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Mesenchymal stem cells reside in virtually all post-natal organs and tissues

Meirelles, Lindolfo da Silva, Chagastelles, Pedro Cesar, Nardi, Nance Beyer·2006·Journal of Cell Science
DOI 10.1242/jcs.02932
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Abstract

Mesenchymal stem cells (MSCs) are multipotent cells which can give rise to mesenchymal and non-mesenchymal tissues in vitro and in vivo. Whereas in vitro properties such as (trans)differentiation capabilities are well known, there is little information regarding natural distribution and biology in the living organism. To investigate the subject further, we generated long-term cultures of cells with mesenchymal stem cell characteristics from different organs and tissues from adult mice. These populations have morphology, immunophenotype and growth properties similar to bone marrow-derived MSCs. The differentiation potential was related to the tissue of origin. The results indicate that (1) cells with mesenchymal stem characteristics can be derived and propagated in vitro from different organs and tissues (brain, spleen, liver, kidney, lung, bone marrow, muscle, thymus, pancreas); (2) MSC long-term cultures can be generated from large blood vessels such as the aorta artery and the vena cava, as well as from small vessels such as those from kidney glomeruli; (3) MSCs are not detected in peripheral blood. Taken together, these results suggest that the distribution of MSCs throughout the post-natal organism is related to their existence in a perivascular niche. These findings have implications for understanding MSC biology, and for clinical and pharmacological purposes.

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Metadata

Authors
Meirelles, L. D. S., Chagastelles, P. C., & Nardi, N. B.
Venue
Journal of Cell Science
Publisher
The Company of Biologists
Published
2006-06-01
Volume
119
Issue
11
Pages
2204-2213
ISSN
  • 0021-9533 (ISSN-L)
  • 1477-9137
DOI
10.1242/jcs.02932
OpenAlex
W2155044423
Cited by
2,485
References
1
FWCI
38.90
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Mesenchymal stem cells reside in virtually all post-natal organs and tissues. https://app.cochat.ai/papers/10.1242/jcs.02932
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Meirelles, L. D. S., Chagastelles, P. C., & Nardi, N. B. (2006). Mesenchymal stem cells reside in virtually all post-natal organs and tissues. Journal of Cell Science. https://doi.org/10.1242/jcs.02932

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