. Sedentary behavior and health: update from the 2018 Physical Activity Guidelines Advisory Committee
Open accessAbstract
PURPOSE: To provide an overview of relationships between sedentary behavior and mortality as well as incidence of several noncommunicable diseases and weight status reported in the 2018 Physical Activity Guidelines Advisory Committee Scientific Report (2018 PAGAC Scientific Report), and to update the evidence from recent studies. METHODS: Evidence related to sedentary behavior in the 2018 PAGAC Scientific Report was summarized, and a systematic review was undertaken to identify original studies published between January 2017 and February 2018. RESULTS: The 2018 PAGAC Scientific Report concluded there was strong evidence that high amounts of sedentary behavior increase the risk for all-cause and cardiovascular disease (CVD) mortality and incident CVD and type 2 diabetes. Moderate evidence indicated sedentary behavior is associated with incident endometrial, colon and lung cancer. Limited evidence suggested sedentary behavior is associated with cancer mortality and weight status. There was strong evidence that the hazardous effects of sedentary behavior are more pronounced in physically inactive people. Evidence was insufficient to determine if bout length or breaks in sedentary behavior are associated with health outcomes. The new literature search yielded seven new studies for all-cause mortality, two for CVD mortality, two for cancer mortality, four for type 2 diabetes, one for weight status, and four for cancer; no new studies were identified for CVD incidence. Results of the new studies supported the conclusions in the 2018 PAGAC Scientific Report. CONCLUSIONS: The results of the updated search add further evidence on the association between sedentary behavior and health. Further research is required on how sex, age, race/ethnicity, socioeconomic status, and weight status may modify associations between sedentary behavior and health outcomes.
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Prolonged daily sedentary time is associated with higher risk of incident cardiovascular disease or all-cause or cardiovascular disease mortality, regardless of physical activity level.
“prolonged daily sedentary time is associated with a higher risk of incident CVD or of all-cause or CVD mortality, regardless of PA level.[10][11][12][13][14][15][16]”
From Exercise benefits in cardiovascular diseases: From mechanisms to clinical implementation (2023) · cites this paper as [11]
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- Authors
- KATZMARZYK, P. T., POWELL, K. E., JAKICIC, J. M., TROIANO, R. P., PIERCY, K., & TENNANT, B.
- Affiliations
- Pennington Biomedical Research Center (US)
- Centers for Disease Control and Prevention (US)
- University of Pittsburgh (US)
- National Cancer Institute (US)
- Office of Disease Prevention and Health Promotion (US)
- ICF International (United States) (US)
- Venue
- Medicine & Science in Sports & Exercise
- Published
- 2019-06
- Volume
- 51
- Issue
- 6
- Pages
- 1227-1241
- ISSN
- 0195-9131 (ISSN-L)
- 1530-0315
- PMC
- PMC6527341
- OpenAlex
- W2946584885
- Cited by
- 616
- References
- 38
- Citations by year
- 2026: 55 · 2025: 98 · 2024: 105 · 2023: 104 · 2022: 93 · 2021: 92 · 2020: 52 · 2019: 17
- FWCI
- 7.46
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Medicine & Science in Sports & Exercise (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (Z99 CA999999)
- Topics
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
- Health Sciences › Medicine › Oncology › Cancer Risks and Factors
- Keywords
- sedentary behavior, physical activity guidelines, all-cause mortality, cardiovascular mortality, cancer mortality, type 2 diabetes, non-communicable diseases, weight status, cancer incidence, physical inactivity
- MeSH terms
- Cardiovascular Diseases, Diabetes Mellitus, Type 2, Health Status, Humans, Mortality, Neoplasms, Obesity, Exercise, Incidence, Practice Guidelines as Topic, Advisory Committees, Risk Reduction Behavior, Sedentary Behavior
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