Evaluation of protective efficacy of Spirulina platensis against collagen-induced arthritis in rats
Abstract
Aim To assess the protective efficacy of Spirulina platensis against collagen-induced arthritis (CIA) in female Wistar rats based on the changes in paws thickness, serum albumin, cholesterol, lipid peroxidation, alkaline phosphatase and acid phosphatase activities and histology of paw joints.Methods Arthritis was induced by intradermal injection of Collagen and Freund's adjuvant incomplete suspension at several sites on the back with a dose of 2 mg kg(-1) of body weight and boosted with 0.1 ml intradermally at the base of the tail. CIA rats were orally treated with 200 and 400 mg kg(-1) per oral of S. platensis from 0 to 45th day.Results S. platensis at 400 mg kg(-1) per oral significantly elevates serum albumin and decreases the serum cholesterol, alkaline phosphatase and acid phosphatase activities, lipid peroxidation, paw thickness as well as normalize the joint histopathology of CIA rats.Conclusions S. platensis (400 mg kg(-1)) significantly normalizes changes observed in arthritic rats to near normal conditions, indicates that S. platensis has promising protective efficacy against CIA rats.
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In rat models of experimental colitis and arthritis, the antioxidant activity of Spirulina was associated with anti-inflammatory effects.
“In rat models of experimental colitis (acetic-acid induced) [48] and arthritis (Freund's adjuvant-induced [49] and collagen-induced [50]) the antioxidant activity of Spirulina was associated with anti-inflammatory effects.”
From Antioxidant, Immunomodulating, and Microbial‐Modulating Activities of the Sustainable and Ecofriendly <i>Spirulina</i> (2017) · cites this paper as [50]
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- Authors
- Kumar, N., Singh, S., Patro, N., & Patro, I.
- Affiliations
- Jiwaji University (IN)
- Banaras Hindu University (IN)
- Corresponding author
- Patro, Ishan
- Venue
- Inflammopharmacology
- Published
- 2009-04-24
- Volume
- 17
- Issue
- 3
- Pages
- 181-190
- ISSN
- 0925-4692 (ISSN-L)
- 1568-5608
- OpenAlex
- W1986975818
- Cited by
- 59
- References
- 51
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 2 · 2023: 4 · 2022: 8 · 2021: 3 · 2020: 5 · 2018: 7 · 2017: 3 · 2016: 3 · 2015: 2 · 2014: 2 · 2013: 6 · 2012: 4
- FWCI
- 8.15
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Inflammopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Department of Biotechnology, Ministry of Science and Technology, India
- Ministry of Environment
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Natural Compounds in Disease Treatment
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
- Keywords
- Spirulina platensis, collagen-induced arthritis, anti-inflammatory activity, lipid peroxidation, serum cholesterol, serum albumin, alkaline phosphatase, acid phosphatase, joint histopathology, Freund's adjuvant, dietary supplementation
- MeSH terms
- Acid Phosphatase, Alkaline Phosphatase, Animals, Arthritis, Experimental, Biological Products, Cholesterol, Female, Foot Diseases, Joints, Serum Albumin, Lipid Peroxidation, Rats, Wistar, Rats, Spirulina
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