al. (2024) · Clinical and Translational Medicine · doi:10.1002/ctm2.1665 · Cited by 34 · see citing works

Grape (Vitis vinifera L.) phytochemicals and their biochemical protective mechanisms against leading pathologies

Majeed, U., Shafi, A., Majeed, H., Akram, K., Liu, X., Ye, J., & Luo, Y. (2022) · Food Chemistry · doi:10.1016/j.foodchem.2022.134762 · Cited by 33 · see citing works

Exosome Derived from Human Neural Stem Cells Improves Motor Activity and Neurogenesis in a Traumatic Brain Injury Model

Abedi, M., Hajinejad, M., Atabi, F., & Negah, S. S. (2022) · BioMed Research International · doi:10.1155/2022/6409346 · Cited by 32 · see citing works

Skull bone marrow and skull meninges channels: redefining the landscape of central nervous system immune surveillance

Liu, L., Zhang, X., Chai, Y., Zhang, J., Deng, Q., & Chen, X. (2025) · Cell Death and Disease · doi:10.1038/s41419-025-07336-2 · Cited by 32 · see citing works

Multi-Mechanistic Approaches to the Treatment of Traumatic Brain Injury: A Review

Lynch, D. G., Narayan, R. K., & Li, C. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12062179 · Cited by 32 · see citing works

Mechanisms of Mitochondrial Oxidative Stress in Brain Injury: From Pathophysiology to Therapeutics

Nguyen, A., Patel, A. B., Kioutchoukova, I. P., Diaz, M. J., & Lucke-Wold, B. P. (2023) · Oxygen · doi:10.3390/oxygen3020012 · Cited by 30 · see citing works

Intraoperative application of intelligent, responsive, self-assembling hydrogel rectifies oxygen and energy metabolism in traumatically injured brain

Han, Y., Weng, W., Zhang, Y., Feng, Q., Ma, Y., Quan, A., Fu, X., Zhao, X., Skudder‐Hill, L., Jiang, J., et al. (2024) · Biomaterials · doi:10.1016/j.biomaterials.2024.122495 · Cited by 30 · see citing works

Vitamin D as therapeutic modulator in cerebrovascular diseases: a mechanistic perspectives

Rihal, V., Khan, H., Kaur, A., & Singh, T. G. (2022) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2022.2050349 · Cited by 32 · see citing works

Mitochondrial dynamics related neurovascular approaches in cerebral ischemic injury

Khan, H., Grewal, A. K., & Singh, T. G. (2022) · Mitochondrion · doi:10.1016/j.mito.2022.08.001 · Cited by 30 · see citing works

Genetic deletion of Krüppel-like factor 11 aggravates traumatic brain injury

Zhou, C., Sun, P., Hamblin, M. H., & Yin, K. (2022) · Journal of Neuroinflammation · doi:10.1186/s12974-022-02638-0 · Cited by 28 · see citing works

Adenosine as a Key Mediator of Neuronal Survival in Cerebral Ischemic Injury

Khan, H., Kaur, P., Singh, T. G., Grewal, A. K., & Sood, S. (2022) · Neurochemical Research · doi:10.1007/s11064-022-03737-3 · Cited by 26 · see citing works

Extracellular vesicles as nanotheranostic platforms for targeted neurological disorder interventions

Choi, H. K., Chen, M., Goldston, L. L., & Lee, K.-B. (2024) · Nano Convergence · doi:10.1186/s40580-024-00426-5 · Cited by 26 · see citing works

Metabolomic in severe traumatic brain injury: exploring primary, secondary injuries, diagnosis, and severity

Banoei, M. M., Hutchison, J. S., Panenka, W. J., Wong, A., Wishart, D. S., Winston, B. W., Canadian Biobank and Database for Traumatic Brain Injury (CanTBI) study investigators, Wellington, C. L., Silverberg, N. D., Murthy, S. K., et al. (2025) · Critical Care · doi:10.1186/s13054-025-05258-1 · Cited by 26 · see citing works

Artificial Intelligence in The Management of Neurodegenerative Disorders

Dhankhar, S., Mujwar, S., Garg, N., Chauhan, S., Saini, M., Sharma, P., Kumar, S., Sharma, S. K., Kamal, M. A., & Rani, N. (2023) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/0118715273266095231009092603 · Cited by 25 · see citing works

ROS-responsive biomimetic nanosystem camouflaged by hybrid membranes of platelet-exosomes engineered with neuronal targeting peptide for TBI therapy

Li, Y., Xin, X., Zhou, X. C., Liu, J., Liu, H., Yuan, S., Liu, H., Hao, W., Sun, J., Wang, Y., et al. (2024) · Journal of Controlled Release · doi:10.1016/j.jconrel.2024.06.018 · Cited by 25 · see citing works

Aquaporins: Gatekeepers of Fluid Dynamics in Traumatic Brain Injury

Czyżewski, W., Litak, J., Sobstyl, J., Mandat, T. S., Torres, K., & Staśkiewicz, G. J. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25126553 · Cited by 25 · see citing works

Hydrogel in the Treatment of Traumatic Brain Injury

Li, S., Xu, J., Qian, Y., & Zhang, R. (2024) · Biomaterials Research · doi:10.34133/bmr.0085 · Cited by 25 · see citing works

Akkermansia muciniphila-Nlrp3 is involved in the neuroprotection of phosphoglycerate mutase 5 deficiency in traumatic brain injury mice

Chen, Y., Chen, J., Wei, H., Gong, K., Meng, J., Long, T.-L., Guo, J.-F., Hong, J., Yang, L.-J., Qiu, J., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1172710 · Cited by 23 · see citing works

Role of regulatory non-coding RNAs in traumatic brain injury

Li, S., Qiu, N., Ni, A., Hamblin, M. H., & Yin, K. (2023) · Neurochemistry International · doi:10.1016/j.neuint.2023.105643 · Cited by 26 · see citing works

The neuroprotective potential of phytochemicals in traumatic brain injury: mechanistic insights and pharmacological implications

Hasan, G. M., Anwar, S., Shamsi, A., Sohal, S. S., & Hassan, M. I. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1330098 · Cited by 26 · see citing works

Immune regulation in neurovascular units after traumatic brain injury

Wang, Z., & Chen, G. (2023) · Neurobiology of Disease · doi:10.1016/j.nbd.2023.106060 · Cited by 24 · see citing works

An integrated deep learning and supervised learning approach for early detection of brain tumor using magnetic resonance imaging

Lamba, K., Rani, S., Anand, M., & Maguluri, L. P. (2024) · Healthcare Analytics · doi:10.1016/j.health.2024.100336 · Cited by 23 · see citing works

Implantation of MSC spheroid-derived 3D decellularized ECM enriched with the MSC secretome ameliorates traumatic brain injury and promotes brain repair

Chen, G. H., Sia, K., Liu, S., Kao, Y., Yang, P., Ho, C.-H., Huang, S.-C., Lee, P.-Y., Liang, M.-Z., Chen, L., et al. (2024) · Biomaterials · doi:10.1016/j.biomaterials.2024.122941 · Cited by 23 · see citing works

Catalpol Ameliorates Oxidative Stress and Neuroinflammation after Traumatic Brain Injury in Rats

Ni, H., Qin, R., Kan, X., Gao, R., Li, Z., & Zhang, B. (2022) · Neurochemical Research · doi:10.1007/s11064-022-03796-6 · Cited by 23 · see citing works

Therapeutic implication of Sonic Hedgehog as a potential modulator in ischemic injury

Mohan, M., Mannan, A., & Singh, T. G. (2023) · Pharmacological Reports · doi:10.1007/s43440-023-00505-0 · Cited by 22 · see citing works

Claudin-1 impairs blood–brain barrier by downregulating endothelial junctional proteins in traumatic brain injury

Gowrikumar, S., Tarudji, A. W., McDonald, B. Z., Balusa, S. S., Kievit, F. M., & Dhawan, P. (2025) · Tissue Barriers · doi:10.1080/21688370.2025.2470482 · Cited by 21 · see citing works

A novel approach of brain-computer interfacing (BCI) and Grad-CAM based explainable artificial intelligence: Use case scenario for smart healthcare

Lamba, K., & Rani, S. (2024) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2024.110159 · Cited by 21 · see citing works

NLRP1 inflammasome in neurodegenerative disorders: From pathology to therapies

Zhang, M.-J., Yang, L., Li, Z.-Y., Zhou, L.-Y., Wang, Y.-J., Wang, H.-S., Cui, X.-J., & Yao, M. (2024) · Cytokine &amp; Growth Factor Reviews · doi:10.1016/j.cytogfr.2024.10.004 · Cited by 21 · see citing works

Insights into Advances and Applications of Biomaterials for Nerve Tissue Injuries and Neurodegenerative Disorders

Pai, V., Singh, B. N., & Singh, A. K. (2024) · Macromolecular Bioscience · doi:10.1002/mabi.202400150 · Cited by 20 · see citing works

Bioactive hydrogel synergizes neuroprotection, macrophage polarization, and angiogenesis to improve repair of traumatic brain injury

Hao, Y., Feng, L., Liu, H., Zhou, L., Yu, X., He, X., Cheng, H., Jin, L., Wang, C., & Guo, R. (2024) · Materials Today Bio · doi:10.1016/j.mtbio.2024.101335 · Cited by 20 · see citing works

Pathological changes in the brain after peripheral burns

Chen, J., Zhang, D., Zhang, J., & Wang, Y. (2023) · Burns & Trauma · doi:10.1093/burnst/tkac061 · Cited by 20 · see citing works

Nanocarrier-mediated siRNA delivery: a new approach for the treatment of traumatic brain injury–related Alzheimer’s disease

Jin, J., Zhang, H., Lu, Q., Tian, L., Yao, S., Lai, F., Liang, Y., Liu, C., Lu, Y., Tian, S., et al. (2024) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-24-00303 · Cited by 20 · see citing works

Recent Advances in Biomaterials‐Based Therapies for Alleviation and Regeneration of Traumatic Brain Injury

Hu, H., Chen, X., Zhao, K., Zheng, W., & Gao, C. (2023) · Macromolecular Bioscience · doi:10.1002/mabi.202200577 · Cited by 20 · see citing works

C-Reactive Protein/Albumin Ratio Is Associated with Mortality in Patients with Moderate to Severe Traumatic Brain Injury

Wang, Y., Gong, Y., Chen, D., Xu, F., & Yang, P. (2023) · World Neurosurgery · doi:10.1016/j.wneu.2023.02.037 · Cited by 19 · see citing works

Satureja khuzistanica Jamzad essential oil and pure carvacrol attenuate TBI-induced inflammation and apoptosis via NF-κB and caspase-3 regulation in the male rat brain

Abbasloo, E., Amiresmaili, S., Shirazpour, S., Khaksari, M., Kobeissy, F. H., & Thomas, T. C. (2023) · Scientific Reports · doi:10.1038/s41598-023-31891-3 · Cited by 19 · see citing works

Applications of hydrogels and nanoparticles in the treatment of traumatic brain injury

Shi, J., Tang, J., Jin, X., Jiang, N., Yang, Y., Chen, H., Han, Y., & Fu, X. (2025) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2024.1515164 · Cited by 20 · see citing works

Transient post-operative overexpression of CXCR2 on monocytes of traumatic brain injury patients drives monocyte chemotaxis toward cerebrospinal fluid and enhances monocyte-mediated immunogenic cell death of neurons in vitro

Wang, H., Huang, Q., Zhang, Z., Ji, J., Sun, T., & Wang, D. (2022) · Journal of Neuroinflammation · doi:10.1186/s12974-022-02535-6 · Cited by 20 · see citing works

Roles of Astrocytic Endothelin ETB Receptor in Traumatic Brain Injury

Michinaga, S., Hishinuma, S., & Kōyama, Y. (2023) · Cells · doi:10.3390/cells12050719 · Cited by 18 · see citing works

Immunomodulatory Effect of Electromagnetic Field in the Treatment of Traumatic Brain Injury

Patchana, T., Agrawal, D. K., Connett, D. A., Baron, D. A., & Miulli, D. E. (2023) · Journal of Biotechnology and Biomedicine · doi:10.26502/jbb.2642-91280069 · Cited by 18 · see citing works

The immunological landscape of traumatic brain injury: insights from pathophysiology to experimental models

Abikenari, M. A., Ha, J. H., Liu, J., Ren, A. L., Cho, K. B., Lim, J., Kim, L. H., Medikonda, R. T., Choi, J. H., & Lim, M. K. (2025) · Frontiers in Neurology · doi:10.3389/fneur.2025.1668480 · Cited by 18 · see citing works

The mechanism of bone healing after traumatic brain injury

Xiong, Y., Zhong, W., & Mi, B. (2023) · Brain‐X · doi:10.1002/brx2.31 · Cited by 17 · see citing works

Unraveling the dual role of bilirubin in neurological Diseases: A Comprehensive exploration of its neuroprotective and neurotoxic effects

Kaur, A., Rohit, & Aran, K. R. (2025) · Brain Research · doi:10.1016/j.brainres.2025.149472 · Cited by 17 · see citing works

Advances in research on biomaterials and stem cell/exosome-based strategies in the treatment of traumatic brain injury

Chi, W., He, Y., Chen, S., Guo, L., Yuan, Y., Li, R., Liu, R., Zhou, D., Du, J., Xu, T., et al. (2025) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2025.05.010 · Cited by 16 · see citing works

Role of damage-associated molecular patterns in the pathogenesis and therapeutics of traumatic brain injury

Sun, B., Zhang, J., Li, Z., Wang, J., Zhao, C., & Xu, X. (2025) · Burns & Trauma · doi:10.1093/burnst/tkaf043 · Cited by 17 · see citing works

Multimodal Nanoregulator Rescues Impaired Neurovascular Units to Attenuate Secondary Injury Following Traumatic Brain Injury

Zhang, P., Jiang, Y., Li, X., Xu, Y., Geng, T., Luo, F., Li, W., Jin, X., & Qi, J. (2025) · Advanced Materials · doi:10.1002/adma.202509444 · Cited by 15 · see citing works

Cytokines and related signaling pathways in traumatic brain injury

Zhu, L., Huang, S., Chen, W., Li, K., & Sheng, J. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1738589 · Cited by 15 · see citing works

Effects and neuroprotective mechanisms of vagus nerve stimulation on cognitive impairment with traumatic brain injury in animal studies: A systematic review and meta-analysis

Zhang, H., Li, C.-L., Qu, Y., Yang, Y., Du, J., & Zhao, Y. (2022) · Frontiers in Neurology · doi:10.3389/fneur.2022.963334 · Cited by 15 · see citing works

Will Sirtuin 2 Be a Promising Target for Neuroinflammatory Disorders?

Zhang, F., & Li, B. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.915587 · Cited by 14 · see citing works

Evaluating the neuroprotective effects of progesterone receptors on experimental traumatic brain injury: The PI3K/Akt pathway

Amirkhosravi, L., Khaksari, M., Amiresmaili, S., Sanjari, M., Khorasani, P., & Hashemian, M. (2023) · Brain and Behavior · doi:10.1002/brb3.3244 · Cited by 14 · see citing works

Candidate Molecular Biomarkers of Traumatic Brain Injury: A Systematic Review

Butkova, T. V., Malsagova, K. A., Игоревна, Н. В., Petrovskiy, D. V., Izotov, A., Balakin, E. I., Yurku, K. A., Umnikov, A. S., Pustovoyt, V. I., & Kaysheva, A. L. (2024) · Biomolecules · doi:10.3390/biom14101283 · Cited by 14 · see citing works

Non-pharmacological interventions for traumatic brain injury

Davis, C. K., Arruri, V. K., Joshi, P., & Vemuganti, R. (2024) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x241234770 · Cited by 14 · see citing works

Post-traumatic hydrocephalus after decompressive craniectomy: a multidimensional analysis of clinical, radiological, and surgical risk factors

Romualdo, S. M. F., Juratli, T. A., Eyüpoglu, I. Y., Schackert, G., Dengl, M., Prem, M., Hijazi, M. M., & Sitoci-Ficici, K.-H. (2025) · Neurosurgical Review · doi:10.1007/s10143-025-03673-0 · Cited by 12 · see citing works

IRAK4 exacerbates traumatic brain injury via activation of TAK1 signaling pathway

Xu, X., Zhi, T., Hua, L., Jiang, K., & Chen, C. (2022) · Experimental Neurology · doi:10.1016/j.expneurol.2022.114007 · Cited by 12 · see citing works

Efficacy of combined subanesthetic ketamine infusion and cervical sympathetic blockade as a symptomatic treatment of PTSD/TBI in a special forces patient with a 1-year follow-up: A case report

Lipov, E., Sethi, Z., Nandra, G. S., & Frueh, C. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e14891 · Cited by 12 · see citing works

The longitudinal biochemical profiling of TBI in a drop weight model of TBI

Yılmaz, A., Zaltsman, S. L., Shohami, E., Gordevičius, J., Kerševičiūtė, I., Sherman, E., Bahado-Singh, R. O., & Graham, S. F. (2023) · Scientific Reports · doi:10.1038/s41598-023-48539-x · Cited by 12 · see citing works

Polynitroxylated PEGylated hemoglobin protects pig brain neocortical gray and white matter after traumatic brain injury and hemorrhagic shock

Wang, J., Shi, Y., Cao, S., Liu, X., Martin, L. J., Simoni, J., Soltys, B. J., Hsia, C. J. C., & Koehler, R. C. (2023) · Frontiers in Medical Technology · doi:10.3389/fmedt.2023.1074643 · Cited by 12 · see citing works

p17/C18-ceramide–mediated mitophagy is an endogenous neuroprotective response in preclinical and clinical brain injury

Karakaya, E., Oleinik, N. V., Edwards, J. M., Tomberlin, J., Barker, R. B., Berber, B., Ericsson, M., Alsudani, H., Ergul, A., Beyaz, S., et al. (2024) · PNAS Nexus · doi:10.1093/pnasnexus/pgae018 · Cited by 12 · see citing works

A study on the relationship between neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in neurosurgery and the occurrence and prognosis of progressive hemorrhagic brain injury (PHI) in patients with traumatic brain injury

Li, W., Wang, Z., Gao, M., Wang, Y., & Ke, Y. (2024) · BMC Neurology · doi:10.1186/s12883-024-03986-5 · Cited by 13 · see citing works

Hybrid membrane-coated Cyclosporine A nanocrystals preventing secondary brain injury via alleviating neuroinflammatory and oxidative stress

Zhou, Y., Qiao, S., Zhang, L., Liu, M., Ji, Q., Zhang, B., Gao, H., Zhou, S., & Liu, D. (2025) · Journal of Controlled Release · doi:10.1016/j.jconrel.2025.113795 · Cited by 11 · see citing works

Irisin suppressed the progression of TBI via modulating AMPK/MerTK/autophagy and SYK/ROS/inflammatory signaling

Zhang, K., Du, Y., Yang, S. Z., & Sun, G. (2025) · Scientific Reports · doi:10.1038/s41598-025-00066-7 · Cited by 11 · see citing works

Advances in ERK Signaling Pathway in Traumatic Brain Injury: Mechanisms and Therapeutic Potential

Wang, X., Wang, Q., Hou, L., Wei, G., He, C., Li, H., & Liu, L. (2025) · Neurochemical Research · doi:10.1007/s11064-025-04449-0 · Cited by 10 · see citing works

In-vivo time course of organ uptake and blood-brain-barrier permeation of poly(L-lactide) and poly(perfluorodecyl acrylate) nanoparticles with different surface properties in unharmed and brain-traumatized rats

Bechinger, P., Serrano, L. E., Grützner, V., Musyanovych, A., Jussen, D., Krenzlin, H., Eldahaby, D., Riede, N., Kempski, O. S., Ringel, F. A., et al. (2023) · Frontiers in Neurology · doi:10.3389/fneur.2023.994877 · Cited by 10 · see citing works

Multimodal evaluation of the effects of low-intensity ultrasound on cerebral blood flow after traumatic brain injury in mice

Yi, H., Wu, S., Wang, X., Liu, L., Wang, W., Yu, Y., Li, Z., Jin, Y., Liu, J., Zheng, T., et al. (2024) · BMC Neuroscience · doi:10.1186/s12868-024-00849-0 · Cited by 10 · see citing works

Essential role of p21Waf1/Cip1 in the modulation of post-traumatic hippocampal Neural Stem Cells response

Chiani, F., Mastrorilli, V., Marchetti, N., Macioce, A., Nappi, C., Strimpakos, G., Pasquini, M., Gambadoro, A., Battistini, J. I., Cutuli, D., et al. (2024) · Stem Cell Research & Therapy · doi:10.1186/s13287-024-03787-0 · Cited by 10 · see citing works

Evidence for Altered White Matter Organization After Mild Traumatic Brain Injury: A Scoping Review on the Use of Diffusion Magnetic Resonance Imaging and Blood-Based Biomarkers to Investigate Acute Pathology and Relationship to Persistent Post-Concussion Symptoms

Papini, M. G., Avila, A. N., Fitzgerald, M., & Hellewell, S. C. (2024) · Journal of Neurotrauma · doi:10.1089/neu.2024.0039 · Cited by 10 · see citing works

Traumatic brain injury and sleep in military and veteran populations: A literature review

Landvater, J., Kim, S. Y., Caswell, K., Kwon, C., Odafe, E., Roe, G., Tripathi, A., Vukovics, C., Wang, J., Ryan, K., et al. (2024) · Neurorehabilitation · doi:10.3233/nre-230380 · Cited by 11 · see citing works

Albumin in Normovolemic Fluid Management for Severe Traumatic Brain Injury: Controversies and Research Gaps

Wiedermann, C. J. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13185452 · Cited by 10 · see citing works

Exploring therapeutic potential: Targeting TRPM7 in neurodegenerative diseases

Soni, D., Khan, H., Chauhan, S., Kaur, A., Dhankhar, S., Garg, N., & Singh, T. G. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.113142 · Cited by 10 · see citing works

Emerging role of Nrf2 in Parkinson’s disease therapy: a critical reassessment

Sharma, V., Sharma, P., & Singh, T. G. (2024) · Metabolic Brain Disease · doi:10.1007/s11011-024-01452-2 · Cited by 10 · see citing works

Near-Infrared Imaging of Glymphatic Clearance in a Pre-Clinical Model of Repetitive Closed Head Traumatic Brain Injury

Michalaki, E., Pulliam, A. N., Roy, P. M. D., Dixon, J. B., & LaPlaca, M. C. (2025) · Neurotrauma Reports · doi:10.1089/neur.2024.0128 · Cited by 10 · see citing works

Insights into the functional characteristics of rhubarb (Rheum officinale Baill) treatment on experimental traumatic brain injury through network pharmacology with metagenomics

Zheng, F., Guo, X., Zhang, W., Wang, Y., Hu, E., Guo, X., Su, H., & Deng, C.-Q. (2025) · Phytomedicine · doi:10.1016/j.phymed.2025.156853 · Cited by 10 · see citing works

From Acute Injury to Chronic Neurodegeneration: Molecular Mechanisms Linking Secondary Brain Injury to Long-Term Pathology

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