Matrix stiffness-induced myofibroblast differentiation is mediated by intrinsic mechanotransduction
Open accessAbstract
The mechanical properties of the extracellular matrix have recently been shown to promote myofibroblast differentiation and lung fibrosis. Mechanisms by which matrix stiffness regulates myofibroblast differentiation are not fully understood. The goal of this study was to determine the intrinsic mechanisms of mechanotransduction in the regulation of matrix stiffness–induced myofibroblast differentiation. A well established polyacrylamide gel system with tunable substrate stiffness was used in this study. Megakaryoblastic leukemia factor-1 (MKL1) nuclear translocation was imaged by confocal immunofluorescent microscopy. The binding of MKL1 to the α-smooth muscle actin (α-SMA) gene promoter was quantified by quantitative chromatin immunoprecipitation assay. Normal human lung fibroblasts responded to matrix stiffening with changes in actin dynamics that favor filamentous actin polymerization. Actin polymerization resulted in nuclear translocation of MKL1, a serum response factor coactivator that plays a central role in regulating the expression of fibrotic genes, including α-SMA, a marker for myofibroblast differentiation. Mouse lung fibroblasts deficient in Mkl1 did not respond to matrix stiffening with increased α-SMA expression, whereas ectopic expression of human MKL1 cDNA restored the ability of Mkl1 null lung fibroblasts to express α-SMA. Furthermore, matrix stiffening promoted production and activation of the small GTPase RhoA, increased Rho kinase (ROCK) activity, and enhanced fibroblast contractility. Inhibition of RhoA/ROCK abrogated stiff matrix–induced actin cytoskeletal reorganization, MKL1 nuclear translocation, and myofibroblast differentiation. This study indicates that actin cytoskeletal remodeling–mediated activation of MKL1 transduces mechanical stimuli from the extracellular matrix to a fibrogenic program that promotes myofibroblast differentiation, suggesting an intrinsic mechanotransduction mechanism.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
MKL-1 and YAP/TAZ directly regulate myofibroblast phenotype.
“Both MKL-1 and YAP/TAZ directly regulate myofibroblast phenotype.”
From Unraveling SSc Pathophysiology; The Myofibroblast (2018) · cites this paper as [68]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Role of YAP/TAZ in mechanotransduction
Dupont, S., Morsut, L., Aragona, M., Enzo, E., Giulitti, S., Cordenonsi, M., Zanconato, F., Le Digabel, J., Forcato, M., Bicciato, S., et al. (2011) · Nature · doi:10.1038/nature10137 · Cited by 5,979 · see citing works
Etienne‐Manneville, S., & Hall, A. (2002) · Nature · doi:10.1038/nature01148 · Cited by 4,796 · see citing works
Myofibroblasts and mechano-regulation of connective tissue remodelling
Tomasek, J. J., Gabbiani, G., Hinz, B., Chaponnier, C., & Brown, R. A. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm809 · Cited by 4,290 · see citing works
Cell locomotion and focal adhesions are regulated by substrate flexibility.
Pelham, R., & Wang, Y.-L. (1997) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.94.25.13661 · Cited by 3,156 · see citing works
Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN
Stambolic, V., Suzuki, A., de la Pompa, J. L., Brothers, G. M., Mirtsos, C., Sasaki, T., Ruland, J., Penninger, J. M., Siderovski, D. P., & Mak, T. W. (1998) · Cell · doi:10.1016/s0092-8674(00)81780-8 · Cited by 2,551 · see citing works
Hinz, B., Phan, S. H., Thannickal, V. J., Galli, A., Bochaton-Piallat, M.-L., & Gabbiani, G. (2007) · The American Journal of Pathology · doi:10.2353/ajpath.2007.070112 · Cited by 2,068 · see citing works
Self-citationCell adhesion: integrating cytoskeletal dynamics and cellular tension
Parsons, J. T., Horwitz, A. R., & Schwartz, M. A. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2957 · Cited by 1,991 · see citing works
Burridge, K., & Wennerberg, K. (2004) · Cell · doi:10.1016/s0092-8674(04)00003-0 · Cited by 1,790 · see citing works
Myofibroblast contraction activates latent TGF-β1 from the extracellular matrix
Wipff, P.-J., Rifkin, D. B., Meister, J.-J., & Hinz, B. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200704042 · Cited by 1,346 · see citing works
Actin dynamics control SRF activity by regulation of its coactivator MAL
Miralles, F., Posern, G., Zaromytidou, A.-I., & Treisman, R. (2003) · Cell · doi:10.1016/s0092-8674(03)00278-2 · Cited by 1,327 · see citing works
Substrate Compliance versus Ligand Density in Cell on Gel Responses
Engler, A. J., Bačáková, L., Newman, C., Hategan, A. P., Griffin, M. A., & Discher, D. E. (2004) · Biophysical Journal · doi:10.1016/s0006-3495(04)74140-5 · Cited by 1,127 · see citing works
Preparation of Hydrogel Substrates with Tunable Mechanical Properties
Tse, J. R., & Engler, A. J. (2010) · Current Protocols in Cell Biology · doi:10.1002/0471143030.cb1016s47 · Cited by 1,070 · see citing works
Dynamic molecular processes mediate cellular mechanotransduction
Hoffman, B. D., Grashoff, C., & Schwartz, M. A. (2011) · Nature · doi:10.1038/nature10316 · Cited by 956 · see citing works
Perspective Article: Tissue repair, contraction, and the myofibroblast
Desmoulière, A., Chaponnier, C., & Gabbiani, G. (2005) · Wound Repair and Regeneration · doi:10.1111/j.1067-1927.2005.130102.x · Cited by 892 · see citing works
Feedback amplification of fibrosis through matrix stiffening and COX-2 suppression
Liu, F., Mih, J. D., Shea, B. S., Kho, A. T., Sharif, A. S., Tager, A. M., & Tschumperlin, D. J. (2010) · The Journal of Cell Biology · doi:10.1083/jcb.201004082 · Cited by 799 · see citing works
Focal adhesion size controls tension-dependent recruitment of α-smooth muscle actin to stress fibers
Goffin, J. M., Pittet, P., Csúcs, G., Lussi, J. W., Meister, J.-J., & Hinz, B. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200506179 · Cited by 703 · see citing works
Signal-Regulated Activation of Serum Response Factor Is Mediated by Changes in Actin Dynamics
Sotiropoulos, A., Gineitis, D., Copeland, J. W. R., & Treisman, R. (1999) · Cell · doi:10.1016/s0092-8674(00)81011-9 · Cited by 656 · see citing works
Mechanotransduction – a field pulling together?
Chen, C. S. (2008) · Journal of Cell Science · doi:10.1242/jcs.023507 · Cited by 520 · see citing works
Cell type-specific response to growth on soft materials
Georges, P. C., & Janmey, P. A. (2005) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01121.2004 · Cited by 498 · see citing works
Arora, P. D., Narani, N., & McCulloch, C. A. (1999) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)65334-5 · Cited by 465 · see citing works
The Mouse Formin mDia1 Is a Potent Actin Nucleation Factor Regulated by Autoinhibition
Li, F., & Higgs, H. N. (2003) · Current Biology · doi:10.1016/s0960-9822(03)00540-2 · Cited by 449 · see citing works
Gα12 and Gα13 Stimulate Rho-dependent Stress Fiber Formation and Focal Adhesion Assembly
Buhl, A. M., Johnson, N. L., Dhanasekaran, N., & Johnson, G. L. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.42.24631 · Cited by 448 · see citing works
Regulation of PI3-kinase/Akt signaling by muscle-enriched microRNA-486
Small, E. M., O'Rourke, J. R., Moresi, V., Sutherland, L. B., McAnally, J., Gerard, R. D., Richardson, J. A., & Olson, E. N. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000300107 · Cited by 411 · see citing works
The actin cytoskeleton: a key regulator of apoptosis and ageing?
Gourlay, C. W., & Ayscough, K. R. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1682 · Cited by 405 · see citing works
Mack, C. P., Somlyo, A. V., Hautmann, M. B., Somlyo, A. P., & Owens, G. K. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m005505200 · Cited by 376 · see citing works
Hinz, B. (2009) · Current Rheumatology Reports · doi:10.1007/s11926-009-0017-1 · Cited by 373 · see citing works
Lévy, R., & Maaloum, M. (2001) · Nanotechnology · doi:10.1088/0957-4484/13/1/307 · Cited by 370 · see citing works
Small, E. M., Thatcher, J. E., Sutherland, L. B., Kinoshita, H., Gerard, R. D., Richardson, J. A., DiMaio, J. M., Sadek, H. A., Kuwahara, K., & Olson, E. N. (2010) · Circulation Research · doi:10.1161/circresaha.110.223172 · Cited by 368 · see citing works
Evolving Concepts of Apoptosis in Idiopathic Pulmonary Fibrosis
Thannickal, V. J., & Horowitz, J. C. (2006) · Proceedings of the American Thoracic Society · doi:10.1513/pats.200601-001tk · Cited by 361 · see citing works
Self-citationHepatic stellate cells require a stiff environment for myofibroblastic differentiation
Olsen, A. L., Bloomer, S. A., Chan, E. P., Gaça, M. D. A., Georges, P. C., Sackey, B., Uemura, M., Janmey, P. A., & Wells, R. G. (2011) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00412.2010 · Cited by 355 · see citing works
Li, Z., Dranoff, J. A., Chan, E. P., Uemura, M., Sévigny, J., & Wells, R. G. (2007) · Hepatology · doi:10.1002/hep.21792 · Cited by 336 · see citing works
Danen, E. H. J., Sonneveld, P., Brakebusch, C., Fässler, R., & Sonnenberg, A. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200205014 · Cited by 333 · see citing works
Smad3 Mediates Transforming Growth Factor-β–Induced α-Smooth Muscle Actin Expression
Hu, B., Wu, Z., & Phan, S. H. (2003) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2003-0063oc · Cited by 325 · see citing works
Force activates smooth muscle α-actin promoter activity through the Rho signaling pathway
Zhao, X.-H., Laschinger, C. A., Arora, P. D., Szászi, K., Kapùs, A., & McCulloch, C. A. (2007) · Journal of Cell Science · doi:10.1242/jcs.001586 · Cited by 325 · see citing works
Dallas, S. L., Sivakumar, P., Jones, C. J. P., Chen, Q., Peters, D. M. P., Mosher, D. F., Humphries, M. J., & Kielty, C. M. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m410762200 · Cited by 318 · see citing works
The Actin Cytoskeleton in T Cell Activation
Burkhardt, J. K., Carrizosa, E., & Shaffer, M. H. (2008) · Annual Review of Immunology · doi:10.1146/annurev.immunol.26.021607.090347 · Cited by 314 · see citing works
Cen, B., Selvaraj, A., Burgess, R. C., Hitzler, J. K., Ma, Z., Morris, S. W., & Prywes, R. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.18.6597-6608.2003 · Cited by 289 · see citing works
Self-citationMorita, T., Mayanagi, T., & Sobue, K. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200708174 · Cited by 262 · see citing works
Gohla, A., Harhammer, R., & Schultz, G. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.8.4653 · Cited by 261 · see citing works
Khatiwala, C. B., Peyton, S. R., & Putnam, A. J. (2006) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00455.2005 · Cited by 257 · see citing works
Rigidity Sensing at the Leading Edge through αvβ3 Integrins and RPTPα
Jiang, G., Huang, A., Cai, Y., Tanase, M., & Sheetz, M. P. (2005) · Biophysical Journal · doi:10.1529/biophysj.105.072462 · Cited by 234 · see citing works
Asano, Y., Ihn, H., Yamane, K., Jinnin, M., Mimura, Y., & Tamaki, K. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.11.7708 · Cited by 231 · see citing works
Poncelet, A.-C., & Schnaper, H. W. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m006442200 · Cited by 229 · see citing works
Hong, X., Diebold, D., Nho, R. S., Perlman, D., Kleidon, J., Kahm, J., Avdulov, S. V., Peterson, M., Nerva, J. D., Bitterman, P. B., et al. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20080001 · Cited by 213 · see citing works
LIM kinase and Diaphanous cooperate to regulate serum response factor and actin dynamics
Geneste, O., Copeland, J. W. R., & Treisman, R. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200203126 · Cited by 206 · see citing works
Chen, J., Chen, W. L. K., Sider, K. L., Yip, C. Y. Y., & Simmons, C. A. (2010) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.110.220061 · Cited by 188 · see citing works
Fontana, L., Chen, Y., Prijatelj, P., Sakai, T., Fässler, R., Sakai, L. Y., & Rifkin, D. B. (2005) · The FASEB Journal · doi:10.1096/fj.05-4134com · Cited by 181 · see citing works
Fan, L., Sebe, A., Péterfi, Z., Masszi, A., Thirone, A. C. P., Rotstein, O. D., Nakano, H., McCulloch, C. A., Szászi, K., Mucsi, I., et al. (2007) · Molecular Biology of the Cell · doi:10.1091/mbc.e06-07-0602 · Cited by 173 · see citing works
Gα13 Stimulates Na+-H+ Exchange through Distinct Cdc42-dependent and RhoA-dependent Pathways
Hooley, R., Yu, C.-Y., Symons, M. H., & Barber, D. L. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.11.6152 · Cited by 171 · see citing works
Acute Myeloid Leukemia-Associated Mkl1 (Mrtf-a) Is a Key Regulator of Mammary Gland Function
Sun, Y., Boyd, K. L., Xu, W., Ma, J., Jackson, C. W., Fu, A., Shillingford, J. M., Robinson, G. W., Hennighausen, L. G., Hitzler, J. K., et al. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.00024-06 · Cited by 167 · see citing works
Self-citationJiang, P., Enomoto, A., & Takahashi, M. (2009) · Cancer Letters · doi:10.1016/j.canlet.2009.02.034 · Cited by 163 · see citing works
Pathologic Caveolin-1 Regulation of PTEN in Idiopathic Pulmonary Fibrosis
Hong, X., Khalil, W., Kahm, J., Jessurun, J., Kleidon, J., & Henke, C. A. (2010) · American Journal Of Pathology · doi:10.2353/ajpath.2010.091117 · Cited by 146 · see citing works
Carracedo, S., Lü, N., Popova, S. N., Jonsson, R., Eckes, B., & Gullberg, D. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.078766 · Cited by 145 · see citing works
Fate-determining mechanisms in epithelial–myofibroblast transition: major inhibitory role for Smad3
Masszi, A., Speight, P., Charbonney, E., Lodyga, M., Nakano, H., Szászi, K., & Kapùs, A. (2010) · The Journal of Cell Biology · doi:10.1083/jcb.200906155 · Cited by 130 · see citing works
Crider, B. J., Risinger, G. M., Haaksma, C. J., Howard, E. W., & Tomasek, J. J. (2011) · Journal of Investigative Dermatology · doi:10.1038/jid.2011.219 · Cited by 124 · see citing works
Zhou, Y., Hagood, J. S., Lu, B., Merryman, W. D., & Murphy-Ullrich, J. E. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.126227 · Cited by 118 · see citing works
Self-citationDelayed stress fiber formation mediates pulmonary myofibroblast differentiation in response to TGF-β
Sandbo, N. K., Lau, A., Kach, J., Ngam, C. R., Yau, D. M., & Dulin, N. O. (2011) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00166.2011 · Cited by 104 · see citing works
Miao, H., Li, S., Hu, Y.-L., Yuan, S., Zhao, Y., Chen, B. P. C., Puzon-McLaughlin, W., Tarui, T., Shyy, J. Y.-J., Takada, Y., et al. (2002) · Journal of Cell Science · doi:10.1242/jcs.115.10.2199 · Cited by 99 · see citing works
Relaxin Regulates Myofibroblast Contractility and Protects against Lung Fibrosis
Huang, X., Gai, Y., Yang, N., Lu, B., Samuel, C. S., Thannickal, V. J., & Zhou, Y. (2011) · American Journal Of Pathology · doi:10.1016/j.ajpath.2011.08.018 · Cited by 94 · see citing works
Self-citationAsano, Y., Ihn, H., Jinnin, M., Mimura, Y., & Tamaki, K. (2006) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700331 · Cited by 93 · see citing works
Role of the actin cytoskeleton in tuning cellular responses to external mechanical stress
Asparuhova, M. B., Gelman, L., & Chiquet, M. (2009) · Scandinavian Journal of Medicine and Science in Sports · doi:10.1111/j.1600-0838.2009.00928.x · Cited by 92 · see citing works
Isolation and Phenotypic Characterization of Lung Fibroblasts
Baglole, C. J., Reddy, S., Pollock, S. J., Feldon, S. E., Sime, P. J., Smith, T. J., & Phipps, R. P. (2005) · Humana Press eBooks · doi:10.1385/1-59259-940-0:115 · Cited by 85 · see citing works
αv integrins play an important role in myofibroblast differentiation
Lygoe, K. A., Norman, J. T., Marshall, J. F., & Lewis, M. P. (2004) · Wound Repair and Regeneration · doi:10.1111/j.1067-1927.2004.12402.x · Cited by 81 · see citing works
MKL1 mediates TGF-β1-induced α-smooth muscle actin expression in human renal epithelial cells
Elberg, G., Chen, L., Elberg, D., Chan, M. D., Logan, C. J., & Turman, M. A. (2008) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00142.2007 · Cited by 75 · see citing works
Galie, P. A., Westfall, M. V., & Stegemann, J. P. (2011) · Cardiovascular Pathology · doi:10.1016/j.carpath.2010.10.001 · Cited by 71 · see citing works
Flagged first, then by citations
Research works printed but not linked: 3
- Desmouliere A, Chaponnier C, Gabbiani G. Tissue repair, contraction, and the myofibroblast. Wound Repair Regen 2005;13:7-12.
- Hooley R, Yu CY, Symons M, Barber DL. G alpha 13 stimulates na1- h1 exchange through distinct cdc42-dependent and rhoa-dependent pathways. J Biol Chem 1996;271:6152-6158.
- Danen EH, Sonneveld P, Brakebusch C, Fassler R, Sonnenberg A. The fibronectin-binding integrins alpha5beta1 and alphavbeta3 differen- tially modulate rhoa-gtp loading, organization of cell matrix adhe- sions, and fibronectin fibrillogenesis. J Cell Biol 2002;159:1071-1086.
Cited by
Sorted by citations
Richeldi, L., Collard, H. R., & Jones, M. G. (2017) · The Lancet · doi:10.1016/s0140-6736(17)30866-8 · Cited by 2,020 · see citing works
Fibroblasts: Origins, definitions, and functions in health and disease
Plikus, M. V., Wang, X., Sinha, S., Forte, E., Thompson, S. M., Herzog, E. L., Driskell, R. R., Rosenthal, N. A., Biernaskie, J. A., & Horsley, V. (2021) · Cell · doi:10.1016/j.cell.2021.06.024 · Cited by 1,162 · see citing works
Extracellular Matrix and Dermal Fibroblast Function in the Healing Wound
Tracy, L. E., Minasian, R. A., & Caterson, E. J. (2016) · Advances in Wound Care · doi:10.1089/wound.2014.0561 · Cited by 1,008 · see citing works
Mechanosignaling through YAP and TAZ drives fibroblast activation and fibrosis
Liu, F., Lagares, D., Choi, K. M., Stopfer, L., Marinković, A., Vrbanac, V., Probst, C. K., Hiemer, S. E., Sisson, T. H., Horowitz, J. C., et al. (2015) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00300.2014 · Cited by 874 · see citing works
Pathogenic Mechanisms Underlying Idiopathic Pulmonary Fibrosis
Moss, B. J., Ryter, S. W., & Rosas, I. O. (2021) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathol-042320-030240 · Cited by 838 · see citing works
Booth, A. J., Hadley, R., Cornett, A. M., Dreffs, A. A., Matthes, S. A., Tsui, J. L., Weiss, K., Horowitz, J. C., Fiore, V. F., Barker, T. H., et al. (2012) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201204-0754oc · Cited by 665 · see citing works
Self-citationTherapy for Fibrotic Diseases: Nearing the Starting Line
Friedman, S. L., Sheppard, D., Duffield, J. S., & Violette, S. (2013) · Science Translational Medicine · doi:10.1126/scitranslmed.3004700 · Cited by 655 · see citing works
Tissue Stiffness Dictates Development, Homeostasis, and Disease Progression
Handorf, A. M., Zhou, Y., Halanski, M. A., & Li, W. (2015) · Organogenesis · doi:10.1080/15476278.2015.1019687 · Cited by 647 · see citing works
Self-citationExtracellular matrix as a driver of progressive fibrosis
Herrera, J., Henke, C. A., & Bitterman, P. B. (2018) · Journal of Clinical Investigation · doi:10.1172/jci93557 · Cited by 616 · see citing works
The extracellular matrix and transforming growth factor-β1: Tale of a strained relationship
Hinz, B. (2015) · Matrix Biology · doi:10.1016/j.matbio.2015.05.006 · Cited by 618 · see citing works
Engineered In Vitro Disease Models
Benam, K. H., Dauth, S., Hassell, B., Herland, A., Jain, A., Jang, K.-J., Karalis, K., Kim, H. J., MacQueen, L., Mahmoodian, R., et al. (2015) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-012414-040418 · Cited by 554 · see citing works
The good and the bad collagens of fibrosis – Their role in signaling and organ function
Karsdal, M. A., Nielsen, S. H., Leeming, D. J., Langholm, L. L., Nielsen, M. J., Manon-Jensen, T., Siebuhr, A., Gudmann, N. S., Rønnow, S., Sand, J. M., et al. (2017) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2017.07.014 · Cited by 509 · see citing works
The COVID-19 pandemic: a global health crisis
Pollard, C., Morran, M. P., & Nestor‐Kalinoski, A. L. (2020) · Physiological Genomics · doi:10.1152/physiolgenomics.00089.2020 · Cited by 518 · see citing works
YAP/TAZ Are Mechanoregulators of TGF-β-Smad Signaling and Renal Fibrogenesis
Szeto, S. G., Narimatsu, M., Lu, M., He, X., Sidiqi, A. M., Tolosa, M. F., Chan, L., Freitas, K. D., Bialik, J. F., Majumder, S., et al. (2016) · Journal of the American Society of Nephrology · doi:10.1681/asn.2015050499 · Cited by 463 · see citing works
Zhou, Y., Huang, X., Hecker, L., Kurundkar, D., Kurundkar, A., Liu, H., Jin, T. H., Desai, L. P., Bernard, K. F., & Thannickal, V. J. (2013) · Journal of Clinical Investigation · doi:10.1172/jci66700 · Cited by 452 · see citing works
Self-citationGibb, A., Lazaropoulos, M. P., & Elrod, J. W. (2020) · Circulation Research · doi:10.1161/circresaha.120.316958 · Cited by 443 · see citing works
New cellular and molecular mechanisms of lung injury and fibrosis in idiopathic pulmonary fibrosis
Fernandez, I. E., & Eickelberg, O. (2012) · The Lancet · doi:10.1016/s0140-6736(12)61144-1 · Cited by 434 · see citing works
Wells, R. G. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.02.007 · Cited by 384 · see citing works
Endothelial–mesenchymal transition in atherosclerosis
Souilhol, C., Harmsen, M. C., Evans, P. C., & Krenning, G. (2018) · Cardiovascular Research · doi:10.1093/cvr/cvx253 · Cited by 402 · see citing works
The interplay of fibroblasts, the extracellular matrix, and inflammation in scar formation
Moretti, L., Stalfort, J., Barker, T. H., & Abebayehu, D. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.101530 · Cited by 393 · see citing works
Self-citationEsnault, C., Stewart, A., Gualdrini, F., East, P., Horswell, S. D., Matthews, N., & Treisman, R. (2014) · Genes & Development · doi:10.1101/gad.239327.114 · Cited by 355 · see citing works
Myofibroblasts: Trust your heart and let fate decide
Davis, J., & Molkentin, J. D. (2013) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2013.10.019 · Cited by 339 · see citing works
Tschumperlin, D. J., Ligresti, G., Hilscher, M. B., & Shah, V. H. (2018) · Journal of Clinical Investigation · doi:10.1172/jci93561 · Cited by 338 · see citing works
Idiopathic pulmonary fibrosis: Epithelial-mesenchymal interactions and emerging therapeutic targets
Hewlett, J. C., Kropski, J. A., & Blackwell, T. S. (2018) · Matrix Biology · doi:10.1016/j.matbio.2018.03.021 · Cited by 327 · see citing works
Chilosi, M., Carloni, A., Rossi, A., & Poletti, V. E. (2013) · Translational research · doi:10.1016/j.trsl.2013.06.004 · Cited by 314 · see citing works
Potential of nintedanib in treatment of progressive fibrosing interstitial lung diseases
Wollin, L., Distler, J. H. W., Redente, E. F., Riches, D. W. H., Stowasser, S., Schlenker‐Herceg, R., Maher, T. M., & Kolb, M. R. J. (2019) · European Respiratory Journal · doi:10.1183/13993003.00161-2019 · Cited by 300 · see citing works
The Nano-Scale Mechanical Properties of the Extracellular Matrix Regulate Dermal Fibroblast Function
Achterberg, V., Buscemi, L., Diekmann, H., Smith-Clerc, J., Schwengler, H., Meister, J.-J., Wenck, H., Gallinat, S., & Hinz, B. (2014) · Journal of Investigative Dermatology · doi:10.1038/jid.2014.90 · Cited by 288 · see citing works
Extracellular matrix in lung development, homeostasis and disease
Zhou, Y., Horowitz, J. C., Naba, A., Ambalavanan, N., Atabai, K., Balestrini, J. L., Bitterman, P. B., CORLEY, R. A., Ding, B., Engler, A. J., et al. (2018) · Matrix Biology · doi:10.1016/j.matbio.2018.03.005 · Cited by 285 · see citing works
Self-citationStem Cell Differentiation is Regulated by Extracellular Matrix Mechanics
Smith, L., Cho, S., & Discher, D. E. (2017) · Physiology · doi:10.1152/physiol.00026.2017 · Cited by 280 · see citing works
Manetti, M., Romano, E., Rosa, I., Guiducci, S., Bellando-Randone, S., De Paulis, A., Ibba-Manneschi, L., & Matucci-Cerinic, M. (2017) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2016-210229 · Cited by 278 · see citing works
Microfluidic platforms for mechanobiology
Polacheck, W. J., Li, R., Uzel, S. G. M., & Kamm, R. D. (2013) · Lab on a Chip · doi:10.1039/c3lc41393d · Cited by 272 · see citing works
Yamauchi, M., Barker, T. H., Gibbons, D. L., & Kurie, J. M. (2018) · Journal of Clinical Investigation · doi:10.1172/jci93554 · Cited by 273 · see citing works
Self-citationThe natural history of progressive fibrosing interstitial lung diseases
Kolb, M. R. J., & Vašáková, M. (2019) · Respiratory Research · doi:10.1186/s12931-019-1022-1 · Cited by 275 · see citing works
Myofibroblast transcriptome indicates SFRP2hi fibroblast progenitors in systemic sclerosis skin
Tabib, T., Huang, M., Morse, N., Papazoglou, A., Behera, R., Jia, M., Bulik, M., Monier, D., Benos, P. V., Chen, W., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-24607-6 · Cited by 270 · see citing works
Oxidative Stress in Pulmonary Fibrosis
Otoupalova, E., Smith, S., Cheng, G., & Thannickal, V. J. (2020) · Comprehensive physiology · doi:10.1002/cphy.c190017 · Cited by 309 · see citing works
Self-citationVan De Water, L., Varney, S., & Tomasek, J. J. (2013) · Advances in Wound Care · doi:10.1089/wound.2012.0393 · Cited by 251 · see citing works
The double edge sword of fibrosis in cancer
Chandler, C., Liu, T., Buckanovich, R. J., & Coffman, L. G. (2019) · Translational research · doi:10.1016/j.trsl.2019.02.006 · Cited by 248 · see citing works
Dou, C., Liu, Z., Tu, K., Zhang, H., Chen, C., Yaqoob, U., Wang, Y., Wen, J., van Deursen, J., Sicard, D., et al. (2018) · Gastroenterology · doi:10.1053/j.gastro.2018.02.015 · Cited by 240 · see citing works
Knipe, R. S., Tager, A. M., & Liao, J. K. (2015) · Pharmacological Reviews · doi:10.1124/pr.114.009381 · Cited by 233 · see citing works
Future Directions in Idiopathic Pulmonary Fibrosis Research. An NHLBI Workshop Report
Blackwell, T. S., Tager, A. M., Borok, Z., Moore, B. B., Schwartz, D. A., Anstrom, K. J., Bar‐Joseph, Z., Bitterman, P. B., Blackburn, M. R., Bradford, W. S., et al. (2013) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201306-1141ws · Cited by 236 · see citing works
Self-citationAhluwalia, N., Shea, B. S., & Tager, A. M. (2014) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201403-0509pp · Cited by 233 · see citing works
Mechanical control of cardiac myofibroblasts
van Putten, S., Shafieyan, Y., & Hinz, B. (2015) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2015.11.025 · Cited by 235 · see citing works
Huang, J., Heng, S., Zhang, W., Liu, Y., Xia, T., Ji, C., & Zhang, L.-J. (2022) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2022.02.027 · Cited by 238 · see citing works
The Strength of Mechanical Forces Determines the Differentiation of Alveolar Epithelial Cells
Li, J., Wang, Z., Chu, Q., Jiang, K., Li, J., & Tang, N. (2018) · Developmental Cell · doi:10.1016/j.devcel.2018.01.008 · Cited by 226 · see citing works
COVID-19 and pulmonary fibrosis: a potential role for lung epithelial cells and fibroblasts
John, A. E., Joseph, C., Jenkins, G., & Tatler, A. L. (2021) · Immunological Reviews · doi:10.1111/imr.12977 · Cited by 219 · see citing works
Foster, C. T., Gualdrini, F., & Treisman, R. (2017) · Genes & Development · doi:10.1101/gad.304501.117 · Cited by 202 · see citing works
Extracellular matrix directs phenotypic heterogeneity of activated fibroblasts
Avery, D., Govindaraju, P., Jacob, M., Todd, L., Monslow, J., & Puré, E. (2018) · Matrix Biology · doi:10.1016/j.matbio.2017.12.003 · Cited by 206 · see citing works
Stretch-induced Activation of Transforming Growth Factor-β1 in Pulmonary Fibrosis
Froese, A. R., Shimbori, C., Bellaye, P.-S., Inman, M., Obex, S., Fatima, S., Jenkins, G., Gauldie, J., Ask, K., & Kolb, M. (2016) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201508-1638oc · Cited by 214 · see citing works
Jiang, S., Lyu, C., Zhao, P., Li, W., Kong, W., Huang, C., Genin, G. M., & Du, Y. (2019) · Nature Communications · doi:10.1038/s41467-019-11397-1 · Cited by 210 · see citing works
Hydrogel scaffolds as in vitro models to study fibroblast activation in wound healing and disease
Smithmyer, M. E., Sawicki, L. A., & Kloxin, A. M. (2014) · Biomaterials Science · doi:10.1039/c3bm60319a · Cited by 205 · see citing works
Mechanotransduction and fibrosis
Duscher, D., Maan, Z. N., Wong, V., Rennert, R. C., Januszyk, M., Rodrigues, M., Hu, M. S.-M., Whitmore, A. J., Whittam, A. J., Longaker, M. T., et al. (2014) · Journal of Biomechanics · doi:10.1016/j.jbiomech.2014.03.031 · Cited by 202 · see citing works
Collagen microarchitecture mechanically controls myofibroblast differentiation
Seo, B. R., Chen, X., Lu, L., Song, Y. H., Shimpi, A. A., Choi, S., Gonzalez, J., Sapudom, J., Wang, K., Eguiluz, R. C. A., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1919394117 · Cited by 192 · see citing works
Johnson, L. A., Rodansky, E. S., Haak, A. J., Larsen, S. D., Neubig, R. R., & Higgins, P. (2013) · Inflammatory Bowel Diseases · doi:10.1097/01.mib.0000437615.98881.31 · Cited by 198 · see citing works
Urbanczyk, M., Layland, S. L., & Schenke‐Layland, K. (2019) · Matrix Biology · doi:10.1016/j.matbio.2019.11.005 · Cited by 196 · see citing works
Mechanical regulation of myofibroblast phenoconversion and collagen contraction
Hinz, B., McCulloch, C. A., & Coelho, N. M. (2019) · Experimental Cell Research · doi:10.1016/j.yexcr.2019.03.027 · Cited by 182 · see citing works
Johnson, L. A., Rodansky, E. S., Sauder, K. L., Horowitz, J. C., Mih, J. D., Tschumperlin, D. J., & Higgins, P. (2013) · Inflammatory Bowel Diseases · doi:10.1097/mib.0b013e3182813297 · Cited by 181 · see citing works
Molecular Mechanisms of Pulmonary Fibrogenesis and Its Progression to Lung Cancer: A Review
Kinoshita, T., & Goto, T. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20061461 · Cited by 176 · see citing works
Shin, Y. J., Shafranek, R. T., Tsui, J. H., Walcott, J. C., Nelson, A., & Kim, D. (2020) · Acta Biomaterialia · doi:10.1016/j.actbio.2020.11.006 · Cited by 178 · see citing works
Aging and ocular tissue stiffness in glaucoma
Liu, B., McNally, S., Kilpatrick, J. I., Jarvis, S., & O'Brien, C. J. (2017) · Survey of Ophthalmology · doi:10.1016/j.survophthal.2017.06.007 · Cited by 175 · see citing works
Strategies for anti-fibrotic therapies
Rosenbloom, J., Mendoza, F. A., & Jiménez, S. A. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2012.12.007 · Cited by 171 · see citing works
Mechanical Forces and Growth in Animal TissuesPreprint
LeGoff, L., & Lecuit, T. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a019232 · Cited by 169 · see citing works
Barkauskas, C. E., & Noble, P. W. (2014) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00321.2013 · Cited by 166 · see citing works
Matrices of Physiologic Stiffness Potently Inactivate Idiopathic Pulmonary Fibrosis Fibroblasts
Marinković, A., Liu, F., & Tschumperlin, D. J. (2012) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2012-0335oc · Cited by 162 · see citing works
Sisson, T. H., Ajayi, I. O., Subbotina, N., Dodi, A. E., Rodansky, E. S., Chibucos, L. N., Kim, K. K., Keshamouni, V. G., White, E. S., Zhou, Y., et al. (2015) · American Journal Of Pathology · doi:10.1016/j.ajpath.2014.12.005 · Cited by 160 · see citing works
Self-citationHuman Fibrotic Diseases: Current Challenges in Fibrosis Research
Rosenbloom, J., Macarak, E. J., Piera-Velázquez, S., & Jiménez, S. A. (2017) · Methods in molecular biology · doi:10.1007/978-1-4939-7113-8_1 · Cited by 157 · see citing works
Wang, H., Tibbitt, M. W., Langer, S. J., Leinwand, L. A., & Anseth, K. S. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1306369110 · Cited by 154 · see citing works
Unraveling SSc Pathophysiology; The Myofibroblast
van Caam, A., Vonk, M., van den Hoogen, F., van Lent, P., & van der Kraan, P. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02452 · Cited by 153 · see citing works
Extracellular matrix synthesis in vascular disease: hypertension, and atherosclerosis
Ponticos, M., & Barbara, D. (2014) · Journal of Biomedical Research · doi:10.7555/jbr.27.20130064 · Cited by 153 · see citing works
From tissue mechanics to transcription factors
Janmey, P. A., Wells, R. G., Assoian, R. K., & McCulloch, C. A. (2013) · Differentiation · doi:10.1016/j.diff.2013.07.004 · Cited by 149 · see citing works
Engineered cell and tissue models of pulmonary fibrosis
Sundarakrishnan, A., Chen, Y. G., Black, L. D., Aldridge, B. B., & Kaplan, D. L. (2017) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2017.12.013 · Cited by 150 · see citing works
Stromal dynamic reciprocity in cancer: intricacies of fibroblastic-ECM interactions
Alexander, J. I., & Cukierman, E. (2016) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2016.05.002 · Cited by 144 · see citing works
Cancer-associated fibroblasts: how do they contribute to metastasis?
Kwa, M. Q., Herum, K. M., & Brakebusch, C. (2019) · Clinical & Experimental Metastasis · doi:10.1007/s10585-019-09959-0 · Cited by 144 · see citing works
Gordon, S. (2015) · ALTEX · doi:10.14573/altex.1510051 · Cited by 142 · see citing works
Herum, K. M., Lunde, I. G., Skrbic, B., Florholmen, G., Behmen, D., Sjaastad, I., Carlson, C. R., Gomez, M. F., & Christensen, G. (2012) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2012.11.006 · Cited by 142 · see citing works
Molecular networks underlying myofibroblast fate and fibrosis
Stempien‐Otero, A., Kim, D., & Davis, J. (2016) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2016.05.002 · Cited by 141 · see citing works
Keloid disorder: Fibroblast differentiation and gene expression profile in fibrotic skin diseases
Macarak, E. J., Wermuth, P. J., Rosenbloom, J., & Uitto, J. (2020) · Experimental Dermatology · doi:10.1111/exd.14243 · Cited by 142 · see citing works
Current concepts related to hypertrophic scarring in burn injuries
Chiang, R. S., Borovikova, A. A., King, K., Banyard, D. A., Lalezari, S., Toranto, J. D., Paydar, K. Z., Wirth, G. A., Evans, G. R. D., & Widgerow, A. D. (2016) · Wound Repair and Regeneration · doi:10.1111/wrr.12432 · Cited by 138 · see citing works
Matrix stiffness regulates migration of human lung fibroblasts
Asano, S., Ito, S., Takahashi, K., Furuya, K., Kondo, M., Sokabe, M., & Hasegawa, Y. (2017) · Physiological Reports · doi:10.14814/phy2.13281 · Cited by 138 · see citing works
Ling, Z., Chen, Z., Deng, J. G., Wang, Y., Yuan, B., Yang, X., Lin, H., Cao, J., Zhu, X., & Zhang, X. (2021) · Chemical Engineering Journal · doi:10.1016/j.cej.2021.130302 · Cited by 138 · see citing works
Human pericytes adopt myofibroblast properties in the microenvironment of the IPF lung
Sava, P., Ramanathan, A., Dobronyi, A., Peng, X., Sun, H., Ledesma-Mendoza, A., Herzog, E. L., & Gonzalez, A. L. (2017) · JCI Insight · doi:10.1172/jci.insight.96352 · Cited by 130 · see citing works
Matrix Remodeling in Pulmonary Fibrosis and Emphysema
Kulkarni, T., O’Reilly, P. J., Antony, V. B., Gaggar, A., & Thannickal, V. J. (2016) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2015-0166ps · Cited by 126 · see citing works
Self-citationFibroblasts and the Ground They Walk On
Tschumperlin, D. J. (2013) · Physiology · doi:10.1152/physiol.00024.2013 · Cited by 124 · see citing works
Fiore, V. F., Wong, S. S., Tran, C., Tan, C., Xu, W., Sulchek, T., White, E. S., Hagood, J. S., & Barker, T. H. (2018) · JCI Insight · doi:10.1172/jci.insight.97597 · Cited by 121 · see citing works
Self-citationThe extracellular matrix and mechanotransduction in pulmonary fibrosis
Deng, Z., Fear, M. W., Choi, Y. S., Wood, F. M., Allahham, A., Mutsaers, S. E., & Prêle, C. M. (2020) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2020.105802 · Cited by 122 · see citing works
Knipe, R. S., Probst, C. K., Lagares, D., Franklin, A., Spinney, J. J., Brazee, P. L., Grasberger, P. E., Zhang, L., Black, K. E., Sakai, N., et al. (2017) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2017-0075oc · Cited by 121 · see citing works
Collagen Density Modulates the Immunosuppressive Functions of Macrophages
Larsen, A. M. H., Kuczek, D. E., Kalviša, A., Siersbæk, M. S., Thorseth, M., Johansen, A. Z., Carretta, M., Grøntved, L., Vang, O., & Madsen, D. H. (2020) · The Journal of Immunology · doi:10.4049/jimmunol.1900789 · Cited by 120 · see citing works
Matrix Biology of Idiopathic Pulmonary Fibrosis
Thannickal, V. J., Henke, C. A., Horowitz, J. C., Noble, P. W., Roman, J., Sime, P. J., Zhou, Y., Wells, R. G., White, E. S., & Tschumperlin, D. J. (2014) · American Journal Of Pathology · doi:10.1016/j.ajpath.2014.02.003 · Cited by 117 · see citing works
Self-citationMiller, A. E., Hu, P., & Barker, T. H. (2020) · Advanced Healthcare Materials · doi:10.1002/adhm.201901445 · Cited by 114 · see citing works
Self-citationNADPH Oxidases in Lung Health and Disease
Bernard, K. F., Hecker, L., Luckhardt, T., Cheng, G., & Thannickal, V. J. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2013.5608 · Cited by 108 · see citing works
Self-citationNADPH oxidases: redox regulation of cell homeostasis and disease
Kračun, D., Lopes, L. R., Cifuentes-Pagano, E., & Pagano, P. J. (2025) · Physiological Reviews · doi:10.1152/physrev.00034.2023 · Cited by 104 · see citing works
Haak, A. J., Tsou, P.-S., Amin, M. A., Ruth, J. H., Campbell, P., Fox, D. A., Khanna, D., Larsen, S. D., & Neubig, R. R. (2014) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.114.213520 · Cited by 103 · see citing works
Wnt/β-catenin signaling links embryonic lung development and asthmatic airway remodeling
Hussain, M., Xu, C., Lu, M., Wu, X., Tang, L., & Wu, X. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2017.08.031 · Cited by 98 · see citing works
Collagen matrix as a tool in studying fibroblastic cell behavior
Kanta, J. (2015) · Cell Adhesion & Migration · doi:10.1080/19336918.2015.1005469 · Cited by 97 · see citing works
Matrix biomechanics and dynamics in pulmonary fibrosis
Haak, A. J., Tan, Q., & Tschumperlin, D. J. (2018) · Matrix Biology · doi:10.1016/j.matbio.2017.12.004 · Cited by 95 · see citing works
A Role of Myocardin Related Transcription Factor-A (MRTF-A) in Scleroderma Related Fibrosis
Shiwen, X., Stratton, R. J., Nikitorowicz-Buniak, J., Abdi, B. A., Ponticos, M., Denton, C. P., Abraham, D., Takahashi, A., Suki, B., Layne, M. D., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0126015 · Cited by 95 · see citing works
Cheng, B., Lin, M., Huang, G., Li, Y., Ji, B., Genin, G. M., Deshpande, V. S., Lu, T. J., & Xu, F. (2017) · Physics of Life Reviews · doi:10.1016/j.plrev.2017.06.016 · Cited by 95 · see citing works
Biomimetic tumor microenvironments based on collagen matrices
Sapudom, J., & Pompe, W. (2018) · Biomaterials Science · doi:10.1039/c8bm00303c · Cited by 91 · see citing works
Is it time for a paradigm shift in drug research and development in endometriosis/adenomyosis?
Guo, S., & Groothuis, P. G. (2018) · Human Reproduction Update · doi:10.1093/humupd/dmy020 · Cited by 93 · see citing works
CBX5/G9a/H3K9me-mediated gene repression is essential to fibroblast activation during lung fibrosis
Ligresti, G., Caporarello, N., Meridew, J. A., Jones, D. L., Tan, Q., Choi, K. M., Haak, A. J., Aravamudhan, A., Roden, A. C., Prakash, Y. S., et al. (2019) · JCI Insight · doi:10.1172/jci.insight.127111 · Cited by 94 · see citing works
Lauer, J. C., Selig, M., Hart, M. L., Kurz, B., & Rolauffs, B. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22063279 · Cited by 92 · see citing works
- Authors
- Huang, X., Yang, N., Fiore, V. F., Barker, T. H., Sun, Y., Morris, S. W., Ding, Q., Thannickal, V. J., & Zhou, Y.
- Affiliations
- University of Alabama at Birmingham (US)
- Georgia Institute of Technology (US)
- St. Jude Children's Research Hospital (US)
- Corresponding author
- Zhou, Yong
- Venue
- American Journal of Respiratory Cell and Molecular Biology
- Publisher
- Oxford University Press (OUP)
- Published
- 2012-09-01
- Volume
- 47
- Issue
- 3
- Pages
- 340-348
- ISSN
- 1044-1549 (ISSN-L)
- 1535-4989
- PMC
- PMC3488695
- OpenAlex
- W2172237567
- Cited by
- 530
- References
- 65
- Citations by year
- 2026: 39 · 2025: 35 · 2024: 44 · 2023: 45 · 2022: 35 · 2021: 44 · 2020: 41 · 2019: 34 · 2018: 47 · 2017: 36 · 2016: 22 · 2015: 39 · 2014: 26 · 2013: 32 · 2012: 11
- FWCI
- 16.35
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- American Journal of Respiratory Cell and Molecular Biology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Foundation
- American Heart Association
- St. Jude Children's Research Hospital
- American Lebanese Syrian Associated Charities
- National Institutes of Health
- National Heart, Lung, and Blood Institute (R21HL097215, HL107181, HL 067967, P50HL107181, R01HL067967, R01HL085324, HL097215)
- National Cancer Institute (R01CA087064, CA87064)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Keywords
- extracellular matrix stiffness, myofibroblast differentiation, mechanotransduction, MKL1, RhoA/ROCK signaling, actin cytoskeleton remodeling, alpha-smooth muscle actin, pulmonary fibrosis, lung fibroblasts
- MeSH terms
- Animals, Base Sequence, Cell Differentiation, Cells, Cultured, DNA-Binding Proteins, Electrophoresis, Polyacrylamide Gel, Extracellular Matrix, Humans, Phosphorylation, Oncogene Proteins, Fusion, Trans-Activators, Extracellular Matrix Proteins, DNA Primers, Mice, Knockout, Mechanotransduction, Cellular, Mice, Myofibroblasts
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
