The DOI matches its Crossref record; 56 of the 56 references it cites were found in a registry or an index.
Neuroprotective Effects of the Green Tea Components Theanine and Catechins
Open accessAbstract
The neuroprotective effects of theanine and catechins contained in green tea are discussed. Although the death of cultured rat cortical neurons was induced by the application of glutamic acid, this neuronal death was suppressed with exposure to theanine. The death of hippocampal CA1 pyramidal neurons caused by transient forebrain ischemia in the gerbil was inhibited with the ventricular preadministration of theanine. The neuronal death of the hippocampal CA3 region by kainate was also prevented by the administration of theanine. Theanine has a higher binding capacity for the AMPA/kainate receptors than for NMDA receptors, although the binding capacity in all cases is markedly less than that of glutamic acid. The results of the present study suggest that the mechanism of the neuroprotective effect of theanine is related not only to the glutamate receptor but also to other mechanisms such as the glutamate transporter, although further studies are needed. One of the onset mechanisms for arteriosclerosis, a major factor in ischemic cerebrovascular disease, is probably the oxidative alteration of low-density lipoprotein (LDL) by active oxygen species. The oxidative alterations of LDL were shown to be prevented by tea catechins. Scavenging of *O(2)(-) was also exhibited by tea catechins. The neuroprotective effects of theanine and catechins contained in green tea are a focus of considerable attention, and further studies are warranted.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Structurally theanine is similar to the excitatory neurotransmitter glutamate which binds to glutamate receptors with weak interaction in the micromolar range, including the a-amino-3hydroxy-5-methyl-4-isoxazolepropionic acid and kainate receptors, and to a lesser extent, the N-methyl-D-aspartic acid receptor [15][16][17][18].”
From l -theanine: A potential multifaceted natural bioactive amide as health supplement (2017) · cites this paper as [17]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Benveniste, H., Drejer, J., Schousboe, A., & Diemer, N. H. (1984) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1984.tb05396.x · Cited by 2,863
Delayed neuronal death in the gerbil hippocampus following ischemia
Kirino, T. (1982) · Brain Research · doi:10.1016/0006-8993(82)90833-2 · Cited by 2,856
Temporal profile of neuronal damage in a model of transient forebrain ischemia
Pulsinelli, W. A., Brierley, J. B., & Plum, F. (1982) · Annals of Neurology · doi:10.1002/ana.410110509 · Cited by 2,688
The Role Of Glutamate Neurotoxicity In Hypoxic-Ischemic Neuronal Death
Choi, D. W., & Rothman, S. M. (1990) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.13.030190.001131 · Cited by 2,210
Book ReviewAmbulatory Pediatric Care
Steinberg, J. B. (1989) · New England Journal of Medicine · doi:10.1056/nejm198901053200122 · Cited by 2,105
Glutamate: A Neurotransmitter in Mammalian Brain
Fonnum, F. (1984) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1984.tb09689.x · Cited by 2,008
Busto, R., Dietrich, W. D., Globus, M. Y. ‐., Valdés, I., Scheinberg, P., & Ginsberg, M. D. (1987) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1987.127 · Cited by 1,786
Ben-Ari, Y. (1985) · Neuroscience · doi:10.1016/0306-4522(85)90299-4 · Cited by 1,753
NMDA-dependent superoxide production and neurotoxicity
Lafon‐Cazal, M., Pietri, S., Culcasi, M., & Bockaert, J. (1993) · Nature · doi:10.1038/364535a0 · Cited by 1,183
Glutamine Synthetase: Glial Localization in Brain
Martinez-Hernandez, A., Bell, K. P., & Norenberg, M. D. (1977) · Science · doi:10.1126/science.14400 · Cited by 1,183
Flagged first, then by citations
Research works printed but not linked: 1
- 49) Yokogoshi H., Kobayashi M., Mochizuki M., Terashima T., Neurochem. Res., 23, 667—673 (1998). · DOI · Paper page
Cited by
Sorted by citations
Beneficial Effects of Green Tea—A Review
Cabrera, C., Artacho, R., & Giménez, R. (2006) · Journal of the American College of Nutrition · doi:10.1080/07315724.2006.10719518 · Cited by 1,904
Mechanisms of action of green tea catechins, with a focus on ischemia-induced neurodegeneration
Sutherland, B. A., Rahman, R. M. A., & Appleton, I. (2005) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2005.10.005 · Cited by 325
“[150] for review).”
Saeed, M., Naveed, M., Arif, M. A., Kakar, M. U., Manzoor, R., El-Hack, M. E. A., Alagawany, M. M., Tiwari, R., Khandia, R., Munjal, A. K., et al. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.09.024 · Cited by 246
Kim, T. I., Lee, Y. K., Park, S. G., Choi, I. S., Ban, J. O., Park, H. K., Nam, S.-Y., Yun, Y. W., Han, S., Oh, K. W., et al. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.09.008 · Cited by 194
Li, C.-F., Zhu, Y., Yu, Y., Zhao, Q.-Y., Wang, S.-J., Wang, X.-C., Yao, M.-Z., Luo, D., Li, X., Chen, L., et al. (2015) · BMC Genomics · doi:10.1186/s12864-015-1773-0 · Cited by 180
“Theanine was reported to act as an antagonist against caffeine-induced paralysis [10–13].”
Background
Metadata
- Authors
- Kakuda, T.
- Affiliations
- Central Research Institute (IN)
- Corresponding author
- Kakuda, Takami
- Venue
- Biological & Pharmaceutical Bulletin
- Publisher
- Pharmaceutical Society of Japan
- Published
- 2002
- Volume
- 25
- Issue
- 12
- Pages
- 1513-1518
- ISSN
- 0918-6158 (ISSN-L)
- 1347-5215
- OpenAlex
- W2085517462
- Cited by
- 165
- References
- 56
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 7 · 2023: 3 · 2022: 5 · 2021: 3 · 2020: 9 · 2019: 7 · 2018: 8 · 2017: 8 · 2016: 6 · 2015: 10 · 2014: 4 · 2013: 9 · 2012: 9
- FWCI
- 0.66
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Biological and Pharmaceutical Bulletin (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Tea Polyphenols and Effects
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Keywords
- theanine, tea catechins, green tea, neuroprotection, glutamate excitotoxicity, transient forebrain ischemia, NMDA receptor, glutamate transporters, superoxide radical scavenging, arteriosclerosis, ischemic cerebrovascular disease
- MeSH terms
- Animals, Catechin, Cell Survival, Glutamates, Humans, Tea, Cell Death, Neuroprotective Agents
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
