Cited by 1,312Autophagy in Disease and TherapyCellular transport and secretionATP Synthase and ATPases Research

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Bafilomycin A1 prevents maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes in rat hepatoma cell line, H-4-II-E cells

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Yamamoto, Akitsugu, Tagawa, Yoshihiro, Yoshimori, Tamotsu, Moriyama, Yoshinori, Masaki, Ryuichi, Tashiro, Yutaka·1998·Cell Structure and Function

DOI 10.1247/csf.23.33

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Abstract

We studied the effects of bafilomycin A1, a potent and specific inhibitor of vacuolar H+ ATPase (V-ATPase), on the process of autophagy in rat hepatoma cell line, H-4-II-E cells. To induce autophagy, cells were transferred from Dulbecco's modified Eagle medium containing 12% fetal calf serum into Hanks' balanced salt solution. When bafilomycin A1 was added to Hanks' balanced salt solution, endogenous protein degradation was strongly inhibited and numerous autophagosomes accumulated in H-4-II-E cells, whereas autolysosomes decreased in number. Acid phosphatase activity was not detected in the autophagosomes which accumulated in the presence of bafilomycin A1, suggesting that fusion between autophagosomes and lysosomes was disturbed by this drug. Inhibition of the fusion was reversible, and the autophagosomes changed into autolysosomes after the removal of the inhibitor. Bafilomycin A1 also prevented the appearance of endocytosed HRP in autophagic vacuoles. These results suggested that acidification of the lumenal space of autophagosomes or lysosomes by V-ATPase is important for the fusion between autophagosomes and lysosomes.

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Authors: Yamamoto, A., Tagawa, Y., Yoshimori, T., Moriyama, Y., Masaki, R., & Tashiro, Y.
Affiliations: Kansai Medical University (JP)
National Institute for Basic Biology (JP)
The Institute of Scientific and Industrial Research, The University of Osaka (JP)
ORCID: Yoshimori, Tamotsu
Moriyama, Yoshinori
Tashiro, Yutaka
Venue: Cell Structure and Function
Publisher: Japan Society for Cell Biology
Published: 1998
Volume: 23
Issue: 1
Pages: 33-42
ISSN: 0386-7196 (ISSN-L)
1347-3700
DOI: 10.1247/csf.23.33
OpenAlex: W2077731318
Cited by: 1,312
References: 41
Citations by year: 2026: 33 · 2025: 49 · 2024: 32 · 2023: 50 · 2022: 58 · 2021: 80 · 2020: 71 · 2019: 99 · 2018: 62 · 2017: 80 · 2016: 97 · 2015: 97 · 2014: 99 · 2013: 90 · 2012: 69
FWCI: 3.47
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Cell Structure and Function (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › ATP Synthase and ATPases Research
Keywords: bafilomycin A1, autophagy, autophagosome-lysosome fusion, autolysosomes, lysosomal acidification, hepatoma cells, acid phosphatase activity
MeSH terms: Amino Acids, Animals, Anti-Bacterial Agents, Autophagy, Cell Differentiation, Growth Inhibitors, Carcinoma, Hepatocellular, Histocytochemistry, Hydrogen-Ion Concentration, Kinetics, Lysosomes, Neoplasm Proteins, Phagosomes, Tumor Cells, Cultured, Vacuoles, Culture Media, Serum-Free, Culture Media, Conditioned, Macrolides, Rats

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Bafilomycin A1 prevents maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes in rat hepatoma cell line, H-4-II-E cells

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