The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
From Cdc2 to Cdk1: when did the cell cycle kinase join its cyclin partner?
Abstract
The idea that Cdc2 and cyclins play a key role in the control of the G2/M transition of the cell cycle came largely from genetic analysis of fission yeast and physiological studies of clam, frog, sea urchin and starfish eggs and oocytes. However, it took a long time to realise that Cdc2 and cyclins form a stoichiometric complex and that a cyclin subunit is necessary for the Cdc2 subunit to gain its protein kinase activity. Cyclins were first recognized as proteins whose abundance oscillates during the early cell cycles of marine invertebrate eggs and their connection with MPF (maturation-promoting factor), the entity defined in frog and starfish oocytes whose activity controls entry into M phase, was far from clear at first. Indeed, it was a long time before MPF was shown to be a protein kinase,and direct proof that MPF is a heterodimer comprising one molecule of cyclin and one molecule of Cdc2 was finally obtained only when the Cdc2-associated component of purified starfish MPF was sequenced and found to be cyclin B. When this fundamental discovery was confirmed in vertebrates and mammalian members of the Cdc2 family were also shown to bind cyclins, Cdc2 became Cdk1,the first cyclin-dependent protein kinase.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Cytoplasmic control of nuclear behavior during meiotic maturation of frog oocytes
Masui, Y., & Markert, C. L. (1971) · Journal of Experimental Zoology · doi:10.1002/jez.1401770202 · Cited by 1,545
Evans, T., Rosenthal, E. T., Youngblom, J., Distel, D., & Hunt, T. (1983) · Cell · doi:10.1016/0092-8674(83)90420-8 · Cited by 1,516
Self-citationCyclin synthesis drives the early embryonic cell cycle
Murray, A. W., & Kirschner, M. W. (1989) · Nature · doi:10.1038/339275a0 · Cited by 1,191
Complementation used to clone a human homologue of the fission yeast cell cycle control gene cdc2
Lee, M. G., & Nurse, P. (1987) · Nature · doi:10.1038/327031a0 · Cited by 1,140
Negative regulation of mitosis by wee1+, a gene encoding a protein kinase homolog
Russell, P., & Nurse, P. (1987) · Cell · doi:10.1016/0092-8674(87)90458-2 · Cited by 1,017
Gautier, J., Norbury, C., Lohka, M., Nurse, P., & Maller, J. (1988) · Cell · doi:10.1016/0092-8674(88)90206-1 · Cited by 871
Human cyclin A is adenovirus E1A-associated protein p60 and behaves differently from cyclin B
Pines, J., & Hunter, T. (1990) · Nature · doi:10.1038/346760a0 · Cited by 715
Draetta, G., Luca, F., Westendorf, J., Brizuela, L., Ruderman, J., & Beach, D. (1989) · Cell · doi:10.1016/0092-8674(89)90687-9 · Cited by 654
Purification of maturation-promoting factor, an intracellular regulator of early mitotic events.
Lohka, M. J., Hayes, M. K., & Maller, J. L. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.9.3009 · Cited by 644
Dephosphorylation and activation of a p34cdc2/cyclin B complex in vitro by human CDC25 protein
Strausfeld, U., Labbé, J. C., Fesquet, D., Cavadore, J. C., Picard, A., Sadhu, K., Russell, P., & Dorée, M. (1991) · Nature · doi:10.1038/351242a0 · Cited by 578
Cited by
Martinez, F. O., Gordon, S., Locati, M., & Mantovani, A. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.10.7303 · Cited by 2,125
Treating cancer with selective CDK4/6 inhibitors
O'Leary, B., Finn, R. S., & Turner, N. C. (2016) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2016.26 · Cited by 1,137
Meiosis in oocytes: predisposition to aneuploidy and its increased incidence with age
Jones, K. T. (2008) · Human Reproduction Update · doi:10.1093/humupd/dmm043 · Cited by 228
The Role of Schwann Cell-Axon Interaction in Peripheral Nerve Regeneration
Namgung, U. (2014) · Cells Tissues Organs · doi:10.1159/000370324 · Cited by 135
Astrocyte reactivity after brain injury—: The role of galectins 1 and 3
Sirko, S., Irmler, M., Gascón, S., Bek, S., Schneider, S., Dimou, L., Obermann, J., De Souza Paiva, D., Poirier, F., Beckers, J., et al. (2015) · Glia · doi:10.1002/glia.22898 · Cited by 126
Metadata
- Authors
- Dorée, M., & Hunt, T.
- Venue
- Journal of Cell Science
- Publisher
- The Company of Biologists
- Published
- 2002-06-15
- Volume
- 115
- Issue
- 12
- Pages
- 2461-2464
- ISSN
- 0021-9533 (ISSN-L)
- 1477-9137
- OpenAlex
- W1493893483
- Cited by
- 274
- References
- 34
- FWCI
- 6.44
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: From Cdc2 to Cdk1: when did the cell cycle kinase join its cyclin partner? https://app.cochat.ai/papers/10.1242/jcs.115.12.2461
- The paper
- Dorée, M., & Hunt, T. (2002). From Cdc2 to Cdk1: when did the cell cycle kinase join its cyclin partner? Journal of Cell Science. https://doi.org/10.1242/jcs.115.12.2461
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
