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Cited by 73Garlic and Onion StudiesAntioxidants, Aging, Portulaca oleraceaGenetics, Aging, and Longevity in Model Organisms

Prolongation of Life Span and Improved Learning in the Senescence Accelerated Mouse Produced by Aged Garlic Extract

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MORIGUCHI, Toru, TAKASHINA, Ken, CHU, PengJang, SAITO, Hiroshi, NISHIYAMA, Nobuyoshi·1994·Biological and Pharmaceutical Bulletin
DOI 10.1248/bpb.17.1589
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Abstract

The effects of aged garlic extract (AGE) on longevity and learning and memory performances were studied in the senescence accelerated mouse (SAM). A solid diet containing 2% (w/w) AGE was given to SAM from 2 months of age. The survival ratio of SAM P8, senescence accelerated animals, treated with AGE was significantly higher than that of untreated controls. AGE, however, did not affect the life span of SAM R1, a senescence-resistant strain. AGE had no effect on body weight and motor activity. In the passive and conditioned avoidance tests, AGE markably improved a memory acquisition process in the step-down and shuttle-box tests, and also a retention process in the step-through and step-down tests in SAM P8. The beneficial effects of AGE were observed in a memory retention process in the step-down test and in an acquisition stage in lever-press test in SAM R1. These results suggest the possibility that AGE might be useful for treating physiological aging and age-related memory deficits in humans.

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  • SAMP8 mice fed for 2 months with a diet containing 2% aged garlic extract (AGE) show improved lifespan and learning scores compared to untreated counterparts.

    “Concerning aging, SAMP8 mice fed for 2 months with a diet containing 2% of aged garlic extract (AGE), which has been reported to have a higher antioxidant activity compared to fresh garlic extract [204], show improved lifespan and learning scores compared to the untreated counterpart [205,206,207].”

    From The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence (2022) · cites this paper as [206]

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  1. [1]S. Nakagawa, K. Masamoto, H. Sumiyoshi, K. Kunihiro, T. Fuwa, J. Toxicol. Sci., 5, 91 (1980).
  2. [2]K. N. Shashikanth, S. C. Basappa, V. S. Murthy, Nutr. Reports International, 33, 313 (1986).
  3. [3]H. Sumiyoshi, A. Kanezawa, K. Masamoto, H. Harada, S. Nakagami, A. Yokota, M. Nishikawa, S. Nakagawa, J. Toxicol. Sci., 9, 61 (1984).
  4. [4]N. Takasugi, K. Kotoo, T. Fuwa, H. Saito, Oyo Yakuri-Pharmacometrics, 28, 991 (1984).
  5. [5]S. Nakagawa, S. Yoshida, Y. Hirao, S. Kasuga, T. Fuwa, Hiroshima J. Med. Sci., 34, 303 (1985).
  6. [6]H. Nishino, A. Iwashima, Y. Itakura, H. Matsuura, T. Fuwa, Oncology, 46, 277 (1989).
  7. [7]H. Sumiyoshi, M. J. Wargovich, Cancer Res., 50, 5084 (1990).
  8. [21]M. Yoshikawa, S. Hirai, J. Gerontol., 22, 162 (1967).
  9. [22]M. Uchiyama, M. Mihara, Analyt. Biochem., 86, 271 (1978).
  10. [23]N. Takeuchi, F. Tanaka, Y. Katayama, K. Matsumiya, Y. Yamamura, Exp. Geront., 11, 179 (1976).
  11. [24]P. I. Ceballos, A. Nicole, M. Clement, J. M. Bourre, P. M. Sinet, Mutat. Res., 275, 281 (1992).
  12. [25]Q. G. Barja, C. R. Perez, T. M. Lopez, J. Neurosci. Res., 26, 370 (1990).
  13. [26]Y. Nomura, B. X. Wang, S. B. Qi, T. Namba, S. Kaneko, Exp. Gerontol., 24, 49 (1989).
  14. [27]T. Horie, T. Murayama, T. Mishima, F. Itoh, Y. Minamide, T. Fuwa, S. Awazu, Planta Med., 55, 506 (1989).
  15. [28]T. Horie, S. Awazu, Y. Itakura, T. Fuwa, Planta Med., 58, 468 (1992).
  16. [29]J. P. Perchellet, E. M. Perchellet, N. L. Abney, J. A. Zirnstein, S. Belman, Cancer Biochem. Biophys., 8, 299 (1986).
  17. [30]V. L. Sparnins, A. W. Mott, G. Barany, L. W. Wattenberg, Nutr. Cancer, 8, 211 (1986).
  18. [31]D. Harman, J. Gerontol., 23, 476 (1968).
  19. [33]J. Miquel, A. C. Economos, Exp. Gerontol., 14, 279 (1979).
  20. [32]A. Comfort, Nature (London), 229, 254 (1971).
  21. [34]T. Makinodan, M. M. B. Kaye, "Advances in Immunology," Vol. 29, ed. by H. Kunkel, F. Dixon, Academic Press, San Diego, CA, 1980, pp. 287—330.
  22. [8]T. Takeda, M. Hosokawa, S. Takeshita, M. Irino, K. Higuchi, T. Matsushita, Y. Tomita, K. Yasuhira, H. Hamamoto, K. Shimizu, M. Ishii, T. Yamamuro, Mech. Ageing Dev., 17, 183 (1981).
  23. [35]D. C. Powers, J. E. Morley, J. F. Flood, Cell. Immunol., 141, 444 (1992).
  24. [36]Y. Zhang, K. Takashina, H. Saito, N. Nishiyama, Biol. Pharm. Bull., in press.
  25. [37]B. H. Lau, T. Yamasaki, D. S. Gridley, Mol. Biother., 3, 103 (1991).
  26. [38]N. Morioka, L. L. Sze, D. L. Morton, R. F. Irie, Cancer Immunol. Immunother., 37, 316 (1993).
  27. Y. Hirao, S. Sumioka, M. Yamamoto, S. Hatono, S. Yoshida, T. Fuwa, S. Nakagawa, Phytother. Res., 1, 161 (1987).
  28. H. Sugiyama, H. Akiyama, I. Akiguchi, M. Kameyama, T. Takeda, Clin. Neurol., 27, 841 (1987).
  29. [12]K. Nishizawa, H. Saito, N. Nishiyama, Jpn. J. Pharmacol., 54, 375 41) M. Takemura, S. Nakamura, I. Akiguchi, M. Ueno, N. Oka, S. (1990). Ishikawa, A. Shimada, J. Kimura, T. Takeda, Am. J. Pathol., 142, 1887 (1993).
  30. [13]M. Segawa, H. Saito, N. Nishiyama, Biogenic. Amines., 7, 171 (1990).
  31. [14]A. Kohno, T. Yonezu, M. Matsushita, M. Irino, K. Higuchi, K. Higuchi, S. Takeshita, M. Hosokawa, T. Takeda, J. Nutr., 115, 1259 (1985).
  32. [15]M. Umezawa, K. Hanada, H. Naiki, W. H. Chen, M. Hosokawa, M. Hosono, T. Hosokawa, T. Takeda, J. Nutr., 120, 1393 (1990).
  33. [17]M. H. Ross, J. Nutr., 75, 197 (1961).
  34. [42]H. Akiyama, M. Kameyama, I. Akiguchi, H. Sugiyama, T. Kawamata, H. Fukuyama, H. Kimura, M. Matsushita, T. Takeda, Acta Neuropathol. Berl., 72, 124 (1986).
  35. [43]H. Yagi, M. Irino, T. Matsushita, S. Katoh, M. Umezawa, T. Tsuboyama, M. Hosokawa, I. Akiguchi, R. Tokunaga, T. Takeda, J. Neuropathol. Exp. Neurol., 48, 577 (1989).
  36. [46]Y. Kitamura, X. H. Zhao, T. Ohnuki, M. Takei, Y. Nomura, Neurosci. Lett., 137, 169 (1992).
  37. [45]X. H. Zhao, Y. Nomura, Int. J. Dev. Neurosci., 8, 267 (1990).
  38. [18]S. Umezawa, K. Hanada, H. Matsuzawa, T. Yoshida, K. Hashimoto, S. Sasaki, Jikken Doubutsu, 40, 523 (1991).
  39. [19]J. Venkatraman, G. Fernandes, Mech. Ageing Dev., 63, 27 (1992). 47)
  40. [20]D. Harman, J. Gerontol., 11, 293 (1956).
  41. J. F. Flood, J. E. Morley, M. La Reginna, Neurobiol. Aging., 14, 159 (1993).
  42. [9]M. Hosokawa, R. Kasai, K. Higuchi, S. Takeshita, K. Shimizu, H. Hamamoto, A. Honma, M. Irino, K. Toda, A. Matsumura, M. Matsushita, T. Takeda, Mech. Ageing Dev., 26, 91 (1984).

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Authors
MORIGUCHI, T., TAKASHINA, K., CHU, P., SAITO, H., & NISHIYAMA, N.
Affiliations
The University of Tokyo (JP)
ORCID
Venue
Biological and Pharmaceutical Bulletin
Publisher
Pharmaceutical Society of Japan
Published
1994
Volume
17
Issue
12
Pages
1589-1594
ISSN
  • 0918-6158 (ISSN-L)
  • 1347-5215
DOI
10.1248/bpb.17.1589
OpenAlex
W2325926641
Cited by
73
References
0
Citations by year
2025: 1 · 2023: 2 · 2022: 1 · 2021: 1 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 4 · 2015: 4 · 2013: 2 · 2012: 3
FWCI
2.48
Type
journal article
Language
en
Open access
Locations
  • Biological and Pharmaceutical Bulletin (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Garlic and Onion Studies
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Antioxidants, Aging, Portulaca oleracea
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Keywords
aged garlic extract, senescence-accelerated mice, longevity, lifespan extension, learning and memory, age-related memory decline, avoidance learning, memory retention, physiological aging, dietary supplementation
MeSH terms
Aging, Animals, Avoidance Learning, Body Weight, Garlic, Longevity, Male, Mice, Inbred Strains, Motor Activity, Plant Extracts, Plants, Medicinal, Mice

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