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Cited by 77Garlic and Onion StudiesAntioxidants, Aging, Portulaca oleraceaGenetics, Aging, and Longevity in Model Organisms

Aged Garlic Extract Prolongs Longevity and Improves Spatial Memory Deficit in Senescence-Accelerated Mouse

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MORIGUCHI, Toru, SAITO, Hiroshi, NISHIYAMA, Nobuyoshi·1996·Biological and Pharmaceutical Bulletin
DOI 10.1248/bpb.19.305
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Abstract

The effects of aged garlic extract (AGE), chronically administered in the diet, on longevity and spatial learning performances were studied using the senescence-accelerated mouse (SAM). A solid diet containing 2% AGE was given to senescence-accelerated-prone mouse 8 (SAMP8) and senescence-accelerated-resistant mouse 1 (SAMR1) from 2 months of age. The survival ratio of SAMP8, a substrain of senescence-accelerated-prone mouse, was significantly lower than that of SAMR1, a substrain of senescence-resistant mouse. In the SAMP8, administration of AGE perfectly prevented the decrease in survival ratio. Moreover, AGE markedly improved the learning deficits of SAMP8 in the Morris water maze test. These results suggest the possibility that AGE prevents physiological aging and age-related memory disorders in human.

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  • SAMP8 mice fed for 2 months with a diet containing 2% aged garlic extract (AGE) show improved lifespan and learning scores compared to untreated counterparts.

    “Concerning aging, SAMP8 mice fed for 2 months with a diet containing 2% of aged garlic extract (AGE), which has been reported to have a higher antioxidant activity compared to fresh garlic extract [204], show improved lifespan and learning scores compared to the untreated counterpart [205,206,207].”

    From The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence (2022) · cites this paper as [205]

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Authors
MORIGUCHI, T., SAITO, H., & NISHIYAMA, N.
Affiliations
The University of Tokyo (JP)
ORCID
MORIGUCHI, Toru
Venue
Biological and Pharmaceutical Bulletin
Publisher
Pharmaceutical Society of Japan
Published
1996
Volume
19
Issue
2
Pages
305-307
ISSN
  • 0918-6158 (ISSN-L)
  • 1347-5215
DOI
10.1248/bpb.19.305
OpenAlex
W2015756895
Cited by
77
References
1
Citations by year
2026: 1 · 2025: 1 · 2024: 1 · 2023: 2 · 2022: 2 · 2021: 1 · 2020: 3 · 2018: 1 · 2017: 2 · 2016: 3 · 2015: 3 · 2013: 2 · 2012: 2
FWCI
5.57
Type
journal article
Language
en
Open access
Locations
  • Biological and Pharmaceutical Bulletin (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Garlic and Onion Studies
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Antioxidants, Aging, Portulaca oleracea
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Keywords
aged garlic extract, longevity, spatial memory, senescence-accelerated mice, SAMP8 mice, SAMR1, age-related memory impairment, dietary supplementation, survival, anti-aging, learning deficits
MeSH terms
Aging, Animals, Garlic, Longevity, Male, Memory Disorders, Plant Extracts, Plants, Medicinal, Mice

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