p21 in Cancer Research

Genome engineering using the CRISPR-Cas9 system

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Comprehensive molecular characterization of human colon and rectal cancer

The Cancer Genome Atlas Network (2012) · Nature · doi:10.1038/nature11252 · Cited by 8,499 · see citing works

WAF1, a potential mediator of p53 tumor suppression

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The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases.

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TGFβ in Cancer

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p21 in cancer: Intricate networks and multiple activities

Abbas, T., & Dutta, A. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2657 · Cited by 2,712 · see citing works

The emerging role of lncRNAs in cancer

Huarte, M. (2015) · Nature Medicine · doi:10.1038/nm.3981 · Cited by 2,686 · see citing works

Cepharanthine potently enhances the sensitivity of anticancer agents in K562 cells

Ikeda, R., Che, X., Yamaguchi, T., Ushiyama, M., Zheng, C., Okumura, H., Takeda, Y., Shibayama, Y., Nakamura, K. T., Jeung, H., et al. (2005) · Cancer Science · doi:10.1111/j.1349-7006.2005.00057.x · Cited by 2,268 · see citing works

Hybrid restriction enzymes: zinc finger fusions to Fok I cleavage domain.

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A Large Intergenic Noncoding RNA Induced by p53 Mediates Global Gene Repression in the p53 Response

Huarte, M., Guttman, M., Feldser, D., Garber, M., Koziol, M. J., Kenzelmann-Broz, D., Khalil, A. M., Zuk, O., Amit, I., Rabani, M., et al. (2010) · Cell · doi:10.1016/j.cell.2010.06.040 · Cited by 2,053 · see citing works

Altering the Genome by Homologous Recombination

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Targeting DNA Double-Strand Breaks with TAL Effector Nucleases

Christian, M. L., Čermák, T., Doyle, E., Schmidt, C. L., Zhang, F., Hummel, A. W., Bogdanove, A. J., & Voytas, D. F. (2010) · Genetics · doi:10.1534/genetics.110.120717 · Cited by 2,033 · see citing works

Hematopoietic Stem Cell Quiescence Maintained by p21 ^cip1/waf1

Cheng, T., Rodrigues, N., Shen, H., Yang, Y.-G., Dombkowski, D., Sykes, M., & Scadden, D. T. (2000) · Science · doi:10.1126/science.287.5459.1804 · Cited by 1,339 · see citing works

Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells

Zhou, B. P., Liao, Y., Xia, W., Spohn, B., Lee, M., & Hung, M. (2001) · Nature Cell Biology · doi:10.1038/35060032 · Cited by 1,135 · see citing works

p53-dependent and independent expression of p21 during cell growth, differentiation, and DNA damage.Preprint

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The role of the cyclin-dependent kinase inhibitor p21 in apoptosis.

Gartel, A. L., & Tyner, A. L. (2002) · PubMed · Cited by 924 · see citing works

Induction of WAF1/CIP1 by a p53-independent pathway.

Michieli, P., Chedid, M., Lin, D. P., Pierce, J. H., Mercer, W. E., & Givol, D. (1994) · PubMed · Cited by 768 · see citing works

Combination Cancer Therapy Can Confer Benefit via Patient-to-Patient Variability without Drug Additivity or Synergy

Palmer, A. C., & Sorger, P. K. (2017) · Cell · doi:10.1016/j.cell.2017.11.009 · Cited by 642 · see citing works

Gene Essentiality Profiling Reveals Gene Networks and Synthetic Lethal Interactions with Oncogenic Ras

Wang, T., Yu, H., Hughes, N. W., Liu, B., Kendirli, A., Klein, K., Chen, W. W., Lander, E. S., & Sabatini, D. M. (2017) · Cell · doi:10.1016/j.cell.2017.01.013 · Cited by 632 · see citing works

RNA-triggered gene silencing

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Towards a complete map of the human long non-coding RNA transcriptome

Uszczyńska-Ratajczak, B., Lagarde, J., Frankish, A., Guigó, R., & Johnson, R. (2018) · Nature Reviews Genetics · doi:10.1038/s41576-018-0017-y · Cited by 611 · see citing works

Viral Vectors for Gene Therapy

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Reciprocal Regulation of HIF-1α and LincRNA-p21 Modulates the Warburg Effect

Yang, F., Zhang, H., Mei, Y., & Wu, M. (2013) · Molecular Cell · doi:10.1016/j.molcel.2013.11.004 · Cited by 510 · see citing works

p21: a two-faced genome guardian.

Georgakilas, A. G., Martin, O. A., & Bonner, W. M. (2017) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2017.02.001 · Cited by 489 · see citing works

LincRNA-p21 Regulates Neointima Formation, Vascular Smooth Muscle Cell Proliferation, Apoptosis, and Atherosclerosis by Enhancing p53 Activity

Wu, G., Cai, J., Han, Y., Chen, J., Huang, Z., Chen, C., Cai, Y., Huang, H., Yang, Y., Liu, Y., et al. (2014) · Circulation · doi:10.1161/circulationaha.114.011675 · Cited by 486 · see citing works

An integrated database of genes responsive to the Myc oncogenic transcription factor: identification of direct genomic targets

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Examination of the expanding pathways for the regulation of p21 expression and activity

Jung, Y.-S., Qian, Y., & Chen, X. (2010) · Cellular Signalling · doi:10.1016/j.cellsig.2010.01.013 · Cited by 418 · see citing works

Tumor susceptibility of p21(Waf1/Cip1)-deficient mice.

Martín‐Caballero, J., Flores, J. M., Garcı́a, P., & Serrano, M. (2001) · PubMed · Cited by 352 · see citing works

mdm-2 Inhibits the G1 Arrest and Apoptosis Functions of the p53 Tumor Suppressor Protein

Chen, J., Wu, X., Lin, J., & Levine, A. J. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.5.2445 · Cited by 350 · see citing works

SOX2 promotes dedifferentiation and imparts stem cell-like features to pancreatic cancer cells

Herreros‐Villanueva, M., Js, Z., König, A. O., Abel, E. V., Smyrk, T. C., Bamlet, W. R., de Narvajas, A. A.-M., Gomez, T. S., Simeone, D. M., Bujanda, L., et al. (2013) · Oncogenesis · doi:10.1038/oncsis.2013.23 · Cited by 326 · see citing works

The p53-p21-DREAM-CDE/CHR pathway regulates G 2 /M cell cycle genes

Fischer, M., Quaas, M., Steiner, L., & Engeland, K. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv927 · Cited by 324 · see citing works

Myc represses differentiation-induced p21CIP1 expression via Miz-1-dependent interaction with the p21 core promoter

Wu, S., Cetinkaya, C., Muñoz-Alonso, M. J., von der Lehr, N., Bahram, F., Beuger, V., Eilers, M., León, J., & Larsson, L. (2003) · Oncogene · doi:10.1038/sj.onc.1206145 · Cited by 314 · see citing works

Synthetic lethality: General principles, utility and detection using genetic screens in human cells

Nijman, S. M. B. (2010) · FEBS Letters · doi:10.1016/j.febslet.2010.11.024 · Cited by 313 · see citing works

Chronic p53-independent p21 expression causes genomic instability by deregulating replication licensing

Galanos, P., Vougas, K., Walter, D., Polyzos, A., Maya-Mendoza, A., Haagensen, E. J., Kokkalis, A., Roumelioti, F.-M., Gagos, S., Tzetis, M., et al. (2016) · Nature Cell Biology · doi:10.1038/ncb3378 · Cited by 308 · see citing works

Cell-cycle restriction limits DNA damage and maintains self-renewal of leukaemia stem cells

Viale, A., Franco, F., Orleth, A., Cambiaghi, V., Giuliani, V., Bossi, D., Ronchini, C., Ronzoni, S., Muradore, I., Monestiroli, S., et al. (2008) · Nature · doi:10.1038/nature07618 · Cited by 303 · see citing works

p21Waf1/Cip1 protects against p53-mediated apoptosis of human melanoma cells

Gorospe, M., Cirielli, C., Wang, X., Seth, P. K., Capogrossi, M. C., & Holbrook, N. J. (1997) · Oncogene · doi:10.1038/sj.onc.1200897 · Cited by 294 · see citing works

Viral vectors for gene therapy

Robbins, P. D., Tahara, H., & Ghivizzani, S. C. (1998) · Trends in biotechnology · doi:10.1016/s0167-7799(97)01137-2 · Cited by 292 · see citing works

NSUN2-Mediated m5C Methylation and METTL3/METTL14-Mediated m6A Methylation Cooperatively Enhance p21 Translation

Qiu, L., Li, X., Tang, H., Jiang, B., Dou, Y., Gorospe, M., & Wang, W. (2017) · Journal of Cellular Biochemistry · doi:10.1002/jcb.25957 · Cited by 284 · see citing works

p53-independent induction of WAF1/CIP1 in human leukemia cells is correlated with growth arrest accompanying monocyte/macrophage differentiation.

Zhang, W., Grasso, L., McClain, C. D., Gambel, A. M., Cha, Y., Travali, S., Deisseroth, A., & Mercer, W. E. (1995) · PubMed · Cited by 254 · see citing works

P21 activated kinase signaling in cancer

Rane, C. K., & Minden, A. (2018) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2018.01.006 · Cited by 247 · see citing works

The genetics of Pak

Hofmann, C., Shepelev, M. V., & Chernoff, J. (2004) · Journal of Cell Science · doi:10.1242/jcs.01392 · Cited by 240 · see citing works

Potential Role of WAF1/Cip1/p21 as a Mediator of TGF-β Cytoinhibitory Effect

Li, C., Suardet, L., & Little, J. B. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.10.4971 · Cited by 239 · see citing works

Cytoplasmic p21 expression levels determine cisplatin resistance in human testicular cancer

Koster, R., di Pietro, A., Timmer‐Bosscha, H., Gibcus, J. H., van den Berg, A., Suurmeijer, A. J. H., Bischoff, R., Gietema, J. A., & de Jong, S. (2010) · Journal of Clinical Investigation · doi:10.1172/jci41939 · Cited by 227 · see citing works

P21 activated kinases

Rane, C. K., & Minden, A. (2014) · Small GTPases · doi:10.4161/sgtp.28003 · Cited by 227 · see citing works

Loss of microRNA-143/145 disturbs cellular growth and apoptosis of human epithelial cancers by impairing the MDM2-p53 feedback loop

Zhang, J., Sun, Q., Zhang, Z., Ge, S., Han, Z.-G., & Chen, W.-T. (2012) · Oncogene · doi:10.1038/onc.2012.28 · Cited by 224 · see citing works

PAK signaling in cancer

Ye, D. Z., & Field, J. M. (2012) · Cellular Logistics · doi:10.4161/cl.21882 · Cited by 220 · see citing works

In vivo gene therapy with p53 or p21 adenovirus for prostate cancer.

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Long noncoding RNA PANDA and scaffold-attachment-factor SAFA control senescence entry and exit

Pavan Kumar, P., Desetty, R. D., Pineau, P., Marchio, A., Moon, A., Dejean, A., & Bischof, O. (2014) · Nature Communications · doi:10.1038/ncomms6323 · Cited by 200 · see citing works

The p53-induced lincRNA-p21 derails somatic cell reprogramming by sustaining H3K9me3 and CpG methylation at pluripotency gene promoters

Bao, X., Wu, H., Zhu, X., Guo, X., Hutchins, A. P., Luo, Z., Song, H., Chen, Y., Lai, K., Yin, M., et al. (2014) · Cell Research · doi:10.1038/cr.2014.165 · Cited by 186 · see citing works

Phosphorylation/Cytoplasmic Localization of p21Cip1/WAF1 Is Associated with HER2/ neu Overexpression and Provides a Novel Combination Predictor for Poor Prognosis in Breast Cancer Patients

Xia, W., Chen, J., Zhou, X. C., Sun, P.-R., Lee, D., Liao, Y., Zhou, B. P., & Hung, M. (2004) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-03-0527 · Cited by 167 · see citing works

Deubiquitylation and stabilization of p21 by USP11 is critical for cell-cycle progression and DNA damage responses

Deng, T., Yan, G., Song, X., Xie, L. Y., Zhou, Y., Li, J., Hu, X., Li, Z., Hu, J., Zhang, Y., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1714938115 · Cited by 162 · see citing works

Comparative analysis of ear-hole closure identifies epimorphic regeneration as a discrete trait in mammals

Gawriluk, T. R., Simkin, J., Thompson, K. L., Biswas, S. K., Clare-Salzler, Z., Kimani, J. M., Kiama, S. G., Smith, J. J., Ezenwa, V. O., & Seifert, A. W. (2016) · Nature Communications · doi:10.1038/ncomms11164 · Cited by 158 · see citing works

Targeted inactivation of the p21(WAF1/cip1) gene enhances Apc-initiated tumor formation and the tumor-promoting activity of a Western-style high-risk diet by altering cell maturation in the intestinal mucosal.

Yang, W., Mathew, J., Velcich, A., Edelmann, W., Kucherlapati, R., Lipkin, M., Yang, K., & Augenlicht, L. H. (2001) · PubMed · Cited by 145 · see citing works

P21 RNA and protein expression in non-small cell lung carcinomas: Evidence of p53-independent expression and association with tumoral differentiation

Histology, M. I. P. A. (1996) · Lung Cancer · doi:10.1016/s0169-5002(97)89503-7 · Cited by 124 · see citing works

Curcumin improves the efficacy of cisplatin by targeting cancer stem-like cells through p21 and cyclin D1-mediated tumour cell inhibition in non-small cell lung cancer cell lines

Baharuddin, P., Satar, N. A., Fakiruddin, K. S., Zakaria, N., Lim, M. N., Yusoff, N. M., Zakaria, Z., & Yahaya, B. H. (2015) · Oncology Reports · doi:10.3892/or.2015.4371 · Cited by 123 · see citing works

PSMD2 regulates breast cancer cell proliferation and cell cycle progression by modulating p21 and p27 proteasomal degradation

Li, Y., Huang, J., Zeng, B., Yang, D., Sun, J., Yin, X., Lu, M., Qiu, Z., Peng, W., Xiang, T., et al. (2018) · Cancer Letters · doi:10.1016/j.canlet.2018.05.018 · Cited by 120 · see citing works

p21 Blocks Irradiation-Induced Apoptosis Downstream of Mitochondria by Inhibition of Cyclin-Dependent Kinase–Mediated Caspase-9 Activation

Sohn, D., Eßmann, F., Schulze‐Osthoff, K., & Jänicke, R. U. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-1569 · Cited by 118 · see citing works

PAK family kinases

Zhao, Z.-S., & Manser, E. (2012) · Cellular Logistics · doi:10.4161/cl.21912 · Cited by 114 · see citing works

FBXO22 promotes the development of hepatocellular carcinoma by regulating the ubiquitination and degradation of p21

Zhang, L., Chen, J., Deng, N., Liu, Q., Wang, C., Zhang, Z., Chu, L., Yu, C., Liang, H., Zhang, B., et al. (2019) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-019-1058-6 · Cited by 112 · see citing works

Two variants of the CIP1/WAF1 gene occur together and are associated with human cancer

Mousses, S., Özçelik, H., D.Lee, P., Malkin, D. M., Bull, S. B., & Andrulis, I. L. (1995) · Human Molecular Genetics · doi:10.1093/hmg/4.6.1089 · Cited by 109 · see citing works

PAK4: a pluripotent kinase that regulates prostate cancer cell adhesion

Wells, C. M., Whale, A. D., Parsons, M., Masters, J. R., & Jones, G. E. (2010) · Journal of Cell Science · doi:10.1242/jcs.055707 · Cited by 104 · see citing works

Adenovirus-Mediated p21 (WAF1/SDII/CIP1) Gene Transfer Induces Apoptosis of Human Cervical Cancer Cell Lines

Tsao, Y., Huang, S.-J., Chang, J.-L., Hsieh, J., Pong, R.-C., & Chen, S. (1999) · Journal of Virology · doi:10.1128/jvi.73.6.4983-4990.1999 · Cited by 103 · see citing works

Defective G1-S cell cycle checkpoint function sensitizes cells to microtubule inhibitor-induced apoptosis.

Stewart, Z. A., Mays, D. J., & Pietenpol, J. A. (1999) · PubMed · Cited by 101 · see citing works

MicroRNA-7 inhibits the stemness of prostate cancer stem-like cells and tumorigenesis by repressing KLF4/PI3K/Akt/p21 pathway

Chang, Y., Zhou, P.-J., Wei, L., Li, W., Ji, Z., Fang, Y., & Gao, W. (2015) · Oncotarget · doi:10.18632/oncotarget.4447 · Cited by 98 · see citing works

p53-dependent gene repression through p21 is mediated by recruitment of E2F4 repression complexes

Benson, E. K., Mungamuri, S. K., Attie, O., Kracikova, M., Sachidanandam, R., Manfredi, J. J., & Aaronson, S. A. (2013) · Oncogene · doi:10.1038/onc.2013.378 · Cited by 93 · see citing works

The Degree of Liver Injury Determines the Role of P21 in Liver Regeneration And Hepatocarcinogenesis in Mice

Buitrago‐Molina, L. E., Marhenke, S., Longerich, T., Sharma, A. D., Boukouris, A. E., Geffers, R., Guigas, B., Manns, M. P., & Vogel, A. (2013) · Hepatology · doi:10.1002/hep.26412 · Cited by 92 · see citing works

Loss of p21WAF1/CIP1 accelerates Ras oncogenesis in a transgenic/knockout mammary cancer model

Adnane, J., Jackson, R. J., Nicosia, S. V., Cantor, A. B., Pledger, W. J., & Sebti, S. M. (2000) · Oncogene · doi:10.1038/sj.onc.1203956 · Cited by 91 · see citing works

Tumor suppressor functions for the Cdk inhibitor p21 in the mouse colon

Poole, A. J., Heap, D., Carroll, R. E., & Tyner, A. L. (2004) · Oncogene · doi:10.1038/sj.onc.1207994 · Cited by 91 · see citing works

PAKs in Human Cancer Progression

Kumar, R., & Li, D.-Q. (2016) · Advances in cancer research · doi:10.1016/bs.acr.2016.01.002 · Cited by 90 · see citing works

Oridonin‐induced mitochondria‐dependent apoptosis in esophageal cancer cells by inhibiting PI3K/AKT/mTOR and Ras/Raf pathways

Jiang, J., Pi, J., Jin, H., & Cai, J. (2018) · Journal of Cellular Biochemistry · doi:10.1002/jcb.27654 · Cited by 90 · see citing works

LincRNa-p21: function and mechanism in cancer

Chen, S., Liang, H., Yang, H., Zhou, K., Xu, L., Liu, J., Lai, B., Li, S., Luo, H., Peng, J., et al. (2017) · Medical Oncology · doi:10.1007/s12032-017-0959-5 · Cited by 89 · see citing works

MiR-146b-5p overexpression attenuates stemness and radioresistance of glioma stem cells by targeting HuR/lincRNA-p21/β-catenin pathway

Yang, W., Yu, H., Shen, Y., Liu, Y., Yang, Z., & Sun, T. (2016) · Oncotarget · doi:10.18632/oncotarget.9214 · Cited by 87 · see citing works

Dose and Schedule Determine Distinct Molecular Mechanisms Underlying the Efficacy of the p53–MDM2 Inhibitor HDM201

Jeay, S., Ferretti, S., Holzer, P., Fuchs, J., Chapeau, E. A., Wartmann, M., Sterker, D., Romanet, V., Murakami, M., Kerr, G., et al. (2018) · Cancer Research · doi:10.1158/0008-5472.can-18-0338 · Cited by 87 · see citing works

Tumor suppression by p53: making cells senescent.

Qian, Y., & Chen, X. (2010) · PubMed · doi:10.14670/hh-25.515 · Cited by 85 · see citing works

Oridonin inhibits oral cancer growth and PI3K/Akt signaling pathway

Yang, J., Ren, X., Zhang, L., Li, Y., Cheng, B., & Xia, J. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.02.011 · Cited by 82 · see citing works

Dual Role of p21 in the Progression of Cancer and Its Treatment

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Relationship between p21 expression and mutation of the p53 tumor suppressor gene in normal and malignant ovarian epithelial cells.

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WAF1/Cip1 gene polymorphism and expression in carcinomas of the breast, ovary, and endometrium.

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p-21 activated kinase 4 (PAK4) maintains stem cell-like phenotypes in pancreatic cancer cells through activation of STAT3 signaling

Tyagi, N., Marimuthu, S., Bhardwaj, A., Deshmukh, S. K., Srivastava, S. K., Singh, A. P., McClellan, S. B., Carter, J. E., & Singh, S. (2015) · Cancer Letters · doi:10.1016/j.canlet.2015.10.028 · Cited by 80 · see citing works

Induction of the WAF1/CIP1 protein and apoptosis in human T-cell leukemia virus type I-transformed lymphocytes after treatment with adriamycin by using a p53-independent pathway.

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miRNA-regulated delivery of lincRNA-p21 suppresses β-catenin signaling and tumorigenicity of colorectal cancer stem cells

Wang, J., Lei, Z., Guo, Y., Wang, T., Qin, Z., Xiao, H., Fan, L., Chen, D., Bian, X., Liu, J., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.5635 · Cited by 78 · see citing works

RNA-Binding Protein FXR1 Regulates p21 and TERC RNA to Bypass p53-Mediated Cellular Senescence in OSCC

Majumder, M., House, R. P., Palanisamy, N., Qie, S., Day, T. A., Neskey, D. M., Diehl, J. A., & Palanisamy, V. (2016) · PLoS Genetics · doi:10.1371/journal.pgen.1006306 · Cited by 78 · see citing works

Loss of the cell cycle inhibitors p21Cip1 and p27Kip1 enhances tumorigenesis in knockout mouse models

Jackson, R. J., Adnane, J., Coppola, D., Cantor, A. B., Sebti, S. M., & Pledger, W. J. (2002) · Oncogene · doi:10.1038/sj.onc.1205946 · Cited by 77 · see citing works

Synthetic lethality of Chk1 inhibition combined with p53 and/or p21 loss during a DNA damage response in normal and tumor cells

Origanti, S., Cai, S.-R., Munir, A. Z., White, L. S., & Piwnica-Worms, H. (2013) · Oncogene · doi:10.1038/onc.2012.84 · Cited by 74 · see citing works

Induction of p21CIP/WAF-1 and G2 arrest by ionizing irradiation impedes caspase-3-mediated apoptosis in human carcinoma cells

Wendt, J., Radetzki, S., von Haefen, C., Hemmati, P., Güner, D., Schulze‐Osthoff, K., Dörken, B., & Daniel, P. T. (2005) · Oncogene · doi:10.1038/sj.onc.1209031 · Cited by 71 · see citing works

Transcription regulation of CDKN1A (p21/CIP1/WAF1) by TRF2 is epigenetically controlled through the REST repressor complex

Hussain, T., Saha, D., Purohit, G., Kar, A., Mukherjee, A. K., Sharma, S., Sengupta, S., Dhapola, P., Maji, B., Sreekanth, V., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-11177-1 · Cited by 70 · see citing works

p16Ink4a and p21Cip1/Waf1 promote tumour growth by enhancing myeloid-derived suppressor cells chemotaxis

Okuma, A., Hanyu, A., Watanabe, S., & Hara, E. (2017) · Nature Communications · doi:10.1038/s41467-017-02281-x · Cited by 69 · see citing works

Rbm24, an RNA-binding Protein and a Target of p53, Regulates p21 Expression via mRNA Stability

Jiang, Y., Zhang, M., Qian, Y., Xu, E., Zhang, J., & Chen, X. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.524413 · Cited by 66 · see citing works

The Dual Role Played by p21 May Influence the Apoptotic or Anti-Apoptotic Fate in Cancer

Piccolo, M. T., & Crispi, S. (2012) · Journal of cancer research updates · doi:10.6000/1929-2279.2012.01.02.5 · Cited by 65 · see citing works

LincRNA-p21: Implications in Human Diseases

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Ex vivo targeting of p21Cip1/Waf1 permits relative expansion of human hematopoietic stem cells

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The emerging roles of TRIM21 in coordinating cancer metabolism, immunity and cancer treatment

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Marine peptides in breast cancer: Therapeutic and mechanistic understanding

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The Role of Cell Cycle Regulators in Cell Survival—Dual Functions of Cyclin-Dependent Kinase 20 and p21Cip1/Waf1

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Aloperine executes antitumor effects through the induction of apoptosis and cell cycle arrest in prostate cancer in vitro and in vivo

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MDA-9/Syntenin/SDCBP: new insights into a unique multifunctional scaffold protein

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LMNB2 promotes the progression of colorectal cancer by silencing p21 expression

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Out of the cycle: Impact of cell cycle aberrations on cancer metabolism and metastasis

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Aging, ROS, and cellular senescence: a trilogy in the progression of liver fibrosis

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TTK inhibitor promotes radiosensitivity of liver cancer cells through p21

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Loperamide potentiates doxorubicin sensitivity in triple‐negative breast cancer cells by targeting MDR1 and JNK and suppressing mTOR and Bcl‐2: In vitro and molecular docking study

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Isoliquiritigenin inhibits the proliferation, migration and metastasis of Hep3B cells via suppressing cyclin D1 and PI3K/AKT pathway

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Cyclin-dependent kinase inhibitors (CDKIs) and the DNA damage response: The link between signaling pathways and cancer

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Immunohistochemical Profile of Parathyroid Tumours: A Comprehensive Review

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To target cellular senescence in diabetic kidney disease: the known and the unknown

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Swertia chirayita suppresses the growth of non-small cell lung cancer A549 cells and concomitantly induces apoptosis via downregulation of JAK1/STAT3 pathway

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PI3K/Akt signaling in urological cancers: Tumorigenesis function, therapeutic potential, and therapy response regulation

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Smad4 and p53 synergize in suppressing autochthonous intestinal cancer

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Nuclear receptor tyrosine kinase transport and functions in cancer

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The interaction between MALAT1 target, miR-143-3p, and RALGAPA2 is affected by functional SNP rs3827693 in breast cancer

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The Intricate Interplay between Cell Cycle Regulators and Autophagy in Cancer

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Rumex Vesicarius L. extract improves the efficacy of doxorubicin in triple-negative breast cancer through inhibiting Bcl2, mTOR, JNK1 and augmenting p21 expression

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Synthesis, molecular docking, and in-vitro studies of pyrimidine-2-thione derivatives as antineoplastic agents via potential RAS/PI3K/Akt/JNK inhibition in breast carcinoma cells

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p21 limits S phase DNA damage caused by the Wee1 inhibitor MK1775

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USP39 mediates p21‐dependent proliferation and neoplasia of colon cancer cells by regulating the p53/p21/CDC2/cyclin B1 axis

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Non‐coding RNA‐associated competitive endogenous RNA regulatory networks: Novel diagnostic and therapeutic opportunities for hepatocellular carcinoma

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Targeting the p53-p21 axis in liver cancer: Linking cellular senescence to tumor suppression and progression

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Natural compound catechol induces DNA damage, apoptosis, and G1 cell cycle arrest in breast cancer cells

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The Effect of Resveratrol or Curcumin on Head and Neck Cancer Cells Sensitivity to the Cytotoxic Effects of Cisplatin

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Magnesium in Combinatorial With Valproic Acid Suppressed the Proliferation and Migration of Human Bladder Cancer Cells

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Activation of DNA damage response signaling in mammalian cells by ionizing radiation

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Knockdown of the prognostic cancer stem cell marker Musashi-1 decreases radio-resistance while enhancing apoptosis in hormone receptor-positive breast cancer cells via p21WAF1/CIP1

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In vitro anticancer activity of ethanol extract of Adhatoda vasica Nees on human ovarian cancer cell lines

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uL3 Mediated Nucleolar Stress Pathway as a New Mechanism of Action of Antiproliferative G-quadruplex TBA Derivatives in Colon Cancer Cells

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SH3GL3 functions as a potent tumor suppressor in lung cancer in a SH3 domain dependent manner

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Dynamic Spatiotemporal Expression Pattern of the Senescence-Associated Factor p16Ink4a in Development and Aging

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Critical roles of microRNA-141-3p and CHD8 in hypoxia/reoxygenation-induced cardiomyocyte apoptosis

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p21-Activated kinase 3 promotes cancer stem cell phenotypes through activating the Akt-GSK3β-β-catenin signaling pathway in pancreatic cancer cells

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Do Bacteria Provide an Alternative to Cancer Treatment and What Role Does Lactic Acid Bacteria Play?

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Carotenoid pigment of Halophilic archaeon Haloarcula sp. A15 induces apoptosis of breast cancer cells

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Ubiquitin-specific protease-44 inhibits the proliferation and migration of cells via inhibition of JNK pathway in clear cell renal cell carcinoma

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DHMMF, a natural flavonoid from Resina Draconis, inhibits hepatocellular carcinoma progression via inducing apoptosis and G2/M phase arrest mediated by DNA damage-driven upregulation of p21

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Paradigm shift: microRNAs interact with target gene promoters to cause transcriptional gene activation or silencing

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Annona senegalensis extract demonstrates anticancer properties in N-diethylnitrosamine-induced hepatocellular carcinoma in male Wistar rats

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Caprylic Acid (FFA C8:0) promotes the progression of prostate cancer by up-regulating G protein-coupled receptor 84/ Krüppel-like factor 7

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Small nucleolar RNA 42 promotes the growth of hepatocellular carcinoma through the p53 signaling pathway

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ARIH2 regulates the proliferation, DNA damage and chemosensitivity of gastric cancer cells by reducing the stability of p21 via ubiquitination

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Milk-Derived miR-22-3p Promotes Proliferation of Human Intestinal Epithelial Cells (HIECs) by Regulating Gene Expression

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The Interplay between Noncoding RNAs and p21 Signaling in Gastrointestinal Cancer: From Tumorigenesis to Metastasis

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Therapeutic strategies targeting cellular senescence for cancer and other diseases

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<scp>FOXD1</scp> promotes dedifferentiation and targeted therapy resistance in melanoma by regulating the expression of connective tissue growth factor

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GATA6 Exerts Potent Lung Cancer Suppressive Function by Inducing Cell Senescence

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The phytochemical brazilin suppress DNMT1 expression by recruiting p53 to its promoter resulting in the epigenetic restoration of p21 in MCF7cells

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Synthetic Design and Biological Evaluation of New p53-MDM2 Interaction Inhibitors Based on Imidazoline Core

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Simultaneous suppression of PKM2 and PHGDH elicits synergistic anti-cancer effect in NSCLC

Wang, K., Lu, H., Wang, X., Liu, Q., Hu, J., Liu, Y., Jin, M., & Kong, D. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1200538 · Cited by 20 · see citing works

Modulation of Apoptotic, Cell Cycle, DNA Repair, and Senescence Pathways by Marine Algae Peptides in Cancer Therapy

Visuddho, V., Halim, P., Helen, H., Muhar, A. M., Iqhrammullah, M., Mayulu, N., Surya, R., Tjandrawinata, R. R., Ribeiro, R. I. M. D. A., Tallei, T. E., et al. (2024) · Marine Drugs · doi:10.3390/md22080338 · Cited by 20 · see citing works

Glucosinolate-Degradation Products as Co-Adjuvant Therapy on Prostate Cancer in Vitro

Núñez-Iglesias, M. J., Novío, S., Garcı́a, C., Pérez-Muñuzuri, M. E., Soengas, P., Cartea, M. E., Velasco, P., & Freire‐Garabal, M. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20204977 · Cited by 21 · see citing works

ZFP36L1 plays an ambiguous role in the regulation of cell expansion and negatively regulates CDKN1A in chronic myeloid leukemia cells

Kaehler, M., Dworschak, M., Rodin, J. P., Ruemenapp, J., Vater, I., Penas, E. M. M., Liu, C., Cascorbi, I., & Nagel, I. (2021) · Experimental Hematology · doi:10.1016/j.exphem.2021.05.006 · Cited by 19 · see citing works

Anticancer and Antibacterial Properties of Curcumin-Loaded Mannosylated Solid Lipid Nanoparticles for the Treatment of Lung Diseases

Chae, J., Choi, Y., Hong, J., Kim, N., Kim, J., Lee, H., & Choi, J. H. (2024) · ACS Applied Bio Materials · doi:10.1021/acsabm.3c01145 · Cited by 19 · see citing works

LncRNA‐ZXF1 stabilizes P21 expression in endometrioid endometrial carcinoma by inhibiting ubiquitination‐mediated degradation and regulating the miR‐378a‐3p/PCDHA3 axis

Kong, D., Hou, Y., Li, W., Ma, X., & Jiang, J. (2021) · Molecular Oncology · doi:10.1002/1878-0261.12940 · Cited by 19 · see citing works

Integrated miRNA and mRNA omics reveal the anti-cancerous mechanism of Licochalcone B on Human Hepatoma Cell HepG2

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PSMC2 Regulates Cell Cycle Progression Through the p21/Cyclin D1 Pathway and Predicts a Poor Prognosis in Human Hepatocellular Carcinoma

Liu, Y., Chen, H., Li, X., Zhang, F., Kong, L., Wang, X., Bai, J., & Wu, X. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.607021 · Cited by 19 · see citing works

Oncogenic activity and cellular functionality of melanoma associated antigen A3

Schäfer, P., Paraschiakos, T., & Windhorst, S. (2021) · Biochemical Pharmacology · doi:10.1016/j.bcp.2021.114700 · Cited by 20 · see citing works

Function and regulation of the Spt-Ada-Gcn5-Acetyltransferase (SAGA) deubiquitinase module

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Sulfonamide derivatives of cis-imidazolines as potent p53-MDM2/MDMX protein-protein interaction inhibitors

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Addiction of Merkel cell carcinoma to MUC1-C identifies a potential new target for treatment

Morimoto, Y., Fushimi, A., Yamashita, N., Hagiwara, M., Bhattacharya, A., Cheng, J., Frost, T. C., Ahmad, R., Daimon, T., Huang, L. H., et al. (2022) · Oncogene · doi:10.1038/s41388-022-02361-3 · Cited by 18 · see citing works

Tumors driven by RAS signaling harbor a natural vulnerability to oncolytic virus M1

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Doxorubicin delivery by magnetic nanotheranostics enhances the cell death in chemoresistant colorectal cancer-derived cells

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Interplay Between Thiamine and p53/p21 Axes Affects Antiproliferative Action of Cisplatin in Lung Adenocarcinoma Cells by Changing Metabolism of 2-Oxoglutarate/Glutamate

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Di-(2-ethylhexyl) phthalate triggers DNA methyltransferase 1 expression resulting in elevated CpG-methylation and enrichment of MECP2 in the p21 promoter in vitro

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Characteristics of SOX9-positive progenitor-like cells during cholestatic liver regeneration in biliary atresia

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Poly(rC)-binding proteins as pleiotropic regulators in hematopoiesis and hematological malignancy

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Traditional herbs: mechanisms to combat cellular senescence

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