The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
ER-phagy at a glance
Abstract
Selective autophagy represents the major quality control mechanism that ensures proper turnover of exhausted or harmful organelles, among them the endoplasmic reticulum (ER), which is fragmented and delivered to the lysosome for degradation via a specific type of autophagy called ER-phagy. The recent discovery of ER-resident proteins that bind to mammalian Atg8 proteins has revealed that the selective elimination of ER involves different receptors that are specific for different ER subdomains or ER stresses. FAM134B (also known as RETREG1) and RTN3 are reticulon-type proteins that are able to remodel the ER network and ensure the basal membrane turnover. SEC62 and CCPG1 are transmembrane ER receptors that function in response to ER stress signals. This task sharing reflects the complexity of the ER in terms of biological functions and morphology. In this Cell Science at a Glance article and the accompanying poster, we summarize the most recent findings about ER-phagy in yeast and in mammalian cells.
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Cites
Mechanism and medical implications of mammalian autophagy
Dikic, I., & Elazar, Z. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0003-4 · Cited by 2,771
Cargo recognition and trafficking in selective autophagy
Stolz, A., Ernst, A., & Dikic, I. (2014) · Nature Cell Biology · doi:10.1038/ncb2979 · Cited by 1,207
Self-citationRogov, V., Dötsch, V., Johansen, T., & Kirkin, V. (2014) · Molecular Cell · doi:10.1016/j.molcel.2013.12.014 · Cited by 992
Regulation of endoplasmic reticulum turnover by selective autophagy
Khaminets, A., Heinrich, T., Mari, M., Grumati, P., Huebner, A. K., Akutsu, M., Liebmann, L., Stolz, A., Nietzsche, S., Koch, N., et al. (2015) · Nature · doi:10.1038/nature14498 · Cited by 956
Self-citationPlasma membrane contributes to the formation of pre-autophagosomal structures
Ravikumar, B., Moreau, K., Jahreiss, L., Puri, C., & Rubinsztein, D. C. (2010) · Nature Cell Biology · doi:10.1038/ncb2078 · Cited by 902
Microautophagy of Cytosolic Proteins by Late Endosomes
Sahu, R., Kaushik, S., Clement, C. C., Cannizzo, E. S., Scharf, B., Follenzi, A., Potolicchio, I., Nieves, E., Cuervo, A. M., & Santambrogio, L. (2011) · Developmental Cell · doi:10.1016/j.devcel.2010.12.003 · Cited by 902
Receptor-mediated selective autophagy degrades the endoplasmic reticulum and the nucleus
Mochida, K., Oikawa, Y., Kimura, Y., Kirisako, H., Hirano, H., Ohsumi, Y., & Nakatogawa, H. (2015) · Nature · doi:10.1038/nature14506 · Cited by 611
Autophagy requires endoplasmic reticulum targeting of the PI3-kinase complex via Atg14L
Matsunaga, K., Morita, E., Saitoh, T., Akira, S., Ktistakis, N. T., Izumi, T., Noda, T., & Yoshimori, T. (2010) · Journal of Cell Biology · doi:10.1083/jcb.200911141 · Cited by 456
Kurth, I., Pamminger, T., Hennings, J. C., Soehendra, D., Huebner, A. K., Rotthier, A., Baets, J., Senderek, J., Topaloglu, H., Farrell, S. A., et al. (2009) · Nature Genetics · doi:10.1038/ng.464 · Cited by 260 · cited 2×
“Even though FAM134B has been directly linked to the pathogenesis of hereditary sensory neuropathy HSAN-II (Kurth et al., 2009; Murphy et al., 2012), the molecular mechanism through which FAM134B causes the pathology is only partially understood.”
BackgroundMutation in FAM134B causing severe hereditary sensory neuropathy: Figure 1
Murphy, S. M., Davidson, G. L., Brandner, S., Houlden, H., & Reilly, M. M. (2012) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.2010.228965 · Cited by 62
Cited by
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) 1
Klionsky, D. J., Abdel-Aziz, A. K., Abdelfatah, S., Abdellatif, M., Abdoli, A., Abel, S., Abeliovich, H., Abildgaard, M. H., Abudu, Y. P., Acevedo-Arozena, A., et al. (2021) · Autophagy · doi:10.1080/15548627.2020.1797280 · Cited by 2,897
Self-citationCellular quality control by the ubiquitin–proteasome system and autophagy
Pohl, C., & Dikic, I. (2019) · Science · doi:10.1126/science.aax3769 · Cited by 1,212
Self-citationSelective autophagy of intracellular organelles: Recent research advances
Li, W., He, P., Huang, Y., Li, Y.-F., Lu, J., Li, M., Kurihara, H., Luo, Z., Meng, T., Onishi, M., et al. (2021) · Theranostics · doi:10.7150/thno.49860 · Cited by 507
Stavoe, A. K. H., & Holzbaur, E. L. F. (2019) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-100818-125242 · Cited by 328
“One mechanism for turnover is ERphagy (also referred to as reticulophagy), the selective removal of ER segments by autophagy (Grumati et al. 2018).”
BackgroundATL3 Is a Tubular ER-Phagy Receptor for GABARAP-Mediated Selective Autophagy
Chen, Q., Xiao, Y., Chai, P., Zheng, P., Teng, J., & Chen, J. (2019) · Current Biology · doi:10.1016/j.cub.2019.01.041 · Cited by 304
Metadata
- Authors
- Grumati, P., Dikic, I., & Stolz, A.
- Venue
- Journal of Cell Science
- Publisher
- The Company of Biologists
- Published
- 2018-09-01
- Volume
- 131
- Issue
- 17
- ISSN
- 0021-9533 (ISSN-L)
- 1477-9137
- OpenAlex
- W2890512899
- Cited by
- 193
- References
- 10
- FWCI
- 17.05
- Type
- journal article
- Language
- en
- Open access
- closed
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