PEGylated Polymer Micelle-based Nitric Oxide (NO) Photodonor with NO-mediated Antitumor Activity
Abstract
PEGylated polymer micelles containing 4-nitro-3-trifluoromethylphenyl units within the core moiety were prepared, and their phototriggered nitric oxide (NO)-generating ability was confirmed by electron spin resonance (ESR) spin-trapping and the Griess method. These micelles were found to be capable of delivering exogenous NO into tumor cells in a photocontrolled manner and showed an NO-mediated antitumor effect, indicating the usability of this molecular system in NO-based tumor therapy.
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Cites
Nitric oxide: physiology, pathophysiology, and pharmacology.
Moncada, S., Palmer, R. M., & Higgs, E. A. (1991) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)06663-3 · Cited by 15,525 · see citing works
Matsumura, Y., & Maeda, H. (1986) · PubMed · Cited by 6,771 · see citing works
Block copolymer micelles for drug delivery: design, characterization and biological significance
Kataoka, K., Harada, A., & Nagasaki, Y. (2001) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(00)00124-1 · Cited by 3,506 · see citing works
Self-citationNitric oxide donors: chemical activities and biological applications
Wang, P. G., Xian, M., Tang, X., Wu, X., Wen, Z., Cai, T., & Janczuk, A. J. (2002) · Chemical Reviews · doi:10.1021/cr000040l · Cited by 1,337 · see citing works
The role of nitric oxide in tumour progression
Fukumura, D., Kashiwagi, S., & Jain, R. K. (2006) · Nature reviews. Cancer · doi:10.1038/nrc1910 · Cited by 1,260 · see citing works
Nishiyama, N., & Kataoka, K. (2006) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2006.05.006 · Cited by 1,052 · see citing works
The chemical biology of nitric oxide: Implications in cellular signaling
Thomas, D. D., Ridnour, L. A., Isenberg, J. S., Flores-Santana, W., Switzer, C. H., Donzelli, S., Hussain, P., Vecoli, C., Paolocci, N., Ambs, S., et al. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.03.020 · Cited by 975 · see citing works
The physiological role of nitric oxide
Butler, A. R., & Williams, D. L. H. (1993) · Chemical Society Reviews · doi:10.1039/cs9932200233 · Cited by 555 · see citing works
Measurement of nitrate and nitrite in biological samples using nitrate reductase and Griess reaction
Granger, D. L., Taintor, R. R., Boockvar, K. S., & Hibbs, J. B. (1996) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(96)68016-1 · Cited by 511 · see citing works
Photoactive ruthenium nitrosyls: Effects of light and potential application as NO donors
Rose, M. J., & Mascharak, P. K. (2007) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2007.11.011 · Cited by 354 · see citing works
Nitric oxide-releasing vehicles for biomedical applications
Seabra, A. B., & Durán, N. (2009) · Journal of Materials Chemistry · doi:10.1039/b912493b · Cited by 230 · see citing works
Ford, P. C. (2008) · Accounts of Chemical Research · doi:10.1021/ar700128y · Cited by 227 · see citing works
In Vivo Spin Trapping of Nitric Oxide in Mice
Komarov, A., Mattson, D. L., Jones, M. M., et al. (1993) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1993.2170 · Cited by 177 · see citing works
de Visser, S. P., Ogliaro, F., Sharma, P. K., & Shaik, S. S. (2002) · Angewandte Chemie International Edition · doi:10.1002/1521-3773(20020603)41:11 · Cited by 144 · see citing works
Photoinduced Nitric Oxide Release from Nitrobenzene Derivatives
Suzuki, T., Nagae, O., Kato, Y., Nakagawa, H., Fukuhara, K., & Miyata, N. (2005) · Journal of the American Chemical Society · doi:10.1021/ja0512024 · Cited by 121 · see citing works
Design of Core−Shell-Type Nanoparticles Carrying Stable Radicals in the Core
Yoshitomi, T., Miyamoto, D., & Nagasaki, Y. (2009) · Biomacromolecules · doi:10.1021/bm801278n · Cited by 113 · see citing works
Self-citationNO donors with anticancer activity
Janczuk, A. J., Jia, Q., Xian, M., Wen, Z., Wang, P. G., & Cai, T. (2002) · Expert Opinion on Therapeutic Patents · doi:10.1517/13543776.12.6.819 · Cited by 49 · see citing works
Sortino, S., Condorelli, G., & Marconi, G. (2001) · Chemical Communications · doi:10.1039/b102359b · Cited by 43 · see citing works
Photosensitive Precursors to Nitric Oxide
Pavlos, C. M., Xu, H., & Toscano, J. P. (2005) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026054679326 · Cited by 37 · see citing works
Sortino, S., Petralia, S., Compagnini, G., Sabrina Conoci, A., & Condorelli, G. (2002) · Angewandte Chemie · doi:10.1002/1521-3757(20020603)114:11 · Cited by 22 · see citing works
Recent developments in anticancer nitric oxide donors
Cai, T., & Wang, P. G. (2004) · Expert Opinion on Therapeutic Patents · doi:10.1517/13543776.14.6.849 · Cited by 11 · see citing works
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Wo, Y., Brisbois, E. J., Bartlett, R. H., & Meyerhoff, M. E. (2016) · Biomaterials Science · doi:10.1039/c6bm00271d · Cited by 251 · see citing works
Polymer‐Based Nitric Oxide Therapies: Recent Insights for Biomedical Applications
Jen, M. C., Serrano, M. C., van Lith, R., & Ameer, G. A. (2012) · Advanced Functional Materials · doi:10.1002/adfm.201101707 · Cited by 194 · see citing works
Seabra, A. B., Justo, G. Z., & Haddad, P. S. (2015) · Biotechnology Advances · doi:10.1016/j.biotechadv.2015.01.005 · Cited by 151 · see citing works
- Authors
- Kanayama, N., Yamaguchi, K., & Nagasaki, Y.
- Affiliations
- University of Tsukuba (JP)
- Venue
- Chemistry Letters
- Publisher
- Oxford University Press (OUP)
- Published
- 2010-08-14
- Volume
- 39
- Issue
- 9
- Pages
- 1008-1009
- ISSN
- 0366-7022 (ISSN-L)
- 1348-0715
- OpenAlex
- W2039743179
- Cited by
- 25
- References
- 21
- Citations by year
- 2026: 2 · 2024: 2 · 2023: 1 · 2022: 1 · 2020: 1 · 2019: 2 · 2018: 1 · 2017: 2 · 2016: 2 · 2015: 4 · 2013: 3 · 2012: 1
- FWCI
- 1.32
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Chemistry Letters (publishedVersion)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Photodynamic Therapy Research Studies
- Keywords
- nitric oxide production, anticancer activity
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