Oxidation of nonplasma fatty acids during exercise is increased in women with abdominal obesity
Open accessAbstract
We evaluated plasma fatty acid availability and plasma and whole body fatty acid oxidation during exercise in five lean and five abdominally obese women (body mass index = 21 ± 1 vs. 38 ± 1 kg/m 2), who were matched on aerobic fitness, to test the hypothesis that obesity alters the relative contribution of plasma and nonplasma fatty acids to total energy production during exercise. Subjects exercised on a recumbent cycle ergometer for 90 min at 54% of their peak oxygen consumption. Stable isotope tracer methods ([13 C]palmitate) were used to measure fatty acid rate of appearance in plasma and the rate of plasma fatty acid oxidation, and indirect calorimetry was used to measure whole body substrate oxidation. During exercise, palmitate rate of appearance increased progressively and was similar in obese and lean groups between 60 and 90 min of exercise [3.9 ± 0.4 vs. 4.0 ± 0.3 μmol · kg fat free mass (FFM)−1 · min−1]. The rate of plasma fatty acid oxidation was also similar in obese and lean subjects (12.8 ± 1.7 vs. 14.5 ± 1.8 μmol · kg FFM−1 · min−1; P = not significant). However, whole body fatty acid oxidation during exercise was 25% greater in obese than in lean subjects (21.9 ± 1.2 vs. 17.5 ± 1.6 μmol · kg FFM−1 · min−1; P < 0.05). These results demonstrate that, although plasma fatty acid availability and oxidation are similar during exercise in lean and obese women, women with abdominal obesity use more fat as a fuel by oxidizing more nonplasma fatty acids.
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Athletes display lower spontaneous lipolysis than untrained individuals.
“Athletes display lower spontaneous lipolysis than untrained individuals (233).”
From Sex differences in the metabolism of glucose and fatty acids by adipose tissue and skeletal muscle in humans (2025) · cites this paper as [233]
The introduction compares fatty-acid metabolism in lean and abdominally obese subjects, while the Discussion addresses regulation of lipolysis during exercise (page numbers unavailable). Neither reports spontaneous lipolysis in athletes versus untrained individuals; searches for athletes, training, and basal or resting lipolysis found no such comparison. (LLM, conf=0.73)
Experimental — accuracy not yet measuredLipid oxidation during exercise was higher in obese/insulin-resistant than lean subjects.
“On the other hand, lipid oxidation during exercise was higher in obese/insulin-resistant vs. lean subjects (14,16).”
From Metabolic flexibility to lipid availability during exercise is enhanced in individuals with high insulin sensitivity (2018) · cites this paper as [16]
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- Authors
- Horowitz, J. F., & Klein, S.
- Affiliations
- Washington University in St. Louis (US)
- Venue
- Journal of Applied Physiology
- Publisher
- American Physiological Society
- Published
- 2000-12-01
- Volume
- 89
- Issue
- 6
- Pages
- 2276-2282
- ISSN
- 0161-7567 (ISSN-L)
- 8750-7587
- 1522-1601
- OpenAlex
- W2110221236
- Cited by
- 85
- References
- 49
- Citations by year
- 2026: 1 · 2025: 4 · 2023: 4 · 2022: 9 · 2021: 4 · 2020: 4 · 2019: 1 · 2018: 3 · 2017: 1 · 2016: 5 · 2015: 3 · 2013: 3 · 2012: 1
- FWCI
- 1.42
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Applied Physiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsches Krebsforschungszentrum
- National Institutes of Health (5p41rr000954-34, RR‐00036)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK37948, R01DK037948)
- National Center for Research Resources (RR 00954, RR.00036)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Keywords
- abdominal obesity, fatty acid oxidation, physical activity, plasma fatty acids, fat oxidation, women, energy metabolism
- MeSH terms
- Abdomen, Adult, Bicycling, Fatty Acids, Female, Glycerol, Hormones, Humans, Kinetics, Obesity, Osmolar Concentration, Oxidation-Reduction, Exercise
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