Cited by 165Tea Polyphenols and EffectsNeuroscience and Neuropharmacology ResearchMedicinal Plants and Neuroprotection

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Neuroprotective Effects of the Green Tea Components Theanine and Catechins

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Kakuda, Takami·2002·Biological & Pharmaceutical Bulletin

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The neuroprotective effects of theanine and catechins contained in green tea are discussed. Although the death of cultured rat cortical neurons was induced by the application of glutamic acid, this neuronal death was suppressed with exposure to theanine. The death of hippocampal CA1 pyramidal neurons caused by transient forebrain ischemia in the gerbil was inhibited with the ventricular preadministration of theanine. The neuronal death of the hippocampal CA3 region by kainate was also prevented by the administration of theanine. Theanine has a higher binding capacity for the AMPA/kainate receptors than for NMDA receptors, although the binding capacity in all cases is markedly less than that of glutamic acid. The results of the present study suggest that the mechanism of the neuroprotective effect of theanine is related not only to the glutamate receptor but also to other mechanisms such as the glutamate transporter, although further studies are needed. One of the onset mechanisms for arteriosclerosis, a major factor in ischemic cerebrovascular disease, is probably the oxidative alteration of low-density lipoprotein (LDL) by active oxygen species. The oxidative alterations of LDL were shown to be prevented by tea catechins. Scavenging of *O(2)(-) was also exhibited by tea catechins. The neuroprotective effects of theanine and catechins contained in green tea are a focus of considerable attention, and further studies are warranted.

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Authors: Kakuda, T.
Affiliations: Central Research Institute (IN)
Corresponding author: Kakuda, Takami
Venue: Biological & Pharmaceutical Bulletin
Publisher: Pharmaceutical Society of Japan
Published: 2002
Volume: 25
Issue: 12
Pages: 1513-1518
ISSN: 0918-6158 (ISSN-L)
1347-5215
DOI: 10.1248/bpb.25.1513
OpenAlex: W2085517462
Cited by: 165
References: 56
Citations by year: 2026: 3 · 2025: 7 · 2024: 7 · 2023: 3 · 2022: 5 · 2021: 3 · 2020: 9 · 2019: 7 · 2018: 8 · 2017: 8 · 2016: 6 · 2015: 10 · 2014: 4 · 2013: 9 · 2012: 9
FWCI: 0.66
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Biological and Pharmaceutical Bulletin (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Agricultural and Biological Sciences › Food Science › Tea Polyphenols and Effects
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
Keywords: theanine, tea catechins, green tea, neuroprotection, glutamate excitotoxicity, transient forebrain ischemia, NMDA receptor, glutamate transporters, superoxide radical scavenging, arteriosclerosis, ischemic cerebrovascular disease
MeSH terms: Animals, Catechin, Cell Survival, Glutamates, Humans, Tea, Cell Death, Neuroprotective Agents

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Neuroprotective Effects of the Green Tea Components Theanine and Catechins

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