Two new polyporusterones isolated from the sclerotia of Polyporus umbellatus
Open accessAbstract
In the course of searching for marker components, two new polyporusterones were isolated from the sclerotia of Polyporus umbellatus, together with another three known analogs. The structures of the new ones were elucidated as (20S,22R,24R)-16,22-epoxy-3beta,14alpha,23beta,25-tetrahydroxyergost-7-en-6-one (1) and (23R,24R,25R)-23,26-epoxy-3beta,14alpha,21alpha,22alpha-tetrahydroxyergost-7-en-6-one (2) by chemical and spectroscopic means, including HR-FAB-MS, 1D- and 2D-NMR.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Five new ecdysteroids, (20S,20R,24R)-16,22-epoxy-3β,14α,23β,25-tetrahydroxyergost-7-en-6-one (206), (23R,24R,25R)-23,26-epoxy-3β,14α,20α,22α-tetrahydroxyergost-7-en-6-one (207), polyporoid A (208), polyporoid B (209), and polyporoid C (210), were isolated from Polyporus umbellatus.
“five new ecdysteroids, (20S,20R,24R)-16,22-epoxy-3β,14α,23β,25-tetrahydroxyergost-7-en-6-one (206), (23R,24R,25R)-23,26-epoxy-3β,14α,20α,22α-tetrahydroxyergost-7-en-6-one (207), polyporoid A (208), polyporoid B (209), and polyporoid C (210) are all isolated from the plant Polyporus umbellatus145,146.”
From The Phytochemical, Biological, and Medicinal Attributes of Phytoecdysteroids: An Updated Review (2021) · cites this paper as [146]
Polyporoids A-C exhibited significant anti-inflammatory activity against TPA-induced inflammation in mice.
“Evaluated anti-inflammatory activity against TPA-induced inflammation in mice and exhibited significant inhibitory activity.”
From The Phytochemical, Biological, and Medicinal Attributes of Phytoecdysteroids: An Updated Review (2021) · cites this paper as [146]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Studies on Constituents of Fruit Body of Polyporus umbellatus and Their Cytotoxic Activity.
Ohsawa, T., YUKAWA, M., TAKAO, C., Murayama, M., & Bando, H. (1992) · Chemical and Pharmaceutical Bulletin · doi:10.1248/cpb.40.143 · Cited by 86 · see citing works
Sarker, S. D., & Nahar, L. (2007) · doi:10.1002/9781118687529.ch6 · Cited by 75 · see citing works
Ogawa, T., & Kasuragi, T. (1982) · Carbohydrate Research · doi:10.1016/s0008-6215(82)80007-4 · Cited by 47 · see citing works
Platelet aggregation potentiators from Cho-Rei.
Lu, W. P., Adachi, I., KANO, K., YASUTA, A., Toriizuka, K., UENO, M., & Horikoshi, I. (1985) · Chemical and Pharmaceutical Bulletin · doi:10.1248/cpb.33.5083 · Cited by 29 · see citing works
Studies on Fungal Polysaccharide. XII. Water-soluble Polysaccharide of Grifora umbellata (FR.) PILAT
Miyazaki, T., & Oikawa, N. (1973) · Chemical and Pharmaceutical Bulletin · doi:10.1248/cpb.21.2545 · Cited by 28 · see citing works
ISHIDA, H., INAOKA, Y., SHIBATANI, J.-I., FUKUSHIMA, M., & Tsuji, K. (1999) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.22.1189 · Cited by 25 · see citing works
Downeyoside A and B, Two New Sulphated Steroid Glucuronides from the Starfish Henricia downeyae
Palagiano, E., Zollo, F., Minale, L., Paloma, L. G., Iorizzi, M., Bryan, P. J., Clintock, J. M., Hopkins, T., Riou, D., & Roussakis, C. (1995) · Tetrahedron · doi:10.1016/0040-4020(95)00775-4 · Cited by 21 · see citing works
Two new Polyporusterones fromPolyorus Umbellatus
Zheng, S.-Z., Yang, H.-P., Ma, X., & Shen, X. (2004) · Natural Product Research · doi:10.1080/14786410310001630528 · Cited by 16 · see citing works
Chemical heterogeneity of .BETA.-D-glucan in sclerotia of Grifora umbellata (Fr.) pilat.
Kato, K., Mutoh, K., Egashira, T., HIURA, M., & Ueno, Y. (1978) · Agricultural and Biological Chemistry · doi:10.1271/bbb1961.42.1073 · Cited by 10 · see citing works
Flagged first, then by citations
Research works printed but not linked: 3
- Xu R.-S., Ye Y., Zhao W.-M., "Natural Product Chemistry," 2nd ed., Science Press, Beijing, 2004, pp. 437-440.
- Cong P.-Z., Li S.-Y., "Natural Organic Mass Spectroscopy," Medical Science and Technology Press, Beijing, 2003, pp. 1185-1191.
- Murayama M., Ohsawa T., Jpn. Patent JP04021696 (1992) [Chem. Abstr., 116, 241924 (1992)].
Cited by
Sorted by citations
Zhao, Y. (2013) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2013.06.031 · Cited by 127 · see citing works
The Phytochemical, Biological, and Medicinal Attributes of Phytoecdysteroids: An Updated Review
Das, N., Mishra, S. K., Bishayee, A., Ali, E. S., & Bishayee, A. (2021) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2020.10.012 · Cited by 115 · see citing works
“Clarke(110), 5b-hydroxypoststerone (140), 14,15-dehydropoststerone 2-acetate (141), poststerone2-acetate (142), 24-epiatrotosterone A (143), ajugasterone C 3-acetate (144), isolated from the plant Cyanotis longifolia(111), callecdysterol A (145), callecdysterol B (146), and callecdysterol C (147), isolated from the pl…”
BackgroundCytotoxic Steroids fromPolyporus umbellatus
Zhao, Y., Xu, C., Zhang, Y., Lin, R., & Sun, W. (2010) · Planta Medica · doi:10.1055/s-0030-1249926 · Cited by 61 · see citing works
Arif, Y., Singh, P., Bajguz, A., & Hayat, S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23158664 · Cited by 50 · see citing works
“(23R,24R,25R)-23,26-epoxy-3β,14α,20α,22αtetrahydroxyergost-7-en-6-one [111]”
Bandara, A. R., Rapior, S., Bhat, D. J., Kakumyan, P., Chamyuang, S., Xu, J., & Hyde, K. D. (2015) · Cryptogamie Mycologie · doi:10.7872/crym.v36.iss1.2015.3 · Cited by 45 · see citing works
Zhao, Y., Cheng, X., Zhang, Y., Zhao, Y., Rui-chao, L., & Sun, W. (2009) · Biomedical Chromatography · doi:10.1002/bmc.1277 · Cited by 38 · see citing works
“umbellatus mainly involve polysaccharides and steroids (Miyazaki and Oikawa, 1973; Ohsawa et al., 1992; Zheng et al., 2004; Zhou et al., 2007; Sun and Yasukawa, 2008), and they are often considered as important bioactive substances.”
BackgroundGu, B., Wu, W., Jiao, F.-R., Jiao, W., Li, L., Sun, F., Wang, S., Yang, F., & Lin, H. (2018) · Organic Letters · doi:10.1021/acs.orglett.8b03530 · Cited by 34 · see citing works
Gu, B., Wu, W., Jiao, F.-R., Jiao, W., Li, L., Sun, F., Wang, S., Yang, F., & Lin, H. (2018) · The Journal of Organic Chemistry · doi:10.1021/acs.joc.8b02679 · Cited by 28 · see citing works
Cytotoxic steroids from the Vietnamese gorgonian Verrucella corona
Nam, N. H., Ngoc, N. T., Hạnh, T. T. H., Cường, N. X., Thành, N. V., Thảo, Đ. T., Thung, Đ. C., Kiệm, P. V., & Minh, C. V. (2018) · Steroids · doi:10.1016/j.steroids.2018.06.006 · Cited by 25 · see citing works
“The relative configurations at C-16, C-17, C-20, and C-22 of 4 were suggested to be identical to those of (20S,22R,24R)-16,22-epoxy3β,14α,23β,25-tetrahydroxyergost-7-en-6-one [20] by agreement of their (13)C NMR data and also supported by NOESY experiment.”
Zhao, Y., Zhao, Y., Zhang, Y., Lin, R., Lin, R.-C., & Sun, W. (2009) · Die Pharmazie · doi:10.31083/ph.2009.8364 · Cited by 22 · see citing works
1β-hydroxylfriedelin, a new natural pentacylic triterpene from the sclerotia of Polyporus umbellatus
Zhao, Y., Yang, L., Wang, M., Wang, L., Cheng, X., Zhang, Y., Lin, R., & Sun, W. (2009) · Journal of Chemical Research · doi:10.3184/030823409x12562954717147 · Cited by 19 · see citing works
Gao, W., Zhang, L., Wu, J., Xu, Y., Qi, S., Liu, W., Liu, P., Shi, S., Wang, H., Zhang, Q., et al. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.123252 · Cited by 17 · see citing works
Dinan, L. N., Mamadalieva, N. Z., & Lafont, R. (2019) · Springer eBooks · doi:10.1007/978-981-13-1745-3_35-1 · Cited by 15 · see citing works
Fungal species residing in the sclerotia of Polyporus umbellatus
Xing, X., Ma, X., & Guo, S. (2012) · Symbiosis · doi:10.1007/s13199-012-0155-5 · Cited by 10 · see citing works
“umbellatus has been well elucidated in recent years (Zheng et al. 2004; Zhou et al. 2007; Zhao et al. 2009, 2010) but the bio-activities of most of the isolated compounds have been focused on anti-tumor and other pharmaceutical activities.”
BackgroundPolyporus umbellatus , A Precious Rare Fungus With Good Pharmaceutical and Food Value
Ren, S., Hua, L., Sang, Q., Sun, Y., Li, L., & Chen, W. (2025) · Engineering in Life Sciences · doi:10.1002/elsc.202400048 · Cited by 8 · see citing works
Sclerotium-Forming Mushrooms as an Emerging Source of Medicinals
Lau, B. F., & Abdullah, N. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802794-3.00007-2 · Cited by 8 · see citing works
Huang, Z.-H., Xiao, L., Gu, Q., Ma, X., & Qi, S. (2022) · Phytochemistry · doi:10.1016/j.phytochem.2022.113511 · Cited by 8 · see citing works
Dinan, L. N., Mamadalieva, N. Z., & Lafont, R. (2021) · Springer eBooks · doi:10.1007/978-981-15-4148-3_35 · Cited by 5 · see citing works
Tao, H., Li, Y., Lin, X., Zhou, X., Dong, J., Liu, Y., & Yang, B. (2018) · Natural Product Communications · doi:10.1177/1934578x1801301214 · Cited by 5 · see citing works
“These observed data suggested that 1 was an ergostane-type pentacyclic steroid, and closely resembled those of polyporoid A [7] and (20S,22R,24R)16,22-epoxy-3β,14α,23β,25-tetrahydroxyergost-7-en-6-one [8].”
ResultGao, W., Xu, Y., Chen, W., Wu, J., & He, Y. (2025) · Food Chemistry X · doi:10.1016/j.fochx.2025.102161 · Cited by 4 · see citing works
Pharmacokinetics and tissue distribution of ergosterol in rats
Song, M., & Bao, H. (2015) · European Journal of BioMedical Research · doi:10.18088/ejbmr.1.4.2015.pp1-6 · Cited by 3 · see citing works
“Steroids are a major chemical component of fungi (1-4) and have been reported to possess anticancer (5,6), antimicrobial (7), diuretic (8), antioxidant (9) and immunosuppressive activities (10).”
BackgroundLiu, M., Xing, Y.-M., & Guo, S. (2015) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b15-00274 · Cited by 2 · see citing works
Terpenes and Steroids in Fungi Used in the Daily Diet
Tomou, E., Barda, C., Lymperis, P., Lytra, K., & Skaltsa, H. D. (2022) · Royal Society of Chemistry eBooks · doi:10.1039/9781839167522-00273 · Cited by 1 · see citing works
Phytosteroids from Roots of Psammosilene tunicoides W.C.Wu et C.Y.Wu
Li, Y., Wang, Z., Li, H., Li, Y., Nie, K., Yang, X., Bai, X., & Huang, X. (2024) · Records of Natural Products · doi:10.25135/rnp.444.2312.2991 · Cited by 1 · see citing works
“The IR absorption spectrum indicated the presence of hydroxyl (3444 cm −1 ) and , -unsaturated cyclic ketone (1632 cm −1 ) [22].”
BackgroundNgoc, N. B., Kim, S., Youn, H., Min, H., Le, T. T., Rizki, M. I., Kim, D. W., Hyeon, K., Park, Y. T., Jung, S. H., et al. (2025) · Applied Biological Chemistry · doi:10.1186/s13765-025-01014-9 · Cited by 1 · see citing works
“PU treatment attenuated DEX-induced C2C12 myotube atrophy by downregulating the key E3 ubiquitin ligase Fbxo32 and upregulating Myh2 and crucial myogenic regulatory factors (MRFs) [9, 10, 45, 46].”
Polyporusterone J (22,23-Epoxy-3β,14α,20β,24β-Tetrahydroxy-7-en-6-one)
(2012) · Springer eBooks · doi:10.1007/978-1-4614-0543-6_340
16,22-Epoxy-3β,14α,23β,25-Tetrahydroxyergost-7-en-6-one
Azimova, S. S. (2012) · Springer eBooks · doi:10.1007/978-1-4614-0543-6_208
23,26-Epoxy-3β,14α,21α,22α-Tetrahydroxyergost-7-en-6-one
(2012) · Springer eBooks · doi:10.1007/978-1-4614-0543-6_209
Polyporusterone H (16,22-Epoxy-3β,14α,23β,25-Tetrahydroxyergost-7-en-6-one)
(2012) · Springer eBooks · doi:10.1007/978-1-4614-0543-6_338
Polyporusterone I (23,26-Epoxy-3β,14α,21α,22α-Tetrahydroxyergost-7-en-6-one)
Azimova, S. S. (2012) · Springer eBooks · doi:10.1007/978-1-4614-0543-6_339
ChemInform Abstract: Two New Polyporusterones Isolated from the Sclerotia of Polyporus umbellatus.
Zhou, W., Lin, W., & Guo, S. (2007) · ChemInform · doi:10.1002/chin.200801182
(2012) · Springer eBooks · doi:10.1007/978-1-4614-0543-6_49
Park, J., Lee, D. Y., Mariano, E., Choi, Y., Han, D., Kim, J. S., Park, J. W. P. J. W., Namkung, S., Lee, S. Y., Lee, H. W., et al. (2026) · Food Science of Animal Resources · doi:10.1007/s44463-025-00003-2
A review of pentacyclic triterpenoids derived from macrofungi and their biological activities
Jia, Z., Liu, Y., Zhang, T., Wang, Z., Zhao, L., Zhang, N., Wang, H., Khassanov, V. T., Gao, Z., Du, C., et al. (2026) · Food Bioscience · doi:10.1016/j.fbio.2026.108781
Lin, Y.-X., Wu, J.-T., Meng, X., Guo, J., Hao, Z., Pan, J., Guan, W., Chen, Q.-S., Zhang, L.-L., Kuang, H., et al. (2026) · Journal of Molecular Structure · doi:10.1016/j.molstruc.2026.146286
Spectroscopic Techniques for the Characterization of Ecdysteroids
Pogam, P. L., & Beniddir, M. A. (2026) · Springer eBooks · doi:10.1007/978-981-95-8423-9_2
- Authors
- Zhou, W.-W., Lin, W.-H., & Guo, S.-X.
- Affiliations
- Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College
- State Key Laboratory of Natural and Biomimetic Drugs, Peking University
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Venue
- Chemical and Pharmaceutical Bulletin
- Publisher
- Pharmaceutical Society of Japan
- Published
- 2007
- Volume
- 55
- Issue
- 8
- Pages
- 1148-1150
- ISSN
- 0009-2363 (ISSN-L)
- 1347-5223
- OpenAlex
- W2085977005
- Cited by
- 36
- References
- 9
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 1 · 2023: 1 · 2022: 3 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 4 · 2016: 1 · 2015: 3 · 2013: 1 · 2012: 7
- FWCI
- 1.11
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Chemical and Pharmaceutical Bulletin (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (30470042)
- Beijing Normal University
- Topics
- Health Sciences › Medicine › Pharmacology › Fungal Biology and Applications
- Health Sciences › Medicine › Pharmacology › Microbial Natural Products and Biosynthesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Steroid Chemistry and Biochemistry
- Keywords
- Polyporus umbellatus, sclerotia, fungal secondary metabolites, ergostane derivatives, natural product isolation, structure elucidation, marker components
- MeSH terms
- Chromatography, High Pressure Liquid, Ergosterol, Kinetics, Molecular Conformation, Magnetic Resonance Spectroscopy, Polyporaceae, Spectrophotometry, Infrared, Spectrophotometry, Ultraviolet, Spectrometry, Mass, Fast Atom Bombardment
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
