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Cited by 730Cellular Mechanics and Interactions3D Printing in Biomedical ResearchCell Image Analysis Techniques

The DOI matches its Crossref record; 142 of the 142 references it cites were found in a registry or an index.

Micropatterning as a tool to decipher cell morphogenesis and functions

Théry, Manuel·2010·Journal of Cell Science
DOI 10.1242/jcs.075150
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Abstract

In situ, cells are highly sensitive to geometrical and mechanical constraints from their microenvironment. These parameters are, however, uncontrolled under classic culture conditions, which are thus highly artefactual. Micro-engineering techniques provide tools to modify the chemical properties of cell culture substrates at sub-cellular scales. These can be used to restrict the location and shape of the substrate regions, in which cells can attach, so-called micropatterns. Recent progress in micropatterning techniques has enabled the control of most of the crucial parameters of the cell microenvironment. Engineered micropatterns can provide a micrometer-scale, soft, 3-dimensional, complex and dynamic microenvironment for individual cells or for multi-cellular arrangements. Although artificial, micropatterned substrates allow the reconstitution of physiological in situ conditions for controlled in vitro cell culture and have been used to reveal fundamental cell morphogenetic processes as highlighted in this review. By manipulating micropattern shapes, cells were shown to precisely adapt their cytoskeleton architecture to the geometry of their microenvironment. Remodelling of actin and microtubule networks participates in the adaptation of the entire cell polarity with respect to external constraints. These modifications further impact cell migration, growth and differentiation.

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Metadata

Authors
Théry, M.
Affiliations
Centre National de la Recherche Scientifique (FR)
Corresponding author
Théry, Manuel
ORCID
Théry, Manuel
Venue
Journal of Cell Science
Publisher
The Company of Biologists
Published
2010-12-15
Volume
123
Issue
24
Pages
4201-4213
ISSN
  • 0021-9533 (ISSN-L)
  • 1477-9137
DOI
10.1242/jcs.075150
OpenAlex
W2057917964
Cited by
730
References
142
Citations by year
2026: 22 · 2025: 22 · 2024: 19 · 2023: 45 · 2022: 55 · 2021: 49 · 2020: 66 · 2019: 58 · 2018: 65 · 2017: 54 · 2016: 50 · 2015: 53 · 2014: 53 · 2013: 63 · 2012: 43
FWCI
3.41
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Cell Science (publishedVersion)
  • PubMed (publishedVersion)
  • HAL (submittedVersion)
  • HighWire Press Open Archive (submittedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
  • Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biophysics › Cell Image Analysis Techniques
Keywords
micropatterning, cell morphogenesis, cell microenvironment, substrate geometry, cell mechanics, actin cytoskeleton, microtubules, cell polarity, cell migration, cell differentiation, cell growth, microengineering, 3D cell culture
MeSH terms
Animals, Cell Differentiation, Cells, Humans, Cell Polarity, Cell Culture Techniques, Cell Shape, Cell Proliferation

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