The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.
Gut microbiota dictates the metabolic response of Drosophila to diet
Open accessAbstract
Animal nutrition is profoundly influenced by the gut microbiota, but knowledge of the scope and underlying mechanisms of the underlying animal-microbial interactions is fragmentary. To investigate the nutritional traits shaped by the gut microbiota of Drosophila, we determined the microbiota-dependent response of multiple metabolic and performance indices to systematically-varied diet composition. Diet-dependent differences between Drosophila bearing its unmanipulated microbiota (conventional flies) and experimentally deprived of its microbiota (axenic flies) revealed evidence for: microbial sparing of dietary B vitamins, especially riboflavin, on low-yeast diets; microbial promotion of protein nutrition, particularly in females; and microbiota-mediated suppression of lipid/carbohydrate storage, especially on high sugar diets. The microbiota also set the relationship between energy storage and body weight, indicative of microbial modulation of the host signaling networks that coordinate metabolism with body size. This analysis identifies the multiple impacts of the microbiota on the metabolism of Drosophila, and demonstrates that the significance of these different interactions varies with diet composition and host sex.
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Citations
Cites
Structure, function and diversity of the healthy human microbiome
The Human Microbiome Project Consortium (2012) · Nature · doi:10.1038/nature11234 · Cited by 11,726
The gut microbiota as an environmental factor that regulates fat storage
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Host-gut microbiota metabolic interactions
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“DISCUSSION It is widely recognized that the relationship between animals and their gut microbiota involves multiple interactions that vary with composition of the microbiota, host genotype and environmental factors, especially diet (Faith et al., 2011; Human Microbiome Project Consortium, 2012; Kau et al., 2011; Turnb…”
BackgroundHuman nutrition, the gut microbiome and the immune system
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The role of the gut microbiota in nutrition and health
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Metabolic Syndrome and Altered Gut Microbiota in Mice Lacking Toll-Like Receptor 5
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Sex differences in the gut microbiome drive hormone-dependent regulation of autoimmunity
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Bacteria as vitamin suppliers to their host: A gut microbiota perspective
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“In broad terms, these findings for Drosophila are congruent with evidence that various animals, including other insects and mammals, bear bacteria that are capable of synthesizing B vitamins and contribute to the vitamin nutrition of their host (Akman et al., 2002; Goodman et al., 2009; Hill, 1997; LeBlanc et al., 201…”
BackgroundAntibiotics in early life alter the murine colonic microbiome and adiposity
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Cited by
Promoting Health and Longevity through Diet: From Model Organisms to Humans
Fontana, L., & Partridge, L. (2015) · Cell · doi:10.1016/j.cell.2015.02.020 · Cited by 1,245
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Commensal bacteria and essential amino acids control food choice behavior and reproduction
Leitão-Gonçalves, R., Carvalho-Santos, Z., Francisco, A. P., Fioreze, G. T., Anjos, M., Baltazar, C., Elias, A. P., Itskov, P. M., Piper, M. D. W., & Ribeiro, C. (2017) · PLOS Biology · doi:10.1371/journal.pbio.2000862 · Cited by 315
A gut microbial factor modulates locomotor behaviour in Drosophila
Schretter, C. E., Vielmetter, J., Bartos, I., Marka, Z., Marka, S., Argade, S., & Mazmanian, S. K. (2018) · Nature · doi:10.1038/s41586-018-0634-9 · Cited by 289
Metadata
- Authors
- Wong, A. C.-N., Dobson, A. J., & Douglas, A. E.
- Venue
- Journal of Experimental Biology
- Publisher
- The Company of Biologists
- Published
- 2014-01-01
- Volume
- 217
- Issue
- Pt 11
- Pages
- 1894-901
- ISSN
- 0022-0949 (ISSN-L)
- 1477-9145
- OpenAlex
- W2125452584
- Cited by
- 305
- References
- 53
- FWCI
- 7.18
- Type
- journal article
- Language
- en
- Open access
- bronze
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