The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
The genetics of Pak
Abstract
p21-activated kinases (Paks) are a highly conserved family of enzymes that bind to and are activated by small GTPases of the Cdc42 and Rac families. With the notable exception of plants, nearly all eukaryotes encode one or more Pak genes, indicating an ancient origin and important function for this family of enzymes. Genetic approaches in many different experimental systems, ranging from yeast to mice, are beginning to decipher the different functions of Paks. Although some of these functions are unique to a given organism, certain common themes have emerged, such as the activation of mitogen-activated protein kinase (MAPK) cascades and the regulation of cytoskeletal structure through effects on the actin and tubulin cytoskeletons.
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Penzes, P., Beeser, A., Chernoff, J., Schiller, M. R., Eipper, B. A., Mains, R. E., & Huganir, R. L. (2003) · Neuron · doi:10.1016/s0896-6273(02)01168-6 · Cited by 466
Self-citationHayashi, M. L., Choi, S.-Y., Rao, B. S. S., Jung, H.-Y., Lee, H.-K., Zhang, D., Chattarji, S., Kirkwood, A., & Tonegawa, S. (2004) · Neuron · doi:10.1016/j.neuron.2004.05.003 · Cited by 280
Park, E., Na, M., Choi, J., Kim, S., Lee, J.-R., Yoon, J., Park, D., Sheng, M., & Kim, E. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301052200 · Cited by 175 · cited 1×
“4351The genetics of Pak necessary for dendritic development or for the rapid cytoskeletal reorganizations in dendritic spines associated with synaptic plasticity (Park et al., 2003; Penzes et al., 2003).”
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Cited by
PAK signalling during the development and progression of cancer
Radu, M., Semenova, G., Kosoff, R., & Chernoff, J. (2014) · Nature Reviews Cancer · doi:10.1038/nrc3645 · Cited by 503
Self-citationArias‐Romero, L. E., & Chernoff, J. (2008) · Biology of the Cell · doi:10.1042/bc20070109 · Cited by 364
Self-citationShamloo, B., & Usluer, S. (2019) · Cancers · doi:10.3390/cancers11081178 · Cited by 336
Rho GTPases: functions and association with cancer
Ellenbroek, S. I. J., & Collard, J. G. (2007) · Clinical & Experimental Metastasis · doi:10.1007/s10585-007-9119-1 · Cited by 289
Dlx transcription factors promote migration through repression of axon and dendrite growth
Cobos, I., Borello, U., & Rubenstein, J. L. R. (2007) · Neuron · doi:10.1016/j.neuron.2007.05.024 · Cited by 246
Metadata
- Authors
- Hofmann, C., Shepelev, M., & Chernoff, J.
- Venue
- Journal of Cell Science
- Publisher
- The Company of Biologists
- Published
- 2004-09-01
- Volume
- 117
- Issue
- 19
- Pages
- 4343-4354
- ISSN
- 0021-9533 (ISSN-L)
- 1477-9137
- OpenAlex
- W2035256602
- Cited by
- 239
- References
- 3
- FWCI
- 4.48
- Type
- journal article
- Language
- en
- Open access
- closed
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