Actin stress fibers – assembly, dynamics and biological roles

Matrix elasticity directs stem cell lineage specification

Engler, A. J., Sen, S., Sweeney, H. L., & Discher, D. E. (2006) · Cell · doi:10.1016/j.cell.2006.06.044 · Cited by 13,915

Tissue Cells Feel and Respond to the Stiffness of Their Substrate

Discher, D. E., Janmey, P., & Wang, Y.-L. (2005) · Science · doi:10.1126/science.1116995 · Cited by 6,382

Cell Migration: Integrating Signals from Front to Back

Ridley, A. J., Schwartz, M. A., Burridge, K., Firtel, R., Ginsberg, M. H., Borisy, G. G., Parsons, J. T., & Horwitz, A. R. (2003) · Science · doi:10.1126/science.1092053 · Cited by 5,109

Regulation of Myosin Phosphatase by Rho and Rho-Associated Kinase (Rho-Kinase)

Kimura, K., Ito, M., Amano, M., Chihara, K., Fukata, Y., Nakafuku, M., Yamamori, B., Feng, J., Nakano, T., Okawa, K., et al. (1996) · Science · doi:10.1126/science.273.5272.245 · Cited by 2,889

Environmental sensing through focal adhesions

Geiger, B., Spatz, J. P., & Bershadsky, A. D. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2593 · Cited by 2,543

Actin, a Central Player in Cell Shape and Movement

Pollard, T. D., & Cooper, J. A. (2009) · Science · doi:10.1126/science.1175862 · Cited by 2,178

Non-muscle myosin II takes centre stage in cell adhesion and migration

Vicente‐Manzanares, M., Ma, X., Adelstein, R. S., & Horwitz, A. R. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2786 · Cited by 2,137

Force and focal adhesion assembly: a close relationship studied using elastic micropatterned substrates

Balaban, N. Q., Schwarz, U. S., Riveline, D., Goichberg, P., Tzur, G., Sabanay, I., Mahalu, D., Safran, S. A., Bershadsky, A. D., Addadi, L., et al. (2001) · Nature Cell Biology · doi:10.1038/35074532 · Cited by 2,137

Focal Adhesions: Transmembrane Junctions Between the Extracellular Matrix and the Cytoskeleton

Burridge, K., Fath, K. R., Kelly, T. J., Nuckolls, G. H., & Turner, C. E. (1988) · Annual Review of Cell Biology · doi:10.1146/annurev.cb.04.110188.002415 · Cited by 2,120

Cell adhesion: integrating cytoskeletal dynamics and cellular tension

Parsons, J. T., Horwitz, A. R., & Schwartz, M. A. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2957 · Cited by 2,081

Cellular Mechanotransduction: From Tension to Function

Martino, F. D., Perestrelo, A. R., Vinarský, V., Pagliari, S., & Forte, G. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00824 · Cited by 1,028

Contractility of single cardiomyocytes differentiated from pluripotent stem cells depends on physiological shape and substrate stiffness

Ribeiro, A. J. S., Ang, Y.-S., Fu, J., Rivas, R. N., Mohamed, T., Higgs, G., Srivastava, D., & Pruitt, B. L. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1508073112 · Cited by 479

Apical constriction: themes and variations on a cellular mechanism driving morphogenesis

Martin, A. C., & Goldstein, B. (2014) · Development · doi:10.1242/dev.102228 · Cited by 502

Cellular chirality arising from the self-organization of the actin cytoskeleton

Tee, Y. H., Shemesh, T., Thiagarajan, V., Hariadi, R. F., Anderson, K., Page, C., Volkmann, N., Hanein, D., Sivaramakrishnan, S., Kozlov, M. M., et al. (2015) · Nature Cell Biology · doi:10.1038/ncb3137 · Cited by 420

Substrate curvature as a cue to guide spatiotemporal cell and tissue organization

Callens, S. J. P., Uyttendaele, R. J. C., Fratila-Apachitei, L. E., & ZADPOOR, A. A. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2019.119739 · Cited by 324

Exploring natural silk protein sericin for regenerative medicine: an injectable, photoluminescent, cell-adhesive 3D hydrogel

Wang, Z., Zhang, Y., Zhang, J., Huang, L., Liu, J., Li, Y., Zhang, G., Kundu, S. C., & Wang, L. (2014) · Scientific Reports · doi:10.1038/srep07064 · Cited by 288

Protein Assembly by Design

Zhu, J., Avakyan, N., Kakkis, A., Hoffnagle, A. M., Han, K., Li, Y., Zhang, Z., Choi, T. S., Na, Y., Yu, C.-J., et al. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.1c00308 · Cited by 288

Tropomyosin – master regulator of actin filament function in the cytoskeleton

Gunning, P. W., Hardeman, E. C., Lappalainen, P., & Mulvihill, D. P. (2015) · Journal of Cell Science · doi:10.1242/jcs.172502 · Cited by 281

Effect of Actin Organization on the Stiffness of Living Breast Cancer Cells Revealed by Peak-Force Modulation Atomic Force Microscopy

Calzado‐Martín, A., Encinar, M., Tamayo, J., Calleja, M., & Paulo, Á. S. (2016) · ACS Nano · doi:10.1021/acsnano.5b07162 · Cited by 252

Photo-crosslinkable, injectable sericin hydrogel as 3D biomimetic extracellular matrix for minimally invasive repairing cartilage

Qi, C., Liu, J., Jin, Y., Xu, L., Wang, G., Wang, Z., & Wang, L. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.02.016 · Cited by 248

Mechanical stretch: physiological and pathological implications for human vascular endothelial cells

Jufri, N. F., Mohamedali, A., Avolio, A. P., & Baker, M. S. (2015) · Vascular Cell · doi:10.1186/s13221-015-0033-z · Cited by 246

Architecture and Connectivity Govern Actin Network Contractility

Ennomani, H., Letort, G., Guérin, C., Martiel, J., Cao, W., Nédélec, F., Cruz, E. M. D. L., Théry, M., & Blanchoin, L. (2016) · Current Biology · doi:10.1016/j.cub.2015.12.069 · Cited by 222

Stochastic mechano-chemical kinetics of molecular motors: A multidisciplinary enterprise from a physicist’s perspective

Chowdhury, D. (2013) · Physics Reports · doi:10.1016/j.physrep.2013.03.005 · Cited by 221

Cadherin-6 promotes EMT and cancer metastasis by restraining autophagy

Gugnoni, M., Sancisi, V., Gandolfi, G., Manzotti, G., Ragazzi, M., Giordano, D., Tamagnini, I., Tigano, M., Frasoldati, A., Piana, S., et al. (2016) · Oncogene · doi:10.1038/onc.2016.237 · Cited by 214

Isoflurane, a Commonly Used Volatile Anesthetic, Enhances Renal Cancer Growth and Malignant Potential via the Hypoxia-inducible Factor Cellular Signaling Pathway In Vitro

Benzonana, L. L., Perry, N. J. S., Watts, H. R., Yang, B., Perry, I. A., Coombes, R. C., Takata, M., & Ma, D. (2013) · Anesthesiology · doi:10.1097/aln.0b013e31829e47fd · Cited by 211

Actin Cell Cortex: Structure and Molecular Organization

Svitkina, T. (2020) · Trends in Cell Biology · doi:10.1016/j.tcb.2020.03.005 · Cited by 210

Vimentin intermediate filaments control actin stress fiber assembly through GEF-H1 and RhoA

Jiu, Y., Peränen, J., Schaible, N., Cheng, F., Eriksson, J., Krishnan, R., & Lappalainen, P. (2017) · Journal of Cell Science · doi:10.1242/jcs.196881 · Cited by 213

Autophagy and epithelial–mesenchymal transition: an intricate interplay in cancer

Gugnoni, M., Sancisi, V., Manzotti, G., Gandolfi, G., & Ciarrocchi, A. (2016) · Cell Death and Disease · doi:10.1038/cddis.2016.415 · Cited by 205

Structural basis for cofilin binding and actin filament disassembly

Tanaka, K., Takeda, S., Mitsuoka, K., Oda, T., Kimura-Sakiyama, C., Maéda, Y., & Narita, A. (2018) · Nature Communications · doi:10.1038/s41467-018-04290-w · Cited by 208

Formin-generated actomyosin arcs propel T cell receptor microcluster movement at the immune synapse

Murugesan, S., Hong, J., Yi, J., Li, D., Beach, J. R., Shao, L., Meinhardt, J., Madison, G. P., Wu, X., Betzig, E., et al. (2016) · The Journal of Cell Biology · doi:10.1083/jcb.201603080 · Cited by 192

A multiethnic genome-wide association study of primary open-angle glaucoma identifies novel risk loci

Choquet, H., Paylakhi, S., Kneeland, S. C., Thai, K. K., Hoffmann, T. J., Yin, J., Kvale, M. N., Banda, Y., Tolman, N. G., Williams, P. A., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-04555-4 · Cited by 190

Bidirectional Interplay between Vimentin Intermediate Filaments and Contractile Actin Stress Fibers

Jiu, Y., Lehtimäki, J. I., Tojkander, S., Cheng, F., Jäälinoja, H. T., Liu, X., Varjosalo, M. T., Eriksson, J., & Lappalainen, P. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.05.008 · Cited by 193

Long-range self-organization of cytoskeletal myosin II filament stacks

Hu, S., Dasbiswas, K., Guo, Z., Tee, Y.-H., Thiagarajan, V., Hersen, P., Chew, T., Safran, S. A., Zaidel‐Bar, R., & Bershadsky, A. D. (2017) · Nature Cell Biology · doi:10.1038/ncb3466 · Cited by 183

Mechanical regulation of myofibroblast phenoconversion and collagen contraction

Hinz, B., McCulloch, C. A., & Coelho, N. M. (2019) · Experimental Cell Research · doi:10.1016/j.yexcr.2019.03.027 · Cited by 182

The inner workings of stress fibers − from contractile machinery to focal adhesions and back

Livne, A., & Geiger, B. (2016) · Journal of Cell Science · doi:10.1242/jcs.180927 · Cited by 188

Lipofuscin Redistribution and Loss Accompanied by Cytoskeletal Stress in Retinal Pigment Epithelium of Eyes With Age-Related Macular Degeneration

Ach, T., Tolstik, E., Messinger, J. D., Zarubina, A. V., Heintzmann, R., & Curcio, C. A. (2015) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.14-16274 · Cited by 177

Cell-Type-Resolved Quantitative Proteomics of Murine Liver

Azimifar, S. B., Nagaraj, N., Cox, J., & Mann, M. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.11.002 · Cited by 173

Tropomyosin Isoforms Specify Functionally Distinct Actin Filament Populations In Vitro

Gateva, G., Kremneva, E., Reindl, T., Kotila, T., Kogan, K., Gressin, L., Gunning, P. W., Manstein, D. J., Michelot, A., & Lappalainen, P. (2017) · Current Biology · doi:10.1016/j.cub.2017.01.018 · Cited by 168

Targeting cancer by binding iron: Dissecting cellular signaling pathways

Lui, G. Y. L., Kovačević, Ž., Richardson, V., Merlot, A. M., Kalinowski, D. S., & Richardson, D. R. (2015) · Oncotarget · doi:10.18632/oncotarget.4349 · Cited by 165

A glance on the role of actin in osteogenic and adipogenic differentiation of mesenchymal stem cells

Khan, A. U., Qu, R., Fan, T., Ouyang, J., & Dai, J. (2020) · Stem Cell Research & Therapy · doi:10.1186/s13287-020-01789-2 · Cited by 162

Guiding cell migration by tugging

Plotnikov, S. V., & Waterman, C. M. (2013) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2013.06.003 · Cited by 174

A three-dimensional study of alveologenesis in mouse lung

Branchfield, K., Li, R., Lungová, V., Verheyden, J. M., McCulley, D. J., & Sun, X. (2015) · Developmental Biology · doi:10.1016/j.ydbio.2015.11.017 · Cited by 161

The role of the cell nucleus in mechanotransduction

Janota, C. S., Calero-Cuenca, F. J., & Gomes, E. R. (2020) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2020.03.001 · Cited by 156

Generation of contractile actomyosin bundles depends on mechanosensitive actin filament assembly and disassembly

Tojkander, S., Gateva, G., Husain, A., Krishnan, R., & Lappalainen, P. (2015) · eLife · doi:10.7554/elife.06126 · Cited by 157

mTORC2 Regulates Mechanically Induced Cytoskeletal Reorganization and Lineage Selection in Marrow-Derived Mesenchymal Stem Cells

Sen, B., Xie, Z., Case, N. D., Thompson, W. R., Uzer, G., Styner, M., & Rubin, J. E. (2013) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2031 · Cited by 149

Cytoskeletal Proteins in Cancer and Intracellular Stress: A Therapeutic Perspective

Ong, M. S., Deng, S., Halim, C. E., Cai, W., Tan, T. Z., Huang, R. Y., Sethi, G., Hooi, S. C., Kumar, A. P., & Yap, C. T. (2020) · Cancers · doi:10.3390/cancers12010238 · Cited by 145

Actin stress fibre subtypes in mesenchymal-migrating cells

Vallenius, T. (2013) · Open Biology · doi:10.1098/rsob.130001 · Cited by 154

Metastasis suppressor, NDRG1, mediates its activity through signaling pathways and molecular motors

Sun, J., Zhang, D., Bae, D.-H., Sahni, S., Jansson, P. J., Zheng, Y., Zhao, Q., Yue, F., Zheng, M., Kovačević, Ž., et al. (2013) · Carcinogenesis · doi:10.1093/carcin/bgt163 · Cited by 140

The Yin-Yang of Rigidity Sensing: How Forces and Mechanical Properties Regulate the Cellular Response to Materials

Schoen, I., Pruitt, B. L., & Viola Vogel, B. (2013) · Annual Review of Materials Research · doi:10.1146/annurev-matsci-062910-100407 · Cited by 134

RhoA GTPase inhibition organizes contraction during epithelial morphogenesis

Mason, F. M., Xie, S., Vasquez, C. G., Tworoger, M., & Martin, A. C. (2016) · The Journal of Cell Biology · doi:10.1083/jcb.201603077 · Cited by 138

BNIP3 supports melanoma cell migration and vasculogenic mimicry by orchestrating the actin cytoskeleton

Maes, H., Eygen, S. V., Krysko, D. V., Vandenabeele, P., Nys, K., Rillaerts, K., Garg, A. D., Verfaillie, T., & Agostinis, P. (2014) · Cell Death and Disease · doi:10.1038/cddis.2014.94 · Cited by 130

LIM proteins in actin cytoskeleton mechanoresponse

Smith, M. A., Hoffman, L. M., & Beckerle, M. C. (2014) · Trends in Cell Biology · doi:10.1016/j.tcb.2014.04.009 · Cited by 133

The miR-130 family promotes cell migration and invasion in bladder cancer through FAK and Akt phosphorylation by regulating PTEN

Egawa, H., Jingushi, K., Hirono, T., Ueda, Y., Kitae, K., Nakata, W., Fujita, K., Uemura, M., Nonomura, N., & Tsujikawa, K. (2016) · Scientific Reports · doi:10.1038/srep20574 · Cited by 123

Generation of stress fibers through myosin-driven reorganization of the actin cortex

Lehtimäki, J. I., Rajakylä, E. K., Tojkander, S., & Lappalainen, P. (2021) · eLife · doi:10.7554/elife.60710 · Cited by 130

Stress fibres are embedded in a contractile cortical network

Vignaud, T., Copos, C., Leterrier, C., Toro‐Nahuelpan, M., Tseng, Q., Mahamid, J., Blanchoin, L., Mogilner, A., Théry, M., & Kurzawa, L. (2020) · Nature Materials · doi:10.1038/s41563-020-00825-z · Cited by 120

Stiffness of pancreatic cancer cells is associated with increased invasive potential

Nguyen, A. V., Nyberg, K. D., Scott, M., Welsh, A. M., Nguyen, A. H., Wu, N., Hohlbauch, S. V., Geisse, N. A., Gibb, E. A., Robertson, A. G., et al. (2016) · Integrative Biology · doi:10.1039/c6ib00135a · Cited by 124

Intranuclear Actin Regulates Osteogenesis

Sen, B., Xie, Z., Uzer, G., Thompson, W. R., Styner, M., Wu, X., & Rubin, J. E. (2015) · Stem Cells · doi:10.1002/stem.2090 · Cited by 118

Cyclic Tensile Strain Controls Cell Shape and Directs Actin Stress Fiber Formation and Focal Adhesion Alignment in Spreading Cells

Greiner, A. M., Chen, H., Spatz, J. P., & Kemkemer, R. (2013) · PLoS ONE · doi:10.1371/journal.pone.0077328 · Cited by 115

A biomechanical perspective on stress fiber structure and function

Kassianidou, E., & Kumar, S. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2015.04.006 · Cited by 114

Cofilin-1 and Other ADF/Cofilin Superfamily Members in Human Malignant Cells

Ss, S., Еремина, Л. С., Pashintseva, N. V., Ковалев, Л. И., & Ковалева, М. А. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms18010010 · Cited by 114

Evolutionarily diverse LIM domain-containing proteins bind stressed actin filaments through a conserved mechanism

Winkelman, J. D., Anderson, C. A., Suarez, C., Kovar, D. R., & Gardel, M. L. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2004656117 · Cited by 114

Microtubules at focal adhesions – a double-edged sword

Seetharaman, S., & Etienne‐Manneville, S. (2019) · Journal of Cell Science · doi:10.1242/jcs.232843 · Cited by 120

Ultrastructure of the actin cytoskeleton

Svitkina, T. (2018) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2018.02.007 · Cited by 115

Hypoxia induces epithelial-mesenchymal transition in colorectal cancer cells through ubiquitin-specific protease 47-mediated stabilization of Snail: A potential role of Sox9

Choi, B.-J., Park, S., Lee, S., Nam, Y., & Surh, Y. (2017) · Scientific Reports · doi:10.1038/s41598-017-15139-5 · Cited by 106

Curvature and Rho activation differentially control the alignment of cells and stress fibers

Bade, N. D., Kamien, R. D., Assoian, R. K., & Stebe, K. J. (2017) · Science Advances · doi:10.1126/sciadv.1700150 · Cited by 105

Spatial effects − site-specific regulation of actin and microtubule organization by septin GTPases

Spiliotis, E. T. (2018) · Journal of Cell Science · doi:10.1242/jcs.207555 · Cited by 110

Dynamic reorganization of the actin cytoskeleton

Letort, G., Ennomani, H., Gressin, L., Théry, M., & Blanchoin, L. (2015) · F1000Research · doi:10.12688/f1000research.6374.1 · Cited by 105

Targeting the Metastasis Suppressor, NDRG1, Using Novel Iron Chelators: Regulation of Stress Fiber-Mediated Tumor Cell Migration via Modulation of the ROCK1/pMLC2 Signaling Pathway

Sun, J. P., Zhang, D., Zheng, Y., Zhao, Q., Zheng, M., Kovačević, Ž., & Richardson, D. R. (2012) · Molecular Pharmacology · doi:10.1124/mol.112.083097 · Cited by 103

Sensing the mechano-chemical properties of the extracellular matrix

Ringer, P., Coló, G. P., Fässler, R., & Grashoff, C. (2017) · Matrix Biology · doi:10.1016/j.matbio.2017.03.004 · Cited by 107

Endothelial responses of magnesium and other alloying elements in magnesium-based stent materials

Zhao, N., & Zhu, D. (2014) · Metallomics · doi:10.1039/c4mt00244j · Cited by 101

Muscle-specific stress fibers give rise to sarcomeres in cardiomyocytes

Fenix, A. M., Neininger, A. C., Taneja, N., Hyde, K., Visetsouk, M. R., Garde, R. J., Liu, B., Nixon, B. R., Manalo, A. E., Becker, J. R., et al. (2018) · eLife · doi:10.7554/elife.42144 · Cited by 101

Human brain microvascular endothelial cells resist elongation due to shear stress

Reinitz, A. D., DeStefano, J. G., Ye, M., Wong, A. D., & Searson, P. C. (2015) · Microvascular Research · doi:10.1016/j.mvr.2015.02.008 · Cited by 99

Primary Cilia, Ciliogenesis and the Actin Cytoskeleton: A Little Less Resorption, A Little More Actin Please

Smith, C. E. L., Lake, A. V. R., & Johnson, C. A. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.622822 · Cited by 99

Role of Actin Filaments in Correlating Nuclear Shape and Cell Spreading

Vishavkarma, R., Raghavan, S., Kuyyamudi, C., Majumder, A., Dhawan, J., & Pullarkat, P. A. (2014) · PLoS ONE · doi:10.1371/journal.pone.0107895 · Cited by 95

Gaussian Curvature Directs Stress Fiber Orientation and Cell Migration

Bade, N. D., Xu, T., Kamien, R. D., Assoian, R. K., & Stebe, K. J. (2018) · Biophysical Journal · doi:10.1016/j.bpj.2018.01.039 · Cited by 98

The Hippo signal transduction network in skeletal and cardiac muscle

Wackerhage, H., Del Re, D. P., Judson, R. N., Sudol, M., & Sadoshima, J. (2014) · Science Signaling · doi:10.1126/scisignal.2005096 · Cited by 92

Pericyte mechanics and mechanobiology

Dessalles, C. A., Babataheri, A., & Barakat, A. I. (2021) · Journal of Cell Science · doi:10.1242/jcs.240226 · Cited by 99

Articular Chondrocyte Phenotype Regulation through the Cytoskeleton and the Signaling Processes That Originate from or Converge on the Cytoskeleton: Towards a Novel Understanding of the Intersection between Actin Dynamics and Chondrogenic Function

Lauer, J. C., Selig, M., Hart, M. L., Kurz, B., & Rolauffs, B. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22063279 · Cited by 92

Ultrasound-responsive nutlin-loaded nanoparticles for combined chemotherapy and piezoelectric treatment of glioblastoma cells

Pucci, C., Marino, A., Şen, Ö., Pasquale, D. D., Bartolucci, M., Iturrioz-Rodríguez, N., di Leo, N., de Vito, G., Debellis, D., Petretto, A., et al. (2021) · Acta Biomaterialia · doi:10.1016/j.actbio.2021.04.005 · Cited by 94

Collagen, stiffness, and adhesion: the evolutionary basis of vertebrate mechanobiology

Tang, V. W. (2020) · Molecular Biology of the Cell · doi:10.1091/mbc.e19-12-0709 · Cited by 91

The Cytoskeleton of the Retinal Pigment Epithelium: from Normal Aging to Age-Related Macular Degeneration

Tarau, I., Berlin, A., Curcio, C. A., & Ach, T. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20143578 · Cited by 89

Endothelial cell CD36 regulates membrane ceramide formation, exosome fatty acid transfer and circulating fatty acid levels

Peche, V. S., Pietka, T., Jácome-Sosa, M., Samovski, D., Palacios, H. H., Chatterjee-Basu, G., Dudley, A. C., Beatty, W. L., Meyer, G. A., Goldberg, I. J., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-39752-3 · Cited by 94

Development and Application of an Advanced Biomedical Material‐Silk Sericin

Wang, J., Liu, H., Shi, X., Qin, S., Liu, J., Lv, Q., Liu, J., Li, Q., Wang, Z., & Wang, L. (2024) · Advanced Materials · doi:10.1002/adma.202311593 · Cited by 89

Tunable and Reversible Substrate Stiffness Reveals a Dynamic Mechanosensitivity of Cardiomyocytes

Corbin, E. A., Vite, A., Peyster, E. G., Bhoopalam, M., Brandimarto, J., Wang, X., Bennett, A. I., Clark, A. T., Cheng, X. M., Turner, K. T., et al. (2019) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.9b02446 · Cited by 89

4polar-STORM polarized super-resolution imaging of actin filament organization in cells

Rimoli, C. V., Valades‐Cruz, C. A., Curcio, V., Mavrakis, M., & Brasselet, S. (2022) · Nature Communications · doi:10.1038/s41467-022-27966-w · Cited by 93

Single-site sonoporation disrupts actin cytoskeleton organization

Chen, X., Leow, R. S., Hu, Y., Wan, J. M. F., & Yu, A. C. H. (2014) · Journal of The Royal Society Interface · doi:10.1098/rsif.2014.0071 · Cited by 87

Mechanical cues in cellular signalling and communication

Bukoreshtliev, N. V., Haase, K., & Pelling, A. E. (2012) · Cell and Tissue Research · doi:10.1007/s00441-012-1531-4 · Cited by 90

Cell tension and mechanical regulation of cell volume

Gonzalez, N. P., Tao, J., Rochman, N. D., Vig, D., Chiu, E., Wirtz, D., & Sun, S. X. (2018) · Molecular Biology of the Cell · doi:10.1091/mbc.e18-04-0213 · Cited by 91

Airway smooth muscle in asthma: Linking contraction and mechanotransduction to disease pathogenesis and remodelling

Noble, P. B., Pascoe, C. D., Lan, B., Ito, S., Kistemaker, L. E. M., Tatler, A. L., Pera, T., Brook, B. S., Gosens, R., & West, A. R. (2014) · Pulmonary Pharmacology & Therapeutics · doi:10.1016/j.pupt.2014.07.005 · Cited by 88

Compressive forces stabilize microtubules in living cells

Li, Y., Kučera, O., Cuvelier, D., Rutkowski, D. M., Deygas, M., Rai, D., Pavlovič, T., Vicente, F. N., Piel, M., Giannone, G., et al. (2023) · Nature Materials · doi:10.1038/s41563-023-01578-1 · Cited by 96

Modulation of Wound Healing and Scar Formation by MG53 Protein-mediated Cell Membrane Repair

Li, H., Duann, P., Lin, P., Zhao, L., Fan, Z., Tan, T., Zhou, X., Sun, M., Fu, M., Orange, M., et al. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.680074 · Cited by 86

Actin filament dynamics and endothelial cell junctions: the Ying and Yang between stabilization and motion

Schnittler, H., Taha, M., Odenthal-Schnittler, M., Taha, A. A., Lindemann, N., & Seebach, J. (2014) · Cell and Tissue Research · doi:10.1007/s00441-014-1856-2 · Cited by 85

Assembly of non-contractile dorsal stress fibers requires α-actinin-1 and Rac1 in migrating and spreading cells

Kovac, B., Teo, J. L., Mäkelä, T. P., & Vallenius, T. (2012) · Journal of Cell Science · doi:10.1242/jcs.115063 · Cited by 85

Heading in the Right Direction: Understanding Cellular Orientation Responses to Complex Biophysical Environments

Tamiello, C. C., Buskermolen, A. B. C., Baaijens, F. F., Broers, J. L. V., & Bouten, C. V. C. (2015) · Cellular and Molecular Bioengineering · doi:10.1007/s12195-015-0422-7 · Cited by 87

AP2σ Mutations Impair Calcium-Sensing Receptor Trafficking and Signaling, and Show an Endosomal Pathway to Spatially Direct G-Protein Selectivity

Gorvin, C. M., Rogers, A., Hastoy, B., Tarasov, A. I., Frost, M., Sposini, S., Inoue, A., Whyte, M. P., Rorsman, P., Hanyaloglu, A. C., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2017.12.089 · Cited by 85

The multi-faceted role of the actin cap in cellular mechanosensation and mechanotransduction

Kim, D., Chambliss, A. B., & Wirtz, D. (2013) · Soft Matter · doi:10.1039/c3sm50798j · Cited by 92

Engineering of Micro- to Nanostructured 3D-Printed Drug-Releasing Titanium Implants for Enhanced Osseointegration and Localized Delivery of Anticancer Drugs

Maher, S., Kaur, G., Lima-Marques, L., Evdokiou, A., & Lošić, D. (2017) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.7b09916 · Cited by 83

The ultrastructural organization of actin and myosin II filaments in the contractile ring: new support for an old model of cytokinesis

Henson, J. H., Ditzler, C. E., Germain, A., Irwin, P. M., Vogt, E. T., Yang, S., Wu, X., & Shuster, C. B. (2017) · Molecular Biology of the Cell · doi:10.1091/mbc.e16-06-0466 · Cited by 81

Effect of Polymeric Matrix Stiffness on Osteogenic Differentiation of Mesenchymal Stem/Progenitor Cells: Concise Review

El‐Rashidy, A. A., Moshy, S. E., Radwan, I. A., Rady, D., Abbass, M. M. S., Dörfer, C. E., & El‐Sayed, K. M. F. (2021) · Polymers · doi:10.3390/polym13172950 · Cited by 86

Effects of substrate stiffness on the tenoinduction of human mesenchymal stem cells

Islam, A., Mbimba, T., Younesi, M., & Akkuş, O. (2017) · Acta Biomaterialia · doi:10.1016/j.actbio.2017.05.058 · Cited by 81

Exosomes derived from calcium oxalate-exposed macrophages enhance IL-8 production from renal cells, neutrophil migration and crystal invasion through extracellular matrix

Singhto, N., & Thongboonkerd, V. (2018) · Journal of Proteomics · doi:10.1016/j.jprot.2018.06.015 · Cited by 80

Lamin A/C and Emerin depletion impacts chromatin organization and dynamics in the interphase nucleus

Ranade, D., Pradhan, R., Jayakrishnan, M., Hegde, S., & Sengupta, K. (2019) · BMC Molecular and Cell Biology · doi:10.1186/s12860-019-0192-5 · Cited by 79

Injectable stress relaxation gelatin-based hydrogels with positive surface charge for adsorption of aggrecan and facile cartilage tissue regeneration

Wang, K., Jin, X., Ma, Y., Cai, W., Xiao, W., Li, Z.-W., Qi, X., & Ding, J. (2021) · Journal of Nanobiotechnology · doi:10.1186/s12951-021-00950-0 · Cited by 84

Actin Bundles Dynamics and Architecture

Rajan, S., Kudryashov, D. S., & Reisler, E. (2023) · Biomolecules · doi:10.3390/biom13030450 · Cited by 85

Force percolation of contractile active gels

Alvarado, J., Sheinman, M., Sharma, A., MacKintosh, F. C., & Koenderink, G. H. (2017) · Soft Matter · doi:10.1039/c7sm00834a · Cited by 78

The Filament Sensor for Near Real-Time Detection of Cytoskeletal Fiber Structures

Eltzner, B., Wollnik, C., Gottschlich, C., Huckemann, S., & Rehfeldt, F. (2015) · PLoS ONE · doi:10.1371/journal.pone.0126346 · Cited by 77

Nano-micrometer surface roughness gradients reveal topographical influences on differentiating responses of vascular cells on biodegradable magnesium

Zhou, K., Li, Y., Zhang, L., Jin, L., Yuan, F., Tan, J., Yuan, G., & Jia, P. (2020) · Bioactive Materials · doi:10.1016/j.bioactmat.2020.08.004 · Cited by 76

Polarizing cytoskeletal tension to induce leader cell formation during collective cell migration

Rausch, S., Das, T., Soiné, J. R. D., Hofmann, T. W., Boehm, C. H. J., Schwarz, U. S., Boehm, H., & Spatz, J. P. (2013) · Biointerphases · doi:10.1186/1559-4106-8-32 · Cited by 76

Cofilin-2 Phosphorylation and Sequestration in Myocardial Aggregates

Subramanian, K., Gianni, D., Balla, C., Assenza, G. E., Joshi, M. M., Semigran, M. J., MacGillivray, T. E., Eyk, J. E. V., Agnetti, G., Paolocci, N., et al. (2015) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2015.01.031 · Cited by 77

The Adipocyte Acquires a Fibroblast-Like Transcriptional Signature in Response to a High Fat Diet

Jones, J. E. C., Rabhi, N., Orofino, J., Gamini, R., Perissi, V., Vernochet, C., & Farmer, S. R. (2020) · Scientific Reports · doi:10.1038/s41598-020-59284-w · Cited by 79

Stress fibers are generated by two distinct actin assembly mechanisms in motile cells

Hotulainen, P., & Lappalainen, P. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200511093 · Cited by 969

Mechanisms of actin stress fibre assembly

Naumanen, P., Lappalainen, P., & Hotulainen, P. (2008) · Journal of Microscopy · doi:10.1111/j.1365-2818.2008.02057.x · Cited by 230

A biomechanical perspective on stress fiber structure and function

Kassianidou, E., & Kumar, S. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2015.04.006 · Cited by 114

Stress Made Manifest

(2006) · Science · doi:10.1126/science.312.5775.815d

Organization and Function of Stress Fibers in Cells in Vitro and in Situ

Byers, H. R., White, G. E., & Fujiwara, K. (1984) · Springer eBooks · doi:10.1007/978-1-4684-4592-3_2 · Cited by 115