CoChat
Sign Up
Cited by 674MicroRNA in disease regulationCancer-related molecular mechanisms researchPlant Molecular Biology Research

miRNA interplay: mechanisms and consequences in cancer

Open access
Hill, Meredith, Tran, Nham·2021·Disease Models & Mechanisms
DOI 10.1242/dmm.047662PMC PMC8077553
Open this paper in CoChat — free account

Abstract

Canonically, microRNAs (miRNAs) control mRNA expression. However, studies have shown that miRNAs are also capable of targeting non-coding RNAs, including long non-coding RNAs and miRNAs. The latter, termed a miRNA:miRNA interaction, is a form of self-regulation. In this Review, we discuss the three main modes of miRNA:miRNA regulation: direct, indirect and global interactions, and their implications in cancer biology. We also discuss the cell-type-specific nature of miRNA:miRNA interactions, current experimental approaches and bioinformatic techniques, and how these strategies are not sufficient for the identification of novel miRNA:miRNA interactions. The self-regulation of miRNAs and their impact on gene regulation has yet to be fully understood. Investigating this hidden world of miRNA self-regulation will assist in discovering novel regulatory mechanisms associated with disease pathways.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1242/dmm.047662

Cites

2 of 2 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 81

  1. Ali Syeda, Z., Langden, S. S. S., Munkhzul, C., Lee, M. and Song, S. J. (2020). Regulatory mechanism of MicroRNA expression in cancer. Int. J. Mol. Sci. 21, 1723. 10.3390/ijms21051723 PMC7084905 32138313 · DOI
  2. Alshalalfa, M. (2012). MicroRNA response elements-mediated miRNA-miRNA interactions in prostate cancer. Adv. Bioinformatics 2012, 839837. 10.1155/2012/839837 23193399 PMC3502784 · DOI
  3. Anastasiadou, E., Jacob, L. S. and Slack, F. J. (2018). Non-coding RNA networks in cancer. Nat. Rev. Cancer 18, 5. 10.1038/nrc.2017.99 29170536 PMC6337726 · DOI
  4. Auyeung, V. C., Ulitsky, I., Mcgeary, S. E. and Bartel, D. P. (2013). Beyond secondary structure: primary-sequence determinants license pri-miRNA hairpins for processing. Cell 152, 844- 858. 10.1016/j.cell.2013.01.031 23415231 PMC3707628 · DOI
  5. Bernstein, E., Caudy, A. A., Hammond, S. M. and Hannon, G. J. (2001). Role for a bidentate ribonuclease in the initiation step of RNA interference. Nature 409, 363- 366. 10.1038/35053110 11201747 · DOI
  6. Bertero, T., Lu, Y., Annis, S., Hale, A., Bhat, B., Saggar, R., Saggar, R., Wallace, W. D., Ross, D. J., Vargas, S. O. et al. (2014). Systems-level regulation of microRNA networks by miR-130/301 promotes pulmonary hypertension. J. Clin. Invest. 124, 3514- 3528. 10.1172/JCI74773 24960162 PMC4109523 · DOI
  7. Betel, D., Koppal, A., Agius, P., Sander, C. and Leslie, C. (2010). Comprehensive modeling of microRNA targets predicts functional non-conserved and non-canonical sites. Genome Biol. 11, R90. 10.1186/gb-2010-11-8-r90 20799968 PMC2945792 · DOI · Paper page
  8. Bofill-De Ros, X., Yang, A. and Gu, S. (2020). IsomiRs: expanding the miRNA repression toolbox beyond the seed. Biochim. Biophys. Acta Gene Regul. Mech. 1863, 194373. 10.1016/j.bbagrm.2019.03.005 30953728 PMC6776719 · DOI · Paper page
  9. Borzi, C., Calzolari, L., Centonze, G., Milione, M., Sozzi, G. and Fortunato, O. (2017). mir-660-p53-mir-486 Network: a new key regulatory pathway in lung tumorigenesis. Int. J. Mol. Sci. 18, 222. 10.3390/ijms18010222 PMC5297851 28124991 · DOI
  10. Carthew, R. W. and Sontheimer, E. J. (2009). Origins and mechanisms of miRNAs and siRNAs. Cell 136, 642- 655. 10.1016/j.cell.2009.01.035 19239886 PMC2675692 · DOI
  11. Catalanotto, C., Cogoni, C. and Zardo, G. (2016). MicroRNA in control of gene expression: an overview of nuclear functions. Int. J. Mol. Sci. 17, 1712. 10.3390/ijms17101712 PMC5085744 27754357 · DOI
  12. Chen, P.-S., Su, J.-L., Cha, S.-T., Tarn, W.-Y., Wang, M.-Y., Hsu, H.-C., Lin, M.-T., Chu, C.-Y., Hua, K.-T., Chen, C.-N. et al. (2011). miR-107 promotes tumor progression by targeting the let-7 microRNA in mice and humans. J. Clin. Invest. 121, 3442- 3455. 10.1172/JCI45390 21841313 PMC3163949 · DOI
  13. Chou, C.-H., Shrestha, S., Yang, C.-D., Chang, N.-W., Lin, Y.-L., Liao, K.-W., Huang, W.-C., Sun, T.-H., Tu, S.-J. and Lee, W.-H. (2018). miRTarBase update 2018: a resource for experimentally validated microRNA-target interactions. Nucleic Acids Res. 46, D296- D302. 10.1093/nar/gkx1067 29126174 PMC5753222 · DOI
  14. Cilek, E. E., Ozturk, H. and Gur Dedeoglu, B. (2017). Construction of miRNA-miRNA networks revealing the complexity of miRNA-mediated mechanisms in trastuzumab treated breast cancer cell lines. PLoS ONE 12, e0185558. 10.1371/journal.pone.0185558 28981542 PMC5628841 · DOI
  15. Citron, F., Armenia, J., Franchin, G., Polesel, J., Talamini, R., D'andrea, S., Sulfaro, S., Croce, C. M., Klement, W. and Otasek, D. (2017). An integrated approach identifies mediators of local recurrence in head and neck squamous carcinoma. Clin. Cancer Res. 23, 3769- 3780. 10.1158/1078-0432.CCR-16-2814 28174235 PMC7309652 · DOI
  16. Conrad, T., Ntini, E., Lang, B., Cozzuto, L., Andersen, J. B., Marquardt, J. U., Ponomarenko, J., Tartaglia, G. G. and Ørom, U. A. V. (2020). Determination of primary microRNA processing in clinical samples by targeted pri-miR-sequencing. RNA 26, 1726- 1730. 10.1261/rna.076240.120 32669295 PMC7566579 · DOI
  17. Fabbri, M., Girnita, L., Varani, G. and Calin, G. A. (2019). Decrypting noncoding RNA interactions, structures, and functional networks. Genome Res. 29, 1377- 1388. 10.1101/gr.247239.118 31434680 PMC6724670 · DOI
  18. Finnegan, E. F. and Pasquinelli, A. E. (2013). MicroRNA biogenesis: regulating the regulators. Crit. Rev. Biochem. Mol. Biol. 48, 51- 68. 10.3109/10409238.2012.738643 23163351 PMC3557704 · DOI
  19. Flamand, M. N., Gan, H. H., Mayya, V. K., Gunsalus, K. C. and Duchaine, T. F. (2017). A non-canonical site reveals the cooperative mechanisms of microRNA-mediated silencing. Nucleic Acids Res. 45, 7212- 7225. 10.1093/nar/gkx340 28482037 PMC5499589 · DOI
  20. Forrest, A. R., Kanamori-Katayama, M., Tomaru, Y., Lassmann, T., Ninomiya, N., Takahashi, Y., De Hoon, M. J., Kubosaki, A., Kaiho, A., Suzuki, M. et al. (2010). Induction of microRNAs, mir-155, mir-222, mir-424 and mir-503, promotes monocytic differentiation through combinatorial regulation. Leukemia 24, 460- 466. 10.1038/leu.2009.246 19956200 · DOI
  21. Gagnon, K. T., Li, L., Chu, Y., Janowski, B. A. and Corey, D. R. (2014). RNAi factors are present and active in human cell nuclei. Cell Reports 6, 211- 221. 10.1016/j.celrep.2013.12.013 24388755 PMC3916906 · DOI
  22. Gebert, L. F. and Macrae, I. J. (2019). Regulation of microRNA function in animals. Nat. Rev. Mol. Cell Biol. 20, 21- 37. 10.1038/s41580-018-0045-7 30108335 PMC6546304 · DOI · Paper page
  23. Glogovitis, I., Yahubyan, G., Würdinger, T., Koppers-Lalic, D. and Baev, V. (2021). isomiRs–Hidden Soldiers in the mirna Regulatory Army And How to Find Them? Biomolecules 11, 41. 10.3390/biom11010041 PMC7823672 33396892 · DOI
  24. Gregory, R. I., Yan, K.-P., Amuthan, G., Chendrimada, T., Doratotaj, B., Cooch, N. and Shiekhattar, R. (2004). The Microprocessor complex mediates the genesis of microRNAs. Nature 432, 235- 240. 10.1038/nature03120 15531877 · DOI
  25. Grillone, K., Riillo, C., Scionti, F., Rocca, R., Tradigo, G., Guzzi, P. H., Alcaro, S., Di Martino, M. T., Tagliaferri, P. and Tassone, P. (2020). Non-coding RNAs in cancer: platforms and strategies for investigating the genomic “dark matter”. J. Exp. Clin. Cancer Res. 39, 1- 19. 10.1186/s13046-020-01622-x 32563270 PMC7305591 · DOI
  26. Guo, L., Sun, B., Wu, Q., Yang, S. and Chen, F. (2012). miRNA-miRNA interaction implicates for potential mutual regulatory pattern. Gene 511, 187- 194. 10.1016/j.gene.2012.09.066 23031806 · DOI
  27. Hata, A. and Kashima, R. (2016). Dysregulation of microRNA biogenesis machinery in cancer. Crit. Rev. Biochem. Mol. Biol. 51, 121- 134. 10.3109/10409238.2015.1117054 26628006 PMC5226641 · DOI
  28. Hill, M. and Tran, N. (2018). MicroRNAs regulating microRNAs in cancer. Trends Cancer 4, 465- 468. 10.1016/j.trecan.2018.05.002 29937044 · DOI
  29. Hu, X., Sun, G., Shi, Z., Ni, H. and Jiang, S. (2020). Identification and validation of key modules and hub genes associated with the pathological stage of oral squamous cell carcinoma by weighted gene co-expression network analysis. PeerJ 8, e8505. 10.7717/peerj.8505 32117620 PMC7006519 · DOI
  30. Jia, L.-F., Zheng, Y.-F., Lyu, M.-Y., Huang, Y.-P. and Gan, Y.-H. (2016). miR-29b upregulates miR-195 by targeting DNMT3B in tongue squamous cell carcinoma. Sci. Bull. 61, 212- 219. 10.1007/s11434-016-1001-6 · DOI
  31. Jiao, A. and Slack, F. J. (2012). MicroRNAs micromanage themselves. Circ. Res. 111, 1395- 1397. 10.1161/CIRCRESAHA.112.281014 23139285 PMC4311873 · DOI
  32. Khan, A. A., Betel, D., Miller, M. L., Sander, C., Leslie, C. S. and Marks, D. S. (2009). Transfection of small RNAs globally perturbs gene regulation by endogenous microRNAs. Nat. Biotechnol. 27, 549- 555. 10.1038/nbt.1543 19465925 PMC2782465 · DOI · Paper page
  33. Kim, Y.-K., Kim, B. and Kim, V. N. (2016). Re-evaluation of the roles of DROSHA, Exportin 5, and DICER in microRNA biogenesis. Proc. Natl. Acad. Sci. USA 113, E1881- E1889. 10.1073/pnas.1602532113 26976605 PMC4822641 · DOI
  34. Kim, B., Jeong, K. and Kim, V. N. (2017). Genome-wide mapping of DROSHA cleavage sites on primary microRNAs and noncanonical substrates. Mol. Cell 66, 258- 269.e5. 10.1016/j.molcel.2017.03.013 28431232 · DOI
  35. Kishore, S., Jaskiewicz, L., Burger, L., Hausser, J., Khorshid, M. and Zavolan, M. (2011). A quantitative analysis of CLIP methods for identifying binding sites of RNA-binding proteins. Nat. Methods 8, 559- 564. 10.1038/nmeth.1608 21572407 · DOI
  36. Króliczewski, J., Sobolewska, A., Lejnowski, D., Collawn, J. F. and Bartoszewski, R. (2018). microRNA single polynucleotide polymorphism influences on microRNA biogenesis and mRNA target specificity. Gene 640, 66- 72. 10.1016/j.gene.2017.10.021 29032146 · DOI
  37. Lai, E. C. (2002). Micro RNAs are complementary to 3′ UTR sequence motifs that mediate negative post-transcriptional regulation. Nat. Genet. 30, 363- 364. 10.1038/ng865 11896390 · DOI
  38. Lai, E. C., Wiel, C. and Rubin, G. M. (2004). Complementary miRNA pairs suggest a regulatory role for miRNA:miRNA duplexes. RNA 10, 171- 175. 10.1261/rna.5191904 14730015 PMC1370528 · DOI
  39. Lapa, R. M. L., Barros-Filho, M. C., Marchi, F. A., Domingues, M. A. C., De Carvalho, G. B., Drigo, S. A., Kowalski, L. P. and Rogatto, S. R. (2019). Integrated miRNA and mRNA expression analysis uncovers drug targets in laryngeal squamous cell carcinoma patients. Oral Oncol. 93, 76- 84. 10.1016/j.oraloncology.2019.04.018 31109699 · DOI
  40. Lee, Y., Ahn, C., Han, J., Choi, H., Kim, J., Yim, J., Lee, J., Provost, P., Rådmark, O. and Kim, S. (2003). The nuclear RNase III Drosha initiates microRNA processing. Nature 425, 415- 419. 10.1038/nature01957 14508493 · DOI
  41. Leonov, G., Shah, K., Yee, D., Timmis, J., Sharp, T. V. and Lagos, D. (2015). Suppression of AGO2 by miR-132 as a determinant of miRNA-mediated silencing in human primary endothelial cells. Int. J. Biochem. Cell Biol. 69, 75- 84. 10.1016/j.biocel.2015.10.006 26475020 PMC4679077 · DOI
  42. Lewis, B. P., Shih, I.-H., Jones-Rhoades, M. W., Bartel, D. P. and Burge, C. B. (2003). Prediction of mammalian microRNA targets. Cell 115, 787- 798. 10.1016/S0092-8674(03)01018-3 14697198 · DOI · Paper page
  43. Li, X., Yu, X., He, Y., Meng, Y., Liang, J., Huang, L., Du, H., Wang, X. and Liu, W. (2018). Integrated analysis of MicroRNA (miRNA) and mRNA profiles reveals reduced correlation between MicroRNA and target gene in cancer. BioMed Res. Int. 2018, 1972606. 10.1155/2018/1972606 30627543 PMC6304515 · DOI
  44. Liang, H., Zhang, J., Zen, K., Zhang, C.-Y. and Chen, X. (2013). Nuclear microRNAs and their unconventional role in regulating non-coding RNAs. Protein Cell 4, 325- 330. 10.1007/s13238-013-3001-5 23584808 PMC4883050 · DOI
  45. Liu, Y. and Ye, F. (2019). Construction and integrated analysis of crosstalking ceRNAs networks in laryngeal squamous cell carcinoma. PeerJ 7, e7380. 10.7717/peerj.7380 31367490 PMC6657684 · DOI
  46. Liu, H., Lei, C., He, Q., Pan, Z., Xiao, D. and Tao, Y. (2018). Nuclear functions of mammalian MicroRNAs in gene regulation, immunity and cancer. Mol. Cancer 17, 64. 10.1186/s12943-018-0765-5 29471827 PMC5822656 · DOI
  47. Lu, Z., Liu, M., Stribinskis, V., Klinge, C. M., Ramos, K. S., Colburn, N. H. and Li, Y. (2008). MicroRNA-21 promotes cell transformation by targeting the programmed cell death 4 gene. Oncogene 27, 4373- 4379. 10.1038/onc.2008.72 18372920 PMC11968769 · DOI · Paper page
  48. Lund, E., Güttinger, S., Calado, A., Dahlberg, J. E. and Kutay, U. (2004). Nuclear export of microRNA precursors. Science 303, 95- 98. 10.1126/science.1090599 14631048 · DOI
  49. Macfarlane, L. A. and Murphy, P. R. (2010). MicroRNA: biogenesis, function and role in cancer. Curr. Genomics 11, 537- 561. 10.2174/138920210793175895 21532838 PMC3048316 · DOI
  50. Matkovich, S. J., Hu, Y. and Dorn, G. W. II (2013). Regulation of cardiac microRNAs by cardiac microRNAs. Circ. Res. 113, 62- 71. 10.1161/CIRCRESAHA.113.300975 23625950 PMC3769967 · DOI
  51. Matsuyama, H. and Suzuki, H. I. (2019). Systems and synthetic microRNA biology: from biogenesis to disease pathogenesis. Int. J. Mol. Sci. 21, 132. 10.3390/ijms21010132 PMC6981965 31878193 · DOI
  52. Nguyen, T. A., Jo, M. H., Choi, Y.-G., Park, J., Kwon, S. C., Hohng, S., Kim, V. N. and Woo, J.-S. (2015). Functional anatomy of the human microprocessor. Cell, 161, 1374- 1387. 10.1016/j.cell.2015.05.010 26027739 · DOI
  53. Ooi, J. Y. Y., Bernardo, B. C., Singla, S., Patterson, N. L., Lin, R. C. Y. and Mcmullen, J. R. (2017). Identification of miR-34 regulatory networks in settings of disease and antimiR-therapy: Implications for treating cardiac pathology and other diseases. RNA Biol. 14, 500- 513. 10.1080/15476286.2016.1181251 27124358 PMC5449084 · DOI
  54. Park, J. H., Shin, S. Y. and Shin, C. (2017). Non-canonical targets destabilize microRNAs in human Argonautes. Nucleic Acids Res. 45, 1569- 1583. 10.1093/nar/gkx029 28119422 PMC5389725 · DOI
  55. Ransohoff, J. D., Wei, Y. and Khavari, P. A. (2018). The functions and unique features of long intergenic non-coding RNA. Nat. Rev. Mol. Cell Biol. 19, 143. 10.1038/nrm.2017.104 29138516 PMC5889127 · DOI
  56. Rock, L. D., Minatel, B. C., Marshall, E. A., Guisier, F., Sage, A. P., Barros-Filho, M. C., Stewart, G. L., Garnis, C. and Lam, W. L. (2019). Expanding the transcriptome of head and neck squamous cell carcinoma through novel microRNA discovery. Frontiers in Oncology 9, 1305. 10.3389/fonc.2019.01305 31828039 PMC6890850 · DOI
  57. Schwarz, D. S., Hutvágner, G., Du, T., Xu, Z., Aronin, N. and Zamore, P. D. (2003). Asymmetry in the assembly of the RNAi enzyme complex. Cell 115, 199- 208. 10.1016/S0092-8674(03)00759-1 14567917 · DOI · Paper page
  58. Shahab, S. W., Matyunina, L. V., Mittal, V. K., Wang, L., Hill, C. G., Walker, L. D. and Mcdonald, J. F. (2012). MicroRNAs indirectly regulate other microRNAs in ovarian cancer cells. Br. J. Med. Med. Res. 2, 172. 10.9734/BJMMR/2012/804 · DOI
  59. Shao, T., Wang, G., Chen, H., Xie, Y., Jin, X., Bai, J., Xu, J., Li, X., Huang, J., Jin, Y. et al. (2019). Survey of miRNA-miRNA cooperative regulation principles across cancer types. Brief. Bioinform. 20, 1621- 1638. 10.1093/bib/bby038 29800060 · DOI
  60. Song, M.-S. and Rossi, J. J. (2017). Molecular mechanisms of Dicer: endonuclease and enzymatic activity. Biochem. J. 474, 1603- 1618. 10.1042/BCJ20160759 28473628 PMC5415849 · DOI
  61. Song, J.-J., Smith, S. K., Hannon, G. J. and Joshua-Tor, L. (2004). Crystal structure of Argonaute and its implications for RISC slicer activity. Science 305, 1434- 1437. 10.1126/science.1102514 15284453 · DOI
  62. Song, C., Xu, Z., Jin, Y., Zhu, M., Wang, K. and Wang, N. (2015). The network of microRNAs, transcription factors, target genes and host genes in human renal cell carcinoma. Oncol. Lett. 9, 498- 506. 10.3892/ol.2014.2683 25436016 PMC4246619 · DOI
  63. Suzuki, H. I., Young, R. A. and Sharp, P. A. (2017). Super-enhancer-mediated RNA processing revealed by integrative microRNA network analysis. Cell 168, 1000- 1014.e15. 10.1016/j.cell.2017.02.015 28283057 PMC5350633 · DOI · Paper page
  64. Sylvestre, Y., De Guire, V., Querido, E., Mukhopadhyay, U. K., Bourdeau, V., Major, F., Ferbeyre, G. and Chartrand, P. (2007). An E2F/miR-20a autoregulatory feedback loop. J. Biol. Chem. 282, 2135- 2143. 10.1074/jbc.M608939200 17135249 · DOI
  65. Tang, R., Li, L., Zhu, D., Hou, D., Cao, T., Gu, H., Zhang, J., Chen, J., Zhang, C.-Y. and Zen, K. (2012). Mouse miRNA-709 directly regulates miRNA-15a/16-1 biogenesis at the posttranscriptional level in the nucleus: evidence for a microRNA hierarchy system. Cell Res. 22, 504- 515. 10.1038/cr.2011.137 21862971 PMC3292299 · DOI
  66. Trabucchi, M. and Mategot, R. (2019). Subcellular heterogeneity of the microRNA machinery. Trends Genet. 35, 15- 28. 10.1016/j.tig.2018.10.006 30503571 · DOI
  67. Ulitsky, I. (2018). Interactions between short and long noncoding RNAs. FEBS Lett. 592, 2874- 2883. 10.1002/1873-3468.13085 29749606 · DOI
  68. van Rooij, E., Quiat, D., Johnson, B. A., Sutherland, L. B., Qi, X., Richardson, J. A., Kelm, R. J., Jr and Olson, E. N. (2009). A family of microRNAs encoded by myosin genes governs myosin expression and muscle performance. Dev. Cell 17, 662- 673. 10.1016/j.devcel.2009.10.013 19922871 PMC2796371 · DOI · Paper page
  69. Vedanayagam, J., Chatila, W. K., Aksoy, B. A., Majumdar, S., Skanderup, A. J., Demir, E., Schultz, N., Sander, C. and Lai, E. C. (2019). Cancer-associated mutations in DICER1 RNase IIIa and IIIb domains exert similar effects on miRNA biogenesis. Nat. Commun. 10, 3682. 10.1038/s41467-019-11610-1 31417090 PMC6695490 · DOI
  70. Wang, K., Long, B., Jiao, J.-Q., Wang, J.-X., Liu, J.-P., Li, Q. and Li, P.-F. (2012). miR-484 regulates mitochondrial network through targeting Fis1. Nat. Commun. 3, 781. 10.1038/ncomms1770 22510686 · DOI
  71. Wang, K., Sun, T., Li, N., Wang, Y., Wang, J.-X., Zhou, L.-Y., Long, B., Liu, C.-Y., Liu, F. and Li, P.-F. (2014). MDRL lncRNA regulates the processing of miR-484 primary transcript by targeting miR-361. PLoS Genet 10, e1004467. 10.1371/journal.pgen.1004467 25057983 PMC4109843 · DOI
  72. Wang, D., Sun, X., Wei, Y., Liang, H., Yuan, M., Jin, F., Chen, X., Liu, Y., Zhang, C. Y., Li, L. et al. (2018a). Nuclear miR-122 directly regulates the biogenesis of cell survival oncomiR miR-21 at the posttranscriptional level. Nucleic Acids Res. 46, 2012- 2029. 10.1093/nar/gkx1254 29253196 PMC5829740 · DOI · Paper page
  73. Wang, Y., Bao, W., Liu, Y., Wang, S., Xu, S., Li, X., Li, Y. and Wu, S. (2018b). miR-98-5p contributes to cisplatin resistance in epithelial ovarian cancer by suppressing miR-152 biogenesis via targeting Dicer1. Cell Death Dis. 9, 447. 10.1038/s41419-018-0390-7 29670086 PMC5906447 · DOI
  74. Wei, Y., Li, L., Wang, D., Zhang, C.-Y. and Zen, K. (2014). Importin 8 regulates the transport of mature microRNAs into the cell nucleus. J. Biol. Chem. 289, 10270- 10275. 10.1074/jbc.C113.541417 24596094 PMC4036152 · DOI
  75. Wu, B., Li, C., Zhang, P., Yao, Q., Wu, J., Han, J., Liao, L., Xu, Y., Lin, R., Xiao, D. et al. (2013). Dissection of miRNA-miRNA interaction in esophageal squamous cell carcinoma. PLoS ONE 8, e73191. 10.1371/journal.pone.0073191 24039884 PMC3764179 · DOI
  76. Yoon, A. J., Wang, S., Kutler, D. I., Carvajal, R. D., Philipone, E., Wang, T., Peters, S. M., Laroche, D., Hernandez, B. Y. and Mcdowell, B. D. (2020). MicroRNA–based risk scoring system to identify early–stage oral squamous cell carcinoma patients at high–risk for cancer–specific mortality. Head Neck 42, 1699- 1712. 10.1002/hed.26089 31981257 PMC7369212 · DOI
  77. Yu, J., Ryan, D. G., Getsios, S., Oliveira-Fernandes, M., Fatima, A. and Lavker, R. M. (2008). MicroRNA-184 antagonizes microRNA-205 to maintain SHIP2 levels in epithelia. Proc. Natl. Acad. Sci. USA 105, 19300- 19305. 10.1073/pnas.0803992105 19033458 PMC2587229 · DOI
  78. Yu, Y., Nangia-Makker, P., Farhana, L., Rajendra, S. G., Levi, E. and Majumdar, A. P. N. (2015). miR-21 and miR-145 cooperation in regulation of colon cancer stem cells. Mol. Cancer 14, 98. 10.1186/s12943-015-0372-7 25928322 PMC4415383 · DOI
  79. Zhang, X. and Zeng, Y. (2010). Regulation of mammalian microRNA expression. J Cardiovasc. Transl. Res. 3, 197- 203. 10.1007/s12265-010-9166-x 20560040 · DOI
  80. Zhao, Y., He, S., Liu, C., Ru, S., Zhao, H., Yang, Z., Yang, P., Yuan, X., Sun, S. and Bu, D. (2008). MicroRNA regulation of messenger-like noncoding RNAs: a network of mutual microRNA control. Trends Genet. 24, 323- 327. 10.1016/j.tig.2008.04.004 18514357 · DOI
  81. Zisoulis, D. G., Kai, Z. S., Chang, R. K. and Pasquinelli, A. E. (2012). Autoregulation of microRNA biogenesis by let-7 and Argonaute. Nature 486, 541- 544. 10.1038/nature11134 22722835 PMC3387326 · DOI

Cited by

Sorted by citations

Authors
Hill, M., & Tran, N.
Affiliations
University of Technology Sydney (AU)
Corresponding author
Tran, Nham
ORCID
Venue
Disease Models & Mechanisms
Publisher
The Company of Biologists
Published
2021-04-01
Volume
14
Issue
4
ISSN
  • 1754-8403 (ISSN-L)
  • 1754-8411
DOI
10.1242/dmm.047662
PMC
PMC8077553
OpenAlex
W3158158224
Cited by
674
References
2
Citations by year
2026: 78 · 2025: 168 · 2024: 197 · 2023: 170 · 2022: 59 · 2021: 2
FWCI
13.11
Type
journal article
Language
en
Open access
Licence
Locations
  • Disease Models & Mechanisms (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
Cancer Institute NSW
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Molecular Biology Research
Keywords
microRNA, long non-coding RNA, non-coding RNA regulation, cancer, gene expression regulation, cell type-specific gene regulation
MeSH terms
Animals, Humans, Models, Biological, Neoplasms, Transcription Factors, Gene Expression Regulation, Neoplastic, MicroRNAs

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review