The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Direct mobilisation of lysosomal Ca2+ triggers complex Ca2+ signals
Open accessAbstract
Summary: Accumulating evidence implicates acidic organelles of the endolysosomal system as mobilisable stores of Ca2+ but their relationship to the better-characterised endoplasmic reticulum (ER) Ca2+ store remains unclear. Here we show that rapid osmotic permeabilisation of lysosomes evokes prolonged, spatiotemporally complex Ca2+ signals in primary cultured human fibroblasts. These Ca2+ signals comprised an initial response that correlated with lysosomal disruption and secondary long-lasting spatially heterogeneous Ca2+ oscillations that required ER-localised inositol trisphosphate receptors. Electron microscopy identified extensive membrane contact sites between lysosomes and the ER. Mobilisation of lysosomal Ca2+ stores is thus sufficient to evoke ER-dependent Ca2+ release probably through lysosome–ER membrane contact sites, and akin to the proposed mechanism of action of the Ca2+ mobilising messenger nicotinic acid adenine dinucleotide phosphate (NAADP). Our data identify functional and physical association of discrete Ca2+ stores important for the genesis of Ca2+ signal complexity.
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Cites
The versatility and universality of calcium signalling
Berridge, M. J., Lipp, P., & Bootman, M. D. (2000) · Nature Reviews Molecular Cell Biology · doi:10.1038/35036035 · Cited by 5,701
NAADP mobilizes calcium from acidic organelles through two-pore channels
Calcraft, P. J., Ruas, M., Pan, Z., Cheng, X., Arredouani, A., Hao, X., Tang, J., Rietdorf, K., Teboul, L., Chuang, K.-T., et al. (2009) · Nature · doi:10.1038/nature08030 · Cited by 760
Pryor, P. R., Mullock, B. M., Bright, N. A., Gray, S. R., & Luzio, J. P. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.149.5.1053 · Cited by 347
Coen, K., Flannagan, R. S., Baron, S., Carraro-Lacroix, L. R., Wang, D., Vermeire, W., Michiels, C., Munck, S., Baert, V., Sugita, S., et al. (2012) · Journal of Cell Biology · doi:10.1083/jcb.201201076 · Cited by 208
Cited by
Structure and function of ER membrane contact sites with other organelles
Phillips, M. J., & Voeltz, G. K. (2016) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2015.8 · Cited by 933
Triggered recruitment of ESCRT machinery promotes endolysosomal repair
Skowyra, M. L., Schlesinger, P. H., Naismith, T. V., & Hanson, P. I. (2018) · Science · doi:10.1126/science.aar5078 · Cited by 578
Autophagosome–lysosome fusion is independent of V-ATPase-mediated acidification
Mauvezin, C., Nagy, P., Juhász, G., & Neufeld, T. P. (2015) · Nature Communications · doi:10.1038/ncomms8007 · Cited by 424
A molecular mechanism to regulate lysosome motility for lysosome positioning and tubulation
Li, X., Rydzewski, N., Hider, A., Zhang, X., Yang, J., Wang, W., Gao, Q., Cheng, X., & Xu, H. (2016) · Nature Cell Biology · doi:10.1038/ncb3324 · Cited by 387
Lee, J.-H., McBrayer, M. K., Wolfe, D. M., Haslett, L. J., Kumar, A., Sato, Y., Lie, P. P. Y., Mohan, P., Coffey, E. E., Kompella, U., et al. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.07.050 · Cited by 358
Metadata
- Authors
- Kilpatrick, B. S., Eden, E. R., Schapira, A. H., Futter, C. E., & Patel, S.
- Venue
- Journal of Cell Science
- Publisher
- The Company of Biologists
- Published
- 2013-01-01
- Volume
- 126
- Issue
- 1
- Pages
- 60-66
- ISSN
- 0021-9533 (ISSN-L)
- 1477-9137
- OpenAlex
- W2157869491
- Cited by
- 192
- References
- 4
- FWCI
- 8.92
- Type
- journal article
- Language
- en
- Open access
- green
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- Kilpatrick, B. S., Eden, E. R., Schapira, A. H., Futter, C. E., & Patel, S. (2013). Direct mobilisation of lysosomal Ca2+ triggers complex Ca2+ signals. Journal of Cell Science. https://doi.org/10.1242/jcs.118836
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