Natural and Sun-Induced Aging of Human Skin
Open accessAbstract
With worldwide expansion of the aging population, research on age-related pathologies is receiving growing interest. In this review, we discuss current knowledge regarding the decline of skin structure and function induced by the passage of time (chronological aging) and chronic exposure to solar UV irradiation (photoaging). Nearly every aspect of skin biology is affected by aging. The self-renewing capability of the epidermis, which provides vital barrier function, is diminished with age. Vital thermoregulation function of eccrine sweat glands is also altered with age. The dermal collagenous extracellular matrix, which comprises the bulk of skin and confers strength and resiliency, undergoes gradual fragmentation, which deleteriously impacts skin mechanical properties and dermal cell functions. Aging also affects wound repair, pigmentation, innervation, immunity, vasculature, and subcutaneous fat homeostasis. Altogether, age-related alterations of skin lead to age-related skin fragility and diseases.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
With aging, decreased performance of the cell endogenous antioxidant system occurs, making elderly people more susceptible to oxidative stress.
“With aging, a decreased performance of cell endogenous antioxidant system occurs; thus, elderly people are more susceptible to oxidative stress [2, 3].”
From Antioxidants from Plants Protect against Skin Photoaging (2018) · cites this paper as [3]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Molecular Mechanisms of Stress-Responsive Changes in Collagen and Elastin Networks in Skin
Aziz, J., Shezali, H., Radzi, Z., Yahya, N. A., Abu Kassim, N. H., Czernuszka, J., & Rahman, M. T. (2016) · Skin Pharmacology and Physiology · doi:10.1159/000447017 · Cited by 7,323 · see citing works
Massagué, J. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3434 · Cited by 3,130 · see citing works
Endothelial/Pericyte Interactions
Armulik, A., Abramsson, A., & Betsholtz, C. (2005) · Circulation Research · doi:10.1161/01.res.0000182903.16652.d7 · Cited by 2,048 · see citing works
Mechanisms of photoaging and chronological skin aging
Fisher, G. J., Kang, S., Varani, J., Bata-Csorgo, Z., Wan, Y., Datta, S., & Voorhees, J. J. (2002) · Archives of Dermatology · doi:10.1001/archderm.138.11.1462 · Cited by 1,849 · see citing works
Self-citationProtein tyrosine phosphatases: from genes, to function, to disease
Tonks, N. K. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2039 · Cited by 1,685 · see citing works
Molecular basis of sun-induced premature skin ageing and retinoid antagonism
Fisher, G. J., Datta, S. C., Talwar, H. S., Wang, Z.-Q., Varani, J., Kang, S., & Voorhees, J. J. (1996) · Nature · doi:10.1038/379335a0 · Cited by 1,410 · see citing works
Self-citationThree clonal types of keratinocyte with different capacities for multiplication.
Barrandon, Y., & Green, H. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.8.2302 · Cited by 1,293 · see citing works
Jones, P. H., & Watt, F. M. (1993) · Cell · doi:10.1016/0092-8674(93)90251-k · Cited by 1,100 · see citing works
Tanaka, M., Yamamoto, Y., Misawa, E., Nabeshima, K., Saito, M., Yamauchi, K., Abe, F., & Furukawa, F. (2016) · Skin Pharmacology and Physiology · doi:10.1159/000454718 · Cited by 1,092 · see citing works
Gosain, A., & DiPietro, L. A. (2004) · World Journal of Surgery · doi:10.1007/s00268-003-7397-6 · Cited by 1,048 · see citing works
Rosette, C., & Karin, M. (1996) · Science · doi:10.1126/science.274.5290.1194 · Cited by 1,034 · see citing works
The physical and chemical properties of eumelanin
Meredith, P., & Sarna, T. (2006) · Pigment Cell Research · doi:10.1111/j.1600-0749.2006.00345.x · Cited by 1,033 · see citing works
UV-light-induced signal cascades and skin aging
Rittié, L. (2002) · Ageing Research Reviews · doi:10.1016/s1568-1637(02)00024-7 · Cited by 987 · see citing works
Denu, J. M., & Tanner, K. G. (1998) · Biochemistry · doi:10.1021/bi973035t · Cited by 945 · see citing works
Decreased Collagen Production in Chronologically Aged Skin
Varani, J., Dame, M. K., Rittie, L., Fligiel, S. E. G., Kang, S., Fisher, G. J., & Voorhees, J. J. (2006) · The American Journal of Pathology · doi:10.2353/ajpath.2006.051302 · Cited by 910 · see citing works
Self-citationHarman, D. (1992) · Mutation Research/DNAging · doi:10.1016/0921-8734(92)90030-s · Cited by 902 · see citing works
The Fat Compartments of the Face: Anatomy and Clinical Implications for Cosmetic Surgery
Rohrich, R. J., & Pessa, J. E. (2007) · Plastic & Reconstructive Surgery · doi:10.1097/01.prs.0000265403.66886.54 · Cited by 832 · see citing works
Aging of the innate immune system
Shaw, A. C., Joshi, S., Greenwood, H., Panda, A., & Lord, J. M. (2010) · Current Opinion in Immunology · doi:10.1016/j.coi.2010.05.003 · Cited by 647 · see citing works
Varani, J., Warner, R. L., Gharaee-Kermani, M., Phan, S. H., Kang, S., Chung, J., Wang, Z., Datta, S. C., Fisher, G. J., & Voorhees, J. J. (2000) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2000.00902.x · Cited by 643 · see citing works
Duncan, M. R., Frazier, K. S., Abramson, S., Williams, S. J., Klapper, H., Huang, X., & Grotendorst, G. R. (1999) · The FASEB Journal · doi:10.1096/fasebj.13.13.1774 · Cited by 628 · see citing works
Wang, F., Garza, L. A., Kang, S., Varani, J., Orringer, J. S., Fisher, G. J., & Voorhees, J. J. (2007) · Archives of Dermatology · doi:10.1001/archderm.143.2.155 · Cited by 532 · see citing works
Self-citationMechanotransduction – a field pulling together?
Chen, C. S. (2008) · Journal of Cell Science · doi:10.1242/jcs.023507 · Cited by 520 · see citing works
Quantification of adipose tissue by MRI: relationship with anthropometric variables
Ross, R., Léger, L., Morris, D., de Guise, J. A., & Guardo, R. (1992) · Journal of Applied Physiology · doi:10.1152/jappl.1992.72.2.787 · Cited by 517 · see citing works
Knebel, A., Rahmsdorf, H. J., Ullrich, A., & Herrlich, P. A. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00916.x · Cited by 514 · see citing works
Studies in Cutaneous Aging: I. The Elastic Fiber Network
Braverman, I. M., & Fonferko, E. (1982) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12507866 · Cited by 507 · see citing works
Fisher, G. J., Quan, T., Purohit, T., Shao, Y., Cho, M. K., He, T., Varani, J., Kang, S., & Voorhees, J. J. (2009) · The American Journal of Pathology · doi:10.2353/ajpath.2009.080599 · Cited by 487 · see citing works
Self-citationKollias, N., Sayre, R. M., Zeise, L., & Chedekel, M. R. (1991) · Journal of Photochemistry and Photobiology B: Biology · doi:10.1016/1011-1344(91)80147-a · Cited by 482 · see citing works
Agrawal, A., Agrawal, S., Cao, J.-N., Su, H., Osann, K., & Gupta, S. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.11.6912 · Cited by 435 · see citing works
Comparative Physical Properties of Hyaluronic Acid Dermal Fillers
Kablik, J., Monheit, G. D., Yu, L., et al. (2009) · Dermatologic Surgery · doi:10.1111/j.1524-4725.2008.01046.x · Cited by 425 · see citing works
Reduced Type I and Type III Procollagens in Photodamaged Adult Human Skin
Talwar, H. S., Griffiths, C. E. M., Fisher, G. J., Hamilton, T. A., & Voorhees, J. J. (1995) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12318471 · Cited by 400 · see citing works
Self-citationAnthropometric assessment of 10-y changes in body composition in the elderly
HUGHES, V. A., Roubenoff, R., Wood, M., Frontera, W. R., Evans, W. J., & Singh, M. A. F. (2004) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/80.2.475 · Cited by 394 · see citing works
Quan, T., He, T., Kang, S., Voorhees, J. J., & Fisher, G. J. (2004) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63337-8 · Cited by 386 · see citing works
Self-citationSklar, L. R., Almutawa, F., Lim, H. W., & Hamzavi, I. (2012) · Photochemical & Photobiological Sciences · doi:10.1039/c2pp25152c · Cited by 354 · see citing works
Varani, J., Spearman, D., Perone, P., Fligiel, S., Datta, S. C., Wang, Z. Q., Shao, Y., Kang, S., Fisher, G. J., & Voorhees, J. J. (2001) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64040-0 · Cited by 333 · see citing works
Self-citationEffects of Aging and Chronic Sun Exposure on Melanocytes in Human Skin
Gilchrest, B. A., Blog, F. B., & Szabo, G. (1979) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12581580 · Cited by 328 · see citing works
Structural Changes in Aging Human Skin
Montagna, W., & Carlisle, K. S. (1979) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12532761 · Cited by 322 · see citing works
Magnetic resonance imaging of total body fat
Thomas, E. L., Saeed, N., Hajnal, J. V., Brynes, A. E., Goldstone, A. P., Frost, G. S., & Bell, J. D. (1998) · Journal of Applied Physiology · doi:10.1152/jappl.1998.85.5.1778 · Cited by 311 · see citing works
Fisher, G. J., Datta, S. C., Wang, Z., Li, X.-Y., Quan, T., Chung, J. H., Kang, S., & Voorhees, J. J. (2000) · Journal of Clinical Investigation · doi:10.1172/jci9362 · Cited by 304 · see citing works
Self-citationFisher, G. J., & Voorhees, J. J. (1998) · Journal of Investigative Dermatology Symposium Proceedings · doi:10.1038/jidsymp.1998.15 · Cited by 288 · see citing works
Self-citationMan, M., Xin, S. J., Song, S. P., Cho, S., Zhang, X. J., Tu, C. X., Feingold, K. R., & Elias, P. M. (2009) · Skin Pharmacology and Physiology · doi:10.1159/000231524 · Cited by 285 · see citing works
Perspectives and Problems in Cutaneous Gerontology
Kligman, A. M. (1979) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12532758 · Cited by 284 · see citing works
Mammalian Epidermal Barrier Layer Lipids: Composition and Influence on Structure
Elias, P. M., Goerke, J., & Friend, D. S. (1977) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12687968 · Cited by 284 · see citing works
Exploring the role of stem cells in cutaneous wound healing
Lau, K., Paus, R., Tiede, S., Day, P., & Bayat, A. (2009) · Experimental Dermatology · doi:10.1111/j.1600-0625.2009.00942.x · Cited by 279 · see citing works
Connective Tissue Biochemistry of the Aging Dermis
Uitto, J. (1986) · Dermatologic Clinics · doi:10.1016/s0733-8635(18)30806-4 · Cited by 276 · see citing works
Aged Skin: A Study by Light, Transmission Electron, and Scanning Electron Microscopy.
Lavker, R. M., Zheng, P., & Dong, G. (1987) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12468934 · Cited by 274 · see citing works
Chung, J. H. (2003) · Photodermatology Photoimmunology & Photomedicine · doi:10.1034/j.1600-0781.2003.00027.x · Cited by 269 · see citing works
Mine, S., Fortunel, N. O., Pageon, H., & Asselineau, D. (2008) · PLoS ONE · doi:10.1371/journal.pone.0004066 · Cited by 255 · see citing works
Regulation of collagen synthesis in fibroblasts within a three-dimensional collagen gel
Mauch, C., Hatamochi, A., Scharffetter, K., & Krieg, T. (1988) · Experimental Cell Research · doi:10.1016/0014-4827(88)90417-x · Cited by 253 · see citing works
Quan, T., Wang, F., Shao, Y., Rittié, L., Xia, W., Orringer, J. S., Voorhees, J. J., & Fisher, G. J. (2012) · Journal of Investigative Dermatology · doi:10.1038/jid.2012.364 · Cited by 248 · see citing works
Self-citationNew Insights into the Molecular Control of the Lymphatic Vascular System and its Role in Disease
Cueni, L. N., & Detmar, M. J. (2006) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700464 · Cited by 246 · see citing works
Aging and Regional Differences in Fat Cell Progenitors – A Mini-Review
Sepe, A., Tchkonia, T., Thomou, T., Zamboni, M., & Kirkland, J. L. (2011) · Gerontology · doi:10.1159/000279755 · Cited by 232 · see citing works
Delvoye, P., Wiliquet, P., Lévêque, J., Nusgens, B., & Lapiere, C. M. (1991) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12491651 · Cited by 231 · see citing works
The architecture of black and white facial skin
Montagna, W., & Carlisle, K. (1991) · Journal of the American Academy of Dermatology · doi:10.1016/0190-9622(91)70148-u · Cited by 226 · see citing works
Brenneisen, P., Wenk, J., Klotz, L., Wlaschek, M., Briviba, K., Krieg, T., Sies, H., & Scharffetter‐Kochanek, K. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.9.5279 · Cited by 223 · see citing works
Stratum Corneum Acidification Is Impaired in Moderately Aged Human and Murine Skin
Choi, E., Man, M., Xu, P., Xin, S., Liu, Z., Crumrine, D. A., Jiang, Y. J., Fluhr, J. W., Feingold, K. R., Elias, P. M., et al. (2007) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700913 · Cited by 216 · see citing works
Adipose tissue distribution measured by magnetic resonance imaging in obese women
Ross, R., Shaw, K., Martel, Y., de Guise, J. A., & Avruch, L. I. (1993) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/57.4.470 · Cited by 214 · see citing works
Rohrich, R. J., & Pessa, J. E. (2008) · Plastic & Reconstructive Surgery · doi:10.1097/prs.0b013e31816c3c1a · Cited by 213 · see citing works
Epidermal stem cells are retained in vivo throughout skin aging
Giangreco, A., Qin, M., Pintar, J. E., & Watt, F. M. (2008) · Aging Cell · doi:10.1111/j.1474-9726.2008.00372.x · Cited by 212 · see citing works
Gerstein, A., Phillips, T. J., Rogers, G. S., & Gilchrest, B. A. (1993) · Dermatologic Clinics · doi:10.1016/s0733-8635(18)30227-4 · Cited by 199 · see citing works
Effect of age on wound healing in healthy human beings.
Holt, D. R., Kirk, S., Regan, M., Hurson, M., Lindblad, W. J., & Barbul, A. (1992) · PubMed · Cited by 191 · see citing works
The effects of aging on the cutaneous microvasculature
Kelly, R. I., Pearse, R. M., Bull, R. H., Lévêque, J., de Rigal, J., & Mortimer, P. S. (1995) · Journal of the American Academy of Dermatology · doi:10.1016/0190-9622(95)91812-4 · Cited by 189 · see citing works
Szabo, G. (1967) · Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences · doi:10.1098/rstb.1967.0029 · Cited by 186 · see citing works
Pigmentary changes of the ageing skin
Ortonne, J. ‐. (1990) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1990.tb16121.x · Cited by 183 · see citing works
Harman, D. (1993) · Birkhäuser Basel eBooks · doi:10.1007/978-3-0348-9116-5_11 · Cited by 182 · see citing works
Age‐related changes in skin barrier function – Quantitative evaluation of 150 female subjects
Luebberding, S., Krueger, N., & Kerscher, M. J. (2012) · International Journal of Cosmetic Science · doi:10.1111/ics.12024 · Cited by 173 · see citing works
Nitric Oxide Is Generated on the Skin Surface by Reduction of Sweat Nitrate
Weller, R., Pattullo, S., Smith, L. M., Golden, M., Ormerod, A. D., & Benjamin, N. (1996) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12363167 · Cited by 172 · see citing works
Varani, J., Perone, P., Fligiel, S., Fisher, G. J., & Voorhees, J. J. (2002) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2002.01810.x · Cited by 162 · see citing works
Self-citationRole of pericytes in vascular morphogenesis
Betsholtz, C., Lindblom, P., & Gerhardt, H. (2005) · Birkhäuser Basel eBooks · doi:10.1007/3-7643-7311-3_8 · Cited by 160 · see citing works
Redox regulation of signal transduction in mammalian cells
Herrlich, P. A., & Böhmer, F. (2000) · Biochemical Pharmacology · doi:10.1016/s0006-2952(99)00298-1 · Cited by 158 · see citing works
Eccrine Sweat Glands are Major Contributors to Reepithelialization of Human Wounds
Rittié, L., Sachs, D. L., Orringer, J. S., Voorhees, J. J., & Fisher, G. J. (2012) · American Journal Of Pathology · doi:10.1016/j.ajpath.2012.09.019 · Cited by 154 · see citing works
Self-citationEpidermal trans -urocanic acid and the UV-A-induced photoaging of the skin
Hanson, K. M., & Simon, J. D. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.18.10576 · Cited by 153 · see citing works
Legg, J. W., Jensen, U. B., Broad, S., Leigh, I. M., & Watt, F. M. (2003) · Development · doi:10.1242/dev.00837 · Cited by 153 · see citing works
Status of anthropometry and body composition data in elderly subjects
Chumlea, W. C., & Baumgartner, R. (1989) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/50.5.1158 · Cited by 152 · see citing works
Oxidants Painting the Cysteine Chapel
Xu, D. L., Rovira, I. I., & Finkel, T. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00132-6 · Cited by 151 · see citing works
Regional and Individual Variations in the Function of the Human Eccrine Sweat Gland
Sato, K., & Dobson, R. L. (1970) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12259272 · Cited by 147 · see citing works
Mechanical Tension and Integrin α2β1 Regulate Fibroblast Functions
Eckes, B., Zweers, M. C., Zhang, Z., Hallinger, R., Mauch, C., Aumailley, M., & Krieg, T. M. (2006) · Journal of Investigative Dermatology Symposium Proceedings · doi:10.1038/sj.jidsymp.5650003 · Cited by 139 · see citing works
Marples, M. J. (1965) · Cited by 138 · see citing works
Differential Effects of Photoaging vs Intrinsic Aging on the Vascularization of Human Skin
Chung, J. H., Yano, K., Lee, M. K., Youn, C. S., Seo, J. Y., Kim, K. H., Cho, K. H., Eun, H. C., & Detmar, M. J. (2002) · Archives of Dermatology · doi:10.1001/archderm.138.11.1437 · Cited by 132 · see citing works
Aged Skin: A Study by Light, Transmission Electron, and Scanning Electron Microscopy
Lavker, R. M., Zheng, P., & Dong, G. (1987) · Journal of Investigative Dermatology · doi:10.1038/jid.1987.9 · Cited by 132 · see citing works
Xu, Y., Shao, Y., Voorhees, J. J., & Fisher, G. J. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m602355200 · Cited by 131 · see citing works
Self-citationAging of the Innate Immune System: An Update
Mahbub, S., Brubaker, A. L., & Kovacs, E. J. (2011) · Current Immunology Reviews · doi:10.2174/157339511794474181 · Cited by 125 · see citing works
Inoue, Y., & Shibasaki, M. (1996) · European Journal of Applied Physiology · doi:10.1007/bf00376498 · Cited by 124 · see citing works
Human Skin Aging Is Associated with Reduced Expression of the Stem Cell Markers β1 Integrin and MCSP
Giangreco, A., Goldie, S. J., Failla, V., Saintigny, G., & Watt, F. M. (2009) · Journal of Investigative Dermatology · doi:10.1038/jid.2009.297 · Cited by 123 · see citing works
Fisher, G. J., & Voorhees, J. J. (1998) · Journal of Investigative Dermatology · doi:10.1038/jidsp.1998.15 · Cited by 115 · see citing works
Self-citationdu Noüy, P. L. (1916) · The Journal of Experimental Medicine · doi:10.1084/jem.24.5.461 · Cited by 114 · see citing works
Receptor-type Protein-tyrosine Phosphatase-κ Regulates Epidermal Growth Factor Receptor Function
Xu, Y., Tan, L.-J., Grachtchouk, V., Voorhees, J. J., & Fisher, G. J. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m507722200 · Cited by 112 · see citing works
Self-citationMaximal skin vascular conductance in subjects aged 5-85 yr
Martin, H. L., Loomis, J. L., & Kenney, W. L. (1995) · Journal of Applied Physiology · doi:10.1152/jappl.1995.79.1.297 · Cited by 108 · see citing works
Turlier, V., Delalleau, A., Casas, C., Rouquier, A., Bianchi, P., Alvarez, S., Josse, G., Briant, A., Dahan, S., Saint‐Martory, C., et al. (2013) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2012.12.006 · Cited by 100 · see citing works
Quan, T., He, T., Voorhees, J. J., & Fisher, G. J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m409647200 · Cited by 97 · see citing works
Self-citationFrederiksen, L., Nielsen, T. L., Wraae, K., Hagen, C., Frystyk, J., Flyvbjerg, A., Brixen, K., & Andersen, M. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-0980 · Cited by 96 · see citing works
Impairment of Thermoregulatory Control of Skin Sympathetic Nerve Traffic in the Elderly
Grassi, G. M., Seravalle, G., Turri, C., Bertinieri, G., Dell’Oro, R., & Mancia, G. (2003) · Circulation · doi:10.1161/01.cir.0000081769.02847.a1 · Cited by 94 · see citing works
Rittié, L., Berton, A., Monboisse, J., Hornebeck, W., & Gillery, P. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.1519 · Cited by 92 · see citing works
Skin Immune Systems and Inflammation: Protector of the Skin or Promoter of Aging?
Bennett, M. F., Robinson, M. K., Baron, E. D., & Cooper, K. D. (2008) · Journal of Investigative Dermatology Symposium Proceedings · doi:10.1038/jidsymp.2008.3 · Cited by 92 · see citing works
Aging-Associated Sensory Neuropathy Alters Pressure-Induced Vasodilation in Humans
Fromy, B., Sigaudo‐Roussel, D., Gaubert‐Dahan, M., Rousseau, P., Abraham, P., Benzoni, D., Berrut, G., & Saumet, J. L. (2009) · Journal of Investigative Dermatology · doi:10.1038/jid.2009.279 · Cited by 92 · see citing works
Aging results in paradoxical susceptibility of fat cell progenitors to lipotoxicity
Guo, W., Pirtskhalava, T., Tchkonia, T., Xie, W., Thomou, T., Han, J., Wang, T., Wong, S., Cartwright, A., Hegardt, F. G., et al. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00557.2006 · Cited by 85 · see citing works
Skin blister and skin biopsy to quantify epidermal nerves
Panoutsopoulou, I. G., Wendelschafer‐Crabb, G., Hodges, J. S., & Kennedy, W. R. (2008) · Neurology · doi:10.1212/01.wnl.0000340984.74563.1c · Cited by 83 · see citing works
Determination of the tensile strength of the healing wound as a clinical test.
Sandblom, P., Petersen, P., & MUREN, A. (1953) · PubMed · Cited by 81 · see citing works
Quan, T., He, T., Kang, S., Voorhees, J. J., & Fisher, G. J. (2002) · Journal of Investigative Dermatology · doi:10.1046/j.0022-202x.2001.01678.x · Cited by 80 · see citing works
Self-citationLavker, R. M., Zheng, P., & Dong, G. (1989) · PubMed · Cited by 80 · see citing works
Mechanisms underlying the age-related decrement in the human sweating response
Inoue, Y., Shibasaki, M., Ueda, H., et al. (1999) · European Journal of Applied Physiology · doi:10.1007/s004210050485 · Cited by 79 · see citing works
UV modulation of subcutaneous fat metabolism
Kim, E. J., Kim, Y. K., Kim, J. E., Kim, S., Kim, M.-K., Park, C.-H., & Chung, J. H. (2011) · Journal of Investigative Dermatology · doi:10.1038/jid.2011.106 · Cited by 79 · see citing works
Epidermal stem cells are resistant to cellular aging
Stern, M. M., & Bickenbach, J. R. (2007) · Aging Cell · doi:10.1111/j.1474-9726.2007.00318.x · Cited by 79 · see citing works
HODGSON, C. (1963) · Archives of Dermatology · doi:10.1001/archderm.1963.01590140059010 · Cited by 76 · see citing works
Dehiscence of laparotomy wounds
Halasz, N. A. (1968) · The American Journal of Surgery · doi:10.1016/0002-9610(68)90495-9 · Cited by 75 · see citing works
Hedgehog signaling maintains hair follicle stem cell phenotype in young and aged human skin
Rittié, L., Stoll, S. W., Kang, S., Voorhees, J. J., & Fisher, G. J. (2009) · Aging Cell · doi:10.1111/j.1474-9726.2009.00526.x · Cited by 75 · see citing works
Self-citationAdipocytokines and aging: adiponectin and leptin.
Gülçelik, N. E., Halil, M. G., Arıoğul, S., & Usman, A. (2013) · PubMed · Cited by 68 · see citing works
Immune responses in the skin in old age
Vukmanovic‐Stejic, M., Rustin, M. H. A., Nikolich‐Žugich, J., & Akbar, A. N. (2011) · Current Opinion in Immunology · doi:10.1016/j.coi.2011.05.008 · Cited by 63 · see citing works
Rs, S., & Bischitz, P. G. (1963) · PubMed · Cited by 62 · see citing works
II. Incidence of Wound Disruption Following Operation
Mendoza, C. B. (1970) · Archives of Surgery · doi:10.1001/archsurg.1970.01340270044012 · Cited by 60 · see citing works
Effect of Increased Pigmentation on the Antifibrotic Response of Human Skin to UV-A1 Phototherapy
Wang, F., Garza, L. A., Cho, S., Kafi, R., Hammerberg, C., Quan, T., Hamilton, T. A., Mayes, M. D., Ratanatharathorn, V., Voorhees, J. J., et al. (2008) · Archives of Dermatology · doi:10.1001/archderm.144.7.851 · Cited by 58 · see citing works
Self-citationDiscordance between facial wrinkling and the presence of basal cell carcinoma.
Brooke, R. C. C., Newbold, S., Telfer, N. R., & Griffiths, C. E. M. (2001) · PubMed · Cited by 57 · see citing works
Gavi, S., Feiner, J., Meléndez, M. M., Mynarcik, D. C., Gelato, M. C., & McNurlan, M. A. (2007) · The Journals of Gerontology Series A · doi:10.1093/gerona/62.9.997 · Cited by 54 · see citing works
Aging and Cultured Human Skin in Fibroblasts
Schneider, E. L. (1979) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12532753 · Cited by 53 · see citing works
The Fat Compartments of the Face: Anatomy and Clinical Implications for Cosmetic Surgery
Rohrich, R. J., & Pessa, J. E. (2008) · Plastic & Reconstructive Surgery · doi:10.1097/01.prs.0000299636.97607.5f · Cited by 50 · see citing works
Reduction of lymphatic vessels in photodamaged human skin
Kajiya, K., Kunstfeld, R., Chung, J. H., & Detmar, M. J. (2007) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2007.05.003 · Cited by 48 · see citing works
Redox regulation of protein tyrosine phosphatase activity by hydroxyl radical
Meng, F.-G., & Zhang, Z. (2012) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2012.06.018 · Cited by 47 · see citing works
Baadsgaard, O., Lisby, S., Wantzin, G. L., et al. (1989) · The Journal of Immunology · doi:10.4049/jimmunol.142.12.4213 · Cited by 40 · see citing works
Immunosenescence and vaccination of the elderly I. Age-related immune impairment
Ongrádi, J., Stercz, B., Kövesdi, V., & Vértes, L. (2009) · Acta Microbiologica et Immunologica Hungarica · doi:10.1556/amicr.56.2009.3.1 · Cited by 35 · see citing works
Hirata, A., Nomura, T., & Laakso, I. (2012) · Physiological Measurement · doi:10.1088/0967-3334/33/8/n51 · Cited by 29 · see citing works
Reinisch, C. M., & Tschachler, E. (2011) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2011.10.009 · Cited by 29 · see citing works
Helmbold, P., Lautenschläger, C., Marsch, W. C., & Nayak, R. C. (2006) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700275 · Cited by 27 · see citing works
Characteristic alterations of cutaneous neurogenic factors in photoaged skin
Toyoda, M., Nakamura, M., Nakada, K., et al. (2005) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2005.06965.x · Cited by 25 · see citing works
Леонидовна, Ш. И., Petrova, G. A., Zor'kina, M. V., Евгеньевна, Ч. О., Сергеевна, Ф. М., Олегович, Э. Д., Agrba, P. D., Kamensky, V. A., & Валерьевна, Д. Е. (2012) · Skin Research and Technology · doi:10.1111/j.1600-0846.2012.00613.x · Cited by 24 · see citing works
Exogenous interleukin-1beta restores impaired Langerhans cell migration in aged skin
Bhushan, M., Cumberbatch, M., Dearman, R. J., Kimber, I., & Griffiths, C. E. M. (2004) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2004.05973.x · Cited by 24 · see citing works
Monocyte chemiluminescence and macrophage precursors in the aged.
Takahashi, I., OHMOTO, E., Aoyama, S., Takizawa, M., Oda, Y., Nonaka, K., Nakada, H., Yorimitsu, S., & Kimura, I. (1985) · PubMed · doi:10.18926/amo/31506 · Cited by 23 · see citing works
Photodamage to the cutaneous sensory nerves: role in photoaging and carcinogenesis of the skin?
Legat, F. J., & Wolf, P. (2005) · Photochemical & Photobiological Sciences · doi:10.1039/b508856a · Cited by 23 · see citing works
MORPHOLOGY OF CUTANEOUS SENSORY RECEPTORS
Montagna, W. (1977) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12497855 · Cited by 21 · see citing works
Epidermal innervation correlates with severity of photodamage
Toyoda, M., Hara, M., & Bhawan, J. (1996) · Experimental Dermatology · doi:10.1111/j.1600-0625.1996.tb00127.x · Cited by 20 · see citing works
Xu, Y. (2006) · Biological Chemistry · Cited by 20 · see citing works
Cutaneous sensory nerves: mediators of phototherapeutic effects?
Legat, F. J. (2009) · Frontiers in bioscience · doi:10.2741/3577 · Cited by 19 · see citing works
Age related changes in human C-fiber function
Namer, B. (2009) · Neuroscience Letters · doi:10.1016/j.neulet.2009.07.023 · Cited by 17 · see citing works
Photosensitivity in the elderly
HAWK, J. L. M. (1990) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1990.tb16122.x · Cited by 15 · see citing works
Elias, P. M., Williams, M. L. K., Crumrine, D. A., et al. (2010) · Current problems in dermatology · doi:10.1159/000321082 · Cited by 9 · see citing works
[The cutaneous neurosensory axis and the neuro-immuno-cutaneous system].
Fraiture, A. L., Piérard-Franchimont, C., & Pierard, G. (1998) · PubMed · Cited by 3 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- Lavker RM. 1995. Cutaneous aging: Chronologic versus photoaging. In Photodamage (ed. Gilchrest BA), pp. 123- 135. Blackwell Science, Cambridge, MA.
Cited by
Sorted by citations
Fighting against Skin Aging: The Way from Bench to Bedside
Zhang, S., & Duan, E. (2018) · Cell Transplantation · doi:10.1177/0963689717725755 · Cited by 739 · see citing works
Single-cell transcriptomes of the human skin reveal age-related loss of fibroblast priming
Solé-Boldo, L., Raddatz, G., Schütz, S., Mallm, J.-P., Rippe, K., Lonsdorf, A. S., Rodríguez-Paredes, M., & Lyko, F. (2020) · Communications Biology · doi:10.1038/s42003-020-0922-4 · Cited by 559 · see citing works
Salminen, A., Kaarniranta, K., & Kauppinen, A. (2022) · Inflammation Research · doi:10.1007/s00011-022-01598-8 · Cited by 432 · see citing works
Biomarkers of cellular senescence and skin aging
Wang, A. S., & Dreesen, O. (2018) · Frontiers in Genetics · doi:10.3389/fgene.2018.00247 · Cited by 404 · see citing works
Mitochondria in skin health, aging, and disease
Sreedhar, A., Aguilera-Aguirre, L., & Singh, K. K. (2020) · Cell Death & Disease · doi:10.1038/s41419-020-2649-z · Cited by 339 · see citing works
Antioxidants from Plants Protect against Skin Photoaging
Petruk, G., Del Giudice, R., Rigano, M. M., & Monti, D. M. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/1454936 · Cited by 283 · see citing works
Asserin, J., Lati, E., Shioya, T., & Prawitt, J. (2015) · Journal of Cosmetic Dermatology · doi:10.1111/jocd.12174 · Cited by 260 · see citing works
Environmentally-Induced (Extrinsic) Skin Aging: Exposomal Factors and Underlying Mechanisms
Krutmann, J., Schikowski, T., Morita, A., & Berneburg, M. (2021) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2020.12.011 · Cited by 253 · see citing works
Subedi, L., Lee, T. H., Wahedi, H. M., Baek, S.-H., & Kim, S. Y. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/8379539 · Cited by 174 · see citing works
Gruber, F., Kremslehner, C., Eckhart, L., & Tschachler, E. (2020) · Experimental Gerontology · doi:10.1016/j.exger.2019.110780 · Cited by 166 · see citing works
Role of Vitamin C in Skin Diseases
Wang, K., Jiang, H., Li, W., Qiang, M., Dong, T., & Li, H. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00819 · Cited by 158 · see citing works
Using Copper to Improve the Well-Being of the Skin
Borkow, G. (2015) · Current Chemical Biology · doi:10.2174/2212796809666150227223857 · Cited by 149 · see citing works
Copper/Zinc Superoxide Dismutase in Human Skin: Current Knowledge
Altobelli, G. G., Van Noorden, S., Balato, A., & Cimini, V. (2020) · Frontiers in Medicine · doi:10.3389/fmed.2020.00183 · Cited by 84 · see citing works
Modeling transcriptomic age using knowledge-primed artificial neural networks
Holzscheck, N., Falckenhayn, C., Söhle, J., Kristof, B., Siegner, R., Werner, A., Schössow, J., Jürgens, C., Völzke, H., Wenck, H., et al. (2021) · npj Aging and Mechanisms of Disease · doi:10.1038/s41514-021-00068-5 · Cited by 71 · see citing works
Myung, D.-B., Han, H.-S., Shin, J.-S., Park, J. Y., Hwang, H. J., Kim, H. J., Ahn, H. S., Lee, S. H., & Lee, K.-T. (2019) · Nutrients · doi:10.3390/nu11102354 · Cited by 56 · see citing works
Jo, S., Jung, Y.-S., Cho, Y.-R., Seo, J.-W., Lim, W.-C., Nam, T.-G., Lim, T.-G., & Byun, S. (2021) · Antioxidants · doi:10.3390/antiox10111663 · Cited by 26 · see citing works
Lee, E.-S., Ahn, Y., Bae, I.-H., Min, D., Park, N. H., Jung, W., Kim, S.-H., Hong, Y. D., Park, W. S., & Lee, C. S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21093198 · Cited by 25 · see citing works
Chajra, H., Salwinski, A., Guillaumin, A., Mignard, B., Hannewald, P., Duriot, L., Warnault, P., Guillet-Claude, C., Fréchet, M., & Bourgaud, F. (2020) · Molecules · doi:10.3390/molecules25184162 · Cited by 15 · see citing works
The Impact of Sunlight on Skin Aging
Kaddurah, H., Braunberger, T. L., Vellaichamy, G., Nahhas, A. F., Lim, H. W., & Hamzavi, I. H. (2018) · Current Geriatrics Reports · doi:10.1007/s13670-018-0262-0 · Cited by 11 · see citing works
- Authors
- Rittie, L., & Fisher, G. J.
- Affiliations
- University of Michigan (US)
- ORCID
- Fisher, G. J.
- Venue
- Cold Spring Harbor Perspectives in Medicine
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2015-01-01
- Volume
- 5
- Issue
- 1
- Pages
- a015370-a015370
- ISSN
- 2157-1422 (ISSN-L)
- PMC
- PMC4292080
- OpenAlex
- W2101089137
- Cited by
- 600
- References
- 134
- Citations by year
- 2026: 86 · 2025: 63 · 2024: 60 · 2023: 88 · 2022: 68 · 2021: 74 · 2020: 49 · 2019: 51 · 2018: 19 · 2017: 18 · 2016: 13 · 2015: 9 · 2012: 1
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cold Spring Harbor Perspectives in Medicine (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01ag031452-04)
- National Institute on Aging (AG031452, R01-AG031452, R01AG019364, AG019364)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (K01AR059678, AR059678)
- Topics
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Skin and Cellular Biology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
- Keywords
- skin aging, chronological aging, photoaging, ultraviolet radiation, skin barrier function, eccrine sweat glands, skin collagen, extracellular matrix, skin biomechanics, wound healing, skin pigmentation, skin innervation, skin immunity, skin vasculature, subcutaneous adipose tissue
- MeSH terms
- Body Temperature Regulation, Collagen, Extracellular Matrix, Humans, Regeneration, Skin, Skin Pigmentation, Sunlight, Ultraviolet Rays, Skin Aging, Subcutaneous Fat
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
