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Smart PEGylated Gold Nanoparticles for the Cytoplasmic Delivery of siRNA to Induce Enhanced Gene Silencing
Abstract
A novel cytoplasmic delivery system of siRNA was developed by complexation between poly(ethylene glycol)-block-poly(2-(N,N-dimethylamino)ethyl methacrylate) copolymer (PEG–PAMA) and gold nanoparticles (GNPs), followed by the immobilization of siRNA bearing a thiol group (SH-siRNA). The PEGylated GNPs containing SH-siRNA showed a significant RNAi activity in HuH-7 cells.
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Cited by
Gold nanoparticles in delivery applications☆
GHOSH, P., HAN, G., DE, M., KIM, C., & ROTELLO, V (2008) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2008.03.016 · Cited by 2,694
Nonviral vectors for gene delivery
Mintzer, M. A., & Simanek, E. E. (2009) · Chemical Reviews · doi:10.1021/cr800409e · Cited by 2,366
Applications of Nanoparticles in Biology
De, M., Ghosh, P. S., & Rotello, V. M. (2008) · Advanced Materials · doi:10.1002/adma.200703183 · Cited by 1,547
Mishra, B., Patel, B. B., & Tiwari, S. (2010) · Nanomedicine: Nanotechnology, Biology and Medicine · doi:10.1016/j.nano.2009.04.008 · Cited by 771
Gene Regulation with Polyvalent siRNA−Nanoparticle Conjugates
Giljohann, D. A., Seferos, D. S., Prigodich, A. E., Patel, P. C., & Mirkin, C. A. (2009) · Journal of the American Chemical Society · doi:10.1021/ja808719p · Cited by 637
Metadata
- Authors
- Oishi, M., Nakaogami, J., Ishii, T., & Nagasaki, Y.
- Venue
- Chemistry Letters
- Publisher
- Oxford University Press (OUP)
- Published
- 2006-08-12
- Volume
- 35
- Issue
- 9
- Pages
- 1046-1047
- ISSN
- 0366-7022 (ISSN-L)
- 1348-0715
- OpenAlex
- W1988171375
- Cited by
- 159
- References
- 0
- FWCI
- 2.95
- Type
- journal article
- Language
- en
- Open access
- closed
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- Oishi, M., Nakaogami, J., Ishii, T., & Nagasaki, Y. (2006). Smart PEGylated Gold Nanoparticles for the Cytoplasmic Delivery of siRNA to Induce Enhanced Gene Silencing. Chemistry Letters. https://doi.org/10.1246/cl.2006.1046
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