The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Cadherin switching: essential for behavioral but not morphological changes during an epithelium-to-mesenchyme transition
Abstract
Epithelium-to-mesenchyme transitions (EMTs) are characterized by morphological and behavioral changes in cells. During an EMT, E-cadherin is downregulated while N-cadherin is upregulated. The goal of this study was to understand the role cadherin switching plays in EMT using a classical model system: transforming growth factor β1 (TGF-β1)-mediated EMT in mammary epithelial cells. We showed that stress fibers and focal adhesions are increased, and cell-cell junctions are decreased in response to TGF-β1. Moreover, these changes were reversible upon removal of TGF-β1. Downregulation of E-cadherin and upregulation of N-cadherin were both transcriptional. Neither experimental knockdown nor experimental overexpression of N-cadherin interfered with the morphological changes. In addition, the morphological changes associated with EMT preceded the downregulation of E-cadherin. Interestingly, TGF-β1-induced motility in N-cadherin-knockdown cells was significantly reduced. Together, these data suggest that cadherin switching is necessary for increased motility but is not required for the morphological changes that accompany EMT.
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Cites
TGF-β Signaling in Tumor Suppression and Cancer Progression
Derynck, R., Akhurst, R. J., & Balmain, A. (2001) · Nature Genetics · doi:10.1038/ng1001-117 · Cited by 2,275
The snail superfamily of zinc-finger transcription factors
Nieto, M. A. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm757 · Cited by 1,719
Cui, W., Fowlis, D. J., Bryson, S., Duffie, E., Ireland, H., Balmain, A., & Akhurst, R. J. (1996) · Cell · doi:10.1016/s0092-8674(00)80127-0 · Cited by 628
Cited by
Beltran, M., Puig, I., Peña, C., García, J. M., Álvarez, A. B., Peña, R., Bonilla, F., & de Herreros, A. G. (2008) · Genes & Development · doi:10.1101/gad.455708 · Cited by 677
A Role for TAZ in Migration, Invasion, and Tumorigenesis of Breast Cancer Cells
Chan, S. W., Lim, C. J., Guo, K., Ng, C. P., Lee, I., Hunziker, W., Zeng, Q., & Hong, W. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-2696 · Cited by 478
SOX4 Induces Epithelial–Mesenchymal Transition and Contributes to Breast Cancer Progression
Zhang, J., Liang, Q., Lei, Y., Yao, M., Li, L., Gao, X., Feng, J., Zhang, Y., Gao, H., Liu, D.-X., et al. (2012) · Cancer Research · doi:10.1158/0008-5472.can-12-1045 · Cited by 264
Liu, X., Sun, H., Qi, J., Wang, L., He, S., Liu, J., Feng, C., Chen, C., Li, W., Guo, Y., et al. (2013) · Nature Cell Biology · doi:10.1038/ncb2765 · Cited by 208
Dubon, M. J., Yu, J., Choi, S., & Park, K. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.25863 · Cited by 76
Metadata
- Authors
- Maeda, M., Johnson, K. R., & Wheelock, M. J.
- Venue
- Journal of Cell Science
- Publisher
- The Company of Biologists
- Published
- 2005-03-01
- Volume
- 118
- Issue
- 5
- Pages
- 873-887
- ISSN
- 0021-9533 (ISSN-L)
- 1477-9137
- OpenAlex
- W2139647802
- Cited by
- 388
- References
- 3
- FWCI
- 6.68
- Type
- journal article
- Language
- en
- Open access
- closed
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- Maeda, M., Johnson, K. R., & Wheelock, M. J. (2005). Cadherin switching: essential for behavioral but not morphological changes during an epithelium-to-mesenchyme transition. Journal of Cell Science. https://doi.org/10.1242/jcs.01634
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