The DOI matches its Crossref record; 116 of the 116 references it cites were found in a registry or an index.
Platelet adhesion signalling and the regulation of thrombus formation
Abstract
Platelets perform a central role in haemostasis and thrombosis. They adhere to subendothelial collagens exposed at sites of blood vessel injury via the glycoprotein (GP) Ib-V-IX receptor complex, GPVI and integrin α2β1. These receptors perform distinct functions in the regulation of cell signalling involving non-receptor tyrosine kinases (e.g. Src, Fyn, Lyn, Syk and Btk), adaptor proteins, phospholipase C and lipid kinases such as phosphoinositide 3-kinase. They are also coupled to an increase in cytosolic calcium levels and protein kinase C activation, leading to the secretion of paracrine/autocrine platelet factors and an increase in integrin receptor affinities. Through the binding of plasma fibrinogen and von Willebrand Factor to integrin αIIbβ3, a platelet thrombus is formed. Although increasing evidence indicates that each of the adhesion receptors GPIb-V-IX and GPVI and integrins α2β1 and αIIbβ3 contribute to the signalling that regulates this process, the individual roles of each are only beginning to be dissected. By contrast, adhesion receptor signalling through platelet endothelial cell adhesion molecule 1 (PECAM-1) is implicated in the inhibition of platelet function and thrombus formation in the healthy circulation. Recent studies indicate that understanding of platelet adhesion signalling mechanisms might enable the development of new strategies to treat and prevent thrombosis.
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Cites
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Cited by
Furie, B. (2005) · Journal of Clinical Investigation · doi:10.1172/jci26987 · Cited by 485
Platelet receptors and signaling in the dynamics of thrombus formation
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Peroxisome Proliferator-Activated Receptor Targets for the Treatment of Metabolic Diseases
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Beyond Hemostasis: Platelet Innate Immune Interactions and Thromboinflammation
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Metadata
- Authors
- Gibbins, J. M.
- Venue
- Journal of Cell Science
- Publisher
- The Company of Biologists
- Published
- 2004-07-15
- Volume
- 117
- Issue
- 16
- Pages
- 3415-3425
- ISSN
- 0021-9533 (ISSN-L)
- 1477-9137
- OpenAlex
- W1963957395
- Cited by
- 292
- References
- 116
- FWCI
- 8.68
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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