The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Mechanotransduction – a field pulling together?
Abstract
Mechanical stresses are ever present in the cellular environment, whether through external forces that are applied to tissues or endogenous forces that are generated within the active cytoskeleton. Despite the wide array of studies demonstrating that such forces affect cellular signaling and function, it remains unclear whether mechanotransduction in different contexts shares common mechanisms. Here, I discuss possible mechanisms by which applied forces, cell-generated forces and changes in substrate mechanics could exert changes in cell function through common mechanotransduction machinery. I draw from examples that are primarily focused on the role of adhesions in transducing mechanical forces. Based on this discussion, emerging themes arise that connect these different areas of inquiry and suggest multiple avenues for future studies.
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Citations
Cites
Matrix elasticity directs stem cell lineage specification
Engler, A. J., Sen, S., Sweeney, H. L., & Discher, D. E. (2006) · Cell · doi:10.1016/j.cell.2006.06.044 · Cited by 13,915
Tissue Cells Feel and Respond to the Stiffness of Their Substrate
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Cell Movement Is Guided by the Rigidity of the Substrate
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Integrin binding specificity regulates biomaterial surface chemistry effects on cell differentiation
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Measurement of the Force-Velocity Relation for Growing Microtubules
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Increased stiffness of the rat liver precedes matrix deposition: implications for fibrosis
Georges, P. C., Hui, J.-J., Gombos, Z., McCormick, M. E., Wang, A. Y., Uemura, M., Mick, R., Janmey, P. A., Furth, E. E., & Wells, R. G. (2007) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00032.2007 · Cited by 577
A mechanical model for epithelial morphogenesis
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Cited by
Environmental sensing through focal adhesions
Geiger, B., Spatz, J. P., & Bershadsky, A. D. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2593 · Cited by 2,543
Deconstructing the third dimension – how 3D culture microenvironments alter cellular cues
Baker, B. M., & Chen, C. S. (2012) · Journal of Cell Science · doi:10.1242/jcs.079509 · Cited by 1,760
Self-citationDynamic molecular processes mediate cellular mechanotransduction
Hoffman, B. D., Grashoff, C., & Schwartz, M. A. (2011) · Nature · doi:10.1038/nature10316 · Cited by 956
Natural and Sun-Induced Aging of Human Skin
Rittie, L., & Fisher, G. J. (2015) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a015370 · Cited by 600
Matrix stiffness-induced myofibroblast differentiation is mediated by intrinsic mechanotransduction
Huang, X., Yang, N., Fiore, V. F., Barker, T. H., Sun, Y., Morris, S. W., Ding, Q., Thannickal, V. J., & Zhou, Y. (2012) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2012-0050oc · Cited by 530
Metadata
- Authors
- Chen, C. S.
- Venue
- Journal of Cell Science
- Publisher
- The Company of Biologists
- Published
- 2008-10-15
- Volume
- 121
- Issue
- 20
- Pages
- 3285-3292
- ISSN
- 0021-9533 (ISSN-L)
- 1477-9137
- OpenAlex
- W2012230802
- Cited by
- 519
- References
- 7
- FWCI
- 13.14
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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