Cited by 55Alzheimer's disease research and treatmentsMedicinal Plants and NeuroprotectionPhytochemistry and Biological Activities

Iridoids and other monoterpenes in the Alzheimer’s brain: Recent development and future prospects

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Habtemariam, Solomon·2018·Molecules

Abstract

Iridoids are a class of monoterpenoid compounds constructed from 10-carbon skeleton of isoprene building units. These compounds in their aglycones and glycosylated forms exist in nature to contribute to mechanisms related to plant defenses and diverse plant-animal interactions. Recent studies have also shown that iridoids and other structurally related monoterpenes display a vast array of pharmacological effects that make them potential modulators of the Alzheimer's disease (AD). This review critically evaluates the therapeutic potential of these natural products by assessing key in vitro and in vivo data published in the scientific literature. Mechanistic approach of scrutiny addressing their effects in the Alzheimer's brain including the τ-protein phosphorylation signaling, amyloid beta (Aβ) formation, aggregation, toxicity and clearance along with various effects from antioxidant to antiinflammatory mechanisms are discussed. The drug likeness of these compounds and future prospects to consider in their development as potential leads are addressed.

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Authors
Habtemariam, S.
Affiliations
University of Greenwich (GB)
Corresponding author
Habtemariam, Solomon
Venue
Molecules
Publisher
MDPI AG
Published
2018-01-07
Volume
23
Issue
1
Pages
117
ISSN
1420-3049 (ISSN-L)
OpenAlex
W2782983616
Cited by
55
References
180
Citations by year
2026: 4 · 2025: 4 · 2024: 6 · 2023: 4 · 2022: 6 · 2021: 6 · 2020: 10 · 2019: 9 · 2018: 6
FWCI
1.02
Type
journal article
Language
en
Open access
Locations
  • Molecules (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Greenwich Academic Literature Archive (University of Greenwich) (acceptedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and Biological Activities
Keywords
iridoids, monoterpenes, Alzheimer's disease, natural products, tau phosphorylation, amyloid-beta aggregation, amyloid-beta clearance, antioxidant activity, anti-inflammatory activity, drug-likeness, Alzheimer's disease therapeutics
MeSH terms
Alzheimer Disease, Animals, Brain, Humans, Amyloid beta-Peptides, Neuroprotective Agents, Monoterpenes, Iridoids

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