Prophylactic Mastectomy in BRCA1/2 Mutation Carriers and Women at Risk of Hereditary Breast Cancer: Long-Term Experiences at the Rotterdam Family Cancer Clinic

Heemskerk-Gerritsen, Bernadette A. M.; Brekelmans, Cecile T. M.; Menke-Pluymers, Marian B. E.; van Geel, Albert N.; Tilanus-Linthorst, Madeleine M. A.; Bartels, Carina C. M.; Tan, Murly; Meijers-Heijboer, Hanne E. J.; Klijn, Jan G. M.; Seynaeve, Caroline

doi:10.1245/s10434-007-9449-x

Cited by 153BRCA gene mutations in cancerBreast Implant and ReconstructionWomen's cancer prevention and management

Prophylactic Mastectomy in BRCA1/2 Mutation Carriers and Women at Risk of Hereditary Breast Cancer: Long-Term Experiences at the Rotterdam Family Cancer Clinic

Open access

Heemskerk-Gerritsen, Bernadette A. M., Brekelmans, Cecile T. M., Menke-Pluymers, Marian B. E., van Geel, Albert N., Tilanus-Linthorst, Madeleine M. A., Bartels, Carina C. M., Tan, Murly, Meijers-Heijboer, Hanne E. J. +2 more·2007·Annals of Surgical Oncology

DOI 10.1245/s10434-007-9449-xPMC PMC2077910

Open this paper in CoChat — free account Open PDF

Abstract

BACKGROUND: BRCA1/2 mutation carriers and women from a hereditary breast(/ovarian) cancer family have a highly increased risk of developing breast cancer (BC). Prophylactic mastectomy (PM) results in the greatest BC risk reduction. Long-term data on the efficacy and sequels of PM are scarce. METHODS: From 358 high-risk women (including 236 BRCA1/2 carriers) undergoing PM between 1994 and 2004, relevant data on the occurrence of BC in relation to PM, complications in relation to breast reconstruction (BR), mutation status, age at PM and preoperative imaging examination results were extracted from the medical records, and analyzed separately for women without (unaffected, n = 177) and with a BC history (affected, n = 181). RESULTS: No primary BCs occurred after PM (median follow-up 4.5 years). In one previously unaffected woman, metastatic BC was detected almost 4 years after PM (primary BC not found). Median age at PM was younger in unaffected women (P < .001), affected women more frequently were 50% risk carriers (P < .001). Unexpected (pre)malignant changes at PM were found in 3% of the patients (in 5 affected, and 5 unaffected women, respectively). In 49.6% of the women opting for BR one or more complications were registered, totaling 215 complications, leading to 153 surgical interventions (71%). Complications were mainly related to cosmetic outcome (36%) and capsular formation (24%). CONCLUSIONS: The risk of developing a primary BC after PM remains low after longer follow-up. Preoperative imaging and careful histological examination is warranted because of potential unexpected (pre)malignant findings. The high complication rate after breast reconstruction mainly concerns cosmetic issues.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1245/s10434-007-9449-x

Cites

38 of 38 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Selection bias for referral to the psychologist occurred, supported by the observation that unaffected women significantly exceeded affected women whereas the institution's prophylactic mastectomy population is about 50% affected.
“The observation that the number of unaffected women significantly exceeded that of the affected women, whereas the number of women having undergone PM at our institution consists of about 50% affected women [26], supports the idea that selection bias for referral to the psychologist has indeed occurred.”
From Standard psychological consultations and follow up for women at increased risk of hereditary breast cancer considering prophylactic mastectomy (2009) · cites this paper as [26]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Genetic heterogeneity and penetrance analysis of the BRCA1 and BRCA2 genes in breast cancer families. The Breast Cancer Linkage Consortium.
Ford, D., Easton, D., Stratton, M. R., Narod, S., Goldgar, D., Devilee, P., Bishop, D., Weber, B., Lenoir, G., Chang-Claude, J., et al. (1998) · American Journal of Human Genetics · doi:10.1086/301749 · Cited by 2,766 · see citing works
The risk of cancer associated with specific mutations of BRCA1 and BRCA2 among Ashkenazi Jews.
Struewing, J., Hartge, P., Wacholder, S., Baker, S. M., Berlin, M., McAdams, M., Timmerman, M. M., Brody, L., & Tucker, M. A. (1997) · New England Journal of Medicine · doi:10.1056/nejm199705153362001 · Cited by 2,399 · see citing works
Breast and Ovarian Cancer Risks Due to Inherited Mutations in BRCA1 and BRCA2
King, M.-C., Marks, J. H., & Mandell, J. B. (2003) · Science · doi:10.1126/science.1088759 · Cited by 2,229 · see citing works
Risks of cancer in BRCA1-mutation carriers
FORD, D. (1994) · The Lancet · doi:10.1016/s0140-6736(94)91578-4 · Cited by 1,850 · see citing works
Efficacy of MRI and Mammography for Breast-Cancer Screening in Women with a Familial or Genetic Predisposition
Kriege, M., Brekelmans, C. T. M., Boetes, C., Besnard, P. E., Zonderland, H. M., Obdeijn, I. M., Manoliu, R. A., Kok, T., Peterse, H. L., Tilanus‐Linthorst, M. M. A., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa031759 · Cited by 1,686 · see citing works
Self-citation
Efficacy of Bilateral Prophylactic Mastectomy in Women with a Family History of Breast Cancer
Hartmann, L. C., Schaid, D. J., Woods, J. E., Crotty, T. P., Myers, J. L., Arnold, P. G., Petty, P. M., Sellers, T. A., Johnson, J. L., McDonnell, S. K., et al. (1999) · New England Journal of Medicine · doi:10.1056/nejm199901143400201 · Cited by 1,428 · see citing works
Bilateral Prophylactic Mastectomy Reduces Breast Cancer Risk in BRCA1 and BRCA2 Mutation Carriers: The PROSE Study Group
Rebbeck, T. R., Friebel, T., Lynch, H. T., Neuhausen, S. L., van ’t Veer, L., Garber, J. E., Evans, G. R., Narod, S. A., Isaacs, C., Matloff, E., et al. (2004) · Journal of Clinical Oncology · doi:10.1200/jco.2004.04.188 · Cited by 1,171 · see citing works
Mammography, Breast Ultrasound, and Magnetic Resonance Imaging for Surveillance of Women at High Familial Risk for Breast Cancer
Kuhl, C. K., Schrading, S., Leutner, C., Morakkabati-Spitz, N., Wardelmann, E., Fimmers, R., Kuhn, W. C., & Schild, H. H. (2005) · Journal of Clinical Oncology · doi:10.1200/jco.2004.00.4960 · Cited by 1,148 · see citing works
Breast Cancer after Prophylactic Bilateral Mastectomy in Women with aBRCA1orBRCA2Mutation
Meijers-Heijboer, H., van Geel, B., van Putten, W. L. J., Henzen-Logmans, S. C., Seynaeve, C., Menke-Pluymers, M. B. E., Bartels, C. C. M., Verhoog, L. C., van den Ouweland, A. M. W., Niermeijer, M. F., et al. (2001) · New England Journal of Medicine · doi:10.1056/nejm200107193450301 · Cited by 973 · cited 3× · see citing works
“33 Necrosis 1 (1) 3 (5) Capsular formation 31 (37) 20 (35) Prosthesis luxation 2 (2) 3 (5) Poor cosmetic appearance d 31 (37) 19 (34) Dog ear 16 (19) 12 (21)”
Self-citation
Efficacy of Bilateral Prophylactic Mastectomy in BRCA1 and BRCA2 Gene Mutation Carriers
Hartmann, L. C., Sellers, T. A., Schaid, D. J., Frank, T. S., Soderberg, C. L., Sitta, D. L., Frost, M. H., Grant, C. S., Donohue, J. H., Woods, J. E., et al. (2001) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/93.21.1633 · Cited by 743 · see citing works
Contralateral Breast Cancer in BRCA1 and BRCA2 Mutation Carriers
Metcalfe, K. A., Lynch, H. T., Ghadirian, P., Tung, N., Olivotto, I. A., Warner, E., Olopade, O. I., Eisen, A. F., Weber, B., McLennan, J., et al. (2004) · Journal of Clinical Oncology · doi:10.1200/jco.2004.04.033 · Cited by 620 · see citing works
Survival and tumour characteristics of breast-cancer patients with germline mutations of BRCA1
Verhoog, L., Brekelmans, C., Seynaeve, C., van den Bosch, L., Dahmen, G., van Geel, A., Tilanus-Linthorst, M., Bartels, C., Wagner, A., van den Ouweland, A., et al. (1998) · The Lancet · doi:10.1016/s0140-6736(97)07065-7 · Cited by 452 · see citing works
Self-citation
Presymptomatic DNA testing and prophylactic surgery in families with a BRCA1 or BRCA2 mutation.
Meijers-Heijboer, E. J., Verhoog, L., Brekelmans, C., Seynaeve, C., Tilanus-Linthorst, M., Wagner, A., Dukel, L., Devilee, P., van den Ouweland, A. V. D., van Geel, A. V., et al. (2000) · The Lancet · doi:10.1016/s0140-6736(00)02347-3 · Cited by 328 · see citing works
Self-citation
BRCA-associated breast cancer in young women.
Robson, M. E., Gilewski, T., Haas, B. R., Levin, D. R., Borgen, P. I., Rajan, P., Hirschaut, Y., Pressman, P., Rosen, P. P., LESSER, M. L., et al. (1998) · Journal of Clinical Oncology · doi:10.1200/jco.1998.16.5.1642 · Cited by 303 · see citing works
Survival in hereditary breast cancer associated with germline mutations of BRCA2.
Verhoog, L., Brekelmans, C., Seynaeve, C., Dahmen, G., van Geel, A. V., Bartels, C., Tilanus-Linthorst, M., Wagner, A., Devilee, P., Halley, D., et al. (1999) · Journal of Clinical Oncology · doi:10.1200/jco.1999.17.11.3396 · Cited by 197 · see citing works
Self-citation
Incidence of Metachronous Testicular Cancer in Patients With Extragonadal Germ Cell Tumors
Hartmann, J. T., Fosså, S. D., Nichols, C. R., Droz, J., Horwich, A., Gerl, A., Beyer, J., Pont, J., Fizazi, K. S., Hecker, H., et al. (2001) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/93.22.1733 · Cited by 162 · see citing works
Use of genetic testing and prophylactic mastectomy and oophorectomy in women with breast or ovarian cancer from families with a BRCA1 or BRCA2 mutation.
Meijers-Heijboer, H., Brekelmans, C., Menke-Pluymers, M., Seynaeve, C., Baalbergen, A., Burger, C., Crepin, E., van den Ouweland, A. V. D., van Geel, B. V., & Klijn, J. (2003) · Journal of Clinical Oncology · doi:10.1200/jco.2003.09.052 · Cited by 150 · see citing works
Self-citation
High Prevalence of Premalignant Lesions in Prophylactically Removed Breasts From Women at Hereditary Risk for Breast Cancer
Hoogerbrugge, N., Bult, P., de Widt-Levert, L. M., Beex, L. V. A. M., Kiemeney, L. A. L. M., Ligtenberg, M. J. L., Massuger, L., Boetes, C., Manders, P., & Brunner, H. G. (2002) · Journal of Clinical Oncology · doi:10.1200/jco.2003.02.137 · Cited by 149 · see citing works
Morbidity of immediate breast reconstruction (IBR) after mastectomy by a subpectorally placed silicone prosthesis:the adverse effect of radiotherapy
Contant, C. M. E., van Geel, A. N., van der Holt, B., Griep, C., Wai, R. T. J., & Wiggers, T. (2000) · European Journal of Surgical Oncology · doi:10.1053/ejso.1999.0896 · Cited by 139 · see citing works
Contralateral breast cancer risk is influenced by the age at onset in BRCA1-associated breast cancer
Verhoog, L., Brekelmans, C., Seynaeve, C., Meijers-Heijboer, E., & Klijn, J. (2000) · British Journal of Cancer · doi:10.1054/bjoc.2000.1239 · Cited by 135 · see citing works
Self-citation
Risk of breast cancer recurrence and contralateral breast cancer in relation to BRCA1 and BRCA2 mutation status following breast-conserving surgery and radiotherapy
Kirova, Y. M., Stoppa-Lyonnet, D., Savignoni, A., Sigal-Zafrani, B., Fabre, N., & Fourquet, A. (2005) · European Journal of Cancer · doi:10.1016/j.ejca.2005.02.037 · Cited by 129 · see citing works
An Outcome Study of Breast Reconstruction: Presurgical Identification of Risk Factors for Complications
Lin, K. Y. K., Johns, F. R., Gibson, J. J., Long, M. D., Drake, D. B., & Moore, M. M. (2001) · Annals of Surgical Oncology · doi:10.1007/s10434-001-0586-3 · Cited by 117 · see citing works
Satisfaction with Prophylactic Mastectomy and Breast Reconstruction in Genetically Predisposed Women
Bresser, P. J. C., Seynaeve, C., Gool, A. R. V., Brekelmans, C. T. M., Meijers-Heijboer, H. E. J., van Geel, A. N., Menke‐Pluijmers, M. B. E., Duivenvoorden, H. J., Klijn, J. G. M., & Tibben, A. (2006) · Plastic & Reconstructive Surgery · doi:10.1097/01.prs.0000217383.99038.f5 · Cited by 117 · see citing works
Self-citation
Outcome of surveillance and prophylactic salpingo-oophorectomy in asymptomatic women at high risk for ovarian cancer.
Meeuwissen, P. A. M., Seynaeve, C., Brekelmans, C., Meijers-Heijboer, H., Klijn, J., & Burger, C. (2005) · Gynecologic Oncology · doi:10.1016/j.ygyno.2005.01.024 · Cited by 107 · see citing works
Self-citation
Selective use of sentinel lymph node surgery during prophylactic mastectomy
Boughey, J. C., Khakpour, N., Meric‐Bernstam, F., Ross, M. I., Kuerer, H. M., Singletary, S. E., Babiera, G. V., Arun, B., Hunt, K. K., & Bedrosian, I. (2006) · Cancer · doi:10.1002/cncr.22176 · Cited by 84 · see citing works
Risk of ovarian cancer in breast-cancer patients with a family history of breast or ovarian cancer: a population-based cohort study.
Bergfeldt, K., Rydh, B., Granath, F., Grönberg, H., Thalib, L., Adami, H., & Hall, P. (2002) · The Lancet · doi:10.1016/s0140-6736(02)11023-3 · Cited by 79 · see citing works
Reoperations after prophylactic mastectomy with or without implant reconstruction
Zion, S. M., Slezak, J. M., Sellers, T. A., Woods, J. E., Arnold, P. G., Petty, P. M., Donohue, J. H., Frost, M. H., Schaid, D. J., & Hartmann, L. C. (2003) · Cancer · doi:10.1002/cncr.11757 · Cited by 79 · see citing works
Clinical experience of prophylactic mastectomy followed by immediate breast reconstruction in women at hereditary risk of breast cancer (HB(O)C) or a proven BRCA1 and BRCA2 germ-line mutation.
Contant, C., Menke-Pluijmers, M., Seynaeve, C., Meijers-Heijboer, E. J., Klijn, J. G., Verhoog, L., Wai, R. T. J., Eggermont, A., & van Geel, A. V. (2002) · European Journal of Surgical Oncology · doi:10.1053/ejso.2002.1279 · Cited by 78 · see citing works
Self-citation
Complications Following Bilateral Prophylactic Mastectomy
Barton, M. B. (2005) · JNCI Monographs · doi:10.1093/jncimonographs/lgi039 · Cited by 78 · see citing works
Large regional differences in the frequency of distinct BRCA1/BRCA2 mutations in 517 Dutch breast and/or ovarian cancer families
Verhoog, L. C., van den Ouweland, A. M. W., Berns, E., van Veghel–Plandsoen, M. M., van Staveren, I. L., Wagner, A., Bartels, C. C. M., Tilanus‐Linthorst, M. M. A., Devilee, P., Seynaeve, C., et al. (2001) · European Journal of Cancer · doi:10.1016/s0959-8049(01)00244-1 · Cited by 76 · see citing works
Self-citation
Prophylactic Mastectomy
Khurana, K. K., Loosmann, A., Numann, P. J., & Khan, S. A. (2000) · Archives of Pathology & Laboratory Medicine · doi:10.5858/2000-124-0378-pmpfih · Cited by 51 · see citing works
Systematic review of management options for women with a hereditary predisposition to ovarian cancer
Rosen, B. P., KWON, J., Fung‐Kee‐Fung, M., Gagliardi, A. R., CHAMBERS, A., & CANCERCAREONTARIOSPRACTICEGUI (2004) · Gynecologic Oncology · doi:10.1016/j.ygyno.2004.02.013 · Cited by 37 · see citing works
High risk of contralateral breast carcinoma in women with hereditary/familial non‐BRCA1/BRCA2 breast carcinoma
Shahedi, K., Emanuelsson, M., Wiklund, F., & Grönberg, H. (2006) · Cancer · doi:10.1002/cncr.21753 · Cited by 29 · see citing works
Selection bias influences reported contralateral breast cancer incidence and survival in high risk non-BRCA1/2 patients
Tilanus‐Linthorst, M. M. A., Bartels, K. C. M., Alves, C., Bakri, B., Crepin, E., van den Ouweland, A., Klijn, J. G. M., Meijers-Heijboer, H. E. J., & Brekelmans, C. T. M. (2005) · Breast Cancer Research and Treatment · doi:10.1007/s10549-005-9054-2 · Cited by 23 · see citing works
Self-citation
Clinical, pathological and genetic features of women at high familial risk of breast cancer undergoing prophylactic mastectomy
Scott, C. L., Iorgulescu, D., Thorne, H., Henderson, M., & Phillips, K. (2003) · Clinical Genetics · doi:10.1034/j.1399-0004.2003.00097.x · Cited by 20 · see citing works
Mastectomy by Inverted Drip Incision and Immediate Reconstruction: Data From 510 Cases
van Geel, A. N., Contant, C. M. E., Wai, R. T. J., Schmitz, P. I. M., Eggermont, A. M. M., & Menke-Pluijmers, M. M. E. (2003) · Annals of Surgical Oncology · doi:10.1245/aso.2003.07.007 · Cited by 17 · see citing works
Long-term follow-up of the Rotterdam study on prophylactic mastectomy versus surveillance in BRCA1/2 mutation carriers
Klijn, J. G. M., van Geel, A. N., Meijers-Heijboer, H. E. J., Tilanus‐Linthorst, M. M. A., Bartels, C. C. M., Crépin, C., Seynaeve, C., Menke‐Pluymers, M. B. E., & Brekelmans, C. T. M. (2004) · Journal of Clinical Oncology · doi:10.1200/jco.2004.22.90140.9502 · Cited by 7 · see citing works
Self-citation
Reoperations after prophylactic mastectomy with or without implant reconstruction
Zion, S. M., Slezak, J. M., Sellers, T. A., & Chang, D. W. (2004) · Breast Diseases A Year Book Quarterly · Cited by 2 · see citing works

Flagged first, then by citations

Sorted by citations

Risk Assessment, Genetic Counseling, and Genetic Testing for BRCA -Related Cancer
US Preventive Services Task Force, Owens, D. K., Davidson, K. W., Krist, A. H., Barry, M. J., Cabana, M. D., Caughey, A. B., Doubeni, C. A., Epling, J. W., Kubik, M., et al. (2019) · JAMA · doi:10.1001/jama.2019.10987 · Cited by 469 · see citing works
Prevention and screening in BRCA mutation carriers and other breast/ovarian hereditary cancer syndromes: ESMO Clinical Practice Guidelines for cancer prevention and screening
Paluch–Shimon, S., Cardoso, F., Sessa, C., Balmañà, J., Cardoso, M. J., Gilbert, F. J., & Senkus, E. (2016) · Annals of Oncology · doi:10.1093/annonc/mdw327 · Cited by 400 · see citing works
Risk-reducing mastectomy for the prevention of primary breast cancer
Carbine, N. E., Lostumbo, L., Wallace, J., & Ko, H. (2018) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd002748.pub4 · Cited by 270 · see citing works
The Role of Risk-Reducing Surgery in Hereditary Breast and Ovarian Cancer
Hartmann, L. C., & Lindor, N. M. (2016) · New England Journal of Medicine · doi:10.1056/nejmra1503523 · Cited by 254 · see citing works
Pathology of hereditary breast cancer
van der Groep, P., van der Wall, E., & van Diest, P. J. (2011) · Cellular Oncology · doi:10.1007/s13402-011-0010-3 · Cited by 180 · see citing works
BRCA mutations in the management of breast cancer: the state of the art
Narod, S. A. (2010) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2010.166 · Cited by 160 · see citing works
Risk Assessment, Genetic Counseling, and Genetic Testing forBRCA-Related Cancer in Women
Nelson, H. D., Pappas, M., Cantor, A. G., Haney, E. M., & Holmes, R. S. (2019) · JAMA · doi:10.1001/jama.2019.8430 · Cited by 145 · see citing works
Bilateral prophylactic mastectomy in women with inherited risk of breast cancer – Prevalence of pain and discomfort, impact on sexuality, quality of life and feelings of regret two years after surgery
Gahm, J., Wickman, M., & Brandberg, Y. (2010) · The Breast · doi:10.1016/j.breast.2010.05.003 · Cited by 143 · see citing works
Nipple-Sparing Mastectomy in BRCA1/2 Mutation Carriers: An Interim Analysis and Review of the Literature
Yao, K. A., Liederbach, E., Tang, R., Lei, L., Czechura, T., Sisco, M., Howard, M. A., Hulick, P. J., Winchester, D. J., Coopey, S. B., et al. (2014) · Annals of Surgical Oncology · doi:10.1245/s10434-014-3883-3 · Cited by 130 · see citing works
Hereditary Breast Cancer: Clinical, Pathological and Molecular Characteristics
Larsen, M. J., Thomassen, M., Gerdes, A., & Kruse, T. A. (2014) · Breast Cancer Basic and Clinical Research · doi:10.4137/bcbcr.s18715 · Cited by 117 · see citing works
Risk‐reducing mastectomy and salpingo‐oophorectomy in unaffected BRCA mutation carriers: uptake and timing*
Skytte, A., Gerdes, A., Andersen, M., Sunde, L., Brøndum‐Nielsen, K., Waldstrøm, M., Kølvraa, S., & Crüger, D. G. (2010) · Clinical Genetics · doi:10.1111/j.1399-0004.2009.01329.x · Cited by 118 · see citing works
Body image issues after bilateral prophylactic mastectomy with breast reconstruction in healthy women at risk for hereditary breast cancer
Gopie, J. P., Mureau, M. A. M., Seynaeve, C., ter Kuile, M. M., Menke‐Pluymers, M. B. E., Timman, R., & Tibben, A. (2012) · Familial Cancer · doi:10.1007/s10689-012-9588-5 · Cited by 118 · see citing works
Self-citation
Determinants of optimal mastectomy skin flap thickness
Robertson, S. A., Rusby, J. E., & Cutress, R. (2014) · British journal of surgery · doi:10.1002/bjs.9470 · Cited by 102 · see citing works
RANKL and RANK: From Mammalian Physiology to Cancer Treatment
Rao, S., Cronin, S. J. F., Sigl, V., & Penninger, J. M. (2017) · Trends in Cell Biology · doi:10.1016/j.tcb.2017.11.001 · Cited by 95 · see citing works
Prophylactic Mastectomy in BRCA1 and BRCA2 Mutation Carriers: Very Low Risk for Subsequent Breast Cancer
Kaas, R., Verhoef, S., Wesseling, J., Rookus, M., Oldenburg, H., Peeters, M., & Rutgers, E. (2010) · Annals of Surgery · doi:10.1097/sla.0b013e3181c3c36d · Cited by 92 · see citing works
Risk reducing mastectomy: outcomes in 10 European centres
Evans, D. G., Baildam, A. D., Anderson, E. D. C., Brain, A., Shenton, A., Vasen, H. F. A., Eccles, D., Lucassen, A., Pichert, G., Hamed, H., et al. (2008) · Journal of Medical Genetics · doi:10.1136/jmg.2008.062232 · Cited by 86 · see citing works
Surveillance of prophylactic mastectomy
McLaughlin, C. C., Lillquist, P. P., & Edge, S. B. (2009) · Cancer · doi:10.1002/cncr.24623 · Cited by 83 · see citing works
Hereditary lobular breast cancer with an emphasis on E-cadherin genetic defect
Corso, G., Figueiredo, J., Vecchia, C. L., Veronesi, P., Pravettoni, G., Macis, D., Karam, R., Gullo, R. L., Provenzano, E., Toesca, A., et al. (2018) · Journal of Medical Genetics · doi:10.1136/jmedgenet-2018-105337 · Cited by 84 · see citing works
Adverse Obstetric and Perinatal Outcomes following Treatment of Adolescent and Young Adult Cancer: A Population-Based Cohort Study
Haggar, F. A., Pereira, G. F., Preen, D. B., Holman, C. D. J., & Einarsdóttir, K. (2014) · PLoS ONE · doi:10.1371/journal.pone.0113292 · Cited by 83 · see citing works
Updates on breast cancer genetics: Clinical implications of detecting syndromes of inherited increased susceptibility to breast cancer
Cobain, E. F., Milliron, K. J., & Merajver, S. D. (2016) · Seminars in Oncology · doi:10.1053/j.seminoncol.2016.10.001 · Cited by 80 · see citing works
Society of Surgical Oncology Breast Disease Working Group Statement on Prophylactic (Risk-Reducing) Mastectomy
Hunt, K. K., Euhus, D., Boughey, J. C., Chagpar, A. B., Feldman, S. M., Hansen, N. M., Kulkarni, S., McCready, D. R., Mamounas, E. P., Wilke, L. G., et al. (2016) · Annals of Surgical Oncology · doi:10.1245/s10434-016-5688-z · Cited by 79 · see citing works
Missed therapeutic and prevention opportunities in women with BRCA‐mutated epithelial ovarian cancer and their families due to low referral rates for genetic counseling and BRCA testing: A review of the literature
Hoskins, P. J., & Gotlieb, W. H. (2017) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.21408 · Cited by 77 · see citing works
Contralateral prophylactic mastectomy and survival: report from the National Cancer Data Base, 1998–2002
Yao, K. A., Winchester, D. J., Czechura, T., & Huo, D. (2013) · Breast Cancer Research and Treatment · doi:10.1007/s10549-013-2745-1 · Cited by 76 · see citing works
Risk-reducing strategies for women carrying brca1/2 mutations with a focus on prophylactic surgery
Salhab, M., Bismohun, S., & Mokbel, K. (2010) · BMC Women s Health · doi:10.1186/1472-6874-10-28 · Cited by 70 · see citing works
Impact that Timing of Genetic Mutation Diagnosis has on Surgical Decision Making and Outcome for BRCA1/BRCA2 Mutation Carriers with Breast Cancer
Chiba, A., Hoskin, T. L., Hallberg, E. J., Cogswell, J. A., Heins, C. N., Couch, F. J., & Boughey, J. C. (2016) · Annals of Surgical Oncology · doi:10.1245/s10434-016-5328-7 · Cited by 70 · see citing works
Breast cancer after bilateral risk-reducing mastectomy
Skytte, A., Crüger, D. G., Gerster, M., Lænkholm, A., Lang, C., Brøndum‐Nielsen, K., Andersen, M., Sunde, L., Kølvraa, S., & Gerdes, A. (2011) · Clinical Genetics · doi:10.1111/j.1399-0004.2010.01604.x · Cited by 66 · see citing works
High-throughput functional evaluation of BRCA2 variants of unknown significance
Ikegami, M., Kohsaka, S., Ueno, T., Momozawa, Y., Inoue, S., Tamura, K., Shimomura, A., Hosoya, N., Kobayashi, H., Tanaka, S., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-16141-8 · Cited by 62 · see citing works
Women’s motives to opt for either implant or DIEP-flap breast reconstruction
Gopie, J. P., Hilhorst, M. T., Kleijne, A., Timman, R., Menke‐Pluymers, M. B. E., Hofer, S. O. P., Mureau, M. A. M., & Tibben, A. (2011) · Journal of Plastic Reconstructive & Aesthetic Surgery · doi:10.1016/j.bjps.2011.03.030 · Cited by 61 · see citing works
Self-citation
Bilateral Prophylactic Mastectomy in Swedish Women at High Risk of Breast Cancer
Arver, B. W., Isaksson, K., Atterhem, H., Baan, A., Bergkvist, L., Brandberg, Y., Ehrencrona, H., Emanuelsson, M., Hellborg, H., Henriksson, K. M., et al. (2011) · Annals of Surgery · doi:10.1097/sla.0b013e318214b55a · Cited by 61 · see citing works
The impact of an interventional counselling procedure in families with a BRCA1/2 gene mutation: efficacy and safety
Sermijn, E., Delesie, L. M., Deschepper, E., Pauwels, I., Bonduelle, M., Teugels, E., & Grève, J. D. (2016) · Familial Cancer · doi:10.1007/s10689-015-9854-4 · Cited by 61 · see citing works
Network-pharmacology-based validation of TAMS/CXCL-1 as key mediator of XIAOPI formula preventing breast cancer development and metastasis
Wang, N., Zheng, Y., Gu, J., Cai, Y., Wang, S., Zhang, F., Chen, J., Situ, H., Lin, Y. H., & Wang, Z. (2017) · Scientific Reports · doi:10.1038/s41598-017-15030-3 · Cited by 60 · see citing works
Genetic counselling and testing for inherited gene mutations in newly diagnosed patients with breast cancer: a review of the existing literature and a proposed research agenda
Meiser, B., Tucker, K., Friedlander, M. L., Barlow-Stewart, K. K., Lobb, E. A., Saunders, C. M., & Mitchell, G. (2008) · Breast Cancer Research · doi:10.1186/bcr2194 · Cited by 58 · see citing works
No Differences in Aesthetic Outcome or Patient Satisfaction between Anatomically Shaped and Round Expandable Implants in Bilateral Breast Reconstructions: A Randomized Study
Gahm, J., Edsander-Nord, Å., Jurell, G., & Wickman, M. (2010) · Plastic & Reconstructive Surgery · doi:10.1097/prs.0b013e3181ef8b01 · Cited by 53 · see citing works
Overview of indications for nipple sparing mastectomy
Tousimis, E. A., & Haslinger, M. L. (2018) · Gland Surgery · doi:10.21037/gs.2017.11.11 · Cited by 53 · see citing works
Patient satisfaction with aesthetic outcome after bilateral prophylactic mastectomy and immediate reconstruction with implants
Gahm, J., Jurell, G., Edsander-Nord, Å., & Wickman, M. (2008) · Journal of Plastic Reconstructive & Aesthetic Surgery · doi:10.1016/j.bjps.2008.11.014 · Cited by 52 · see citing works
A systematic review of men's experiences of their partner's mastectomy: coping with altered bodies
Rowland, E., & Metcalfe, A. (2014) · Psycho-Oncology · doi:10.1002/pon.3556 · Cited by 51 · see citing works
Residual Breast Tissue after Mastectomy: How Often and Where Is It Located?
Griepsma, M., van Zuidewijn, D. B. W. D. R., Grond, A. J. K., Siesling, S., Groen, H., & de Bock, G. H. (2013) · Annals of Surgical Oncology · doi:10.1245/s10434-013-3383-x · Cited by 49 · see citing works
Radiotherapy in the Treatment of Hereditary Breast Cancer
Pierce, L. J., & Haffty, B. G. (2010) · Seminars in Radiation Oncology · doi:10.1016/j.semradonc.2010.08.008 · Cited by 49 · see citing works
Time to prophylactic surgery in BRCA1/2 carriers depends on psychological and other characteristics
Julian‐Reynier, C., Bouhnik, A., Mouret-Fourme, E., Gauthier‐Villars, M., Berthet, P., Lasset, C., Fricker, J., Caron, O., Gesta, P., Luporsi, É., et al. (2010) · Genetics in Medicine · doi:10.1097/gim.0b013e3181f48d1c · Cited by 46 · see citing works
Genetic Risk Assessments in Individuals at High Risk for Inherited Breast Cancer in the Breast Oncology Care Setting
Pal, T., & Vadaparampil, S. T. (2012) · Cancer Control · doi:10.1177/107327481201900402 · Cited by 44 · see citing works
Surgical Decision Making in the BRCA-Positive Population: Institutional Experience and Comparison with Recent Literature
Flippo-Morton, T. S., Walsh, K. K., Chambers, K. M., Amacker-North, L., White, B., Sarantou, T., Boselli, D. M., & White, R. L. (2015) · The Breast Journal · doi:10.1111/tbj.12521 · Cited by 42 · see citing works
High satisfaction rate ten years after bilateral prophylactic mastectomy - a longitudinal study
Wasteson, E., Sandelin, K., Brandberg, Y., Wickman, M., & Arver, B. W. (2010) · European Journal of Cancer Care · doi:10.1111/j.1365-2354.2010.01204.x · Cited by 36 · see citing works
The psychological impact of breast and ovarian cancer preventive options in BRCA1 and BRCA2 mutation carriers
Borreani, C., Manoukian, S., Bianchi, E., Brunelli, C., Peissel, B., Caruso, A., Morasso, G., & Pierotti, M. A. (2014) · Clinical Genetics · doi:10.1111/cge.12298 · Cited by 38 · see citing works
Cardiovascular risk of BRCA1/2 mutation carriers: A review
van Westerop, L., Jong, M. A.-D., Hoogerbrugge, N., de Hullu, J. A., & Maas, A. H. E. M. (2016) · Maturitas · doi:10.1016/j.maturitas.2016.06.012 · Cited by 36 · see citing works
Contralateral prophylactic mastectomy rate and predictive factors among patients with breast cancer who underwent multigene panel testing for hereditary cancer
Elsayegh, N., Webster, R. D., Gutierrez‐Barrera, A. M., Lin, H. Y., Kuerer, H. M., Litton, J. K., Bedrosian, I., & Arun, B. (2018) · Cancer Medicine · doi:10.1002/cam4.1519 · Cited by 34 · see citing works
Hereditary breast cancer: from bench to bedside
Grève, J. D., Sermijn, E., Brakeleer, S. D., Ren, Z., & Teugels, E. (2008) · Current Opinion in Oncology · doi:10.1097/cco.0b013e3283139173 · Cited by 32 · see citing works
Genetic Predisposition Syndromes and Their Management
Euhus, D., & Robinson, L. D. (2013) · Surgical Clinics of North America · doi:10.1016/j.suc.2013.01.005 · Cited by 32 · see citing works
International variation in physicians’ attitudes towards prophylactic mastectomy – Comparison between France, Germany, the Netherlands and the United Kingdom
Heijer, M. D., van Asperen, C. J., Harris, H. J., Nippert, I., Schmidtke, J., Bouhnik, A., Julian‐Reynier, C., Evans, D. G., & Tibben, A. (2013) · European Journal of Cancer · doi:10.1016/j.ejca.2013.04.025 · Cited by 31 · see citing works
Management of breast cancer risk inBRCA1/2mutation carriers who are unaffected with cancer
Collins, J. M., & Isaacs, C. J. (2020) · The Breast Journal · doi:10.1111/tbj.13970 · Cited by 28 · see citing works
Survivorship considerations in adults with hereditary breast and ovarian cancer syndrome: state of the science
Crotser, C. B., & Boehmke, M. M. (2009) · Journal of Cancer Survivorship · doi:10.1007/s11764-008-0077-7 · Cited by 28 · see citing works
Standard psychological consultations and follow up for women at increased risk of hereditary breast cancer considering prophylactic mastectomy
Tan, M. B., Bleiker, E. M., Menke-Pluymers, M. B., Van Gool, A. R., van Dooren, S., Van Geel, B. N., Tilanus-Linthorst, M. M., Bartels, K. C., Klijn, J. G., Brekelmans, C. T., et al. (2009) · Hereditary Cancer in Clinical Practice · doi:10.1186/1897-4287-7-6 · Cited by 27 · see citing works
“The observation that the number of unaffected women significantly exceeded that of the affected women, whereas the number of women having undergone PM at our institution consists of about 50% affected women [26], supports the idea that selection bias for referral to the psychologist has indeed occurred.”
ResultSelf-citation
Novel one-stop multidisciplinary follow-up clinic significantly improves cancer risk management in BRCA1/2 carriers
Pichert, G., Jacobs, C., Jacobs, I. J., Menon, U., Manchanda, R., Johnson, M., Hamed, H., Firth, C., Evison, M., Tutt, A. N. J., et al. (2010) · Familial Cancer · doi:10.1007/s10689-010-9333-x · Cited by 24 · see citing works
Predictors that Influence Contralateral Prophylactic Mastectomy Election Among Women with Ductal Carcinoma In Situ Who Were Evaluated for BRCA Genetic Testing
Elsayegh, N., Kuerer, H. M., Lin, H. Y., Gutierrez‐Barrera, A. M., Jackson, M., Muse, K. I., Litton, J. K., Albarracin, C. T., Afrough, A., Hortobágyi, G. N., et al. (2014) · Annals of Surgical Oncology · doi:10.1245/s10434-014-3747-x · Cited by 23 · see citing works
Incidence of Occult Breast Cancer in Carriers of BRCA1/2 or Other High-Penetrance Pathogenic Variants Undergoing Prophylactic Mastectomy: When is Sentinel Lymph Node Biopsy Indicated?
Wong, S. M., Ferroum, A., Apostolova, C., Alhassan, B., Prakash, I., Basik, M., Boileau, J. F., Meterissian, S. H., Aleynikova, O., Wong, N., et al. (2022) · Annals of Surgical Oncology · doi:10.1245/s10434-022-11916-3 · Cited by 22 · see citing works
Feasibility evaluation of an online tool to guide decisions for BRCA1/2 mutation carriers
Schackmann, E. A., Muñoz, D. F., Mills, M. A., Plevritis, S. K., & Kurian, A. W. (2012) · Familial Cancer · doi:10.1007/s10689-012-9577-8 · Cited by 21 · see citing works
Cost–utility analysis of risk-reducing strategies to prevent breast and ovarian cancer in BRCA-mutation carriers in Switzerland
Bommer, C., Lupatsch, J. E., Bürki, N., & Schwenkglenks, M. M. (2021) · The European Journal of Health Economics · doi:10.1007/s10198-021-01396-9 · Cited by 21 · see citing works
Postoperative Outcomes of Pre-Pectoral Versus Sub-Pectoral Implant Immediate Breast Reconstruction
Houvenaeghel, G. F., Bannier, M., Bouteille, C., Tallet, C., Sabiani, L., Charavil, A., Bertrand, A., Troy, A. V., Buttarelli, M., Teyssandier, C., et al. (2024) · Cancers · doi:10.3390/cancers16061129 · Cited by 19 · see citing works
Risk reducing mastectomy, breast reconstruction and patient satisfaction in Norwegian BRCA1/2 mutation carriers
Hagen, A. I., Mæhle, L., Vedå, N., Høberg‐Vetti, H., Stormorken, A. T., Ludvigsen, T., Guntvedt, B., Isern, A. E., Schlichting, E., Kleppe, G., et al. (2013) · The Breast · doi:10.1016/j.breast.2013.10.002 · Cited by 18 · see citing works
Breast Cancer Prevention
Euhus, D., & Diaz, J. (2014) · The Breast Journal · doi:10.1111/tbj.12352 · Cited by 18 · see citing works
Managing hereditary breast cancer risk in women with and without ovarian cancer
Peters, M. L. B., Garber, J. E., & Tung, N. (2017) · Gynecologic Oncology · doi:10.1016/j.ygyno.2017.04.013 · Cited by 18 · see citing works
Residual fibroglandular breast tissue after mastectomy is associated with an increased risk of a local recurrence or a new primary breast cancer"
Deutschmann, C., Singer, C. F., Gschwantler‐Kaulich, D., Pfeiler, G., Leser, C., Baltzer, P., Helbich, T. H., Kraus, C., Korbatits, R., Marzogi, A., et al. (2023) · BMC Cancer · doi:10.1186/s12885-023-10764-y · Cited by 17 · see citing works
Selected Medical Interventions in Women With a Deleterious Brca Mutation: A Population-Based Study in British Columbia
Hanley, G. E., McAlpine, J. N., Cheifetz, R. E., Schrader, K. A., McCullum, M., & Huntsman, D. D. (2019) · Current Oncology · doi:10.3747/co.26.4068 · Cited by 17 · see citing works
Complications Associated with Contralateral Prophylactic Mastectomy: A Systematic Review and Meta-Analysis
Murphy, A. I., Asadourian, P. A., Mellia, J. A., & Rohde, C. H. (2022) · Plastic & Reconstructive Surgery · doi:10.1097/prs.0000000000009493 · Cited by 16 · see citing works
Genetic Testing Today
Euhus, D. (2014) · Annals of Surgical Oncology · doi:10.1245/s10434-014-3906-0 · Cited by 16 · see citing works
Bilateral Prophylactic Nipple-Sparing Mastectomy: Analysis of the Risk-Reducing Effect in BRCA1/2 Mutation Carriers
Staněk, K., Zimovjanová, M., Suk, P., Jonas, F., Zimovjanová, A., Molitor, M., & Měšťák, O. (2021) · Aesthetic Plastic Surgery · doi:10.1007/s00266-021-02506-x · Cited by 16 · see citing works
Evaluation of Contralateral and Bilateral Prophylactic Mastectomy and Reconstruction Outcomes
Bletsis, P. P., Bucknor, A. E. M., Chattha, A. S., Kamali, P., Chen, A., Flecha‐Hirsch, R., van der Lei, B., Lee, B. T., & Lin, S. J. (2018) · Annals of Plastic Surgery · doi:10.1097/sap.0000000000001358 · Cited by 14 · see citing works
Identification, Evaluation, and Treatment of Patients with Hereditary Cancer Risk within the United States
Cragun, D. L., & Pal, T. (2013) · ISRN Oncology · doi:10.1155/2013/260847 · Cited by 14 · see citing works
A Collaborative Model to Implement Flexible, Accessible and Efficient Oncogenetic Services for Hereditary Breast and Ovarian Cancer: The C-MOnGene Study
Lapointe, J., Dorval, M., Chiquette, J., Joly, Y., Guertin, J. R., Laberge, M., Gekas, J., Hébert, J., Pomey, M., Mariño, T. C., et al. (2021) · Cancers · doi:10.3390/cancers13112729 · Cited by 13 · see citing works
An Overview of the Role of Prophylactic Surgery in the Management of Individuals with a Hereditary Cancer Predisposition
Oseni, T. O., & Jatoi, I. (2008) · Surgical Clinics of North America · doi:10.1016/j.suc.2008.04.010 · Cited by 13 · see citing works
Resource implications of risk-reducing mastectomy and reconstruction
Robertson, S. A., Summerhayes, C., Laws, S., & Rainsbury, R. (2015) · European Journal of Surgical Oncology · doi:10.1016/j.ejso.2015.10.002 · Cited by 12 · see citing works
Surgical Management of Inherited Breast Cancer: Role of Breast-Conserving Surgery
Magnoni, F., Sacchini, V., Veronesi, P., Bianchi, B., Bottazzoli, E. I., Tagliaferri, V., Mazzotta, E., Castelnovo, G., Deguidi, G., Rossi, E. M. C., et al. (2022) · Cancers · doi:10.3390/cancers14133245 · Cited by 12 · see citing works
Towards a New Generation of Hormone Therapies: Design, Synthesis and Biological Evaluation of Novel 1,2,3-Triazoles as Estrogen-Positive Breast Cancer Therapeutics and Non-Steroidal Aromatase Inhibitors
Rashdan, H. R. M., Abdelrahman, M. T., Luca, A. C. D., & Mangini, M. (2024) · Pharmaceuticals · doi:10.3390/ph17010088 · Cited by 11 · see citing works
Breast cancer screening in BRCA1 and BRCA2 mutation carriers after risk reducing salpingo-oophorectomy
Fakkert, I. E., Jansen, L., Meijer, K., Kok, T., Oosterwijk, J. C., Mourits, M. J. E., & de Bock, G. H. (2011) · Breast Cancer Research and Treatment · doi:10.1007/s10549-011-1423-4 · Cited by 11 · see citing works
Multidisciplinary management of risk-reducing mastectomy and immediate reconstruction: treatment algorithm and patient satisfaction
Alamouti, R., Hachach‐Haram, N., & Farhadi, J. (2015) · European Journal of Plastic Surgery · doi:10.1007/s00238-015-1086-1 · Cited by 11 · see citing works
First case of invasive breast cancer following prophylactic bilateral skin sparing mastectomy in a BRCA1 mutation carrier
Maarse, W., Jonasse, Y., Ausems, M. G. E. M., Schipper, M. E. I., & van Hillegersberg, R. (2009) · European Journal of Surgical Oncology · doi:10.1016/j.ejso.2009.03.006 · Cited by 10 · see citing works
Factors Influencing Residual Glandular Breast Tissue after Risk-Reducing Mastectomy in Genetically Predisposed Individuals Detected by MRI Mammography
Dietzel, F., Kolberg, L., Vesper, A., Hoffmann, J., Nestle-Krämling, C., Zwiefel, K., Friebe, V., Sawicki, L. M., Bruckmann, N. M., Jannusch, K., et al. (2023) · Cancers · doi:10.3390/cancers15030829 · Cited by 10 · see citing works
Surgical Management of Hereditary Breast Cancer
Berger, E. R., & Golshan, M. A. (2021) · Genes · doi:10.3390/genes12091371 · Cited by 10 · see citing works
Occult Histopathology and Its Predictors in Contralateral and Bilateral Prophylactic Mastectomies
Mattos, D., Gfrerer, L., Ling, I. T. C., Reish, R. G., Hughes, K. S., Halpern, E. F., Cetrulo, C. L., Colwell, A. S., Winograd, J. M., Yaremchuk, M. J., et al. (2015) · Annals of Surgical Oncology · doi:10.1245/s10434-015-4896-2 · Cited by 10 · see citing works
Managing the Breast in Patients Who Test Positive for Hereditary Breast Cancer
Euhus, D. (2012) · Annals of Surgical Oncology · doi:10.1245/s10434-012-2258-x · Cited by 9 · see citing works
The frequency and outcome of breast cancer risk-reducing surgery in finnish BRCA1 and BRCA2 mutation carriers
Koskenvuo, L. E., Svarvar, C., Suominen, S., Aittomäki, K., & Jahkola, T. (2013) · Scandinavian Journal of Surgery · doi:10.1177/1457496913490460 · Cited by 9 · see citing works
Controversies and Open Questions in Management of Cancer-Free Carriers of Germline Pathogenic Variants in BRCA1/BRCA2
Bernstein‐Molho, R., Friedman, E., & Evron, E. (2022) · Cancers · doi:10.3390/cancers14194592 · Cited by 8 · see citing works
Counselling Framework for Germline BRCA1/2 and PALB2 Carriers Considering Risk-Reducing Mastectomy
Wong, S. M., Apostolova, C., Eisenberg, E., & Foulkes, W. D. (2024) · Current Oncology · doi:10.3390/curroncol31010023 · Cited by 8 · see citing works
Breast Cancer Prevention Across the Cancer Care Continuum
Klemp, J. R. (2015) · Seminars in Oncology Nursing · doi:10.1016/j.soncn.2015.03.002 · Cited by 8 · see citing works
Researching Genes, Behavior, and Society to Improve Population Health: A Primer in Complex Adaptive Systems as an Integrative Approach
Goodson, P. (2015) · Emerald Group Publishing Limited eBooks · doi:10.1108/s1057-629020150000016005 · Cited by 8 · see citing works
Prophylactic Mastectomy: An Appraisal
Zagouri, F., Chrysikos, D., Sergentanis, T. Ν., Γιαννακοπούλου, Γ., Zografos, C. G., PAPADIMITRIOU, C. A., & Zografos, G. (2013) · The American Surgeon · doi:10.1177/000313481307900233 · Cited by 6 · see citing works
The Angelina Jolie Effect in Jewish Law: Prophylactic Mastectomy and Oophorectomy in BRCA Carriers
Grossman, S. G. (2015) · Rambam Maimonides Medical Journal · doi:10.5041/rmmj.10222 · Cited by 6 · see citing works
Triple-Negative Breast Cancer
Ismail-Khan, R. R., Minton, S. E., & Khakpour, N. (2014) · Springer eBooks · doi:10.1007/978-1-4939-1145-5_29 · Cited by 6 · see citing works
Local approaches to hereditary breast cancer.
Cooper, B., Murphy, J., Sacchini, V., & Formenti, S. C. (2013) · Annals of Oncology · doi:10.1093/annonc/mdt327 · Cited by 6 · see citing works
New insights into the prevention and treatment of familial breast cancer
Euhus, D. (2011) · Journal of Surgical Oncology · doi:10.1002/jso.21664 · Cited by 5 · see citing works
Nipple-Sparing Mastectomy: To Spare Or Not To Spare?
Chiba, A., Jakub, J. W., & Hieken, T. J. (2016) · Current Surgery Reports · doi:10.1007/s40137-016-0138-1 · Cited by 5 · see citing works
Risk-Reducing Mastectomy for BRCA Gene Mutation Carriers
Euhus, D. (2015) · Annals of Surgical Oncology · doi:10.1245/s10434-015-4537-9 · Cited by 5 · see citing works
Can chimerism explain breast/ovarian cancers in BRCA non-carriers from BRCA-positive families?
Mitchell, R. L., Buckingham, L. E., Cobleigh, M., Rotmensch, J., Burgess, K. R., & Usha, L. (2018) · PLoS ONE · doi:10.1371/journal.pone.0195497 · Cited by 5 · see citing works
Genetic Issues in Patients with Breast Cancer
Fossland, V. S., Stroop, J., Schwartz, R. C., & Kurtzman, S. H. (2008) · Surgical Oncology Clinics of North America · doi:10.1016/j.soc.2008.08.008 · Cited by 5 · see citing works
Surgical Outcome Measures in a Cohort of Patients at High Risk of Breast Cancer Treated by Bilateral Risk-Reducing Mastectomy and Breast Reconstruction
Gandhi, A., Duxbury, P. J., Clancy, T., Lalloo, F. I., Wisely, J. A., Kirwan, C., Foden, P., Stocking, K., Howell, A., & Evans, D. G. (2022) · Plastic & Reconstructive Surgery · doi:10.1097/prs.0000000000009383 · Cited by 4 · see citing works
Management of Women at High Familial Risk of Breast and Ovarian Cancer
Field, K., & Phillips, K. (2009) · IMPERIAL COLLEGE PRESS eBooks · doi:10.1142/9781848163652_0039 · Cited by 4 · see citing works
Prophylactic Surgery in the Complex Decision-Making Management of BRCA Mutation Carriers
Briasoulis, E. C., Ziogas, D. E., & Fatouros, M. (2008) · Annals of Surgical Oncology · doi:10.1245/s10434-007-9738-4 · Cited by 4 · see citing works
PPAC (programme personnalisé de l’après-cancer) : rationnel et mise en place
Gangler, A., Lesur, A., & Dalenc, F. (2016) · ONCOLOGIE · doi:10.1007/s10269-016-2595-7 · Cited by 3 · see citing works
The genetics of breast cancer, risk-reducing surgery and prevention
Evans, D. G., Kwong, A., & Baildam, A. D. (2014) · Elsevier eBooks · doi:10.1016/b978-0-7020-4959-0.00008-4 · Cited by 3 · see citing works
BRCA1 and BRCA2 Mutations - Diagnostic and Therapeutic Implications
Valarmathi, M. T. (2022) · IntechOpen eBooks · doi:10.5772/intechopen.100842 · Cited by 2 · see citing works
Detection of the 5382insC mutation in the human BRCA1 gene with fluorescent labeled oligonucleotides
Mitrofanov, D. V., Chasovnikova, O. B., Коваленко, С. П., & Lyakhovich, V. V. (2009) · Molecular Biology · doi:10.1134/s002689330906003x · Cited by 3 · see citing works

Annals of Surgical Oncology 14(12):3335–3344 DOI: 10.1245/s10434-007-9449-x Breast Oncology Prophylactic Mastectomy in BRCA1/2 Mutation Carriers and Women at Risk of Hereditary Breast Cancer: Long-Term Experiences at the Rotterdam Family Cancer Clinic
Heemskerk‐Gerritsen, B. A. M., Brekelmans, C. T. M., Menke‐Pluymers, M. B. E., van Geel, A. N., Tilanus-linthorst, M. M. A., Bartels, C. C. M., Tan, M., Meijers-Heijboer, H. E. J., Klijn, J. G. M., & Seynaeve, C. (2013)
Self-citation
Clinical experience of prophylactic mastectomy followed by immediate breast reconstruction in women at hereditary risk of breast cancer (HB(O)C) or a proven BRCA1 and BRCA2 germ-line mutation.
Contant, C., Menke-Pluijmers, M., Seynaeve, C., Meijers-Heijboer, E. J., Klijn, J. G., Verhoog, L., Wai, R. T. J., Eggermont, A., & van Geel, A. V. (2002) · European Journal of Surgical Oncology · doi:10.1053/ejso.2002.1279 · Cited by 78 · see citing works
Self-citation
Risk factors for the incidence of breast cancer after prophylactic mastectomy.
Kiechle, M. B., Thiem, L., Paepke, S., Ettl, J., Niemeyer, M., Heitmann, C., Meindl, A., & Feller, A. M. (2015) · Journal of Clinical Oncology · doi:10.1200/jco.2015.33.15_suppl.e12545
Long-term follow-up of the Rotterdam study on prophylactic mastectomy versus surveillance in BRCA1/2 mutation carriers
Klijn, J. G. M., van Geel, A. N., Meijers-Heijboer, H. E. J., Tilanus‐Linthorst, M. M. A., Bartels, C. C. M., Crépin, C., Seynaeve, C., Menke‐Pluymers, M. B. E., & Brekelmans, C. T. M. (2004) · Journal of Clinical Oncology · doi:10.1200/jco.2004.22.90140.9502 · Cited by 7 · see citing works
Self-citation
Histopathological findings and follow-up after prophylactic mastectomy and immediate breast reconstruction in 100 women from families with hereditary breast cancer
Isern, A. E., Loman, N., Malina, J., Olsson, H. L., & Ringberg, A. (2008) · European Journal of Surgical Oncology · doi:10.1016/j.ejso.2008.03.002 · Cited by 30 · see citing works

Authors: Heemskerk-Gerritsen, B. A. M., Brekelmans, C. T. M., Menke-Pluymers, M. B. E., van Geel, A. N., Tilanus-Linthorst, M. M. A., Bartels, C. C. M., Tan, M., Meijers-Heijboer, H. E. J., Klijn, J. G. M., & Seynaeve, C.
Affiliations: Erasmus MC Cancer Institute (NL)
Corresponding author: Seynaeve, Caroline
ORCID: Meijers-Heijboer, Hanne E. J.
Venue: Annals of Surgical Oncology
Publisher: Springer Science and Business Media LLC
Published: 2007-05-31
Volume: 14
Issue: 12
Pages: 3335-3344
ISSN: 1068-9265 (ISSN-L)
1534-4681
DOI: 10.1245/s10434-007-9449-x
PMC: PMC2077910
OpenAlex: W2108830626
Cited by: 153
References: 38
Citations by year: 2026: 3 · 2025: 3 · 2024: 4 · 2023: 10 · 2022: 7 · 2021: 6 · 2020: 5 · 2019: 5 · 2018: 7 · 2017: 7 · 2016: 11 · 2015: 9 · 2014: 14 · 2013: 14 · 2012: 6
FWCI: 5.89
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc
Locations: Annals of Surgical Oncology (publishedVersion, cc-by-nc)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Pure Amsterdam UMC (publishedVersion, other-oa)
Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion, other-oa)
EUR Research Repository (Erasmus University Rotterdam) (publishedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion)
EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
RePub (Erasmus University Rotterdam) (submittedVersion, other-oa)
Digital Academic REpository of VU University Amsterdam (Vrije Universiteit Amsterdam) (submittedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › BRCA gene mutations in cancer
Health Sciences › Medicine › Surgery › Breast Implant and Reconstruction
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Women's cancer prevention and management
Keywords: prophylactic mastectomy, BRCA1 mutation carriers, BRCA2 mutation carriers, hereditary breast cancer, breast reconstruction complications, capsular contracture, cosmetic outcome, preoperative imaging, breast cancer risk reduction, high-risk women
MeSH terms: Adult, Breast Neoplasms, Female, Follow-Up Studies, Humans, Longitudinal Studies, Mastectomy, Middle Aged, Mutation, Neoplasm Staging, Netherlands, Ovarian Neoplasms, Postoperative Complications, Prospective Studies, Retrospective Studies, Risk Factors, Cohort Studies, Incidence, Mammaplasty, Treatment Outcome, Germ-Line Mutation, BRCA1 Protein, Genetic Predisposition to Disease, BRCA2 Protein

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Prophylactic Mastectomy in BRCA1/2 Mutation Carriers and Women at Risk of Hereditary Breast Cancer: Long-Term Experiences at the Rotterdam Family Cancer Clinic

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks