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The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.

Metabolic Flexibility during Exercise in Children with Obesity and Matched Controls

CHU, LISA, MORRISON, KATHERINE M., RIDDELL, MICHAEL C., RAHA, SANDEEP, TIMMONS, BRIAN W.·2021·Medicine & Science in Sports & Exercise
DOI 10.1249/mss.0000000000002428
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Abstract

Background: Impaired metabolic flexibility (MetFlex) could contribute to ectopic fat accumulation and pathological conditions, such as type 2 diabetes. MetFlex refers to the ability to adapt substrate oxidation to availability. To the best of our knowledge, no studies have examined MetFlex under exercise conditions in children with obesity (OB) compared with a control group (CON) without obesity. Therefore, the primary objective was to compare MetFlex during exercise in children with OB compared with CON matched for chronological age, sex, and biological maturation. A better understanding of MetFlex could help elucidate its role in the pathogenesis of childhood obesity and insulin resistance. Methods: Children with obesity and without obesity age 8 to 17 yr attended two visits, which included anthropometric measurements, blood work (OB group only), a maximal aerobic fitness (V˙O 2max ) test, and MetFlex test with a 13 C-enriched carbohydrate (1.75 g per kg of body mass, up to 75 g) ingested before 60 min of exercise at 45% V˙O 2max . Breath measurements were collected to calculate exogenous CHO (CHO exo ) oxidative efficiency as a measure of MetFlex. Results: CHO exo oxidative efficiency (CHO exo oxidized/CHO ingested × 100) during exercise was significantly lower in OB (17.3% ± 4.0%) compared with CON (22.6% ± 4.7%, P < 0.001). CHO exo contributed less to total energy expenditure during exercise in OB compared with CON ( P < 0.001), whereas the contribution of endogenous CHO ( P = 0.19) and total fat was not significantly different ( P = 0.91). Conclusions: The ability to oxidize oral CHO, an indicator of MetFlex, was 23.5% lower in children with obesity compared with controls, independent of age, sex, and pubertal effects. Thus, obesity at a young age could be associated with reduced MetFlex and future comorbidities.

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Metadata

Authors
CHU, L., MORRISON, K. M., RIDDELL, M. C., RAHA, S., & TIMMONS, B. W.
Venue
Medicine & Science in Sports & Exercise
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2020-06-10
Volume
53
Issue
1
Pages
159-164
ISSN
  • 1530-0315
  • 0195-9131
DOI
10.1249/mss.0000000000002428
Cited by
4
References
7
Language
en

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CoChat. (2026). Citation check: Metabolic Flexibility during Exercise in Children with Obesity and Matched Controls. https://app.cochat.ai/papers/10.1249/mss.0000000000002428
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CHU, L., MORRISON, K. M., RIDDELL, M. C., RAHA, S., & TIMMONS, B. W. (2021). Metabolic Flexibility during Exercise in Children with Obesity and Matched Controls. Medicine & Science in Sports & Exercise. https://doi.org/10.1249/mss.0000000000002428

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