Hormesis in aging

Rattan, Suresh I.S.

doi:10.1016/j.arr.2007.03.002

Cited by 498Genetics, Aging, and Longevity in Model OrganismsEffects of Radiation ExposureTelomeres, Telomerase, and Senescence

Hormesis in aging

Rattan, Suresh I.S.·2008·Ageing Research Reviews

DOI 10.1016/j.arr.2007.03.002

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Abstract

Hormesis in aging is represented by mild stress-induced stimulation of protective mechanisms in cells and organisms resulting in biologically beneficial effects. Single or multiple exposure to low doses of otherwise harmful agents, such as irradiation, food limitation, heat stress, hypergravity, reactive oxygen species and other free radicals have a variety of anti-aging and longevity-extending hormetic effects. Detailed molecular mechanisms that bring about the hormetic effects are being increasingly understood, and comprise a cascade of stress response and other pathways of maintenance and repair. Although the extent of immediate hormetic effects after exposure to a particular stress may only be moderate, the chain of events following initial hormesis leads to biologically amplified effects that are much larger, synergistic and pleiotropic. A consequence of hormetic amplification is an increase in the homeodynamic space of a living system in terms of increased defence capacity and reduced load of damaged macromolecules. Hormetic strengthening of the homeodynamic space provides wider margins for metabolic fluctuation, stress tolerance, adaptation and survival. Hormesis thus counter-balances the progressive shrinkage of the homeodynamic space, which is the ultimate cause of aging, diseases and death. Healthy aging may be achieved by hormesis through mild and periodic, but not severe or chronic, physical and mental challenges, and by the use of nutritional hormesis incorporating mild stress-inducing molecules called hormetins. The established scientific foundations of hormesis are ready to pave the way for new and effective approaches in aging research and intervention.

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A moderate level of ROS production during life can be beneficial by inducing hormetic responses that reinforce the capacity of the organism to respond to stronger injury.
“a moderate level of ROS production during life can be beneficial by inducing hormetic responses that reinforce the capacity of the organism to respond to stronger injury (Rattan, 2008).”
From Mitochondrial Activity and Dynamics Changes Regarding Metabolism in Ageing and Obesity (2017) · cites this paper as Rattan, 2008

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Authors: Rattan, S. I. S.
Affiliations: Aarhus University (DK)
Corresponding author: Rattan, Suresh I.S.
ORCID: Rattan, Suresh I.S.
Venue: Ageing Research Reviews
Publisher: Elsevier BV
Published: 2008-01
Volume: 7
Issue: 1
Pages: 63-78
ISSN: 1568-1637 (ISSN-L)
DOI: 10.1016/j.arr.2007.03.002
OpenAlex: W2073292208
Cited by: 498
References: 222
Citations by year: 2026: 25 · 2025: 25 · 2024: 22 · 2023: 22 · 2022: 19 · 2021: 30 · 2020: 38 · 2019: 25 · 2018: 28 · 2017: 23 · 2016: 17 · 2015: 25 · 2014: 35 · 2013: 26 · 2012: 36
FWCI: 2.30
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Ageing Research Reviews (publishedVersion)
PubMed (publishedVersion)
Funders: Sundhed og Sygdom, Det Frie Forskningsråd
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Effects of Radiation Exposure
Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
Keywords: hormesis, aging, longevity, stress response, low-dose radiation, dietary restriction, heat stress, hypergravity, reactive oxygen species, stress tolerance, anti-aging interventions
MeSH terms: Adaptation, Physiological, Aging, Animals, Dose-Response Relationship, Drug, Hot Temperature, Humans, Stress, Physiological, Stress, Psychological, Exercise, Caloric Restriction

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