Pharmacokinetics and biodistribution of paclitaxel-loaded pluronic P105/L101 mixed polymeric micelles
Open accessAbstract
A mixed polymeric micelle formulation of paclitaxel (PTX) has been developed with the purpose of improving the solubility and prolonging the time of blood circulation of PTX in comparison to current Taxol injection. The mixed micelles were prepared by thin-film method using a nonionic surfactant Pluronic P105, L101 and PTX. The mean size of PTX-loaded mixed micelles was 185 nm with narrow size distribution shown by a dynamic light scattering sizer and a transmission electron microscopy. The in vitro release profiles indicated that PTX release from the mixed micelles exhibited a sustained release behavior. A similar phenomenon was also observed in a pharmacokinetic assessment in rats, in which t(1/2beta) and AUC of the mixed micelle formulation were 5.5 and 4.9-fold higher than that of Taxol injection. The biodistribution study in mice showed that the PTX-loaded mixed micelles not only decreased drug uptake by liver, but also prolonged drug retention in blood, and increased distribution of the drug in lung, spleen and kidney. These results suggested that the mixed polymeric micelles may efficiently load, protect and retain PTX in both in vitro and in vivo environments, and could be a useful drug carrier for intravenous administration of PTX.
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When PTX-loaded pluronic P105 micelles were compared with mixed micelles composed of a similar copolymer with just the addition of hydrophobic lamella, a strong decrease in clearance was observed.
“For example, when PTX-loaded pluronic P105 micelles were compared with mixed micelles composed of a similar copolymer with just the addition of hydrophobic lamella, a strong decrease in clearance was observed [95].”
From Recent Advances in Nanomicelles Delivery Systems. (2020) · cites this paper as [95]
The Discussion (page not available) says that adding hydrophobic L101 to P105 micelles did not significantly change their in vivo behavior. Table 2 reports a strong clearance decrease for the mixed micelles relative to Taxol injection, not relative to P105 micelles as the citing sentence claims. (LLM, conf=0.89)
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- Authors
- WANG, Y., LI, Y., WANG, Q., WU, J., & FANG, X.
- Affiliations
- Anhui University (CN)
- Fudan University (CN)
- Venue
- YAKUGAKU ZASSHI
- Publisher
- Pharmaceutical Society of Japan
- Published
- 2008-06-01
- Volume
- 128
- Issue
- 6
- Pages
- 941-950
- ISSN
- 0031-6903 (ISSN-L)
- 1347-5231
- OpenAlex
- W2054486226
- Cited by
- 29
- References
- 27
- Citations by year
- 2022: 1 · 2021: 1 · 2020: 4 · 2019: 1 · 2018: 3 · 2017: 1 · 2016: 2 · 2015: 4 · 2013: 3 · 2012: 2
- FWCI
- 1.00
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- YAKUGAKU ZASSHI (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Anhui University
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Drug Solubulity and Delivery Systems
- Keywords
- paclitaxel, polymeric micelles, Pluronic P105, mixed micelles, pharmacokinetics, tissue distribution, sustained drug release, drug solubility enhancement, blood circulation time, intravenous drug delivery, drug carriers
- MeSH terms
- Animals, Chemistry, Pharmaceutical, Drug Carriers, Female, Mice, Inbred Strains, Micelles, Particle Size, Polymers, Solubility, Technology, Pharmaceutical, Tissue Distribution, Rats, Sprague-Dawley, Paclitaxel, Poloxamer, Mice, Rats
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