The DOI matches its Crossref record; 155 of the 155 references it cites were found in a registry or an index.
Actin stress fibers – assembly, dynamics and biological roles
Abstract
Actin filaments assemble into diverse protrusive and contractile structures to provide force for a number of vital cellular processes. Stress fibers are contractile actomyosin bundles found in many cultured non-muscle cells, where they have a central role in cell adhesion and morphogenesis. Focal-adhesion-anchored stress fibers also have an important role in mechanotransduction. In animal tissues, stress fibers are especially abundant in endothelial cells, myofibroblasts and epithelial cells. Importantly, recent live-cell imaging studies have provided new information regarding the mechanisms of stress fiber assembly and how their contractility is regulated in cells. In addition, these studies might elucidate the general mechanisms by which contractile actomyosin arrays, including muscle cell myofibrils and cytokinetic contractile ring, can be generated in cells. In this Commentary, we discuss recent findings concerning the physiological roles of stress fibers and the mechanism by which these structures are generated in cells.
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“Bounds of the bending force applied to the first anchor point were determined using literature values for the force exerted by each active myosin-II dimer, the number of myosin-II dimers Nmyo per actin filament and the number of actin filaments in each stress filament Nactin (Eq. 3 in Appendix A) [35, 36], resulting in P1 = Pmax = 0.12–2.25 nN.”
From Macrophages bend long fibres with flexural rigidity lower than 3 mN·nm2 to avoid frustrated phagocytosis (2026) · cites this paper as [35]
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Cellular Mechanotransduction: From Tension to Function
Martino, F. D., Perestrelo, A. R., Vinarský, V., Pagliari, S., & Forte, G. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00824 · Cited by 1,028
Ribeiro, A. J. S., Ang, Y.-S., Fu, J., Rivas, R. N., Mohamed, T., Higgs, G., Srivastava, D., & Pruitt, B. L. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1508073112 · Cited by 479
Apical constriction: themes and variations on a cellular mechanism driving morphogenesis
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Cellular chirality arising from the self-organization of the actin cytoskeleton
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Substrate curvature as a cue to guide spatiotemporal cell and tissue organization
Callens, S. J. P., Uyttendaele, R. J. C., Fratila-Apachitei, L. E., & ZADPOOR, A. A. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2019.119739 · Cited by 324
Metadata
- Authors
- Tojkander, S., Gateva, G., & Lappalainen, P.
- Affiliations
- University of Helsinki (FI)
- Corresponding author
- Lappalainen, Pekka
- Venue
- Journal of Cell Science
- Publisher
- The Company of Biologists
- Published
- 2012-01-01
- Volume
- 125
- Issue
- Pt 8
- Pages
- 1855-64
- ISSN
- 0021-9533 (ISSN-L)
- 1477-9137
- OpenAlex
- W2151492748
- Cited by
- 900
- References
- 155
- Citations by year
- 2026: 23 · 2025: 59 · 2024: 68 · 2023: 59 · 2022: 61 · 2021: 100 · 2020: 99 · 2019: 85 · 2018: 53 · 2017: 73 · 2016: 66 · 2015: 66 · 2014: 48 · 2013: 35 · 2012: 5
- FWCI
- 23.20
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Cell Science (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Academy of Finland
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Skin and Cellular Biology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
- Keywords
- stress fibers, actomyosin contractility, focal adhesions, mechanotransduction, cell adhesion, cell morphogenesis, endothelial cells, myofibroblasts, epithelial cells, contractile ring, myofibrils, non-muscle cells
- MeSH terms
- Actins, Animals, Cell Adhesion, Cell Movement, Humans, Stress Fibers, Mechanotransduction, Cellular
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