Anti-inflammatory effect of Spirulina fusiformis on adjuvant-induced arthritis in mice
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The present study was carried out to evaluate the anti-inflammatory effect of Spirulina fusiformis on adjuvant-induced arthritis in mice. Arthritis was induced by intra dermal injection of complete freund's adjuvant (0.1 ml) into the right hind paw of Swiss albino mice. Spirulina fusiformis (800 mg/kg/b.wt) was orally administered for 8 d (from 11th to 18th day) to arthritic animals after adjuvant injection. The anti-inflammatory activity of Spirulina fusiformis was assessed by measuring paw volume, body weight, levels of lysosomal enzymes, tissue marker enzymes and glycoproteins in control and experimental animals. In adjuvant-induced arthritic animals, the levels of lysosomal enzymes, tissue marker enzymes, glycoproteins and the paw volume were increased significantly. However the body weight was found to be reduced when compared to control animals. Oral administration of Spirulina fusiformis (800 mg/kg/b.wt) significantly altered these above physical and biochemical changes observed in arthritic animals to near normal conditions. Hence results of this study clearly indicate that Spirulina fusiformis has promising anti-inflammatory activity against adjuvant-induced arthritic animals.
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Eating BGA boosts immunity and guards against inflammatory conditions including colitis, arthritis, and allergic rhinitis in animals and people.
“Studies have demonstrated that BGA consumption promotes immunity and protects against inflammatory diseases such as colitis, arthritis, and allergic rhinitis in animals and humans [39–42].”
From Edible blue-green algae reduce the production of pro-inflammatory cytokines by inhibiting NF-κB pathway in macrophages and splenocytes (2013) · cites this paper as [42]
Rasool et al. reported that Spirulina fusiformis supplementation brought inflammatory responses close to normal in mice given an inflammatory inducer.
“In particular, Rasool et al. [42] showed that Spirulina fusiformis supplementation minimized inflammatory response to near normal condition in mice injected with inflammatory inducer.”
From Edible blue-green algae reduce the production of pro-inflammatory cytokines by inhibiting NF-κB pathway in macrophages and splenocytes (2013) · cites this paper as [42]
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- Authors
- Rasool, M., Sabina, E. P., & Lavanya, B.
- Affiliations
- Vellore Institute of Technology University (IN)
- School of Bio-engineering and Biosciences, Vellore Institute of Technology, Deemed University
- ORCID
- Rasool, Mahaboobkhan
- Venue
- Biological and Pharmaceutical Bulletin
- Publisher
- Pharmaceutical Society of Japan
- Published
- 2006
- Volume
- 29
- Issue
- 12
- Pages
- 2483-2487
- ISSN
- 0918-6158 (ISSN-L)
- 1347-5215
- OpenAlex
- W1987129935
- Cited by
- 89
- References
- 34
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 4 · 2023: 9 · 2022: 5 · 2021: 4 · 2020: 4 · 2019: 6 · 2018: 8 · 2017: 2 · 2016: 5 · 2015: 4 · 2014: 5 · 2013: 6 · 2012: 3
- FWCI
- 8.17
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Biological and Pharmaceutical Bulletin (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Health Sciences › Medicine › Complementary and alternative medicine › Natural Compounds in Disease Treatment
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
- Keywords
- anti-inflammatory activity, adjuvant-induced arthritis, complete Freund's adjuvant, lysosomal enzymes, glycoproteins, paw volume, body weight, oral administration
- MeSH terms
- Animals, Anti-Inflammatory Agents, Arthritis, Experimental, Body Weight, Female, Lysosomes, Male, Proteins, Mice, Spirulina
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