Prevention of the Neurotoxicity of the Amyloid Beta Protein by Genipin
Open accessAbstract
Genipin, which was shown in our previous investigation to have prominent neuritogenic activity in paraneurons such as PC12h cells, was studied to determine whether it could prevent the toxicity of Alzheimer's amyloid beta protein (Abeta) in cultured hippocampal neurons. Increased release of lactate dehydrogenase from hippocampal neurons after 2 d of Abeta25-35 administration was prevented dose dependently by the addition of genipin 20-40 microm. Morphological observations and trypan blue staining of cells confirmed the protection of hippocampal neurons from Abeta toxicity by genipin. Geniposide had less effect in preventing Abeta toxicity.
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Genipin protects neuronal cells against the cytotoxicity of Aβ, H2O2, and rotenone by preventing ROS/RNS-induced damage.
“Genipin has also displayed the ability to protect neuronal cells against the cytotoxicity of Aβ, H2O2 and rotenone by preventing widespread damage induced by the increase of ROS and RNS production (Yamazaki et al., 2001; Hughes et al., 2014).”
From Exploring the Therapeutic Potential of Phytochemicals in Alzheimer’s Disease: Focus on Polyphenols and Monoterpenes (2022) · cites this paper as Yamazaki et al., 2001
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Piccialli, I., Tedeschi, V., Caputo, L., D’Errico, S., Ciccone, R., De Feo, V., Secondo, A., & Pannaccione, A. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.876614 · Cited by 73 · see citing works
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- Authors
- YAMAZAKI, M., SAKURA, N., CHIBA, K., & MOHRI, T.
- Affiliations
- Hokuriku University (JP)
- Venue
- Biological and Pharmaceutical Bulletin
- Publisher
- Pharmaceutical Society of Japan
- Published
- 2001
- Volume
- 24
- Issue
- 12
- Pages
- 1454-1455
- ISSN
- 0918-6158 (ISSN-L)
- 1347-5215
- OpenAlex
- W1987721641
- Cited by
- 62
- References
- 13
- Citations by year
- 2024: 1 · 2023: 6 · 2022: 3 · 2021: 2 · 2020: 4 · 2019: 3 · 2018: 2 · 2016: 2 · 2015: 4 · 2014: 4 · 2013: 4 · 2012: 4
- FWCI
- 0.40
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Biological and Pharmaceutical Bulletin (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Health Sciences › Medicine › Complementary and alternative medicine › Ginkgo biloba and Cashew Applications
- Keywords
- genipin, amyloid-beta, neuroprotection, Alzheimer's disease, hippocampal neurons, geniposide, lactate dehydrogenase release, neuronal cell death
- MeSH terms
- Animals, Cells, Cultured, Cholagogues and Choleretics, Dose-Response Relationship, Drug, Embryo, Mammalian, Hippocampus, Neurons, Pyrans, Amyloid beta-Peptides, Nerve Growth Factor, Iridoids, Rats, Iridoid Glycosides
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