Cited by 900Cellular Mechanics and InteractionsSkin and Cellular Biology ResearchMicrotubule and mitosis dynamics

The DOI matches its Crossref record; 155 of the 155 references it cites were found in a registry or an index.

Actin stress fibers – assembly, dynamics and biological roles

Tojkander, Sari, Gateva, Gergana, Lappalainen, Pekka·2012·Journal of Cell Science

Open this paper in CoChat — free account

Abstract

Actin filaments assemble into diverse protrusive and contractile structures to provide force for a number of vital cellular processes. Stress fibers are contractile actomyosin bundles found in many cultured non-muscle cells, where they have a central role in cell adhesion and morphogenesis. Focal-adhesion-anchored stress fibers also have an important role in mechanotransduction. In animal tissues, stress fibers are especially abundant in endothelial cells, myofibroblasts and epithelial cells. Importantly, recent live-cell imaging studies have provided new information regarding the mechanisms of stress fiber assembly and how their contractility is regulated in cells. In addition, these studies might elucidate the general mechanisms by which contractile actomyosin arrays, including muscle cell myofibrils and cytokinetic contractile ring, can be generated in cells. In this Commentary, we discuss recent findings concerning the physiological roles of stress fibers and the mechanism by which these structures are generated in cells.

Integrity signals

Registry

Crossref · 10.1242/jcs.098087

Cites

155 of 155 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Matrix elasticity directs stem cell lineage specification
Engler, A. J., Sen, S., Sweeney, H. L., & Discher, D. E. (2006) · Cell · doi:10.1016/j.cell.2006.06.044 · Cited by 13,915
Tissue Cells Feel and Respond to the Stiffness of Their Substrate
Discher, D. E., Janmey, P., & Wang, Y.-L. (2005) · Science · doi:10.1126/science.1116995 · Cited by 6,382
Cell Migration: Integrating Signals from Front to Back
Ridley, A. J., Schwartz, M. A., Burridge, K., Firtel, R., Ginsberg, M. H., Borisy, G. G., Parsons, J. T., & Horwitz, A. R. (2003) · Science · doi:10.1126/science.1092053 · Cited by 5,109
Regulation of Myosin Phosphatase by Rho and Rho-Associated Kinase (Rho-Kinase)
Kimura, K., Ito, M., Amano, M., Chihara, K., Fukata, Y., Nakafuku, M., Yamamori, B., Feng, J., Nakano, T., Okawa, K., et al. (1996) · Science · doi:10.1126/science.273.5272.245 · Cited by 2,889
Environmental sensing through focal adhesions
Geiger, B., Spatz, J. P., & Bershadsky, A. D. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2593 · Cited by 2,543
Actin, a Central Player in Cell Shape and Movement
Pollard, T. D., & Cooper, J. A. (2009) · Science · doi:10.1126/science.1175862 · Cited by 2,178
Non-muscle myosin II takes centre stage in cell adhesion and migration
Vicente‐Manzanares, M., Ma, X., Adelstein, R. S., & Horwitz, A. R. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2786 · Cited by 2,137
Force and focal adhesion assembly: a close relationship studied using elastic micropatterned substrates
Balaban, N. Q., Schwarz, U. S., Riveline, D., Goichberg, P., Tzur, G., Sabanay, I., Mahalu, D., Safran, S. A., Bershadsky, A. D., Addadi, L., et al. (2001) · Nature Cell Biology · doi:10.1038/35074532 · Cited by 2,137
Focal Adhesions: Transmembrane Junctions Between the Extracellular Matrix and the Cytoskeleton
Burridge, K., Fath, K. R., Kelly, T. J., Nuckolls, G. H., & Turner, C. E. (1988) · Annual Review of Cell Biology · doi:10.1146/annurev.cb.04.110188.002415 · Cited by 2,120
Cell adhesion: integrating cytoskeletal dynamics and cellular tension
Parsons, J. T., Horwitz, A. R., & Schwartz, M. A. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2957 · Cited by 2,081
Phosphorylation and Activation of Myosin by Rho-associated Kinase (Rho-kinase)
Amano, M., Ito, M., Kimura, K., Fukata, Y., Chihara, K., Nakano, T., Matsuura, Y., & Kaibuchi, K. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.34.20246 · Cited by 2,009
Mammalian Rho GTPases: new insights into their functions from in vivo studies
Heasman, S. J., & Ridley, A. J. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2476 · Cited by 1,871
Rho-stimulated contractility drives the formation of stress fibers and focal adhesions.
Chrzanowska‐Wodnicka, M., & Burridge, K. (1996) · The Journal of Cell Biology · doi:10.1083/jcb.133.6.1403 · Cited by 1,684
Signaling from Rho to the Actin Cytoskeleton Through Protein Kinases ROCK and LIM-kinase
Maekawa, M., Ishizaki, T., Boku, S., Watanabe, N., Fujita, A., Iwamatsu, A., Obinata, T., Ohashi, K., Mizuno, K., & Narumiya, S. (1999) · Science · doi:10.1126/science.285.5429.895 · Cited by 1,640
Actin-Based Cell Motility and Cell Locomotion
Mitchison, T. J., & Cramer, L. P. (1996) · Cell · doi:10.1016/s0092-8674(00)81281-7 · Cited by 1,538
Stretching Single Talin Rod Molecules Activates Vinculin Binding
Hernández, A. E. D. R., Pérez‐Jiménez, R., Liu, R., Roca‐Cusachs, P., Fernández, J. M., & Sheetz, M. P. (2009) · Science · doi:10.1126/science.1162912 · Cited by 1,492
Focal Contacts as Mechanosensors
Riveline, D., Zamir, E., Balaban, N. Q., Schwarz, U. S., Ishizaki, T., Narumiya, S., Kam, Z., Geiger, B., & Bershadsky, A. D. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.153.6.1175 · Cited by 1,421
Actin dynamics control SRF activity by regulation of its coactivator MAL
Miralles, F., Posern, G., Zaromytidou, A.-I., & Treisman, R. (2003) · Cell · doi:10.1016/s0092-8674(03)00278-2 · Cited by 1,327
The Rho family GTPases RhoA, Racl , and CDC42Hsregulate transcriptional activation by SRF
Hill, C. S., Wynne, J., & Treisman, R. (1995) · Cell · doi:10.1016/s0092-8674(05)80020-0 · Cited by 1,269
Signal transduction by G‐proteins, Rho‐kinase and protein phosphatase to smooth muscle and non‐muscle myosin II
Somlyo, A. P., & Somlyo, A. V. (2000) · The Journal of Physiology · doi:10.1111/j.1469-7793.2000.t01-2-00177.x · Cited by 1,203
Regulation of Actin Filament Assembly by Arp2/3 Complex and Formins
Pollard, T. D. (2007) · Annual Review of Biophysics and Biomolecular Structure · doi:10.1146/annurev.biophys.35.040405.101936 · Cited by 1,064
Stress fibers are generated by two distinct actin assembly mechanisms in motile cells
Hotulainen, P., & Lappalainen, P. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200511093 · Cited by 969
Self-citation
Force Sensing by Mechanical Extension of the Src Family Kinase Substrate p130Cas
Sawada, Y., Tamada, M., Dubin‐Thaler, B. J., Cherniavskaya, O., Sakai, R., Tanaka, S., & Sheetz, M. P. (2006) · Cell · doi:10.1016/j.cell.2006.09.044 · Cited by 945
The p160 RhoA-Binding Kinase ROKα Is a Member of a Kinase Family and Is Involved in the Reorganization of the Cytoskeleton
LEUNG, T. K. C., Chen, X., Manser, E. J., & Lim, L. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.10.5313 · Cited by 908
Regulation of the interaction between actin and myosin subfragment 1: evidence for three states of the thin filament
McKillop, D. F. A., & Geeves, M. A. (1993) · Biophysical Journal · doi:10.1016/s0006-3495(93)81110-x · Cited by 843
p140mDia, a mammalian homolog of Drosophila diaphanous, is a target protein for Rho small GTPase and is a ligand for profilin
Watanabe, N., Madaule, P., Reid, T., Ishizaki, T., Watanabe, G., Kakizuka, A., Saito, Y., Nakao, K., Jockusch, B. M., & Narumiya, S. (1997) · The EMBO Journal · doi:10.1093/emboj/16.11.3044 · Cited by 823
Two Distinct Actin Networks Drive the Protrusion of Migrating Cells
Ponti, A., Macháček, M., Gupton, S. L., Waterman, C. M., & Danuser, G. M. (2004) · Science · doi:10.1126/science.1100533 · Cited by 820
Harnessing actin dynamics for clathrin-mediated endocytosis
Kaksonen, M., Toret, C. P., & Drubin, D. G. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1940 · Cited by 706
Actin stress fibres
Pellegrin, S., & Mellor, H. (2007) · Journal of Cell Science · doi:10.1242/jcs.018473 · Cited by 700
Distinct Roles of Rock (Rho-Kinase) and Mlck in Spatial Regulation of Mlc Phosphorylation for Assembly of Stress Fibers and Focal Adhesions in 3t3 Fibroblasts
Totsukawa, G., Yamakita, Y., Yamashiro, S., Hartshorne, D. J., Sasaki, Y., & Matsumura, F. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.150.4.797 · Cited by 689
α-Actinin: Immunofluorescent localization of a muscle structural protein in nonmuscle cells
Lazarides, E., & Burridge, K. (1975) · Cell · doi:10.1016/0092-8674(75)90180-4 · Cited by 609
A perinuclear actin cap regulates nuclear shape
Khatau, S. B., Hale, C. M., Stewart-Hutchinson, P. J., Patel, M. S., Stewart, C. L., Searson, P. C., Hodzic, D. M., & Wirtz, D. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0908686106 · Cited by 607
Fibroblast polarization is a matrix-rigidity-dependent process controlled by focal adhesion mechanosensing
Prager‐Khoutorsky, M., Lichtenstein, A., Krishnan, R., Rajendran, K., Mayo, A., Kam, Z., Geiger, B., & Bershadsky, A. D. (2011) · Nature Cell Biology · doi:10.1038/ncb2370 · Cited by 579
Self- and actin-templated assembly of Mammalian septins
Kinoshita, M., Field, C. M., Coughlin, M. L., Straight, A. F., & Mitchison, T. J. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00366-0 · Cited by 526
Differential Transmission of Actin Motion Within Focal Adhesions
Hu, K., Ji, L., Applegate, K. T., Danuser, G. M., & Waterman, C. M. (2007) · Science · doi:10.1126/science.1135085 · Cited by 512
Traction stress in focal adhesions correlates biphasically with actin retrograde flow speed
Gardel, M. L., Sabass, B., Ji, L., Danuser, G. M., Schwarz, U. S., & Waterman, C. M. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200810060 · Cited by 493
Actinin-4, a Novel Actin-bundling Protein Associated with Cell Motility and Cancer Invasion
Honda, K., Yamada, T., Endo, R., Ino, Y., Gotoh, M., Tsuda, H., Yamada, Y., Chiba, H., & Hirohashi, S. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.140.6.1383 · Cited by 484
α-Actinin structure and regulation
Sjöblom, B., Salmazo, A., & Djinović‐Carugo, K. (2008) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-008-8080-8 · Cited by 460
Linear Arrays of Nuclear Envelope Proteins Harness Retrograde Actin Flow for Nuclear Movement
Luxton, G. W. G., Gomes, E. R., Folker, E. S., Vintinner, E. C., & Gundersen, G. G. (2010) · Science · doi:10.1126/science.1189072 · Cited by 457
MECHANOTRANSDUCTION INVOLVING MULTIMODULAR PROTEINS: Converting Force into Biochemical Signals
Viola Vogel, B. (2006) · Annual Review of Biophysics and Biomolecular Structure · doi:10.1146/annurev.biophys.35.040405.102013 · Cited by 444
Forced Unfolding of Proteins Within Cells
Johnson, C. P., Tang, H., Krieger, C. C., Speicher, D. W., & Discher, D. E. (2007) · Science · doi:10.1126/science.1139857 · Cited by 377
Diaphanous-Related Formins Bridge Rho GTPase and Src Tyrosine Kinase Signaling
Tominaga, T., Sahai, E. A., Chardin, P., McCormick, F. P., Courtneidge, S. A., & Alberts, A. S. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)80399-8 · Cited by 376
Mechanical strain in actin networks regulates FilGAP and integrin binding to filamin A
Ehrlicher, A. J., Nakamura, F., Hartwig, J. H., Weitz, D. A., & Stossel, T. P. (2011) · Nature · doi:10.1038/nature10430 · Cited by 363
Optimal matrix rigidity for stress-fibre polarization in stem cells
Zemel, A., Rehfeldt, F., Brown, A. E., Discher, D. E., & Safran, S. A. (2010) · Nature Physics · doi:10.1038/nphys1613 · Cited by 363
A role for actin arcs in the leading-edge advance of migrating cells
Burnette, D. T., Manley, S., Sengupta, P., Sougrat, R., Davidson, M. W., Kachar, B., & Lippincott‐Schwartz, J. (2011) · Nature Cell Biology · doi:10.1038/ncb2205 · Cited by 349
Control of Actin Filament Treadmilling in Cell Motility
Bugyi, B., & Carlier, M. (2010) · Annual Review of Biophysics · doi:10.1146/annurev-biophys-051309-103849 · Cited by 343
Rho-Kinase–Mediated Contraction of Isolated Stress Fibers
Katoh, K., Kano, Y., Amano, M., Onishi, H., Kaibuchi, K., & Fujiwara, K. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.153.3.569 · Cited by 331
Actin Filament Stress Fibers in Vascular Endothelial Cells in Vivo
Wong, A. J., Pollard, T. D., & Herman, I. M. (1983) · Science · doi:10.1126/science.6681677 · Cited by 329
Filamin, a new high-molecular-weight protein found in smooth muscle and non-muscle cells.
Wang, K., Ash, J. F., & Singer, S. J. (1975) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.72.11.4483 · Cited by 321
Understanding cytokinesis: lessons from fission yeast
Pollard, T. D., & Wu, J. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2834 · Cited by 318
Identification of Novel Graded Polarity Actin Filament Bundles in Locomoting Heart Fibroblasts: Implications for the Generation of Motile Force
Cramer, L. P., Siebert, M. C., & Mitchison, T. J. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.136.6.1287 · Cited by 317
Antibody to Myosin: The Specific Visualization of Myosin-Containing Filaments in Nonmuscle Cells
Weber, K. K., & Groeschel-Stewart, U. (1974) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.71.11.4561 · Cited by 302
Mechanism of retraction of the trailing edge during fibroblast movement.
Chen, W. T. (1981) · The Journal of Cell Biology · doi:10.1083/jcb.90.1.187 · Cited by 286
A Molecular Pathway for Myosin II Recruitment to Stress Fibers
Tojkander, S., Gateva, G., Schevzov, G., Hotulainen, P., Naumanen, P., Martin, C., Gunning, P. W., & Lappalainen, P. (2011) · Current Biology · doi:10.1016/j.cub.2011.03.007 · Cited by 282
Self-citation
Tropomyosin antibody: the specific localization of tropomyosin in nonmuscle cells.
Lazarides, E. (1975) · The Journal of Cell Biology · doi:10.1083/jcb.65.3.549 · Cited by 280
Mechanosensing in actin stress fibers revealed by a close correlation between force and protein localization
Colombelli, J., Besser, A., Kress, H., Reynaud, E. G., Girard, P. P., Caussinus, E., Haselmann, U., Small, J. V., Schwarz, U. S., & Stelzer, E. H. K. (2009) · Journal of Cell Science · doi:10.1242/jcs.042986 · Cited by 276
Cell migration without a lamellipodium
Gupton, S. L., Anderson, K., Kole, T. P., Fischer, R. S., Ponti, A., Hitchcock‐DeGregori, S. E., Danuser, G. M., Fowler, V. M., Wirtz, D., Hanein, D., et al. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200406063 · Cited by 268
Assembling an actin cytoskeleton for cell attachment and movement
Small, J. V., Rottner, K., Kaverina, I., & Anderson, K. I. (1998) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/s0167-4889(98)00080-9 · Cited by 259
Actin retrograde flow and actomyosin II arc contraction drive receptor cluster dynamics at the immunological synapse in Jurkat T cells
Yi, J., Wu, X., Crites, T. J., & Hammer, J. A. (2012) · Molecular Biology of the Cell · doi:10.1091/mbc.e11-08-0731 · Cited by 259
Actin stress fibers transmit and focus force to activate mechanosensitive channels
Hayakawa, K., Tatsumi, H., & Sokabe, M. (2008) · Journal of Cell Science · doi:10.1242/jcs.022053 · Cited by 256
Tropomyosin inhibits ADF/cofilin-dependent actin filament dynamics
Ono, S., & Ono, K. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200110013 · Cited by 256
Transgelin: An actin-binding protein and tumour suppressor
Assinder, S. J., Stanton, J. L., & Prasad, P. D. (2008) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2008.02.011 · Cited by 252
Stress fiber organization regulated by MLCK and Rho-kinase in cultured human fibroblasts
Katoh, K., Kano, Y., Amano, M., Kaibuchi, K., & Fujiwara, K. (2001) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.2001.280.6.c1669 · Cited by 243
Mechanical forces facilitate actin polymerization at focal adhesions in a zyxin-dependent manner
Hirata, H., Tatsumi, H., & Sokabe, M. (2008) · Journal of Cell Science · doi:10.1242/jcs.030320 · Cited by 242
Mammalian SEPT2 Is Required for Scaffolding Nonmuscle Myosin II and Its Kinases
Joo, E. E., Surka, M. C., & Trimble, W. S. (2007) · Developmental Cell · doi:10.1016/j.devcel.2007.09.001 · Cited by 238
A mechanical model of actin stress fiber formation and substrate elasticity sensing in adherent cells
Walcott, S., & Sun, S. X. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0912739107 · Cited by 237
Mechanisms of actin stress fibre assembly
Naumanen, P., Lappalainen, P., & Hotulainen, P. (2008) · Journal of Microscopy · doi:10.1111/j.1365-2818.2008.02057.x · Cited by 230
Self-citation
A Zyxin-Mediated Mechanism for Actin Stress Fiber Maintenance and Repair
Smith, M. A., Blankman, E., Gardel, M. L., Luettjohann, L., Waterman, C. M., & Beckerle, M. C. (2010) · Developmental Cell · doi:10.1016/j.devcel.2010.08.008 · Cited by 229
Assembly and mechanosensory function of focal adhesions: experiments and models
Bershadsky, A. D., Ballestrem, C., Carramusa, L., Zilberman, Y., Gilquin, B., Khochbin, S., Alexandrova, A. Y., Verkhovsky, A. B., Shemesh, T., & Kozlov, M. M. (2005) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2005.11.001 · Cited by 229
MicroRNA-200c Represses Migration and Invasion of Breast Cancer Cells by Targeting Actin-Regulatory Proteins FHOD1 and PPM1F
Jurmeister, S., Baumann, M., Balwierz, A., Keklikoglou, I., Ward, A., Uhlmann, S., Zhang, J. D., Wiemann, S., & Şahin, Ö. (2011) · Molecular and Cellular Biology · doi:10.1128/mcb.06212-11 · Cited by 228
Adherens junctions connect stress fibres between adjacent endothelial cells
Millán, J., Cain, R. J., Reglero-Real, N., Bigarella, C. L., Marcos‐Ramiro, B., Fernández‐Martín, L., Correas, I., & Ridley, A. J. (2010) · BMC Biology · doi:10.1186/1741-7007-8-11 · Cited by 226
The NH2-terminal peptide of α–smooth muscle actin inhibits force generation by the myofibroblast in vitro and in vivo
Hinz, B., Gabbiani, G., & Chaponnier, C. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200201049 · Cited by 226
Differential modulation of actin-severing activity of gelsolin by multiple isoforms of cultured rat cell tropomyosin
Ishikawa, R., Yamashiro, S., & Matsumura, F. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)83261-6 · Cited by 223
Coordination of Actin Filament and Microtubule Dynamics during Neurite Outgrowth
Schaefer, A. W., Schoonderwoert, V. T. G., Ji, L., Mederios, N., Danuser, G. M., & Forscher, P. (2008) · Developmental Cell · doi:10.1016/j.devcel.2008.05.003 · Cited by 216
Characterization of Palladin, a Novel Protein Localized to Stress Fibers and Cell Adhesions
Parast, M. M., & Otey, C. A. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.150.3.643 · Cited by 215
How to build a myofibril
Sanger, J. W., Kang, S., Siebrands, C. C., Freeman, N., Du, A., Wang, J., Stout, A. L., & Sanger, J. M. (2006) · Journal of Muscle Research and Cell Motility · doi:10.1007/s10974-005-9016-7 · Cited by 208
The roles of fascins in health and disease
Hashimoto, Y., Kim, D. J., & Adams, J. C. (2011) · The Journal of Pathology · doi:10.1002/path.2894 · Cited by 203
Dynamic Analysis of Actin Cable Function during Drosophila Dorsal Closure
Jacinto, A., Wood, W., Woolner, S., Hiley, C., Turner, L. J., WILSON, C. G., Martínez-Arias, A., & Martin, P. B. (2002) · Current Biology · doi:10.1016/s0960-9822(02)00955-7 · Cited by 201
Simultaneous Stretching and Contraction of Stress Fibers In Vivo
Peterson, L. J., Rajfur, Z., Maddox, A. S., Freel, C. D., Chen, Y., Edlund, M., Otey, C. A., & Burridge, K. (2004) · Molecular Biology of the Cell · doi:10.1091/mbc.e03-09-0696 · Cited by 200
The initial steps of myofibril assembly: integrins pave the way
Sparrow, J. C., & Schöck, F. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2634 · Cited by 199
How the headpiece hinge angle is opened: new insights into the dynamics of integrin activation
Puklin-Faucher, E., Gao, M., Schulten, K. J., & Viola Vogel, B. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200602071 · Cited by 199
Caldesmon Inhibits Nonmuscle Cell Contractility and Interferes with the Formation of Focal Adhesions
Helfman, D. M., Levy, E. T., Berthier, C., Shtutman, M. S., Riveline, D., Grosheva, I., Lachish‐Zalait, A., Elbaum, M., & Bershadsky, A. D. (1999) · Molecular Biology of the Cell · doi:10.1091/mbc.10.10.3097 · Cited by 197
New Roles for the LKB1-NUAK Pathway in Controlling Myosin Phosphatase Complexes and Cell Adhesion
Zagórska, A., Deak, M., Campbell, D. G., Banerjee, S., Hirano, M., Aizawa, S., Prescott, A. R., & Alessi, D. R. (2010) · Science Signaling · doi:10.1126/scisignal.2000616 · Cited by 193
Local Cortical Tension by Myosin II Guides 3D Endothelial Cell Branching
Fischer, R. S., Gardel, M. L., Ma, X., Adelstein, R. S., & Waterman, C. M. (2009) · Current Biology · doi:10.1016/j.cub.2008.12.045 · Cited by 190
Spatial regulation of actin dynamics: a tropomyosin-free, actin-rich compartment at the leading edge
DesMarais, V. M., Ichetovkin, I. E., Condeelis, J. S., & Hitchcock‐DeGregori, S. E. (2002) · Journal of Cell Science · doi:10.1242/jcs.00147 · Cited by 189
Actin cytoskeleton in myofibroblast differentiation: Ultrastructure defining form and driving function
Sandbo, N. K., & Dulin, N. O. (2011) · Translational research · doi:10.1016/j.trsl.2011.05.004 · Cited by 185
Building Distinct Actin Filament Networks in a Common Cytoplasm
Michelot, A., & Drubin, D. G. (2011) · Current Biology · doi:10.1016/j.cub.2011.06.019 · Cited by 183
Building the actin cytoskeleton: filopodia contribute to the construction of contractile bundles in the lamella
Némethová, M., Auinger, S., & Small, J. V. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200709134 · Cited by 183
The molecular organization of myosin in stress fibers of cultured cells.
Langanger, G., Moeremans, M., Daneels, G., Sobieszek, A., Brabander, M. D., & Mey, J. D. (1986) · The Journal of Cell Biology · doi:10.1083/jcb.102.1.200 · Cited by 181
Assembly and Dynamics of Myofibrils
Sanger, J. W., Wang, J., Fan, Y., White, J., & Sanger, J. M. (2010) · BioMed Research International · doi:10.1155/2010/858606 · Cited by 177
Activation of a vinculin‐binding site in the talin rod involves rearrangement of a five‐helix bundle
Papagrigoriou, E., Gingras, A. R., Barsukov, I., Bate, N., FILLINGHAM, I. J., PATEL, B., Frank, R., Ziegler, W. H., Roberts, G. C. K., Critchley, D. R., et al. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600285 · Cited by 172
Rho-Dependent Contractile Responses in the Neuronal Growth Cone Are Independent of Classical Peripheral Retrograde Actin Flow
Zhang, X., Schaefer, A. W., Burnette, D. T., Schoonderwoert, V. T. G., & Forscher, P. (2003) · Neuron · doi:10.1016/s0896-6273(03)00754-2 · Cited by 169
Reducing background fluorescence reveals adhesions in 3D matrices
Kubow, K. E., & Horwitz, A. R. (2010) · Nature Cell Biology · doi:10.1038/ncb0111-3 · Cited by 168
The gelation of actin by actin-binding protein.
Brotschi, E. A., Hartwig, J. H., & Stossel, T. P. (1978) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)34275-8 · Cited by 154
Distribution of actin-binding protein and myosin in polymorphonuclear leukocytes during locomotion and phagocytosis
Valerius, N. H. (1981) · Cell · doi:10.1016/0092-8674(81)90515-8 · Cited by 152
Characterization of Human Palladin, a Microfilament-associated Protein
Mykkänen, O.-M., Grönholm, M., Rönty, M. J., Lalowski, M. M., Salmikangas, P., Suila, H., & Carpén, O. (2001) · Molecular Biology of the Cell · doi:10.1091/mbc.12.10.3060 · Cited by 151
CLP-36 PDZ-LIM Protein Associates with Nonmuscle α-Actinin-1 and α-Actinin-4
Vallenius, T., Luukko, K., & Mäkelä, T. P. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.15.11100 · Cited by 147
Developmental Biology
(2002) · ZOOLOGICAL SCIENCE · doi:10.2108/zsj.19.1437 · Cited by 142
Extracellular regulated kinase (ERK) interaction with actin and the calponin homology (CH) domain of actin-binding proteins
Leinweber, B. D., Leavis, P. C., Grabarek, Z., WANG, C.-L. A., & Morgan, K. G. (1999) · Biochemical Journal · doi:10.1042/bj3440117 · Cited by 139
Behaviour and structure of the leading lamella in moving fibroblasts: I. Occurrence and centripetal movement of arcshaped microfilament bundles beneath the dorsal cell surface
Heath, J. P. (1983) · Journal of Cell Science · doi:10.1242/jcs.60.1.331 · Cited by 136
A new lock-step mechanism of matrix remodelling based on subcellular contractile events
Castella, L. F., Buscemi, L., Godbout, C., Meister, J.-J., & Hinz, B. (2010) · Journal of Cell Science · doi:10.1242/jcs.066795 · Cited by 132
Myofibrillogenesis in skeletal muscle cells in zebrafish
Sanger, J. W., Wang, J., Holloway, B. A., Du, A., & Sanger, J. M. (2009) · Cell Motility and the Cytoskeleton · doi:10.1002/cm.20365 · Cited by 130
Formation of stable microspikes containing actin and the 55 kDa actin bundling protein, fascin, is a consequence of cell adhesion to thrombospondin-1: implications for the anti-adhesive activities of thrombospondin-1
Adams, J. C. (1995) · Journal of Cell Science · doi:10.1242/jcs.108.5.1977 · Cited by 125
Mammalian calponin
Strasser, P., Gimona, M., Moessler, H., Herzog, M., & Small, J. V. (1993) · FEBS Letters · doi:10.1016/0014-5793(93)80909-e · Cited by 121
Regulation of smooth muscle actin—myosin interaction and force by calponin
Winder, S. J., Allen, B. G., Clément‐Chomienne, O., & Walsh, M. P. (1998) · Acta Physiologica Scandinavica · doi:10.1111/j.1365-201x.1998.tb10697.x · Cited by 117
Dynamic regulation of sarcomeric actin filaments in striated muscle
Ono, S. (2010) · Cytoskeleton · doi:10.1002/cm.20476 · Cited by 117
Vertebrate Nonmuscle Myosin II Isoforms Rescue Small Interfering RNA-induced Defects in COS-7 Cell Cytokinesis
Bao, J., Jana, S. S., & Adelstein, R. S. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m501573200 · Cited by 116
Tropomyosin prevents depolymerization of actin filaments from the pointed end.
Broschat, K. O. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)45363-4 · Cited by 114
Annealing of Gelsolin-severed Actin Fragments by Tropomyosin in the Presence of Ca2+
Ishikawa, R., Yamashiro, S., & Matsumura, F. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)84771-3 · Cited by 109
Nucleocytoplasmic functions of the PDZ‐LIM protein family: new insights into organ development
Krcmery, J., Camarata, T., Kulisz, A., & Simon, H. (2010) · BioEssays · doi:10.1002/bies.200900148 · Cited by 107
Palladin Is an Actin Cross-linking Protein That Uses Immunoglobulin-like Domains to Bind Filamentous Actin
Dixon, R. D. S., Arneman, D., Rachlin, A., Sundaresan, N. R., Costello, M. J., Campbell, S. L., & Otey, C. A. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m707694200 · Cited by 106
Functional interdependence between septin and actin cytoskeleton
Schmidt, K., & Nichols, B. J. (2004) · BMC Cell Biology · doi:10.1186/1471-2121-5-43 · Cited by 100
Characterization of 83-kilodalton nonmuscle caldesmon from cultured rat cells: stimulation of actin binding of nonmuscle tropomyosin and periodic localization along microfilaments like tropomyosin.
Yamashiro, S., & Matsumura, F. (1988) · The Journal of Cell Biology · doi:10.1083/jcb.106.6.1973 · Cited by 95
Location of actin, myosin, and microtubular structures during directed locomotion of Dictyostelium amebae.
Rubino, S., Fighetti, M., Unger, E., & Cappuccinelli, P. (1984) · The Journal of Cell Biology · doi:10.1083/jcb.98.2.382 · Cited by 90
Palladin is a novel binding partner for Ena/VASP family members
Boukhelifa, M., Parast, M. M., Bear, J. E., Gertler, F. B., & Otey, C. A. (2004) · Cell Motility and the Cytoskeleton · doi:10.1002/cm.10173 · Cited by 89
The role of palladin in actin organization and cell motility
Goicoechea, S. M., Arneman, D., & Otey, C. A. (2008) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2008.01.010 · Cited by 86
Developmentally regulated expression of calponin isoforms and the effect of h2-calponin on cell proliferation
Hossain, M. M., Hwang, D., Huang, Q.-Q., Sasaki, Y., & Jin, J. (2003) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00233.2002 · Cited by 86
Differential Regulation of Unconventional Fission Yeast Myosins via the Actin Track
Clayton, J. E., Sammons, M. R., Stark, B. C., Hodges, A. R., & Lord, M. (2010) · Current Biology · doi:10.1016/j.cub.2010.07.026 · Cited by 84
Retrograde Flow and Myosin II Activity within the Leading Cell Edge Deliver F-Actin to the Lamella to Seed the Formation of Graded Polarity Actomyosin II Filament Bundles in Migrating Fibroblasts
Anderson, T. W., Vaughan, A. N., & Cramer, L. P. (2008) · Molecular Biology of the Cell · doi:10.1091/mbc.e08-01-0034 · Cited by 84
Structural and Dynamic Characterization of a Vinculin Binding Site in the Talin Rod,
Gingras, A. R., Vogel, K.-P., Steinhoff, H., Ziegler, W. H., PATEL, B., Emsley, J., Critchley, D. R., Roberts, G. C. K., & Barsukov, I. (2006) · Biochemistry · doi:10.1021/bi052136l · Cited by 80
Biorheological views of endothelial cell responses to mechanical stimuli
Sato, M., & OHASHI, T. (2005) · Biorheology · doi:10.1177/0006355x2005042006003 · Cited by 79
Tropomyosin and Myosin-II Cellular Levels Promote Actomyosin Ring Assembly in Fission Yeast
Stark, B. C., Sladewski, T. E., Pollard, L. W., & Lord, M. (2010) · Molecular Biology of the Cell · doi:10.1091/mbc.e09-10-0852 · Cited by 78
Diversification of caldesmon-linked actin cytoskeleton in cell motility
Mayanagi, T., & Sobue, K. (2011) · Cell Adhesion & Migration · doi:10.4161/cam.5.2.14398 · Cited by 77
Role of Focal Adhesions and Mechanical Stresses in the Formation and Progression of the Lamellum Interface
Shemesh, T., Verkhovsky, A. B., Svitkina, T., Bershadsky, A. D., & Kozlov, M. M. (2009) · Biophysical Journal · doi:10.1016/j.bpj.2009.05.065 · Cited by 76
Calponins: Adaptable modular regulators of the actin cytoskeleton
Rozenblum, G. T., & Gimona, M. (2007) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2007.07.010 · Cited by 74
Chicken cardiac myofibrillogenesis studied with antibodies specific for titin and the muscle and nonmuscle isoforms of actin and tropomyosin
Handel, S. E., Greaser, M. L., Schultz, E., Wang, S., Bulinski, J. C., Lin, J. J., & Lessard, J. L. (1991) · Cell and Tissue Research · doi:10.1007/bf00327276 · Cited by 72
Clik1: a novel kinase targeted to actin stress fibers by the CLP-36 PDZ-LIM protein
Vallenius, T., & Mäkelä, T. P. (2002) · Journal of Cell Science · doi:10.1242/jcs.115.10.2067 · Cited by 71
M-RIP Targets Myosin Phosphatase to Stress Fibers to Regulate Myosin Light Chain Phosphorylation in Vascular Smooth Muscle Cells
Surks, H. K., Riddick, N., & Ohtani, K.-I. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m506863200 · Cited by 71
Cysteine-rich protein 1 (CRP1) regulates actin filament bundling
Tran, T. C., Singleton, C., Fraley, T. S., & Greenwood, J. A. (2005) · BMC Cell Biology · doi:10.1186/1471-2121-6-45 · Cited by 71
The proline‐rich protein palladin is a binding partner for profilin
Boukhelifa, M., Moza, M., Johansson, T., Rachlin, A., Parast, M. M., Hüttelmaier, S., Roy, P. S., Jockusch, B. M., Carpén, O., Karlsson, R., et al. (2005) · FEBS Journal · doi:10.1111/j.1742-4658.2005.05036.x · Cited by 69
p116Rip Decreases Myosin II Phosphorylation by Activating Myosin Light Chain Phosphatase and by Inactivating RhoA
Koga, Y., & Ikebe, M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m410909200 · Cited by 68
Tropomyosin isoforms localize to distinct microfilament populations in osteoclasts
McMichael, B. K., Kotadiya, P., Singh, T., Holliday, L. S., & Lee, B. S. (2006) · Bone · doi:10.1016/j.bone.2006.04.031 · Cited by 64
Modulatory role of ERK MAPK-caldesmon pathway in PDGF- stimulated migration of cultured pulmonary artery SMCs
Yamboliev, I. A., & Gerthoffer, W. T. (2001) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.2001.280.6.c1680 · Cited by 62
Live dynamics of GFP-calponin: isoform-specific modulation of the actin cytoskeleton and autoregulation by C-terminal sequences
Danninger, C., & Gimona, M. (2000) · Journal of Cell Science · doi:10.1242/jcs.113.21.3725 · Cited by 62
Coordinate Expression of α-Tropomyosin and Caldesmon Isoforms in Association with Phenotypic Modulation of Smooth Muscle Cells
Kashiwada, K., Nishida, W., Hayashi, K., Ozawa, K., Yamanaka, Y., Saga, H., Yamashita, T., Tohyama, M., Shimada, S., Sato, K., et al. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.24.15396 · Cited by 60
Shifting views on the leading role of the lamellipodium in cell migration: speckle tracking revisited
Vallotton, P., & Small, J. V. (2009) · Journal of Cell Science · doi:10.1242/jcs.042036 · Cited by 55
Caldesmon binds to smooth muscle myosin and myosin rod and crosslinks thick filaments to actin filaments
Marston, S. B., Pintér, K., & Bennett, P. M. (1992) · Journal of Muscle Research and Cell Motility · doi:10.1007/bf01874158 · Cited by 55
An association between NUAK2 and MRIP reveals a novel mechanism for regulation of actin stress fibers
Vallenius, T., Vaahtomeri, K., Kovac, B., Osiceanu, A. M., Viljanen, M., & Mäkelä, T. P. (2011) · Journal of Cell Science · doi:10.1242/jcs.072660 · Cited by 53
Calponin Developmental isoforms and a low molecular weight variant
Draeger, A., Gimona, M., Stuckert, A. J., Celis, J. E., & Small, J. V. (1991) · FEBS Letters · doi:10.1016/0014-5793(91)81095-p · Cited by 50
Palladin is a dynamic actin-associated protein in podocytes
Endlich, N., Schordan, E., Cohen, C. D., Kretzler, M., Lewko, B., Welsch, T., Kriz, W., Otey, C. A., & Endlich, K. (2008) · Kidney International · doi:10.1038/ki.2008.486 · Cited by 48
Effect of Caldesmon on the Assembly of Smooth Muscle Myosin
Katayama, E., Scott-Woo, G. C., & Ikebe, M. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.8.3919 · Cited by 47
Essential role of caldesmon in the actin filament reorganization induced by glucocorticoids.
Castellino, F., Ono, S., Matsumura, F., & Luini, A. (1995) · The Journal of Cell Biology · doi:10.1083/jcb.131.5.1223 · Cited by 47
Tropomyosin 4 defines novel filaments in skeletal muscle associated with muscle remodelling/regeneration in normal and diseased muscle
Vlahovich, N., Schevzov, G., Nair‐Shalliker, V., Ilkovski, B., Artap, S. T., Joya, J. E., Kee, A. J., North, K. N., Gunning, P. W., & Hardeman, E. C. (2007) · Cell Motility and the Cytoskeleton · doi:10.1002/cm.20245 · Cited by 45
Calponin Interaction with α-Actinin-Actin: Evidence for a Structural Role for Calponin
Leinweber, B. D., Tang, J. X., Stafford, W. F., & Chalovich, J. M. (1999) · Biophysical Journal · doi:10.1016/s0006-3495(99)77151-1 · Cited by 44
Stress fibers stabilize the position of intranuclear DNA through mechanical connection with the nucleus in vascular smooth muscle cells
NAGAYAMA, K., Yahiro, Y., & MATSUMOTΟ, T. (2011) · FEBS Letters · doi:10.1016/j.febslet.2011.11.006 · Cited by 42
Interaction of Rho‐kinase with myosin II at stress fibres
Kawabata, S., Usukura, J., Morone, N., Ito, M., Iwamatsu, A., Kaibuchi, K., & Amano, M. (2004) · Genes to Cells · doi:10.1111/j.1356-9597.2004.00749.x · Cited by 41
Characterization of the COOH Terminus of Non-muscle Caldesmon Mutants Lacking Mitosis-specific Phosphorylation Sites
Yamashiro, S., Yamakita, Y., Yoshida, K.-S., Takiguchi, K., & Matsumura, F. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.8.4023 · Cited by 37
The small GTPase Rif is an alternative trigger for the formation of actin stress fibers in epithelial cells
Fan, L., Pellegrin, S., Scott, A. N., & Mellor, H. (2010) · Journal of Cell Science · doi:10.1242/jcs.061754 · Cited by 37
Cease‐fire at the leading edge: New perspectives on actin filament branching, debranching, and cross‐linking
Ydenberg, C., Smith, B. A., Breitsprecher, D., Gelles, J., & Goode, B. L. (2011) · Cytoskeleton · doi:10.1002/cm.20543 · Cited by 36
Phosphorylated l-caldesmon is involved in disassembly of actin stress fibers and postmitotic spreading
Kordowska, J., Hetrick, T. A., Adam, L. P., & ALBERTWANG, C. (2005) · Experimental Cell Research · doi:10.1016/j.yexcr.2005.09.021 · Cited by 34
p116 Is A Novel Filamentous Actin-binding Protein
Mulder, J., Poland, M., Gebbink, M. F. B. G., Calafat, J., Moolenaar, W. H., & Kranenburg, O. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m302399200 · Cited by 33
Direct association and translocation of PKC-α with calponin
Patil, S. B., Pawar, M. D., & Bitar, K. N. (2004) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00477.2003 · Cited by 26
Emerging Issues for Tropomyosin Structure, Regulation, Function and Pathology
Gunning, P. W. (2008) · Advances in experimental medicine and biology · doi:10.1007/978-0-387-85766-4_22 · Cited by 13
Expression of chick Coactosin in cells in morphogenetic movement
Hou, X., Katahira, T., Kimura, J., & Nakamura, H. (2009) · Development Growth & Differentiation · doi:10.1111/j.1440-169x.2009.01146.x · Cited by 10
Developmental isoforms and a low molecular weight variant
Draeger, A., Gimona, M., Stuckert, A. J., et al. (1991) · FEBS Letters · Cited by 10

Sorted by citations

Cellular Mechanotransduction: From Tension to Function
Martino, F. D., Perestrelo, A. R., Vinarský, V., Pagliari, S., & Forte, G. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00824 · Cited by 1,028
Contractility of single cardiomyocytes differentiated from pluripotent stem cells depends on physiological shape and substrate stiffness
Ribeiro, A. J. S., Ang, Y.-S., Fu, J., Rivas, R. N., Mohamed, T., Higgs, G., Srivastava, D., & Pruitt, B. L. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1508073112 · Cited by 479
Apical constriction: themes and variations on a cellular mechanism driving morphogenesis
Martin, A. C., & Goldstein, B. (2014) · Development · doi:10.1242/dev.102228 · Cited by 502
Cellular chirality arising from the self-organization of the actin cytoskeleton
Tee, Y. H., Shemesh, T., Thiagarajan, V., Hariadi, R. F., Anderson, K., Page, C., Volkmann, N., Hanein, D., Sivaramakrishnan, S., Kozlov, M. M., et al. (2015) · Nature Cell Biology · doi:10.1038/ncb3137 · Cited by 420
Substrate curvature as a cue to guide spatiotemporal cell and tissue organization
Callens, S. J. P., Uyttendaele, R. J. C., Fratila-Apachitei, L. E., & ZADPOOR, A. A. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2019.119739 · Cited by 324

See all 900

Authors: Tojkander, S., Gateva, G., & Lappalainen, P.
Affiliations: University of Helsinki (FI)
Corresponding author: Lappalainen, Pekka
ORCID: Tojkander, Sari
Lappalainen, Pekka
Venue: Journal of Cell Science
Publisher: The Company of Biologists
Published: 2012-01-01
Volume: 125
Issue: Pt 8
Pages: 1855-64
ISSN: 0021-9533 (ISSN-L)
1477-9137
DOI: 10.1242/jcs.098087
OpenAlex: W2151492748
Cited by: 900
References: 155
Citations by year: 2026: 23 · 2025: 59 · 2024: 68 · 2023: 59 · 2022: 61 · 2021: 100 · 2020: 99 · 2019: 85 · 2018: 53 · 2017: 73 · 2016: 66 · 2015: 66 · 2014: 48 · 2013: 35 · 2012: 5
FWCI: 23.20
Type: journal article
Language: en
Open access: closed
Locations: Journal of Cell Science (publishedVersion)
PubMed (publishedVersion)
Funders: Academy of Finland
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Skin and Cellular Biology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
Keywords: stress fibers, actomyosin contractility, focal adhesions, mechanotransduction, cell adhesion, cell morphogenesis, endothelial cells, myofibroblasts, epithelial cells, contractile ring, myofibrils, non-muscle cells
MeSH terms: Actins, Animals, Cell Adhesion, Cell Movement, Humans, Stress Fibers, Mechanotransduction, Cellular

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Actin stress fibers – assembly, dynamics and biological roles

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks