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Bafilomycin A1 prevents maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes in rat hepatoma cell line, H-4-II-E cells
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We studied the effects of bafilomycin A1, a potent and specific inhibitor of vacuolar H+ ATPase (V-ATPase), on the process of autophagy in rat hepatoma cell line, H-4-II-E cells. To induce autophagy, cells were transferred from Dulbecco's modified Eagle medium containing 12% fetal calf serum into Hanks' balanced salt solution. When bafilomycin A1 was added to Hanks' balanced salt solution, endogenous protein degradation was strongly inhibited and numerous autophagosomes accumulated in H-4-II-E cells, whereas autolysosomes decreased in number. Acid phosphatase activity was not detected in the autophagosomes which accumulated in the presence of bafilomycin A1, suggesting that fusion between autophagosomes and lysosomes was disturbed by this drug. Inhibition of the fusion was reversible, and the autophagosomes changed into autolysosomes after the removal of the inhibitor. Bafilomycin A1 also prevented the appearance of endocytosed HRP in autophagic vacuoles. These results suggested that acidification of the lumenal space of autophagosomes or lysosomes by V-ATPase is important for the fusion between autophagosomes and lysosomes.
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“In contrast, treatment with bafilomycin A1 (100 nM), an inhibitor of late-phase autophagy (prevents fusion of autophagosomes and lysosomes) [61], significantly reduced the LC3-II: LC3-I ratio (Fig. 5C).”
From Iron accumulation in senescent cells is coupled with impaired ferritinophagy and inhibition of ferroptosis (2018) · cites this paper as [61]
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“bafilomycin A1 (100 nM), an inhibitor of late-phase autophagy (prevents fusion of autophagosomes and lysosomes) [61]”
From Iron accumulation in senescent cells is coupled with impaired ferritinophagy and inhibition of ferroptosis (2018) · cites this paper as [61]
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Metadata
- Authors
- Yamamoto, A., Tagawa, Y., Yoshimori, T., Moriyama, Y., Masaki, R., & Tashiro, Y.
- Affiliations
- Kansai Medical University (JP)
- National Institute for Basic Biology (JP)
- The Institute of Scientific and Industrial Research, The University of Osaka (JP)
- Venue
- Cell Structure and Function
- Publisher
- Japan Society for Cell Biology
- Published
- 1998
- Volume
- 23
- Issue
- 1
- Pages
- 33-42
- ISSN
- 0386-7196 (ISSN-L)
- 1347-3700
- OpenAlex
- W2077731318
- Cited by
- 1,312
- References
- 41
- Citations by year
- 2026: 33 · 2025: 49 · 2024: 32 · 2023: 50 · 2022: 58 · 2021: 80 · 2020: 71 · 2019: 99 · 2018: 62 · 2017: 80 · 2016: 97 · 2015: 97 · 2014: 99 · 2013: 90 · 2012: 69
- FWCI
- 3.47
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cell Structure and Function (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › ATP Synthase and ATPases Research
- Keywords
- bafilomycin A1, autophagy, autophagosome-lysosome fusion, autolysosomes, lysosomal acidification, hepatoma cells, acid phosphatase activity
- MeSH terms
- Amino Acids, Animals, Anti-Bacterial Agents, Autophagy, Cell Differentiation, Growth Inhibitors, Carcinoma, Hepatocellular, Histocytochemistry, Hydrogen-Ion Concentration, Kinetics, Lysosomes, Neoplasm Proteins, Phagosomes, Tumor Cells, Cultured, Vacuoles, Culture Media, Serum-Free, Culture Media, Conditioned, Macrolides, Rats
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