The DOI matches its Crossref record; 75 of the 75 references it cites were found in a registry or an index.
Efficient generation of neural stem cell-like cells from adult human bone marrow stromal cells
Abstract
Clonogenic neural stem cells (NSCs) are self-renewing cells that maintain the capacity to differentiate into brain-specific cell types, and may also replace or repair diseased brain tissue. NSCs can be directly isolated from fetal or adult nervous tissue, or derived from embryonic stem cells. Here, we describe the efficient conversion of human adult bone marrow stromal cells (hMSC) into a neural stem cell-like population (hmNSC, for human marrow-derived NSC-like cells). These cells grow in neurosphere-like structures, express high levels of early neuroectodermal markers, such as the proneural genes NeuroD1, Neurog2, MSl1 as well as otx1 and nestin, but lose the characteristics of mesodermal stromal cells. In the presence of selected growth factors, hmNSCs can be differentiated into the three main neural phenotypes: astroglia, oligodendroglia and neurons. Clonal analysis demonstrates that individual hmNSCs are multipotent and retain the capacity to generate both glia and neurons. Our cell culture system provides a powerful tool for investigating the molecular mechanisms of neural differentiation in adult human NSCs. hmNSCs may therefore ultimately help to treat acute and chronic neurodegenerative diseases.
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2 retracted
RETRACTED ARTICLE: Pluripotency of mesenchymal stem cells derived from adult marrow
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Cited by
Oct4-Induced Pluripotency in Adult Neural Stem Cells
Kim, J. B., Sebastiano, V., Wu, G., Araúzo-Bravo, M. J., Sasse, P., Gentile, L., Ko, K., Ruau, D., Ehrich, M., van den Boom, D., et al. (2009) · Cell · doi:10.1016/j.cell.2009.01.023 · Cited by 934
Concise Review: Wharton's Jelly-Derived Cells Are a Primitive Stromal Cell Population
Troyer, D. L., & Weiss, M. L. (2008) · Stem Cells · doi:10.1634/stemcells.2007-0439 · Cited by 767
Neuronal medium that supports basic synaptic functions and activity of human neurons in vitro
Bardy, C., van den Hurk, M., Eames, T., Marchand, C., Hernandez, R. V., Kellogg, M., Gorris, M., Galet, B., Palomares, V., Brown, J., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1504393112 · Cited by 429
Advances and challenges in stem cell culture
McKee, C., & Chaudhry, G. R. (2017) · Colloids and Surfaces B: Biointerfaces · doi:10.1016/j.colsurfb.2017.07.051 · Cited by 323
Wakao, S., Kitada, M., Kuroda, Y., Shigemoto, T., Matsuse, D., Akashi, H., Tanimura, Y., Tsuchiyama, K., Kikuchi, T., Goda, M., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1100816108 · Cited by 314
Metadata
- Authors
- Hermann, A., Gastl, R., Liebau, S., Popa, M. O., Fiedler, J., Boehm, B. O., Maisel, M., Lerche, H., Schwarz, J., Brenner, R., & Storch, A.
- Venue
- Journal of Cell Science
- Publisher
- The Company of Biologists
- Published
- 2004-09-01
- Volume
- 117
- Issue
- 19
- Pages
- 4411-4422
- ISSN
- 0021-9533 (ISSN-L)
- 1477-9137
- OpenAlex
- W2135463801
- Cited by
- 450
- References
- 75
- FWCI
- 6.39
- Type
- journal article
- Language
- en
- Open access
- closed
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- Hermann, A., Gastl, R., Liebau, S., Popa, M. O., Fiedler, J., Boehm, B. O., Maisel, M., Lerche, H., Schwarz, J., Brenner, R., & Storch, A. (2004). Efficient generation of neural stem cell-like cells from adult human bone marrow stromal cells. Journal of Cell Science. https://doi.org/10.1242/jcs.01307
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
