The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Flexural rigidity of microtubules measured with the use of optical tweezers
Abstract
The flexural rigidity of single microtubules is measured using optical tweezers. Two new methods are presented. In both the optical forces of the laser trap are used to directly manipulate microtubules grown off the ends of Chlamydomonas axonemes. The shapes of the microtubules are observed by video microscopy as the hydrodynamic forces of viscous flow counteract the elastic restoring forces when the microtubules are moved actively relative to the surrounding buffer medium. To determine the flexural rigidity, the bending of a microtubule is analyzed under a given velocity distribution along its length. Microtubules incubated with taxol after polymerization are measured to be more flexible than those without taxol added. On the other hand, MAPs are shown to increase microtubule stiffness.
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Cites
Promotion of microtubule assembly in vitro by taxol
SCHIFF, P. B., FANT, J., & HORWITZ, S. B. (1979) · Nature · doi:10.1038/277665a0 · Cited by 3,600
Direct observation of kinesin stepping by optical trapping interferometry
Svoboda, K., Schmidt, C. F., Schnapp, B. J., & Block, S. M. (1993) · Nature · doi:10.1038/365721a0 · Cited by 1,910
Walker, R. A., O'Brien, E. T., Pryer, N. K., Soboeiro, M. F., Voter, W. A., Erickson, H. P., & Salmon, E. D. (1988) · The Journal of Cell Biology · doi:10.1083/jcb.107.4.1437 · Cited by 980
Cited by
Measurement of the Force-Velocity Relation for Growing Microtubules
Dogterom, M., & Yurke, B. (1997) · Science · doi:10.1126/science.278.5339.856 · Cited by 579
Tau interaction with microtubules in vivo
Samsonov, A., Yu, J.-Z., Rasenick, M., & Popov, S. V. (2004) · Journal of Cell Science · doi:10.1242/jcs.01531 · Cited by 129
Microtubule curvatures under perpendicular electric forces reveal a low persistence length
Van den Heuvel, M. G. L., de Graaff, M. P., & Dekker, C. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0704169105 · Cited by 88
Hoshino, A., Clemente, V., Shetty, M., Castle, B., Odde, D., & Bazzaro, M. (2023) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2023.105355 · Cited by 7
Inferring spatially varying bending stiffness of biopolymers with deep-learning approach
Hong, C., Lim, C., Oh, J., Lee, J.-B., Jeong, E. E., Yoo, J.-Y., Kim, W. K., & Jeon, J.-H. (2025) · Machine Learning: Science and Technology · doi:10.1088/2632-2153/ae1a35
Metadata
- Authors
- Felgner, H., Frank, R., & Schliwa, M.
- Venue
- Journal of Cell Science
- Publisher
- The Company of Biologists
- Published
- 1996-02-01
- Volume
- 109
- Issue
- 2
- Pages
- 509-516
- ISSN
- 0021-9533 (ISSN-L)
- 1477-9137
- OpenAlex
- W2112136921
- Cited by
- 301
- References
- 3
- FWCI
- 3.28
- Type
- journal article
- Language
- en
- Open access
- closed
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- Felgner, H., Frank, R., & Schliwa, M. (1996). Flexural rigidity of microtubules measured with the use of optical tweezers. Journal of Cell Science. https://doi.org/10.1242/jcs.109.2.509
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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