Cited by 730Cellular Mechanics and Interactions3D Printing in Biomedical ResearchCell Image Analysis Techniques

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Micropatterning as a tool to decipher cell morphogenesis and functions

Théry, Manuel·2010·Journal of Cell Science

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Abstract

In situ, cells are highly sensitive to geometrical and mechanical constraints from their microenvironment. These parameters are, however, uncontrolled under classic culture conditions, which are thus highly artefactual. Micro-engineering techniques provide tools to modify the chemical properties of cell culture substrates at sub-cellular scales. These can be used to restrict the location and shape of the substrate regions, in which cells can attach, so-called micropatterns. Recent progress in micropatterning techniques has enabled the control of most of the crucial parameters of the cell microenvironment. Engineered micropatterns can provide a micrometer-scale, soft, 3-dimensional, complex and dynamic microenvironment for individual cells or for multi-cellular arrangements. Although artificial, micropatterned substrates allow the reconstitution of physiological in situ conditions for controlled in vitro cell culture and have been used to reveal fundamental cell morphogenetic processes as highlighted in this review. By manipulating micropattern shapes, cells were shown to precisely adapt their cytoskeleton architecture to the geometry of their microenvironment. Remodelling of actin and microtubule networks participates in the adaptation of the entire cell polarity with respect to external constraints. These modifications further impact cell migration, growth and differentiation.

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Authors: Théry, M.
Affiliations: Centre National de la Recherche Scientifique (FR)
Corresponding author: Théry, Manuel
ORCID: Théry, Manuel
Venue: Journal of Cell Science
Publisher: The Company of Biologists
Published: 2010-12-15
Volume: 123
Issue: 24
Pages: 4201-4213
ISSN: 0021-9533 (ISSN-L)
1477-9137
DOI: 10.1242/jcs.075150
OpenAlex: W2057917964
Cited by: 730
References: 142
Citations by year: 2026: 22 · 2025: 22 · 2024: 19 · 2023: 45 · 2022: 55 · 2021: 49 · 2020: 66 · 2019: 58 · 2018: 65 · 2017: 54 · 2016: 50 · 2015: 53 · 2014: 53 · 2013: 63 · 2012: 43
FWCI: 3.41
Type: journal article
Language: en
Open access: closed
Locations: Journal of Cell Science (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion)
HighWire Press Open Archive (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biophysics › Cell Image Analysis Techniques
Keywords: micropatterning, cell morphogenesis, cell microenvironment, substrate geometry, cell mechanics, actin cytoskeleton, microtubules, cell polarity, cell migration, cell differentiation, cell growth, microengineering, 3D cell culture
MeSH terms: Animals, Cell Differentiation, Cells, Humans, Cell Polarity, Cell Culture Techniques, Cell Shape, Cell Proliferation

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Micropatterning as a tool to decipher cell morphogenesis and functions

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