Madecassoside Reduces Ischemia-Reperfusion Injury on Regional Ischemia Induced Heart Infarction in Rat
Open accessAbstract
Madecassoside (MA), one of the principle terpenoids in Centella asiatica, has shown protect effect on isolated rat hearts and isolated cardiomyocytes against reperfusion injury in our previous studies. The aim of this study is to investigate if MA also protected against myocardial ischemia-reperfusion injury in vivo. The ischemia infarction model was established in rats. Left ventricular function was monitored during the ischemia-reperfusion period by a multi-channel recorder. After the ischemia-reperfusion process the infarcted areas were assessed. The levels of lactate dehydrogenase (LDH), creatinephosphokinase (CK), malondialdehyde (MDA), super-oxide dismutase (SOD) and C-reactive protein (CRP) in serum were determined. Cardiomyocytic apoptosis was measured by terminal-deoxynucleotidyl transferase mediated nick end labeling (TUNEL) staining. Pre-treatment with MA (50, 10 mg/kg) attenuated myocardial damage characteristic of decreasing infarct size, decreasing LDH and CK release. Activities of SOD were increased and MDA level increased obviously in control group whereas pretreatment with MA blunted the decrease of SOD activity, markedly reduced the level of MDA and the activity of CRP, and relieved myocardial cell apoptosis. These results suggest that MA has the protective effect on myocardial ischemia-reperfusion injury. This protection ability possibly due to its anti-lipid peroxidation, anti-inflammation and anti-apoptosis function and the enhancement of SOD activity.
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Madecassoside protects rat models against myocardial ischaemia-reperfusion injury-induced infarction through anti-inflammatory, anti-oxidative and anti-apoptosis properties.
“it is seen to protect rat models against myocardial ischaemia–reperfusion injury‐induced infarction through its anti‐inflammatory, anti‐oxidative and anti‐apoptosis properties.”
From Therapeutic Properties and Pharmacological Activities of Asiaticoside and Madecassoside: A Review (2023) · cites this paper as [127]
The Discussion reports that madecassoside significantly reduced ischemia–reperfusion-induced myocardial infarction in rats. It proposes anti-oxidative, anti-inflammatory and anti-apoptosis effects as possible mechanisms, but does not establish that protection occurs through them. (LLM, conf=0.86)
Experimental — accuracy not yet measuredMadecassoside has protective effect on isolated rat hearts and isolated cardiomyocytes against reperfusion injury in vitro, as well as in vivo.
“Madecassoside has a protective effect on isolated rat hearts and isolated cardiomyocytes against reperfusion injury in vitro, as well as in vivo”
From Therapeutic Properties and Pharmacological Activities of Asiaticoside and Madecassoside: A Review (2023) · cites this paper as [127]
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Mohandas Rao, K. G., Muddanna Rao, S., & Gurumadhva Rao, S. (2006) · Evidence-Based Complementary and Alternative Medicine · doi:10.1093/ecam/nel024 · Cited by 103 · see citing works
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Therapeutic Properties and Pharmacological Activities of Asiaticoside and Madecassoside: A Review
Bandopadhyay, S., Mandal, S., Ghorai, M., Jha, N. K., Kumar, M., Radha, Ghosh, A., Proćków, J., Pérez de la Lastra, J. M., & Dey, A. (2023) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.17635 · Cited by 220 · see citing works
Centella asiatica: Secondary metabolites, biological activities and biomass sources
Kunjumon, R., Johnson, A. J., & Baby, S. (2022) · Phytomedicine Plus · doi:10.1016/j.phyplu.2021.100176 · Cited by 79 · see citing works
Tan, S. C., Bhattamisra, S. K., Chellappan, D. K., & Candasamy, M. (2021) · Applied Sciences · doi:10.3390/app11188475 · Cited by 72 · see citing works
- Authors
- Bian, G.-X., Li, G.-G., Yang, Y., Liu, R.-T., Ren, J.-P., Wen, L.-Q., Guo, S.-M., & Lu, Q.-J.
- Affiliations
- Department of Pharmacology and Toxicology, Beijing Institute of Radiation Medicine
- ORCID
- Yang, Yun
- Venue
- Biological and Pharmaceutical Bulletin
- Publisher
- Pharmaceutical Society of Japan
- Published
- 2008
- Volume
- 31
- Issue
- 3
- Pages
- 458-463
- ISSN
- 0918-6158 (ISSN-L)
- 1347-5215
- OpenAlex
- W2067242082
- Cited by
- 50
- References
- 1
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2023: 3 · 2021: 7 · 2020: 1 · 2019: 4 · 2018: 3 · 2017: 2 · 2016: 2 · 2015: 5 · 2014: 3 · 2013: 5 · 2012: 5
- FWCI
- 1.36
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Biological and Pharmaceutical Bulletin (publishedVersion)
- PubMed (publishedVersion)
- Swinburne figshare (Swinburne University of Technology) (submittedVersion)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Cardiac Ischemia and Reperfusion
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Life Sciences › Neuroscience › Neurology › Neurological Disorders and Treatments
- Keywords
- madecassoside, Centella asiatica, myocardial ischemia-reperfusion injury, myocardial infarction, cardioprotection, oxidative stress, lipid peroxidation, superoxide dismutase, malondialdehyde, cardiomyocyte apoptosis, inflammation, C-reactive protein, infarct size
- MeSH terms
- Animals, Cardiotonic Agents, Hemodynamics, Male, Myocardial Infarction, Superoxide Dismutase, Triterpenes, Lipid Peroxidation, Molecular Structure, Myocardial Reperfusion Injury, Ventricular Function, Left, Rats, Wistar, Apoptosis, Centella, Rats
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