Theanine prevents memory impairment induced by repeated cerebral ischemia in rats
Abstract
The present study investigated the neuroprotective effect of γ‐glutamylethylamide (theanine), a component Japanese green tea (Camellia sinensis), on memory impairment induced by twice‐repeated cerebral ischemia in rats. Theanine was injected i.p. immediately after the first occlusion. Theanine (0.3 and 1 mg/kg) significantly prevented the impairment of spatial memory in rats subjected to repeated cerebral ischemia, 7 days after the second reperfusion. Moreover, theanine (1 mg/kg) significantly inhibited the decrease in the number of surviving cells in the hippocampal CA1 field in the same rats. These results suggest that theanine prevents memory impairment induced by repeated cerebral ischemia, in part by protecting against neuronal cell death, and that it might be useful for preventing cerebrovascular disease. Copyright © 2007 John Wiley & Sons, Ltd.
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L-theanine ameliorates learning and memorizing ability by elimination of acquired memory disorders and oxidative stress, and improves the brain a-wave.
“ameliorates learning and memorizing ability by elimination of acquired memory disorders, oxidative stress, and improves the brain a-wave [66] .”
From l -theanine: A potential multifaceted natural bioactive amide as health supplement (2017) · cites this paper as [66]
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- Authors
- Egashira, N., Ishigami, N., Pu, F., Mishima, K., Iwasaki, K., Orito, K., Oishi, R., & Fujiwara, M.
- Affiliations
- Fukuoka University (JP)
- Kyushu University (JP)
- Corresponding author
- Egashira, Nobuaki
- Venue
- Phytotherapy Research
- Publisher
- Wiley
- Published
- 2007-08-17
- Volume
- 22
- Issue
- 1
- Pages
- 65-68
- ISSN
- 0951-418X (ISSN-L)
- 1099-1573
- OpenAlex
- W2083282968
- Cited by
- 40
- References
- 19
- Citations by year
- 2025: 2 · 2024: 1 · 2022: 1 · 2021: 1 · 2019: 3 · 2018: 3 · 2017: 2 · 2016: 2 · 2015: 3 · 2014: 3 · 2013: 4 · 2012: 5
- FWCI
- 0.85
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Phytotherapy Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Life Sciences › Neuroscience › Neurology › Neurological Disorders and Treatments
- Keywords
- theanine, cerebral ischemia, memory impairment, spatial memory, neuroprotection, neuronal cell death, hippocampal CA1, reperfusion, green tea, Camellia sinensis, cerebrovascular disease
- MeSH terms
- Animals, Brain Ischemia, Dose-Response Relationship, Drug, Glutamates, Injections, Intraperitoneal, Male, Memory Disorders, Tea, Cell Death, Rats, Wistar, Neuroprotective Agents, Maze Learning, Rats
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