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Rab11 regulates exocytosis of recycling vesicles at the plasma membrane

Takahashi, Senye, Kubo, Keiji, Waguri, Satoshi, Yabashi, Atsuko, Shin, Hye-Won, Katoh, Yohei, Nakayama, Kazuhisa·2012·Journal of Cell Science
DOI 10.1242/jcs.102913
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Abstract

Rab11 is known to associate primarily with perinuclear recycling endosomes and regulate recycling of endocytosed proteins. However, the recycling step in which Rab11 participates remains unknown. We here show that, in addition to causing tubulation of recycling endosomes, Rab11 depletion gives rise to accumulation of recycling carriers containing endocytosed transferrin and transferrin receptor beneath the plasma membrane. We also show that the carriers are transported from perinuclear recycling endosomes to the cell periphery along microtubules. Total internal reflection fluorescence microscopy of cells expressing EGFP-tagged transferrin receptor revealed that Rab11 depletion inhibits tethering and fusion of recycling carriers to the plasma membrane. Depletion of a component of the exocyst tethering complex, Sec15 or Exo70, the former which interacts with Rab11, leads to essentially the same phenotypes as those of Rab11 depletion. Thus, in addition to its role in recycling processes at perinuclear recycling endosomes, Rab11 is transported along microtubules to the cell periphery through association with recycling carriers, and directly regulates vesicle exocytosis at the plasma membrane in concert with the exocyst.

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Research works printed but not linked: 34

  1. D'Souza–Schorey, 2006, ARF proteins: roles in membrane traffic and beyond., Nat. Rev. Mol. Cell Biol., 7, 347, 10.1038/nrm1910 · DOI
  2. Grant, 2009, Pathways and mechanisms of endocytic recycling., Nat. Rev. Mol. Cell Biol., 10, 597, 10.1038/nrm2755 · DOI · Paper page
  3. Guichard, 2010, Anthrax toxins cooperatively inhibit endocytic recycling by the Rab11/Sec15 exocyst., Nature, 467, 854, 10.1038/nature09446 · DOI
  4. He, 2009, The exocyst complex in polarized exocytosis., Curr. Opin. Cell Biol., 21, 537, 10.1016/j.ceb.2009.04.007 · DOI · Paper page
  5. He, 2007, Exo70 interacts with phospholipids and mediates the targeting of the exocyst to the plasma membrane., EMBO J., 26, 4053, 10.1038/sj.emboj.7601834 · DOI
  6. Hölttä–Vuori, 2002, Modulation of cellular cholesterol transport and homeostasis by Rab11., Mol. Biol. Cell, 13, 3107, 10.1091/mbc.E02-01-0025 · DOI · Paper page
  7. Ichimura, 2005, 14-3-3 proteins modulate the expression of epithelial Na+ channels by phosphorylation-dependent interaction with Nedd4-2 ubiquitin ligase., J. Biol. Chem., 280, 13187, 10.1074/jbc.M412884200 · DOI
  8. Jedd, 1997, Two new Ypt GTPases are required for exit from the yeast trans-Golgi compartment., J. Cell Biol., 137, 563, 10.1083/jcb.137.3.563 · DOI
  9. Junutula, 2004, Molecular characterization of Rab11 interactions with members of the family of Rab11-interacting proteins., J. Biol. Chem., 279, 33430, 10.1074/jbc.M404633200 · DOI
  10. Lam–Yuk–Tseung, 2006, Distinct targeting and recycling properties of two isoforms of the iron transporter DMT1 (NRAMP2, Slc11A2)., Biochemistry, 45, 2294, 10.1021/bi052307m · DOI
  11. Langevin, 2005, Drosophila exocyst components Sec5, Sec6, and Sec15 regulate DE-Cadherin trafficking from recycling endosomes to the plasma membrane., Dev. Cell, 9, 365, 10.1016/j.devcel.2005.07.013 · DOI
  12. Liu, 2007, Phosphatidylinositol 4,5-bisphosphate mediates the targeting of the exocyst to the plasma membrane for exocytosis in mammalian cells., Mol. Biol. Cell, 18, 4483, 10.1091/mbc.E07-05-0461 · DOI
  13. Maxfield, 2004, Endocytic recycling., Nat. Rev. Mol. Cell Biol., 5, 121, 10.1038/nrm1315 · DOI · Paper page
  14. Mukherjee, 1997, Endocytosis., Physiol. Rev., 77, 759, 10.1152/physrev.1997.77.3.759 · DOI
  15. Munson, 2006, The exocyst defrocked, a framework of rods revealed., Nat. Struct. Mol. Biol., 13, 577, 10.1038/nsmb1097 · DOI · Paper page
  16. Oztan, 2007, Exocyst requirement for endocytic traffic directed toward the apical and basolateral poles of polarized MDCK cells., Mol. Biol. Cell, 18, 3978, 10.1091/mbc.E07-02-0097 · DOI
  17. Prigent, 2003, ARF6 controls post-endocytic recycling through its downstream exocyst complex effector., J. Cell Biol., 163, 1111, 10.1083/jcb.200305029 · DOI
  18. Ren, 1998, Hydrolysis of GTP on rab11 is required for the direct delivery of transferrin from the pericentriolar recycling compartment to the cell surface but not from sorting endosomes., Proc. Natl. Acad. Sci. USA, 95, 6187, 10.1073/pnas.95.11.6187 · DOI · Paper page
  19. Schwartz, 2007, Rab GTPases at a glance., J. Cell Sci., 120, 3905, 10.1242/jcs.015909 · DOI
  20. Shin, 1997, Identification and subcellular localization of a novel mammalian dynamin-related protein homologous to yeast Vps1p and Dnm1p., J. Biochem., 122, 525, 10.1093/oxfordjournals.jbchem.a021784 · DOI
  21. Takahashi, 2011, Distinct roles of Rab11 and Arf6 in the regulation of Rab11-FIP3/arfophilin-1 localization in mitotic cells., Genes Cells, 16, 938, 10.1111/j.1365-2443.2011.01538.x · DOI
  22. Thomas, 2009, Intersectin regulates dendritic spine development and somatodendritic endocytosis but not synaptic vesicle recycling in hippocampal neurons., J. Biol. Chem., 284, 12410, 10.1074/jbc.M809746200 · DOI
  23. Ullrich, 1996, Rab11 regulates recycling through the pericentriolar recycling endosome., J. Cell Biol., 135, 913, 10.1083/jcb.135.4.913 · DOI · Paper page
  24. van Ijzendoorn, 2006, Recycling endosomes., J. Cell Sci., 119, 1679, 10.1242/jcs.02948 · DOI
  25. Vega, 2001, The exocyst complex associates with microtubules to mediate vesicle targeting and neurite outgrowth., J. Neurosci., 21, 3839, 10.1523/JNEUROSCI.21-11-03839.2001 · DOI · Paper page
  26. Volpicelli–Daley, 2005, Isoform-selective effects of the depletion of ADP-ribosylation factors 1-5 on membrane traffic., Mol. Biol. Cell, 16, 4495, 10.1091/mbc.E04-12-1042 · DOI
  27. Waguri, 1999, The induction of autophagic vacuoles and the unique endocytic compartments, C-shaped multivesicular bodies, in GH4C1 cells after treatment with 17β-estradiol, insulin and EGF., Arch. Histol. Cytol., 62, 423, 10.1679/aohc.62.423 · DOI
  28. Wang, 2003, Immunological characterization of exocyst complex subunits in cell differentiation., Hybrid. Hybridomics, 22, 159, 10.1089/153685903322286575 · DOI
  29. Ward, 2005, From sorting endosomes to exocytosis: association of Rab4 and Rab11 GTPases with the Fc receptor, FcRn, during recycling., Mol. Biol. Cell, 16, 2028, 10.1091/mbc.E04-08-0735 · DOI · Paper page
  30. Wilcke, 2000, Rab11 regulates the compartmentalization of early endosomes required for efficient transport from early endosomes to the trans-golgi network., J. Cell Biol., 151, 1207, 10.1083/jcb.151.6.1207 · DOI · Paper page
  31. Wu, 2005, Sec15 interacts with Rab11 via a novel domain and affects Rab11 localization in vivo., Nat. Struct. Mol. Biol., 12, 879, 10.1038/nsmb987 · DOI
  32. Zerial, 2001, Rab proteins as membrane organizers., Nat. Rev. Mol. Cell Biol., 2, 107, 10.1038/35052055 · DOI · Paper page
  33. Zhang, 2004, Sec15 is an effector for the Rab11 GTPase in mammalian cells., J. Biol. Chem., 279, 43027, 10.1074/jbc.M402264200 · DOI · Paper page
  34. Zuo, 2006, Exo70 interacts with the Arp2/3 complex and regulates cell migration., Nat. Cell Biol., 8, 1383, 10.1038/ncb1505 · DOI

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Metadata

Authors
Takahashi, S., Kubo, K., Waguri, S., Yabashi, A., Shin, H.-W., Katoh, Y., & Nakayama, K.
Venue
Journal of Cell Science
Publisher
The Company of Biologists
Published
2012-01-01
ISSN
  • 1477-9137
  • 0021-9533
DOI
10.1242/jcs.102913
Cited by
225
References
2
Language
en
Licence
www.biologists.com/user-licence-1-1 (vor, 425 d)

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