The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Phosphoinositide 3-kinase signalling pathways
Abstract
Phosphoinositide 3-kinases (PI3Ks) phosphorylate the 3′-OH position of the inositol ring of inositol phospholipids, producing three lipid products: PtdIns(3)P, PtdIns(3,4)P2 and PtdIns(3,4,5)P3. These lipids bind to the pleckstrin homology (PH) domains of proteins and control the activity and subcellular localisation of a diverse array of signal transduction molecules. Three major classes of signalling molecule are regulated by binding of D-3 phosphoinositides to PH domains: guanine-nucleotide-exchange proteins for Rho family GTPases, the TEC family tyrosine kinases such as BTK and ITK in B and T lymphocytes, respectively, and the AGC superfamily of serine/threonine protein kinases. These molecules are activated by a variety of extracellular stimuli and have been implicated in a wide range of cellular processes, including cell cycle progression, cell growth, cell motility, cell adhesion and cell survival.
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Protein modules and signalling networks
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Phosphatidylinositol-3-OH kinase direct target of Ras
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Phosphorylation and Activation of p70 s6k by PDK1
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Structure, function, and biology of SHIP proteins
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Glaviano, A., Foo, A. S. C., Lam, H. Y., Yap, K. C. H., Jacot, W., Jones, R. H., Eng, H., Nair, M. G., Makvandi, P., Geoerger, B., et al. (2023) · Molecular Cancer · doi:10.1186/s12943-023-01827-6 · Cited by 2,138
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Metadata
- Authors
- Cantrell, D. A.
- Venue
- Journal of Cell Science
- Publisher
- The Company of Biologists
- Published
- 2001-04-15
- Volume
- 114
- Issue
- 8
- Pages
- 1439-1445
- ISSN
- 0021-9533 (ISSN-L)
- 1477-9137
- OpenAlex
- W1907575477
- Cited by
- 533
- References
- 6
- FWCI
- 13.35
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
