The DOI matches its Crossref record; 152 of the 155 references it cites were found in a registry or an index.
Muscles and their myokines
Open accessAbstract
Summary: In the past, the role of physical activity as a life-style modulating factor has been considered as that of a tool to balance energy intake. Although it is important to avoid obesity, physical inactivity should be discussed in a much broader context. There is accumulating epidemiological evidence that a physically active life plays an independent role in the protection against type 2 diabetes, cardiovascular diseases, cancer, dementia and even depression. For most of the last century, researchers sought a link between muscle contraction and humoral changes in the form of an ‘exercise factor’, which could be released from skeletal muscle during contraction and mediate some of the exercise-induced metabolic changes in other organs such as the liver and the adipose tissue. We have suggested that cytokines or other peptides that are produced, expressed and released by muscle fibres and exert autocrine, paracrine or endocrine effects should be classified as ‘myokines’. Given that skeletal muscle is the largest organ in the human body, our discovery that contracting skeletal muscle secretes proteins sets a novel paradigm: skeletal muscle is an endocrine organ producing and releasing myokines, which work in a hormone-like fashion, exerting specific endocrine effects on other organs. Other myokines work via paracrine mechanisms, exerting local effects on signalling pathways involved in muscle metabolism. It has been suggested that myokines may contribute to exercise-induced protection against several chronic diseases.
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“Skeletal muscle contraction during RT triggers the production and release of cytokines such as interleukin (IL) and irisin, which exert effects both locally and in a crosstalk manner with other organs, such as the liver and adipose tissue, to cope with muscle repair, hypertrophy and fuel metabolism [6].”
From β-hydroxy-β -methylbutyrate supplementation benefits the effects of resistance training on body fat reduction via increased irisin expression in white adipose tissue (2021) · cites this paper as [6]
Experimental — accuracy not yet measuredIn the citing paper
“Several risk factors for MS are associated with physical inactivity, including low-grade inflammation and impaired metabolism (403, 404).”
From Lack of Exercise Is a Major Cause of Chronic Diseases (2012) · cites this paper as [403]
In the citing paper
“Several risk factors for MS are associated with physical inactivity, including low-grade inflammation and impaired metabolism (403, 404).”
From Lack of Exercise Is a Major Cause of Chronic Diseases (2012) · cites this paper as [404]
In the citing paper
“Conversely, prevention of physical inactivity through physical activity improves inflammatory markers by reducing resting CRP, interleukin-6 (IL-6), and tumour necrosis factor-α concentration (403).”
From Lack of Exercise Is a Major Cause of Chronic Diseases (2012) · cites this paper as [403]
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2 retracted
Immunohistochemical detection of interleukin‐6 in human skeletal muscle fibers following exercise
Penkowa, M., Keller, C., Keller, P., Jauffred, S., & Pedersen, B. K. (2003) · The FASEB Journal · doi:10.1096/fj.03-0311fje · Cited by 157
Self-citationRetractedTHIS ARTICLE HAS BEEN RETRACTED Exercise induces interleukin‐8 expression in human skeletal muscle
Akerstrom, T. C. A., Steensberg, A., Keller, P., Keller, C., Penkowa, M., & Pedersen, B. K. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2004.077610 · Cited by 130
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“Physical inactivity increases the risk of type 2 diabetes (Tuomilehto et al., 2001), cardiovascular disease (CVD) (Nocon et al.”
BackgroundActual Causes of Death in the United States, 2000
Mokdad, A. H. (2004) · JAMA · doi:10.1001/jama.291.10.1238 · Cited by 5,211
Neurotrophins: Roles in Neuronal Development and Function
Huang, E. J., & Reichardt, L. F. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.677 · Cited by 4,394
Fitness Effects on the Cognitive Function of Older Adults: A Meta-Analytic Study
Colcombe, S., & Kramer, A. F. (2003) · Psychological Science · doi:10.1111/1467-9280.t01-1-01430 · Cited by 3,782
Be smart, exercise your heart: Exercise effects on brain and cognition
Hillman, C. H., Erickson, K. I., & Kramer, A. F. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2298 · Cited by 3,563
The anti-inflammatory effect of exercise
Petersen, A. M. W., & Pedersen, B. K. (2005) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00164.2004 · Cited by 3,100 · cited 4×
“…low-level inflammation, suggesting that the anti-inflammatory activity induced by regular exercise may exert some of the beneficial health effects of exercise in patients with chronic diseases (reviewed in Wilund, 2007; Petersen and Pedersen, 2005; Petersen and Pedersen, 2006; Pedersen, 2006).”
BackgroundInfluentialSelf-citationRunning enhances neurogenesis, learning, and long-term potentiation in mice
van Praag, H., Christie, B. R., Sejnowski, T. J., & Gage, F. H. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.23.13427 · Cited by 2,904
Flagged first, then by citations
3 of the 155 references couldn’t be matched to a known paper.
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Lack of Exercise Is a Major Cause of Chronic Diseases
Booth, F. W., Roberts, C. K., & Laye, M. J. (2012) · Comprehensive Physiology · doi:10.1002/cphy.c110025 · Cited by 2,575
The Osteocyte: An Endocrine Cell … and More
Dallas, S. L., Prideaux, M., & Bonewald, L. F. (2013) · Endocrine Reviews · doi:10.1210/er.2012-1026 · Cited by 1,042
Exerkines in health, resilience and disease
Chow, L. S., Gerszten, R. E., Taylor, J. M., Pedersen, B. K., van Praag, H., Trappe, S., Febbraio, M. A., Galis, Z. S., Gao, Y., Haus, J. M., et al. (2022) · Nature Reviews Endocrinology · doi:10.1038/s41574-022-00641-2 · Cited by 927
Self-citationSkeletal muscle: A review of molecular structure and function, in health and disease
Mukund, K., & Subramaniam, S. (2019) · WIREs Systems Biology and Medicine · doi:10.1002/wsbm.1462 · Cited by 789
McArdle, M. A., Finucane, O. M., Connaughton, R. M., McMorrow, A. M., & Roche, H. M. (2013) · Frontiers in Endocrinology · doi:10.3389/fendo.2013.00052 · Cited by 552
Metadata
- Authors
- Pedersen, B. K.
- Affiliations
- Rigshospitalet (DK)
- Corresponding author
- Pedersen, Bente Klarlund
- Venue
- Journal of Experimental Biology
- Publisher
- The Company of Biologists
- Published
- 2011-01-15
- Volume
- 214
- Issue
- 2
- Pages
- 337-346
- ISSN
- 0022-0949 (ISSN-L)
- 1477-9145
- OpenAlex
- W2033127864
- Cited by
- 668
- References
- 155
- Citations by year
- 2026: 19 · 2025: 26 · 2024: 55 · 2023: 34 · 2022: 46 · 2021: 58 · 2020: 59 · 2019: 39 · 2018: 49 · 2017: 50 · 2016: 46 · 2015: 45 · 2014: 43 · 2013: 46 · 2012: 41
- FWCI
- 32.56
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Experimental Biology (publishedVersion)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (publishedVersion)
- Funders
- Strategiske Forskningsråd (09-067009 and 09-075724, 09–067009, 09 – 075724)
- Sundhed og Sygdom, Det Frie Forskningsråd
- National Research Foundation
- Danmarks Grundforskningsfond (# 02-512-55, 09-067009, 09-075724)
- Ministério da Ciência, Tecnologia e Inovação
- Medical Research Council
- Topics
- Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- myokines, skeletal muscle, physical activity, paracrine signaling, autocrine signaling, exercise-induced metabolic changes, type 2 diabetes, cardiovascular disease, cancer, dementia, depression, physical inactivity, obesity
- MeSH terms
- Adipose Tissue, Animals, Cardiovascular Diseases, Chronic Disease, Diabetes Mellitus, Type 2, Humans, Motor Activity, Neoplasms, Exercise, Interleukin-6, Cytokines, Muscle, Skeletal, Neurodegenerative Diseases
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